GO:0051010

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Name microtubule plus-end binding
Categary Function
Go Slim No
Go Link GO:0051010
Unique Molecular Interactions 158
Total Molecular Interactions 208
Total Single Events 1224
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for microtubule plus-end binding. They are ordered first by their pain relevance and then by number of times they were reported for microtubule plus-end binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
2 INT253836 Cck Regulation of DST 1 0.03 0.42 0.95
3 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
4 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
5 INT253835 Binding of DST and Fos 1 0.02 0 0.55
6 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
7 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
8 INT335594 Myo5a Regulation of Hmmr 1 0.00 0.39 0.45
9 INT244421 Binding of DST and Ctss 1 0.02 0.42 0.41
10 INT67633 Binding of DST and Gabrd 1 0.03 0 0.41
11 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
12 INT227943 Binding of Vip and Mlph 1 0.01 0.33 0.36
13 INT25526 Dst Regulation of Gh 1 0.00 0.26 0.34
14 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
15 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
16 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
17 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
18 INT244422 Binding of DST and Fig4 1 0.01 0.42 0.29
19 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
20 INT291641 Binding of DST and ESRRG 1 0.16 1.8 0.28
21 INT154834 Stim1 Regulation of Regulation of Ca2 1 0.13 0.9 0.28
22 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
23 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
24 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
25 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
26 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
27 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
28 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
29 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
30 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
31 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
32 INT237824 Stim1 Positive_regulation of soc 1 0.26 1.25 0.21
33 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
34 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
35 INT291642 Binding of DST and GGT1 1 0.00 1.4 0.19
36 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18
37 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
38 INT274353 DST Regulation of Gopc 1 0.00 0 0.17
39 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
40 INT291644 Binding of DST and ESR1 1 0.05 0.84 0.14
41 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
42 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
43 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
44 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
45 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
46 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
47 INT262255 Binding of APC and F2R 1 0.05 3 0.1
48 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09
49 INT214166 DST Negative_regulation of Gene_expression of Npy 1 0.02 0.07 0.09
50 INT311083 DST Regulation of FOS 1 0.03 0.15 0.08
51 INT237825 Binding of soc and Stim1 1 0.21 0.29 0.08
52 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
53 INT237822 Binding of Stim1 and Trpc1 1 0.54 0.27 0.08
54 INT237808 Binding of Stim1 and Trpv1 1 0.01 0.3 0.08
55 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
56 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
57 INT237811 Binding of Esr1 and Stim1 1 0.09 0 0.07
58 INT237821 Binding of Tmie and Stim1 1 0.08 0 0.07
59 INT237823 Binding of Atp2a2 and Stim1 1 0.06 0 0.07
60 INT57965 Myo5a Negative_regulation of Cyp2e1 1 0.01 0.09 0.07
61 INT237815 Binding of Itpr3 and Stim1 1 0.04 0 0.07
62 INT135641 Binding of Dst and Ina 1 0.35 0.34 0.06
63 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
64 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
65 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
66 INT215244 Binding of Racgap1 and Mlph 1 0.04 0.76 0.04
67 INT311082 DST Regulation of MAPK8 1 0.02 0.07 0.04
68 INT214167 Binding of DST and Pomc 1 0.03 0.22 0.03
69 INT214171 Binding of DST and Cartpt 1 0.01 0.21 0.03
70 INT66339 LIF Positive_regulation of Phosphorylation of CLIP2 1 0.45 1.57 0
71 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
72 INT292511 Mlph Regulation of AKT1 1 0.01 0.21 0
73 INT292503 Mlph Regulation of Gene_expression of BCL2 1 0.00 0.4 0
74 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0
75 INT292500 Mlph Regulation of Gene_expression of BAX 1 0.00 0.4 0
76 INT240420 Myo5a Positive_regulation of CD4 1 0.06 0.27 0
77 INT199367 DST Regulation of Igf2 1 0.03 1.03 0
78 INT282331 Binding of DST and Gopc 1 0.01 0.61 0
79 INT292497 Mlph Positive_regulation of Phosphorylation of PTK2 1 0.05 7.24 0
80 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
