GO:0051044

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Name positive regulation of membrane protein ectodomain proteolysis
Categary Process
Go Slim No
Go Link GO:0051044
Unique Molecular Interactions 1878
Total Molecular Interactions 2616
Total Single Events 23677
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of membrane protein ectodomain proteolysis. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of membrane protein ectodomain proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
2 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
3 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
4 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
5 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
6 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
7 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
8 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
9 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
10 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
11 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
12 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
13 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
14 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
15 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
16 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
17 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
18 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
19 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
20 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
21 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
22 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
23 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
24 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
25 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
26 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
27 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
28 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
29 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
30 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
31 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
32 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
33 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
34 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
35 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
36 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
37 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
38 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
39 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
40 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
41 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
42 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
43 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
44 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
45 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
46 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
47 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
48 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
49 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
50 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
51 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
52 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
53 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
54 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
55 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
56 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
57 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
58 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
59 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
60 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
61 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
62 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
63 INT92057 Ifng Positive_regulation of Gene_expression of Ik 1 0.03 0.45 1.49
64 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
65 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
66 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
67 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
68 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
69 INT83626 Ifng Positive_regulation of Gene_expression of Cd59 1 0.33 2.19 1.41
70 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
71 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
72 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
73 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
74 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
75 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
76 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
77 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
78 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
79 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
80 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
81 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
82 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
83 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
84 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
85 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
86 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
87 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
88 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
89 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
90 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
91 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
92 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
93 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
94 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
95 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
96 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
97 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
98 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
99 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
100 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
101 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
102 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
103 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
104 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
105 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
106 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
107 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
108 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
109 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
110 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
111 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
112 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
113 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
114 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
115 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
116 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
117 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
118 INT122889 Ifng Positive_regulation of Gene_expression of HLA-E 1 0.02 0.97 1.1
119 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
120 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
121 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
122 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
123 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
124 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
125 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
126 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
127 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
128 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
129 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
130 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
131 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
132 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
133 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
134 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
135 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
136 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
137 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
138 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
139 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
140 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
141 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
142 INT113235 Tacr1 Regulation of Gene_expression of Ifng 1 0.26 1 1.04
143 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
144 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
145 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
146 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
147 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
148 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
149 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
150 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
151 INT88879 Ifng Positive_regulation of Nfkb1 1 0.01 0.26 1.01
152 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
153 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
154 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
155 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
156 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
157 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
158 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
159 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
160 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
161 INT94493 Avp Positive_regulation of Gene_expression of Ifng 1 0.05 1.73 0.97
162 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
163 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
164 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
165 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
166 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
167 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
168 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
169 INT77142 Binding of IFNG and IL4 2 0.03 1.16 0.95
170 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
171 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
172 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
173 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
174 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
175 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
176 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
177 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
178 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
179 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
180 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
181 INT94501 Il2 Positive_regulation of Gene_expression of Ifng 1 0.03 1.63 0.92
182 INT85879 Il12a Positive_regulation of Gene_expression of Ifng 1 0.20 0.89 0.92
183 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
184 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
185 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
186 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
187 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
188 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
189 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
190 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
191 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
192 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
193 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
194 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
195 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
