GO:0051015

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Name actin filament binding
Categary Function
Go Slim No
Go Link GO:0051015
Unique Molecular Interactions 449
Total Molecular Interactions 687
Total Single Events 6416
Pain Genes Associated 47

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for actin filament binding. They are ordered first by their pain relevance and then by number of times they were reported for actin filament binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
4 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
5 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
6 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
7 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
8 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08
9 INT281381 FSCN1 Positive_regulation of Gene_expression of Gfap 1 0.06 1.13 1.98
10 INT134686 FSCN1 Positive_regulation of Gfap 1 0.00 0.71 1.89
11 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
12 INT122964 FSCN1 Positive_regulation of Bdnf 1 0.01 1.14 1.79
13 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
14 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
15 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
16 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
17 INT131949 ANTXR1 Positive_regulation of NAV1 1 0.03 0.23 1.38
18 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33
19 INT281382 FSCN1 Positive_regulation of Sds 1 0.02 0.84 1.33
20 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
21 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
22 INT169768 Binding of Slc6a4 and Mir16-1 1 0.33 0 1.25
23 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
24 INT281383 FSCN1 Positive_regulation of Fig4 1 0.02 0.44 1.19
25 INT281379 Tcf21 Regulation of FSCN1 1 0.01 0.66 1.19
26 INT125284 FSCN1 Positive_regulation of Positive_regulation of EPHB2 1 0.04 0.4 1.14
27 INT332776 FSCN1 Positive_regulation of Grin1 1 0.02 0.21 1.12
28 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
29 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04
30 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03
31 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
32 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
33 INT281380 Fos Negative_regulation of Gene_expression of FSCN1 1 0.07 0.4 0.96
34 INT281377 FSCN1 Positive_regulation of Gene_expression of Fos 1 0.08 0.49 0.93
35 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
36 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
37 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
38 INT333303 Zic2 Regulation of Gene_expression of Slc6a4 1 0.60 0.47 0.91
39 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
40 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
41 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
42 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
43 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
44 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
45 INT243024 Binding of Dcpp1 and Slc6a4 1 0.08 0.42 0.76
46 INT243025 Dcpp1 Regulation of Slc6a4 1 0.10 0.43 0.76
47 INT159688 Trpv4 Negative_regulation of Trpv3 1 0.31 0.41 0.76
48 INT159689 Trpv4 Negative_regulation of Trpv1 1 0.36 0.41 0.76
49 INT159687 Trpv4 Negative_regulation of Trpv2 1 0.32 0.41 0.76
50 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
51 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
52 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
53 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
54 INT169769 Mir16-1 Regulation of Slc6a4 1 0.24 0 0.74