81 INT292498 Mlph Regulation of Phosphorylation of PTK2 1 0.02 0.33 0
82 INT292514 Mlph Regulation of Positive_regulation of AKT1 1 0.01 0.42 0
83 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
84 INT199368 DST Positive_regulation of Gene_expression of Igf2 1 0.04 1.51 0
85 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
86 INT250316 Mlph Positive_regulation of Regulation of Ccr9 1 0.01 0.11 0
87 INT199371 DST Regulation of Transcription of Igf2 1 0.05 1.47 0
88 INT282330 Binding of DST and Arc 1 0.04 1.1 0
89 INT199366 DST Positive_regulation of Macf1 1 0.01 1.14 0
90 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
91 INT249164 Negative_regulation of CA2 Positive_regulation of Gene_expression of STIM1 1 0.14 0 0
92 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0
93 INT292502 Mlph Regulation of Gene_expression of BAD 1 0.01 0.4 0
94 INT301674 Binding of APC and CD80 1 0.01 0.53 0
95 INT292507 Mlph Regulation of Gene_expression of GEM 1 0.01 0.74 0
96 INT199370 DST Regulation of Gene_expression of Igf2 1 0.02 1.07 0
97 INT195661 Binding of APC and PROC 1 0.23 0.89 0
98 INT199369 DST Regulation of Igf1 1 0.02 0.8 0
99 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0
100 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0
101 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0
102 INT292495 Mlph Regulation of Gene_expression of PTK2 1 0.03 0.21 0
103 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
104 INT301677 Binding of APC and CD8A 1 0.03 1.48 0
105 INT292494 Mlph Positive_regulation of Phosphorylation of AKT1 1 0.01 0.84 0
106 INT66342 LIF Positive_regulation of Phosphorylation of CLIP1 1 0.60 1.57 0
107 INT292508 Mlph Regulation of Phosphorylation of BAD 1 0.01 1.52 0
108 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
109 INT268395 Binding of APC and Kras 1 0.04 1.21 0
110 INT282329 Regulation of Binding of DST and Arc 1 0.03 0.35 0
111 INT292510 Mlph Regulation of Gene_expression of GOPC 1 0.00 0.41 0
112 INT292501 Mlph Positive_regulation of Phosphorylation of BAD 1 0.01 0.39 0
113 INT213009 Hdl1 Positive_regulation of Positive_regulation of Apc 1 0.09 1.14 0
114 INT292504 Mlph Regulation of EIF2AK3 1 0.00 0.21 0
115 INT292499 Mlph Positive_regulation of AKT1 1 0.01 0.87 0
116 INT80660 INS Positive_regulation of APC 1 0.32 0.65 0
117 INT283362 AXIN2 Negative_regulation of APC 1 0.10 1.67 0
118 INT292506 Mlph Regulation of PTK2 1 0.01 0.21 0
119 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0
120 INT292496 Mlph Regulation of MAPK1 1 0.00 0.21 0
121 INT195659 APC Positive_regulation of Gene_expression of PROC 1 0.26 0.31 0
122 INT274622 Binding of CLIP1 and Amph 1 0.40 0 0
123 INT213025 Vtn Positive_regulation of Apc 1 0.01 1.19 0
124 INT292513 Mlph Regulation of Gene_expression of AKT1 1 0.01 0.21 0
125 INT213054 Hdl1 Regulation of Apc 1 0.05 1.24 0
126 INT274581 Binding of CLIP1 and BFAR 1 0.15 0 0
127 INT80659 Positive_regulation of INS Positive_regulation of APC 1 0.32 0.65 0
128 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0
129 INT292509 Mlph Positive_regulation of CALM1 1 0.00 0.4 0
130 INT292493 Mlph Regulation of Gene_expression of MAPK1 1 0.00 0.21 0
131 INT131787 Binding of Myo5a and Pon1 1 0.02 0.06 0
132 INT291643 Binding of DST and INS 1 0.07 0.38 0
133 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0
134 INT341501 Binding of Apc and Pdcd1 1 0.00 0.52 0
135 INT292492 Mlph Regulation of Gene_expression of Birc5 1 0.04 1.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for microtubule plus-end binding. They are ordered first by their pain relevance and then by number of times they were reported in microtubule plus-end binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT67101 Gene_expression of DST 47 0.54 25.92 9.59
2 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
3 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
4 INT38644 Positive_regulation of DST 30 0.53 12.48 6.59
5 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
6 INT114993 Binding of Myo5a 15 0.30 11.46 5.48
7 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
8 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
9 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
10 INT63121 Binding of APC 29 0.41 23.02 3.8
11 INT11761 Negative_regulation of DST 13 0.42 7.66 3.65
12 INT102076 Regulation of DST 15 0.22 10 3.5
13 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16
14 INT3818 Regulation of Apc 13 0.39 12.52 1.68
15 INT135640 Negative_regulation of Dst 5 0.57 2.25 1.56
16 INT220177 Binding of Apc 21 0.37 15.34 1.37
17 INT311241 Transcription of Myo5a 1 0.50 1.61 1.37
18 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
19 INT38645 Negative_regulation of Positive_regulation of DST 3 0.29 1.05 1.29
20 INT101027 Binding of DST 20 0.41 10.9 1.17
21 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
22 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
23 INT227935 Gene_expression of Mlph 4 0.08 0.51 0.94