196 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
197 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
198 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
199 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
200 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of membrane protein ectodomain proteolysis. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of membrane protein ectodomain proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
7 INT6481 Binding of TNF 624 0.48 510.2 214.82
8 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
9 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
10 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
11 INT9660 Regulation of TNF 363 0.62 312.94 139.99
12 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
13 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
14 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
15 INT10166 Localization of Tnf 237 0.81 153.95 88.64
16 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
17 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57
18 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
19 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
20 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
21 INT10359 Gene_expression of Ifng 159 0.78 79.6 72.14
22 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
23 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
24 INT6849 Localization of IL1B 229 0.81 112.56 69.63
25 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6
26 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
27 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
28 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
29 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
30 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
31 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
32 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
33 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
34 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
35 INT13354 Transcription of TNF 108 0.72 85.81 42.32
36 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
37 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
38 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
39 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
40 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
41 INT6484 Binding of IL1B 122 0.47 75.84 35.07
42 INT35406 Localization of Tnf 94 0.81 64.63 31.65
43 INT9347 Localization of Il1b 58 0.81 26.13 31.53
44 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
45 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
46 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
47 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
48 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
49 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
50 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
51 INT56224 Negative_regulation of Gene_expression of Ifng 40 0.58 23.34 25.08
52 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77
53 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
54 INT8518 Localization of Ifng 53 0.81 36.68 24.13
55 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
56 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05
57 INT48081 Localization of Il1b 46 0.80 21.59 22.4
58 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
59 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
60 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
61 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
62 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
63 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
64 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
65 INT25222 Positive_regulation of Gene_expression of Ifng 32 0.50 24.18 19.58
66 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
67 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
68 INT19509 Localization of Ifng 55 0.78 28.25 18.67
69 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
70 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35
71 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
72 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
73 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15
74 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
75 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
76 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
77 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89
78 INT10360 Positive_regulation of Ifng 33 0.68 21.73 15.19
79 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
80 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
81 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
82 INT10173 Binding of Tnf 45 0.48 35.6 14.32
83 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
84 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
85 INT4931 Localization of IFNG 53 0.78 33.25 13.65
86 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
87 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
88 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14
89 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
90 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
91 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
92 INT5057 Negative_regulation of Gene_expression of IFNG 23 0.58 8.33 12.3
93 INT9160 Negative_regulation of Ifng 31 0.58 16.37 11.84
94 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91
95 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
96 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
97 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
98 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
99 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
100 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
101 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
102 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
103 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
104 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
105 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
106 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
107 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
108 INT68299 Binding of Tnf 17 0.39 12.55 7.49
109 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
110 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
111 INT5326 Regulation of Ifng 12 0.55 4.56 7.19
112 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
113 INT197493 Localization of Apoe 61 0.79 27.48 7.06
114 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
115 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
116 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
117 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
118 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
119 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
120 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
121 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
122 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
123 INT74154 Transcription of Ifng 14 0.67 10.33 6.21
124 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
125 INT15803 Regulation of IFNG 21 0.44 12.57 5.98
126 INT80750 Binding of Il1b 11 0.47 7.97 5.95
127 INT5186 Regulation of Ifng 11 0.45 8.78 5.9
128 INT63042 Binding of Apoe 59 0.48 31.23 5.88
129 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
130 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
131 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
132 INT10705 Binding of Il1b 9 0.36 2.8 5.53
133 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
134 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
135 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
136 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
137 INT62132 Regulation of Gene_expression of Ifng 12 0.62 1.28 4.77
138 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74
139 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
140 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
141 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
142 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
143 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12
144 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
145 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
146 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79
147 INT34054 Regulation of Gene_expression of IFNG 8 0.42 3.69 3.76
148 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
149 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
150 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
151 INT87027 Positive_regulation of Localization of IFNG 12 0.67 5.78 3.35
152 INT72141 Binding of Apoe 11 0.37 10.91 3.27
153 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
154 INT97710 Localization of Apoe 1 0.79 7.18 3.2
155 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
156 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
157 INT21758 Negative_regulation of Nrd1 6 0.36 1.15 3.01
158 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
159 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
160 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84
161 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78
162 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
163 INT67078 Binding of Ifng 7 0.48 4.84 2.73
164 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
165 INT15197 Regulation of Gene_expression of Ifng 8 0.34 2.66 2.69
166 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
167 INT50080 Binding of APOE 38 0.45 29.61 2.67
168 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67
169 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64
170 INT111145 Negative_regulation of Positive_regulation of Ifng 7 0.41 2.21 2.61
171 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58
172 INT91669 Negative_regulation of Localization of IFNG 5 0.57 4.1 2.58
173 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56
174 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
175 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
176 INT16964 Binding of IFNG 27 0.48 14.31 2.45
177 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
178 INT73980 Transcription of Ifng 12 0.72 5.42 2.4
179 INT70918 Positive_regulation of Localization of Ifng 5 0.45 2.79 2.33
180 INT67437 Negative_regulation of Localization of Ifng 7 0.47 2.23 2.28
181 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
182 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26
183 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
184 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
185 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21
186 INT112784 Positive_regulation of Positive_regulation of IFNG 11 0.49 7.84 2.18
187 INT114898 Regulation of Transcription of TNF 4 0.35 2.69 2.18
188 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
189 INT73906 Regulation of Transcription of IL1B 5 0.56 3.46 2.1
190 INT140818 Positive_regulation of Positive_regulation of Ifng 2 0.47 4.2 2.06
191 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
192 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
193 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02
194 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01
195 INT111530 Positive_regulation of Regulation of Ifng 1 0.41 0.32 2.01
196 INT122649 Positive_regulation of Regulation of Tnf 2 0.49 2.78 1.96
197 INT171323 Phosphorylation of IL1B 5 0.57 4.13 1.94
198 INT116033 Negative_regulation of Transcription of Il1b 4 0.42 2.05 1.94
199 INT11136 Positive_regulation of Localization of Ifng 4 0.49 3.13 1.89
200 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
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