GO:0051017

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Name actin filament bundle assembly
Categary Process
Go Slim No
Go Link GO:0051017
Unique Molecular Interactions 114
Total Molecular Interactions 147
Total Single Events 1251
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for actin filament bundle assembly. They are ordered first by their pain relevance and then by number of times they were reported for actin filament bundle assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
2 INT281381 FSCN1 Positive_regulation of Gene_expression of Gfap 1 0.06 1.13 1.98
3 INT134686 FSCN1 Positive_regulation of Gfap 1 0.00 0.71 1.89
4 INT122964 FSCN1 Positive_regulation of Bdnf 1 0.01 1.14 1.79
5 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
6 INT281382 FSCN1 Positive_regulation of Sds 1 0.02 0.84 1.33
7 INT281383 FSCN1 Positive_regulation of Fig4 1 0.02 0.44 1.19
8 INT281379 Tcf21 Regulation of FSCN1 1 0.01 0.66 1.19
9 INT125284 FSCN1 Positive_regulation of Positive_regulation of EPHB2 1 0.04 0.4 1.14
10 INT332776 FSCN1 Positive_regulation of Grin1 1 0.02 0.21 1.12
11 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
12 INT281380 Fos Negative_regulation of Gene_expression of FSCN1 1 0.07 0.4 0.96
13 INT281377 FSCN1 Positive_regulation of Gene_expression of Fos 1 0.08 0.49 0.93
14 INT282664 Binding of Aif1 and Gfap 1 0.06 0 0.69
15 INT207111 F2 Positive_regulation of Pawr 2 0.07 1.38 0.64
16 INT281378 FSCN1 Positive_regulation of Gene_expression of Fig4 1 0.02 0.22 0.56
17 INT292075 FSCN1 Positive_regulation of Gene_expression of Csnk1a1 1 0.03 0.57 0.52
18 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
19 INT143504 IFNG Positive_regulation of Gene_expression of Aif1 1 0.04 1.26 0.51
20 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5
21 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
22 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45
23 INT110744 Faah Positive_regulation of Positive_regulation of Aif1 1 0.10 0.36 0.4
24 INT353332 Binding of F2r and Pawr 1 0.18 0.67 0.39
25 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39
26 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31
27 INT296448 Ush1c Regulation of Binding of Gria2 1 0.06 0.29 0.28
28 INT44091 Binding of ACTN1 and CAMSAP2 1 0.08 0 0.28
29 INT262820 Binding of Aif1 and Serpinf1 1 0.01 1.3 0.27
30 INT345008 Binding of ACTN1 and CSF2 1 0.02 0.53 0.26
31 INT101312 Samhd1 Positive_regulation of Gene_expression of Aif1 1 0.03 0.38 0.23
32 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
33 INT110745 Bphl Positive_regulation of Positive_regulation of Aif1 1 0.03 0.18 0.2
34 INT326390 Binding of PROC and Ezr 1 0.00 1 0.17
35 INT143505 Aif1 Positive_regulation of CETN1 1 0.01 0.35 0.16
36 INT207144 F2r Positive_regulation of Pawr 1 0.14 0.51 0.16
37 INT211311 Trav6-3 Positive_regulation of Gene_expression of Lcp1 1 0.13 0.2 0.15
38 INT241177 Abl2 Regulation of Cat 1 0.14 0.3 0.15
39 INT325952 Gene_expression of Ezr Positive_regulation of Mapk1 1 0.02 1.69 0.15
40 INT326379 Binding of Ezr and Slc9a3r2 2 0.03 0.34 0.13
41 INT101310 Samhd1 Positive_regulation of Gene_expression of Aif1 1 0.04 0.19 0.12
42 INT287267 EGF Positive_regulation of CDC42 1 0.12 0.16 0.11
43 INT210989 Binding of FSCN1 and SP3 1 0.00 0.17 0.1