55 INT333296 Gtf3a Regulation of Gene_expression of Slc6a4 1 0.01 0 0.74
56 INT129919 IFNA2 Positive_regulation of Gene_expression of SLC6A4 1 0.02 0.38 0.69
57 INT282664 Binding of Aif1 and Gfap 1 0.06 0 0.69
58 INT74727 Binding of Slc6a4 and Hpic1 1 0.00 0.49 0.68
59 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
60 INT129921 IL4 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.38 0.68
61 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
62 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
63 INT333305 Zic2 Positive_regulation of Transcription of Slc6a4 1 0.68 0 0.66
64 INT144107 Binding of SLC6A2 and SLC6A4 1 0.00 0.18 0.62
65 INT333302 Zic2 Positive_regulation of Slc6a4 1 0.68 0.11 0.57
66 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
67 INT129271 Binding of ANTXR1 and Efs 1 0.00 0 0.56
68 INT281378 FSCN1 Positive_regulation of Gene_expression of Fig4 1 0.02 0.22 0.56
69 INT333991 Binding of FLNA and SELL 1 0.00 1.69 0.55
70 INT202157 Binding of CSF1R and SLC6A4 1 0.08 0.9 0.54
71 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54
72 INT128431 SLC6A4 Regulation of S100A4 1 0.48 0.65 0.53
73 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53
74 INT292075 FSCN1 Positive_regulation of Gene_expression of Csnk1a1 1 0.03 0.57 0.52
75 INT47745 Binding of Slc6a4 and Htr2a 1 0.33 0.09 0.52
76 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
77 INT143504 IFNG Positive_regulation of Gene_expression of Aif1 1 0.04 1.26 0.51
78 INT271191 Bdnf Regulation of Slc6a4 1 0.03 0.29 0.51
79 INT263228 Prkcg Regulation of Trpv4 1 0.07 0.36 0.5
80 INT235870 Bdnf Regulation of Gene_expression of Slc6a4 1 0.09 0.77 0.5
81 INT263235 Trpv4 Regulation of Trpv1 1 0.17 0.7 0.5
82 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
83 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
84 INT322131 Binding of Prkcg and Trpv4 1 0.04 0.75 0.46
85 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45
86 INT113248 Olr1259 Negative_regulation of Slc6a4 1 0.00 0.23 0.44
87 INT110744 Faah Positive_regulation of Positive_regulation of Aif1 1 0.10 0.36 0.4
88 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39
89 INT305407 Binding of ST8SIA2 and ANTXR1 1 0.00 0.09 0.38
90 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38
91 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
92 INT305405 Binding of KCNMA1 and ANTXR1 1 0.00 0.09 0.38
93 INT154782 Binding of SLC6A4 and Ndst2 1 0.01 0 0.37
94 INT140667 IFNG Regulation of Gene_expression of SLC6A4 1 0.40 0.41 0.34
95 INT140666 TNF Regulation of Gene_expression of SLC6A4 1 0.40 0.41 0.34
96 INT279705 CALM3 Regulation of TRPV4 2 0.08 0 0.33
97 INT324525 PGE Positive_regulation of Positive_regulation of Egfr 1 0.41 1.05 0.33
98 INT324522 PGE Positive_regulation of Phosphorylation of Egfr 1 0.56 1.04 0.33
99 INT324524 PGE Positive_regulation of Egfr 1 0.38 1.05 0.33
100 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
101 INT113950 FLNA Regulation of Oprd1 1 0.00 0.16 0.32
102 INT344036 Binding of NOS1 and SPTB 1 0.01 0.31 0.32
103 INT235869 Binding of Slc6a4 and Ppp2ca 1 0.04 0.21 0.31
104 INT235877 Prkaca Regulation of Transcription of Slc6a4 1 0.06 0.13 0.31
105 INT341777 SLC6A4 Regulation of EPHB1 1 0.02 0.96 0.3
106 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
107 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
108 INT109098 Binding of ABL2 and PON1 1 0.36 1.32 0.28
109 INT235874 Camk2a Positive_regulation of Slc6a4 1 0.11 0.14 0.28
110 INT64892 ANTXR1 Regulation of Gtpbp4 1 0.00 0.47 0.28
111 INT44091 Binding of ACTN1 and CAMSAP2 1 0.08 0 0.28
112 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