24 INT192785 Regulation of Myo5a 4 0.05 9.05 0.93
25 INT242134 Localization of Apc 8 0.74 4.83 0.88
26 INT154833 Regulation of Stim1 3 0.27 1.56 0.88
27 INT57958 Positive_regulation of Myo5a 9 0.41 7.52 0.77
28 INT57062 Regulation of APC 24 0.58 14.3 0.7
29 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
30 INT244420 Positive_regulation of Gene_expression of DST 4 0.41 2.05 0.59
31 INT154830 Binding of Stim1 1 0.48 1.48 0.56
32 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
33 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
34 INT214136 Localization of DST 7 0.65 2.59 0.42
35 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
36 INT215830 Gene_expression of Stim1 3 0.32 0 0.4
37 INT135638 Binding of Dst 4 0.36 2.76 0.38
38 INT200744 Regulation of Gene_expression of DST 5 0.20 2.64 0.36
39 INT195574 Localization of Myo5a 4 0.34 1.1 0.36
40 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
41 INT118243 Transcription of APC 4 0.45 3.33 0.33
42 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
43 INT225667 Transcription of Apc 3 0.52 3.73 0.32
44 INT75628 Gene_expression of Dst 4 0.60 0.78 0.31
45 INT195672 Localization of APC 7 0.74 3.76 0.3
46 INT309066 Regulation of Gene_expression of Stim1 1 0.14 0 0.3
47 INT237801 Gene_expression of Stim1 1 0.78 1.94 0.29
48 INT237807 Negative_regulation of Stim1 1 0.43 2.55 0.26
49 INT1475 Localization of CLIP1 1 0.06 0 0.24
50 INT75626 Positive_regulation of Dst 2 0.50 0.52 0.23
51 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
52 INT282322 Regulation of Binding of DST 1 0.04 0.35 0.22
53 INT240411 Negative_regulation of Binding of Myo5a 1 0.09 0.97 0.21
54 INT135637 Regulation of Dst 3 0.44 1.03 0.2
55 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
56 INT200745 Negative_regulation of Gene_expression of DST 3 0.10 2.75 0.17
57 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
58 INT341899 Regulation of Stim1 1 0.01 0 0.17
59 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
60 INT237794 Positive_regulation of Stim1 1 0.70 1.27 0.16
61 INT237795 Positive_regulation of Gene_expression of Stim1 1 0.70 0.94 0.15
62 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
63 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
64 INT227937 Regulation of Mlph 1 0.01 0.34 0.13
65 INT75625 Localization of Dst 1 0.75 0.15 0.13
66 INT192783 Phosphorylation of Myo5a 1 0.04 2.01 0.12
67 INT242140 Regulation of Localization of Apc 1 0.12 0.12 0.11
68 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1
69 INT42713 Binding of CLIP1 2 0.36 0 0.1
70 INT46301 Positive_regulation of CLIP1 2 0.60 0 0.1
71 INT160258 Negative_regulation of Myo5a 3 0.35 3.96 0.09
72 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09
73 INT227936 Localization of Mlph 3 0.10 0.1 0.08
74 INT237793 Binding of Stim1 1 0.36 0.26 0.08
75 INT237796 Localization of Stim1 1 0.75 0 0.07
76 INT227938 Binding of Mlph 1 0.01 0.07 0.07
77 INT214135 Transcription of DST 1 0.05 0.41 0.06
78 INT244419 Positive_regulation of Binding of DST 1 0.02 0.15 0.06
79 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05
80 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05
81 INT66352 Phosphorylation of CLIP1 2 0.63 0.88 0.05
82 INT326581 Positive_regulation of Gene_expression of Dst 1 0.36 0.17 0.05
83 INT192784 Positive_regulation of Gene_expression of Myo5a 2 0.45 3.39 0.04
84 INT242139 Protein_catabolism of Apc 1 0.17 0.27 0.03
85 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0
86 INT169815 Positive_regulation of Mlph 3 0.04 0.32 0
87 INT66351 Phosphorylation of CLIP2 1 0.65 0.78 0
88 INT337657 Negative_regulation of Negative_regulation of APC 1 0.37 0.99 0
89 INT104591 Negative_regulation of Negative_regulation of Apc 1 0.04 0.16 0
90 INT337673 Regulation of Positive_regulation of APC 1 0.38 1.44 0
91 INT292440 Negative_regulation of Mlph 1 0.02 0.42 0
92 INT286005 Positive_regulation of Binding of Myo5a 1 0.41 0.97 0
93 INT292439 Phosphorylation of Mlph 1 0.05 8.87 0
94 INT191087 Regulation of Regulation of Apc 1 0.06 1.02 0
95 INT286004 Positive_regulation of Positive_regulation of Myo5a 1 0.41 0.58 0
96 INT337117 Gene_expression of CLIP1 1 0.13 0.08 0
97 INT283365 Positive_regulation of Binding of APC 1 0.50 1.43 0
98 INT249283 Positive_regulation of Gene_expression of STIM1 1 0.35 0 0
99 INT337667 Regulation of Transcription of APC 1 0.23 1 0
100 INT66349 Positive_regulation of Phosphorylation of CLIP1 1 0.36 0.78 0
101 INT291645 Positive_regulation of Localization of DST 1 0.41 0.49 0
102 INT286093 Regulation of Binding of Apc 1 0.39 1.08 0
103 INT292442 Positive_regulation of Phosphorylation of Mlph 1 0.03 1.31 0
104 INT292438 Positive_regulation of Positive_regulation of Mlph 1 0.03 0.21 0
105 INT283563 Regulation of Localization of Mlph 1 0.06 0 0
106 INT249294 Gene_expression of STIM1 1 0.39 0 0
107 INT292441 Negative_regulation of Phosphorylation of Mlph 1 0.03 1.79 0
108 INT249244 Binding of STIM1 1 0.24 0 0
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