44 INT352303 Binding of AIF1 and CD68 1 0.01 0.71 0.1
45 INT210991 Binding of FSCN1 and PKDREJ 1 0.00 0.17 0.1
46 INT159852 Gene_expression of IL2 Regulation of Gene_expression of ACTN1 1 0.03 0.16 0.07
47 INT325954 Binding of Cttn and Ezr 1 0.22 1.61 0.07
48 INT267000 Mdk Negative_regulation of Positive_regulation of Baiap2 1 0.03 0.1 0.06
49 INT246441 Ccl5 Positive_regulation of Gene_expression of Aif1 1 0.03 0.71 0.06
50 INT246436 Ccl5 Regulation of Aif1 1 0.01 0.67 0.06
51 INT326377 Ezr Positive_regulation of Positive_regulation of Rhoa 1 0.05 0.16 0.06
52 INT267040 Negative_regulation of NOS1 Negative_regulation of Positive_regulation of Baiap2 1 0.02 0.1 0.06
53 INT167271 Binding of Ezr and Clic5 1 0.54 0.07 0.06
54 INT326378 Binding of Rhoa and Ezr 1 0.04 0.17 0.06
55 INT178430 Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05
56 INT178447 Negative_regulation of Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05
57 INT181083 Binding of Akt1 and Cdc42 1 0.00 0.79 0.03
58 INT238003 Aif1 Regulation of IgG 1 0.00 0.21 0.03
59 INT241450 Binding of Rhoa and Dpysl3 1 0.02 0 0.03
60 INT354617 Binding of Ezr and Gpbar1 1 0.02 0 0.03
61 INT220634 Binding of Bace1 and Pawr 2 0.06 0.2 0
62 INT283862 Binding of CALD1 and MYH14 1 0.02 0 0
63 INT325945 Binding of Cd44 and Ezr 1 0.25 0.39 0
64 INT269585 MAPKAP1 Negative_regulation of Phosphorylation of ACTN1 1 0.00 0 0
65 INT276586 Binding of Wt1 and Actn1 1 0.34 0.41 0
66 INT325942 Binding of Icam1 and Ezr 1 0.15 0.39 0
67 INT325949 Binding of Spn and Ezr 1 0.14 0.39 0
68 INT349315 Hspg2 Regulation of Gene_expression of Aif1 1 0.01 0 0
69 INT234996 Ctnnd1 Positive_regulation of CDC42 1 0.01 0.07 0
70 INT325948 Ezr Regulation of Pcx 1 0.00 0.84 0
71 INT289510 Binding of ODF2 and Ezr 1 0.10 0.47 0
72 INT263248 Binding of ADD1 and RAPGEF5 1 0.01 0.84 0
73 INT283859 Binding of ACTN4 and TREH 1 0.00 1.61 0
74 INT249192 Binding of ACTN1 and S100A9 1 0.01 0 0
75 INT104529 Ada Negative_regulation of Positive_regulation of FSCN1 1 0.03 0 0
76 INT249149 Binding of Cdc42 and Was 1 0.08 0.18 0
77 INT325953 Ezr Positive_regulation of Mapk1 1 0.02 0.4 0
78 INT355221 Binding of Espn and Ocln 1 0.01 0 0
79 INT263584 Hspa5 Positive_regulation of Myo1b 1 0.00 1.02 0
80 INT321968 Rock1 Positive_regulation of EZR 1 0.42 1.02 0
81 INT104530 Ada Negative_regulation of FSCN1 1 0.03 0 0
82 INT325955 Ezr Regulation of Mia1 1 0.09 1.68 0
83 INT355223 Binding of Espn and Tjp2 1 0.01 0 0
84 INT104528 Binding of FSCN1 and Pck1 1 0.01 0 0
85 INT276582 Binding of Espn and Plce1 1 0.01 0.34 0
86 INT325946 Gene_expression of Ezr Positive_regulation of Positive_regulation of Mapk1 1 0.02 0.28 0
87 INT256983 Binding of Cd9 and Ezr 1 0.06 0.12 0
88 INT276591 Binding of Actn1 and KTWS 1 0.02 0.41 0
89 INT189992 Binding of Ptger2 and Pawr 1 0.00 2.89 0
90 INT325947 Ezr Regulation of Zfp369 1 0.00 0.84 0
91 INT256989 Binding of Ezr and Slc9a3r1 1 0.10 0 0
92 INT325950 Binding of Icam2 and Ezr 1 0.17 0.39 0
93 INT249186 Binding of ACTN1 and S100A8 1 0.01 0 0
94 INT181085 Binding of Cdc42 and Errfi1 1 0.08 0.67 0
95 INT268051 FSCN1 Regulation of Gene_expression of Kcnj5 1 0.01 0.1 0