113 INT221918 TRPV4 Positive_regulation of TRPM8 1 0.05 0 0.28
114 INT322132 Binding of Mbp and Trpv4 1 0.11 0.39 0.27
115 INT262820 Binding of Aif1 and Serpinf1 1 0.01 1.3 0.27
116 INT345008 Binding of ACTN1 and CSF2 1 0.02 0.53 0.26
117 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
118 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24
119 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
120 INT101312 Samhd1 Positive_regulation of Gene_expression of Aif1 1 0.03 0.38 0.23
121 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23
122 INT309751 Binding of CA2 and TRPV4 1 0.08 0 0.23
123 INT272753 Positive_regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.23
124 INT208084 Tlr4 Positive_regulation of Eps8l1 1 0.00 0.5 0.23
125 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
126 INT333298 Zic2 Regulation of Transcription of Slc6a4 1 0.44 0.09 0.2
127 INT352355 Binding of CNR1 and EGFR 1 0.19 0.76 0.2
128 INT118435 HGF Positive_regulation of TRPV4 1 0.54 0.13 0.2
129 INT110745 Bphl Positive_regulation of Positive_regulation of Aif1 1 0.03 0.18 0.2
130 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
131 INT301782 Binding of Dmd and Utrn 1 0.24 0.15 0.18
132 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
133 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
134 INT142227 Urb1 Regulation of Trpv4 1 0.02 0.1 0.17
135 INT326390 Binding of PROC and Ezr 1 0.00 1 0.17
136 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17
137 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17
138 INT142229 Trpa1 Regulation of Trpv4 1 0.15 0.1 0.17
139 INT352354 EGFR Regulation of Gene_expression of CNR1 1 0.23 1.16 0.17
140 INT208083 Binding of Arid3b and Eps8l1 1 0.01 0.4 0.16
141 INT112132 Gast Positive_regulation of Positive_regulation of Egfr 1 0.33 0.13 0.16
142 INT247656 Binding of Tnnc1 and Gdf15 1 0.02 0.94 0.16
143 INT143505 Aif1 Positive_regulation of CETN1 1 0.01 0.35 0.16
144 INT117191 Binding of CXCR4 and Coro1a 1 0.39 0.28 0.16
145 INT211311 Trav6-3 Positive_regulation of Gene_expression of Lcp1 1 0.13 0.2 0.15
146 INT235883 Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
147 INT325952 Gene_expression of Ezr Positive_regulation of Mapk1 1 0.02 1.69 0.15
148 INT235879 Regulation of Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
149 INT144027 Binding of Slc6a4 and Pdgfrb 1 0.23 0.25 0.14
150 INT82802 Binding of ABL2 and POMC 1 0.00 0 0.14
151 INT326379 Binding of Ezr and Slc9a3r2 2 0.03 0.34 0.13
152 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13
153 INT178446 Binding of Egfr and ras 1 0.04 0.13 0.13
154 INT178431 Positive_regulation of Binding of Egfr and ras 1 0.05 0.13 0.13
155 INT304824 Binding of Rasa1 and Tnnc1 1 0.01 0 0.13
156 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
157 INT341828 Binding of BTC and EGFR 1 0.22 0.95 0.12
158 INT101310 Samhd1 Positive_regulation of Gene_expression of Aif1 1 0.04 0.19 0.12
159 INT301789 Binding of Sntb1 and Utrn 1 0.03 0.05 0.12
160 INT315829 Binding of EGFR and TKT 1 0.03 1.14 0.12
161 INT171390 Src Positive_regulation of Phosphorylation of Egfr 1 0.13 0 0.11
162 INT137672 Baa1 Positive_regulation of Trpv4 1 0.17 0 0.11
163 INT272750 Prkaca Positive_regulation of EGFR 1 0.02 0 0.11
164 INT171385 Ppp1cc Positive_regulation of Phosphorylation of Egfr 1 0.15 0 0.11
165 INT272752 Regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.11
166 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1
167 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1
168 INT210989 Binding of FSCN1 and SP3 1 0.00 0.17 0.1
169 INT356272 Egf Negative_regulation of Gene_expression of Egfr 1 0.15 0.2 0.1
170 INT220743 Binding of AR and EGFR 1 0.01 0.46 0.1
171 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1
172 INT352303 Binding of AIF1 and CD68 1 0.01 0.71 0.1
173 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1
174 INT28816 Binding of TRPV4 and MND1 1 0.27 0.52 0.1
175 INT165324 Binding of TRPV4 and Trpv4 1 0.11 0.66 0.1
176 INT210991 Binding of FSCN1 and PKDREJ 1 0.00 0.17 0.1
177 INT309724 Regulation of Binding of TYRP1 and TRPV4 1 0.01 0 0.09
178 INT202392 Binding of Osm and Nexn 1 0.02 0.13 0.09
179 INT231273 Binding of Egfr and Nrg1 1 0.12 0 0.09
180 INT145153 JUN Positive_regulation of EGFR 1 0.24 0.94 0.09
181 INT145154 Positive_regulation of JUN Positive_regulation of EGFR 1 0.24 0.95 0.09
182 INT309754 Binding of TYRP1 and TRPV4 1 0.02 0 0.09
183 INT302167 PTGER2 Positive_regulation of EGFR 1 0.10 3.08 0.09
184 INT202393 Binding of Mapk14 and Nexn 1 0.03 0.13 0.09
185 INT210788 Ihh Negative_regulation of Coro1a 1 0.02 0 0.08
186 INT309722 TRPV4 Positive_regulation of CA2 1 0.11 0 0.08
187 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
188 INT249465 Positive_regulation of Slc6a4 Positive_regulation of Gene_expression of Bdnf 1 0.31 0.3 0.08
189 INT249332 GPNMB Positive_regulation of EGFR 1 0.17 2.63 0.08
190 INT88054 ABL2 Regulation of Gh 1 0.02 0.57 0.08
191 INT343792 Binding of TCF21 and CORO7 1 0.01 0.51 0.07
192 INT159852 Gene_expression of IL2 Regulation of Gene_expression of ACTN1 1 0.03 0.16 0.07
193 INT249466 Slc6a4 Positive_regulation of Phosphorylation of Creb1 1 0.09 0.36 0.07
194 INT241246 Pkd2 Negative_regulation of Gene_expression of Trpv4 1 0.48 0.47 0.07
195 INT236531 Binding of Cacna1f and Flna 1 0.08 0 0.07
196 INT325954 Binding of Cttn and Ezr 1 0.22 1.61 0.07
197 INT356379 DMD Positive_regulation of Negative_regulation of Utrn 1 0.54 0.84 0.07
198 INT27764 Binding of FANCB and MYH14 1 0.31 0.28 0.07
199 INT120569 Binding of Egfr and Pik3r1 1 0.40 1.22 0.06
200 INT246441 Ccl5 Positive_regulation of Gene_expression of Aif1 1 0.03 0.71 0.06

Single Events

The table below shows the top 100 pain related interactions that have been reported for actin filament binding. They are ordered first by their pain relevance and then by number of times they were reported in actin filament binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64
2 INT221172 Binding of Flna 32 0.42 1.37 51.59
3 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47
4 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68
5 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
6 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23
7 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84
8 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
9 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6
10 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9
11 INT112174 Gene_expression of Trpv4 47 0.78 26.26 20.09
12 INT104523 Positive_regulation of FSCN1 14 0.12 10.09 20.08
13 INT104527 Binding of FSCN1 18 0.23 14.75 19.6
14 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09
15 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3
16 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42
17 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
18 INT100096 Regulation of Slc6a4 24 0.62 7.25 12.28
19 INT47743 Negative_regulation of Slc6a4 22 0.59 6.23 12.23
20 INT221167 Gene_expression of Flna 11 0.60 0.69 11.81
21 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
22 INT66303 Regulation of Slc6a4 10 0.45 4.82 10.55
23 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55
24 INT47744 Binding of Slc6a4 21 0.48 5.52 9.45