96 INT263249 Binding of ADD1 and REN 1 0.03 0.82 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for actin filament bundle assembly. They are ordered first by their pain relevance and then by number of times they were reported in actin filament bundle assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47
2 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68
3 INT104523 Positive_regulation of FSCN1 14 0.12 10.09 20.08
4 INT104527 Binding of FSCN1 18 0.23 14.75 19.6
5 INT32692 Positive_regulation of Aif1 33 0.35 13.29 9.03
6 INT109724 Phosphorylation of FSCN1 5 0.07 3.15 8.82
7 INT75684 Regulation of Aif1 32 0.47 8.03 7.89
8 INT79770 Regulation of Gene_expression of Aif1 13 0.45 5.28 6.82
9 INT189177 Positive_regulation of Gene_expression of FSCN1 12 0.11 3.77 6.12
10 INT129685 Negative_regulation of FSCN1 7 0.05 3.44 5.69
11 INT89959 Positive_regulation of Gene_expression of Aif1 14 0.58 7.44 5.05
12 INT104342 Regulation of FSCN1 4 0.15 3.18 4.84
13 INT79767 Negative_regulation of Aif1 30 0.42 5.14 4.73
14 INT79768 Negative_regulation of Gene_expression of Aif1 8 0.58 5.15 4.52
15 INT167174 Negative_regulation of Gene_expression of FSCN1 6 0.06 3.05 4.25
16 INT325930 Gene_expression of Ezr 75 0.77 59.77 4.06
17 INT101301 Gene_expression of Aif1 17 0.42 16.43 4.06
18 INT57397 Binding of Aif1 15 0.28 4.06 3.49
19 INT115348 Localization of Baiap2 1 0.68 1.76 2.99
20 INT332774 Positive_regulation of Phosphorylation of FSCN1 1 0.02 0.69 2.63
21 INT111298 Gene_expression of ACTN4 12 0.70 9.42 2.6
22 INT134916 Localization of Aif1 3 0.73 1.58 2
23 INT104524 Localization of FSCN1 3 0.13 1.76 1.75
24 INT134915 Binding of Aif1 4 0.36 1.72 1.72
25 INT130195 Positive_regulation of ACTN4 4 0.42 3.48 1.7
26 INT257754 Positive_regulation of Gene_expression of ACTN4 1 0.45 4.58 1.7
27 INT53532 Gene_expression of Lcp1 10 0.70 11.57 1.69
28 INT325940 Positive_regulation of Gene_expression of Ezr 42 0.69 27.79 1.56
29 INT335495 Regulation of Regulation of Aif1 5 0.21 1.22 1.51
30 INT77311 Localization of Aif1 10 0.75 4.21 1.5
31 INT115350 Positive_regulation of Localization of Baiap2 1 0.45 0.76 1.36
32 INT101302 Positive_regulation of Gene_expression of Aif1 5 0.37 3.56 1.23
33 INT268027 Regulation of Gene_expression of FSCN1 3 0.03 0.64 1.23
34 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19
35 INT272172 Regulation of Positive_regulation of Aif1 3 0.26 0 1.11
36 INT207091 Positive_regulation of Pawr 2 0.36 1.95 1.1
37 INT130262 Gene_expression of Abl2 2 0.58 1.06 1
38 INT71917 Gene_expression of ACTN1 4 0.24 2.27 0.96
39 INT191478 Negative_regulation of Positive_regulation of Aif1 2 0.25 0.31 0.95
40 INT46783 Negative_regulation of Abl2 2 0.15 0.2 0.95
41 INT332775 Regulation of Phosphorylation of FSCN1 1 0.02 0.19 0.95
42 INT125903 Gene_expression of Espn 2 0.06 0.77 0.94
43 INT161682 Positive_regulation of Cdc42 8 0.53 4.55 0.9
44 INT134918 Positive_regulation of Localization of Aif1 1 0.49 0.32 0.88
45 INT207103 Positive_regulation of Positive_regulation of Pawr 2 0.36 1.45 0.85
46 INT124092 Gene_expression of Myo1b 3 0.41 1.22 0.82
47 INT124091 Negative_regulation of Gene_expression of Myo1b 1 0.04 1.08 0.8
48 INT130263 Positive_regulation of Gene_expression of Abl2 1 0.45 0.61 0.78
49 INT207108 Gene_expression of Pawr 5 0.40 1.61 0.77
50 INT237991 Positive_regulation of Aif1 4 0.04 4.87 0.77