25 INT77490 Positive_regulation of Tnnc1 85 0.68 43.54 9.07
26 INT32692 Positive_regulation of Aif1 33 0.35 13.29 9.03
27 INT109724 Phosphorylation of FSCN1 5 0.07 3.15 8.82
28 INT221173 Negative_regulation of Binding of Flna 4 0.33 0.13 8.25
29 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2
30 INT75684 Regulation of Aif1 32 0.47 8.03 7.89
31 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
32 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
33 INT119651 Binding of Slc6a4 12 0.32 4.65 7.07
34 INT79770 Regulation of Gene_expression of Aif1 13 0.45 5.28 6.82
35 INT15092 Positive_regulation of SLC6A4 17 0.67 7.32 6.7
36 INT46714 Positive_regulation of TNNC1 76 0.67 75.99 6.66
37 INT11154 Binding of EGFR 149 0.48 96.23 6.29
38 INT124881 Binding of Trpv4 35 0.47 7.71 6.24
39 INT109714 Transcription of SLC6A4 7 0.72 3.8 6.19
40 INT189177 Positive_regulation of Gene_expression of FSCN1 12 0.11 3.77 6.12
41 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02
42 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01
43 INT129685 Negative_regulation of FSCN1 7 0.05 3.44 5.69
44 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
45 INT137593 Regulation of Gene_expression of SLC6A4 7 0.60 2.59 5.23
46 INT119711 Positive_regulation of Slc6a4 16 0.69 4.44 5.21
47 INT89959 Positive_regulation of Gene_expression of Aif1 14 0.58 7.44 5.05
48 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
49 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86
50 INT104342 Regulation of FSCN1 4 0.15 3.18 4.84
51 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81
52 INT79767 Negative_regulation of Aif1 30 0.42 5.14 4.73
53 INT122675 Negative_regulation of Gene_expression of Slc6a4 14 0.59 6.4 4.69
54 INT79768 Negative_regulation of Gene_expression of Aif1 8 0.58 5.15 4.52
55 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
56 INT39948 Binding of FLNA 45 0.42 58.05 4.27
57 INT167174 Negative_regulation of Gene_expression of FSCN1 6 0.06 3.05 4.25
58 INT325930 Gene_expression of Ezr 75 0.77 59.77 4.06
59 INT101301 Gene_expression of Aif1 17 0.42 16.43 4.06
60 INT79343 Positive_regulation of Slc6a4 10 0.50 1.77 4.05
61 INT221168 Localization of Flna 1 0.58 0.05 4.05
62 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98
63 INT63880 Positive_regulation of FLNA 29 0.59 13.88 3.97
64 INT140670 Negative_regulation of Gene_expression of SLC6A4 4 0.51 2.7 3.88
65 INT20925 Binding of ANTXR1 15 0.01 4.2 3.8
66 INT103021 Transcription of Slc6a4 16 0.70 3.93 3.77
67 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
68 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
69 INT137702 Binding of TTN 7 0.35 4.48 3.62
70 INT57397 Binding of Aif1 15 0.28 4.06 3.49
71 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
72 INT99291 Transcription of Slc6a4 7 0.46 1.16 3.28
73 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23
74 INT127455 Positive_regulation of Gene_expression of Slc6a4 9 0.59 5.62 3.2
75 INT100190 Regulation of Gene_expression of Slc6a4 5 0.39 1.8 3.14
76 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
77 INT112175 Negative_regulation of Gene_expression of Trpv4 8 0.59 3.7 3.12
78 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
79 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
80 INT130441 Phosphorylation of MARCKS 8 0.37 3.24 3.09
81 INT124438 Regulation of Gene_expression of Slc6a4 9 0.62 3.5 2.97
82 INT221171 Positive_regulation of Localization of Flna 1 0.39 0.05 2.9
83 INT168744 Negative_regulation of Regulation of Trpv4 1 0.42 3.26 2.87
84 INT169402 Binding of Trpv4 8 0.47 5.13 2.78
85 INT115852 Transcription of Trpv4 9 0.71 2.23 2.65
86 INT332774 Positive_regulation of Phosphorylation of FSCN1 1 0.02 0.69 2.63
87 INT12619 Positive_regulation of ANTXR1 7 0.49 3.17 2.61
88 INT111298 Gene_expression of ACTN4 12 0.70 9.42 2.6
89 INT80320 Negative_regulation of Gene_expression of Slc6a4 4 0.42 0.85 2.6
90 INT28817 Binding of TRPV4 6 0.39 3.92 2.59
91 INT99550 Regulation of FLNA 51 0.54 27.88 2.58
92 INT46646 Localization of FLNA 19 0.73 18.83 2.53
93 INT109822 Negative_regulation of Gene_expression of Trpv4 8 0.55 1.98 2.53
94 INT259224 Negative_regulation of Flna 1 0.23 0.15 2.51
95 INT115199 Localization of Trpv4 12 0.79 3.65 2.5
96 INT159809 Localization of Trpv4 6 0.78 3.67 2.46
97 INT156301 Regulation of Trpv4 11 0.60 2.81 2.35
98 INT120726 Positive_regulation of Gene_expression of Slc6a4 4 0.68 0.51 2.34
99 INT156299 Phosphorylation of Trpv4 8 0.80 2.46 2.31
100 INT46713 Binding of TNNC1 10 0.35 6.35 2.28
101 INT17617 Gene_expression of ABL2 8 0.75 2.73 2.25
102 INT221177 Negative_regulation of Gene_expression of Flna 2 0.33 0 2.22
103 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18
104 INT152554 Regulation of Transcription of SLC6A4 3 0.62 1.52 2.18
105 INT15090 Regulation of ANTXR1 4 0.31 2.4 2.05
106 INT221179 Regulation of Flna 1 0.24 0.13 2.04
107 INT134916 Localization of Aif1 3 0.73 1.58 2
108 INT93789 Gene_expression of Tnnc1 28 0.76 17.3 1.99
109 INT195430 Regulation of Positive_regulation of SLC6A4 1 0.42 1.01 1.98
110 INT125974 Localization of Slc6a4 5 0.66 2.27 1.97
111 INT47062 Gene_expression of ANTXR1 10 0.66 4.63 1.93
112 INT243017 Negative_regulation of Binding of Slc6a4 1 0.25 0.22 1.89
113 INT65545 Localization of EGFR 35 0.79 20.8 1.88
114 INT112131 Positive_regulation of Positive_regulation of Egfr 10 0.49 9.95 1.85
115 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82
116 INT44723 Positive_regulation of ABL2 7 0.49 2.23 1.82
117 INT141937 Negative_regulation of Regulation of SLC6A4 1 0.41 0.27 1.8
118 INT137670 Positive_regulation of Gene_expression of Trpv4 12 0.68 3.42 1.77
119 INT78044 Regulation of Tnnc1 9 0.52 12.3 1.76
120 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75
121 INT104524 Localization of FSCN1 3 0.13 1.76 1.75
122 INT149153 Positive_regulation of Gene_expression of Trpv4 12 0.70 3.37 1.72
123 INT134915 Binding of Aif1 4 0.36 1.72 1.72
124 INT130195 Positive_regulation of ACTN4 4 0.42 3.48 1.7
125 INT221166 Positive_regulation of Flna 2 0.39 0.09 1.7
126 INT257754 Positive_regulation of Gene_expression of ACTN4 1 0.45 4.58 1.7
127 INT53532 Gene_expression of Lcp1 10 0.70 11.57 1.69
128 INT147808 Positive_regulation of Gene_expression of SLC6A4 4 0.50 1.03 1.57
129 INT325940 Positive_regulation of Gene_expression of Ezr 42 0.69 27.79 1.56
130 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
131 INT93840 Gene_expression of TNNC1 15 0.57 10.07 1.54
132 INT149152 Negative_regulation of Trpv4 5 0.58 1.8 1.52
133 INT335495 Regulation of Regulation of Aif1 5 0.21 1.22 1.51
134 INT77311 Localization of Aif1 10 0.75 4.21 1.5
135 INT259219 Negative_regulation of Negative_regulation of Flna 1 0.23 0 1.47
136 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
137 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3
138 INT104636 Regulation of TTN 2 0.33 0 1.29
139 INT57425 Binding of MYH14 12 0.11 2.33 1.26
140 INT101302 Positive_regulation of Gene_expression of Aif1 5 0.37 3.56 1.23
141 INT149384 Negative_regulation of TRPV4 4 0.43 2.41 1.23
142 INT268027 Regulation of Gene_expression of FSCN1 3 0.03 0.64 1.23
143 INT1787 Binding of Antxr1 13 0.32 2.62 1.22
144 INT343806 Gene_expression of CORO7 3 0.57 2.54 1.18
145 INT47839 Localization of Slc6a4 4 0.79 0.96 1.14