51 INT142083 Positive_regulation of AIF1 4 0.12 4.86 0.77
52 INT287270 Binding of Ezr 8 0.36 1.78 0.76
53 INT139945 Transcription of Aif1 2 0.65 0.89 0.76
54 INT309322 Gene_expression of AIF1 7 0.14 2.64 0.68
55 INT46784 Binding of Abl2 1 0.09 0 0.66
56 INT44092 Binding of ACTN1 7 0.20 1.52 0.62
57 INT115347 Regulation of Localization of Baiap2 1 0.23 0.38 0.62
58 INT252860 Negative_regulation of Binding of FSCN1 1 0.02 0.85 0.61
59 INT180107 Regulation of Cdc42 3 0.16 0.18 0.6
60 INT318499 Regulation of AIF1 2 0.03 4.89 0.6
61 INT142079 Negative_regulation of Positive_regulation of AIF1 1 0.00 1.01 0.57
62 INT241175 Positive_regulation of Abl2 4 0.19 0.34 0.56
63 INT97956 Negative_regulation of CDC42 3 0.27 1.58 0.55
64 INT155214 Negative_regulation of ACTN1 1 0.28 0.16 0.51
65 INT175068 Localization of Ezr 1 0.19 0 0.5
66 INT207074 Binding of Pawr 2 0.18 0.87 0.48
67 INT292074 Transcription of FSCN1 1 0.04 0.56 0.48
68 INT130966 Binding of EZR 2 0.36 0.24 0.41
69 INT324921 Regulation of Localization of Aif1 1 0.23 0.46 0.38
70 INT257765 Localization of ACTN4 1 0.63 1.02 0.38
71 INT155215 Regulation of ACTN1 1 0.30 0.17 0.37
72 INT354234 Regulation of Binding of Aif1 1 0.30 0.57 0.36
73 INT289505 Negative_regulation of Ezr 2 0.43 3.04 0.35
74 INT243709 Regulation of Lcp1 1 0.44 0.66 0.32
75 INT325934 Localization of Ezr 1 0.80 3.78 0.27
76 INT230957 Positive_regulation of CALD1 3 0.45 1.88 0.24
77 INT139301 Regulation of Espn 1 0.02 0.38 0.24
78 INT246430 Regulation of Aif1 1 0.01 0.86 0.24
79 INT183881 Localization of CDC42 3 0.49 1.92 0.23
80 INT166268 Positive_regulation of Lcp1 2 0.49 2.79 0.21
81 INT213438 Gene_expression of CALD1 2 0.31 0.39 0.21
82 INT113855 Regulation of Phosphorylation of Espn 1 0.04 0.06 0.2
83 INT113856 Phosphorylation of Espn 1 0.08 0.06 0.2
84 INT333083 Positive_regulation of Regulation of AIF1 1 0.06 3.65 0.2
85 INT113857 Positive_regulation of Phosphorylation of Espn 1 0.06 0.06 0.2
86 INT183876 Regulation of CDC42 3 0.30 1.94 0.19
87 INT325939 Regulation of Gene_expression of Ezr 1 0.61 5.27 0.19
88 INT152521 Gene_expression of Ezr 1 0.47 2.95 0.18
89 INT269610 Phosphorylation of ACTN1 1 0.03 0.19 0.18
90 INT296438 Positive_regulation of Ush1c 1 0.11 0.21 0.18
91 INT191479 Negative_regulation of Negative_regulation of Aif1 1 0.08 0.09 0.17
92 INT167360 Negative_regulation of Regulation of Aif1 2 0.38 0.59 0.16
93 INT197290 Gene_expression of Cdc42 9 0.35 2.52 0.15
94 INT299254 Negative_regulation of Gene_expression of Aif1 1 0.01 1.71 0.15
95 INT166269 Negative_regulation of Positive_regulation of Lcp1 1 0.42 1.89 0.15
96 INT44093 Positive_regulation of ACTN1 3 0.24 0 0.14
97 INT211307 Negative_regulation of Gene_expression of Lcp1 1 0.41 0.2 0.14
98 INT206133 Binding of CDC42 3 0.25 0.8 0.12
99 INT287283 Gene_expression of EZR 1 0.01 0.14 0.12
100 INT208920 Regulation of Ezr 6 0.61 2.97 0.11
101 INT267034 Gene_expression of Baiap2 1 0.24 0.15 0.1
102 INT325927 Phosphorylation of Ezr 1 0.82 2.74 0.09
103 INT197282 Positive_regulation of Gene_expression of Cdc42 3 0.26 0.12 0.08
104 INT208274 Negative_regulation of Espn 1 0.03 0.66 0.08
105 INT152522 Regulation of Gene_expression of Ezr 1 0.16 1.03 0.08
106 INT159857 Positive_regulation of Binding of ACTN1 1 0.08 0.16 0.08