146 INT147286 Negative_regulation of Regulation of Slc6a4 1 0.21 0 1.13
147 INT272172 Regulation of Positive_regulation of Aif1 3 0.26 0 1.11
148 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1
149 INT181497 Regulation of Regulation of TRPV4 1 0.23 0.69 1.08
150 INT261816 Positive_regulation of Localization of Trpv4 2 0.47 1.16 1.07
151 INT98174 Positive_regulation of Gene_expression of ABL2 1 0.49 1.1 1.05
152 INT128444 Phosphorylation of SLC6A4 2 0.61 0.49 1.02
153 INT130444 Positive_regulation of MARCKS 2 0.12 0.61 1.02
154 INT100171 Gene_expression of Utrn 17 0.75 3.93 0.98
155 INT129674 Regulation of Negative_regulation of Slc6a4 1 0.38 0.46 0.98
156 INT71916 Gene_expression of TTN 9 0.75 1.69 0.97
157 INT86384 Negative_regulation of Localization of EGFR 4 0.43 2.5 0.97
158 INT4099 Regulation of Antxr1 2 0.17 0.09 0.97
159 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96
160 INT71917 Gene_expression of ACTN1 4 0.24 2.27 0.96
161 INT191478 Negative_regulation of Positive_regulation of Aif1 2 0.25 0.31 0.95
162 INT332775 Regulation of Phosphorylation of FSCN1 1 0.02 0.19 0.95
163 INT125903 Gene_expression of Espn 2 0.06 0.77 0.94
164 INT130439 Negative_regulation of Phosphorylation of MARCKS 2 0.19 1.03 0.94
165 INT75425 Binding of Tnnc1 7 0.35 5.39 0.91
166 INT57370 Gene_expression of Coro1a 4 0.58 1.36 0.91
167 INT131649 Positive_regulation of Negative_regulation of Slc6a4 2 0.44 0.32 0.91
168 INT92428 Regulation of Myo7a 2 0.44 1.23 0.91
169 INT286694 Positive_regulation of Localization of Slc6a4 1 0.26 0 0.9
170 INT142423 Negative_regulation of Positive_regulation of FLNA 2 0.05 0.99 0.89
171 INT152101 Regulation of Transcription of Slc6a4 1 0.14 0 0.89
172 INT134918 Positive_regulation of Localization of Aif1 1 0.49 0.32 0.88
173 INT144415 Regulation of Positive_regulation of Egfr 2 0.27 0.42 0.86
174 INT117347 Positive_regulation of Positive_regulation of EGFR 15 0.69 11.17 0.84
175 INT144416 Regulation of Egfr 5 0.57 4.97 0.83
176 INT41534 Negative_regulation of ANTXR1 4 0.42 1.17 0.83
177 INT171361 Regulation of Egfr 16 0.62 8.36 0.81
178 INT156175 Positive_regulation of Positive_regulation of Trpv4 5 0.50 0.86 0.8
179 INT47937 Positive_regulation of Gene_expression of ANTXR1 3 0.49 0.86 0.8
180 INT208060 Positive_regulation of Eps8l1 1 0.05 0.86 0.8
181 INT144414 Positive_regulation of Positive_regulation of Egfr 1 0.49 0.65 0.8
182 INT41536 Localization of ANTXR1 7 0.60 2.24 0.79
183 INT131286 Binding of Egfr 26 0.44 13.58 0.78
184 INT138955 Transcription of EGFR 18 0.71 11.39 0.78
185 INT237991 Positive_regulation of Aif1 4 0.04 4.87 0.77
186 INT142083 Positive_regulation of AIF1 4 0.12 4.86 0.77
187 INT158547 Negative_regulation of Positive_regulation of Trpv4 2 0.57 0.47 0.77
188 INT287270 Binding of Ezr 8 0.36 1.78 0.76
189 INT186119 Protein_catabolism of EGFR 6 0.98 3.68 0.76
190 INT202359 Binding of Nexn 4 0.08 1.43 0.76
191 INT139945 Transcription of Aif1 2 0.65 0.89 0.76
192 INT243015 Regulation of Binding of Slc6a4 1 0.16 0.43 0.75
193 INT147809 Localization of SLC6A4 5 0.71 1.69 0.74
194 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7
195 INT263225 Positive_regulation of Positive_regulation of Trpv4 3 0.46 0.75 0.7
196 INT309322 Gene_expression of AIF1 7 0.14 2.64 0.68
197 INT156302 Positive_regulation of Phosphorylation of Trpv4 2 0.46 0.92 0.68
198 INT186117 Negative_regulation of Protein_catabolism of EGFR 1 0.42 0.67 0.68
199 INT186118 Positive_regulation of Protein_catabolism of EGFR 1 0.68 0.66 0.68
200 INT93787 Negative_regulation of Tnnc1 6 0.26 5.81 0.67
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