107 INT96587 Binding of Lcp1 1 0.18 0.46 0.08
108 INT309320 Binding of AIF1 3 0.07 1.08 0.07
109 INT159859 Regulation of Binding of ACTN1 1 0.04 0.16 0.07
110 INT246431 Positive_regulation of Positive_regulation of Aif1 1 0.03 0.71 0.06
111 INT267025 Positive_regulation of Baiap2 1 0.15 0.1 0.06
112 INT246433 Regulation of Gene_expression of Aif1 1 0.02 0.67 0.06
113 INT189988 Regulation of Pawr 3 0.13 3.26 0.05
114 INT206169 Gene_expression of CDC42 2 0.26 1.05 0.05
115 INT178410 Negative_regulation of Pawr 1 0.12 0.29 0.05
116 INT206167 Positive_regulation of Gene_expression of CDC42 1 0.08 0.05 0.05
117 INT272173 Positive_regulation of Positive_regulation of Aif1 1 0.03 0 0.04
118 INT269625 Positive_regulation of Phosphorylation of ACTN1 1 0.02 0.08 0.04
119 INT325931 Negative_regulation of Gene_expression of Ezr 1 0.58 3.57 0.04
120 INT325937 Positive_regulation of Ezr 1 0.50 2.17 0.03
121 INT254795 Negative_regulation of Cdc42 2 0.12 1.53 0
122 INT175071 Binding of Ezr 2 0.12 0.07 0
123 INT321574 Regulation of ACTN4 1 0.01 0.52 0
124 INT283895 Negative_regulation of Phosphorylation of ACTN4 1 0.09 0.91 0
125 INT270614 Localization of Cdc42 1 0.55 0.95 0
126 INT321573 Negative_regulation of ACTN4 1 0.01 0.67 0
127 INT283880 Phosphorylation of ACTN4 1 0.12 1.63 0
128 INT197294 Regulation of Gene_expression of Cdc42 1 0.13 0 0
129 INT283886 Positive_regulation of Positive_regulation of CALD1 1 0.18 0 0
130 INT263567 Positive_regulation of Myo1b 1 0.01 1.01 0
131 INT283883 Positive_regulation of Gene_expression of CALD1 1 0.28 0 0
132 INT283889 Binding of ACTN4 1 0.05 0 0
133 INT276555 Gene_expression of Actn1 1 0.59 0.76 0
134 INT282269 Binding of Cdc42 1 0.08 0.33 0
135 INT268025 Positive_regulation of Positive_regulation of FSCN1 1 0.02 0 0
136 INT325935 Regulation of Regulation of Ezr 1 0.45 0.14 0
137 INT283897 Positive_regulation of Phosphorylation of CALD1 1 0.32 0.32 0
138 INT263252 Negative_regulation of ADD1 1 0.04 0.27 0
139 INT283890 Phosphorylation of CALD1 1 0.37 1.95 0
140 INT104526 Positive_regulation of Localization of FSCN1 1 0.08 0 0
141 INT287281 Positive_regulation of Positive_regulation of CDC42 1 0.26 0 0
142 INT282272 Positive_regulation of Binding of Cdc42 1 0.11 0.33 0
143 INT167359 Positive_regulation of Regulation of Aif1 1 0.41 0.06 0
144 INT104525 Negative_regulation of Positive_regulation of FSCN1 1 0.08 0 0
145 INT325933 Regulation of Phosphorylation of Ezr 1 0.45 0.75 0
146 INT309319 Positive_regulation of Binding of AIF1 1 0.09 0.06 0
147 INT263253 Positive_regulation of ADD1 1 0.11 0.83 0
148 INT325932 Positive_regulation of Positive_regulation of Ezr 1 0.50 0.28 0
149 INT325936 Positive_regulation of Phosphorylation of Ezr 1 0.69 0.62 0
150 INT276546 Regulation of Myo1b 1 0.16 0 0
151 INT272171 Regulation of Negative_regulation of Aif1 1 0.02 0 0
152 INT269658 Negative_regulation of Phosphorylation of ACTN1 1 0.02 0.11 0
153 INT321966 Positive_regulation of EZR 1 0.45 1 0
154 INT181212 Transcription of Lcp1 1 0.02 0.71 0
155 INT241408 Binding of Dpysl3 1 0.05 0 0
156 INT321572 Negative_regulation of Gene_expression of ACTN4 1 0.01 0.35 0
157 INT278429 Positive_regulation of Localization of Aif1 1 0.13 0.47 0
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