GO:0051056

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Name regulation of small GTPase mediated signal transduction
Categary Process
Go Slim No
Go Link GO:0051056
Unique Molecular Interactions 256
Total Molecular Interactions 342
Total Single Events 1961
Pain Genes Associated 48

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of small GTPase mediated signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for regulation of small GTPase mediated signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
2 INT240057 Binding of RHOB and NME8 1 0.41 4.11 1.5
3 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
4 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
5 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
6 INT125234 Positive_regulation of Binding of BCR and CD40LG 1 0.31 0.76 0.86
7 INT125233 Binding of BCR and CD40LG 1 0.23 0.75 0.85
8 INT201241 Positive_regulation of GDI2 Positive_regulation of Regulation of AGFG1 1 0.01 0 0.82
9 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
10 INT81975 Binding of OPRL1 and RASGRP1 1 0.03 0 0.76
11 INT197115 Binding of MCF2 and RETNLB 1 0.00 1.06 0.7
12 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
13 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
14 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
15 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
16 INT164973 Binding of RASA1 and Rgs7 1 0.00 0 0.54
17 INT249717 Binding of NCL and MCF2L 1 0.23 0 0.54
18 INT164972 Binding of RASA1 and Rgs8 1 0.00 0 0.53
19 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
20 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5
21 INT106074 IL1B Positive_regulation of Gene_expression of A2M 1 0.03 0.75 0.49
22 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
23 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43
24 INT333512 Binding of GPI and MCF2L 1 0.09 0.75 0.41
25 INT291625 Binding of CSTA and RAPGEF5 1 0.03 4.81 0.37
26 INT241742 Negative_regulation of Sdhb Regulation of Rapgef5 1 0.02 0.39 0.33
27 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
28 INT295722 PTGER2 Positive_regulation of RAC1 1 0.02 2.14 0.32
29 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32
30 INT241740 Sdhb Regulation of Rapgef5 1 0.02 0.34 0.32
31 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32
32 INT295725 PTGER2 Positive_regulation of RAC2 1 0.05 1.92 0.32
33 INT197114 IL1B Regulation of Binding of MCF2 1 0.03 0.48 0.31
34 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3
35 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3
36 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
37 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28
38 INT94849 A2M Negative_regulation of Gene_expression of COL7A1 1 0.01 0.27 0.28
39 INT118848 GNA14 Positive_regulation of RAC1 1 0.01 0.14 0.26
40 INT262354 TRIP10 Negative_regulation of Cyp4a3 1 0.00 0.8 0.26
41 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
42 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
43 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
44 INT193029 CHRM2 Positive_regulation of RHOA 1 0.01 0.12 0.24
45 INT312726 AASS Positive_regulation of FGD1 1 0.02 0.08 0.24
46 INT269561 TMPO Positive_regulation of RHOA 1 0.22 0 0.23
47 INT292561 MAP3K5 Positive_regulation of Positive_regulation of RAC1 1 0.03 0 0.23
48 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
49 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
50 INT65013 SOS1 Positive_regulation of Gene_expression of PTGER2 1 0.09 0.16 0.22
51 INT181765 WISP3 Regulation of Gene_expression of RHOC 1 0.49 1.46 0.21
52 INT257397 Binding of FGD1 and INS 1 0.07 0.27 0.21
53 INT257989 PTGER2 Positive_regulation of RASGRP1 1 0.01 0.61 0.21
54 INT189196 RASGRP1 Positive_regulation of SP1 1 0.05 0.63 0.21
55 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2
56 INT257398 Binding of FGD1 and GHRH 1 0.03 0.27 0.2
57 INT58588 IFNG Positive_regulation of ARHGAP4 1 0.31 1.22 0.19
58 INT103197 Nf1 Negative_regulation of ras 1 0.04 1.19 0.17
59 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17
60 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17
61 INT103198 NF1 Negative_regulation of ras 1 0.05 1.19 0.16
62 INT130918 HMHA1 Positive_regulation of BAX 1 0.04 1.37 0.14
63 INT306268 CRKL Positive_regulation of RASGRP1 1 0.02 0.54 0.14
64 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
65 INT130923 HMHA1 Positive_regulation of Protein_catabolism of CASP8 1 0.04 1.37 0.14
66 INT130922 HMHA1 Positive_regulation of Protein_catabolism of CYCS 1 0.06 1.39 0.14
67 INT130917 HMHA1 Positive_regulation of CYCS 1 0.06 1.39 0.14
68 INT130921 HMHA1 Positive_regulation of CASP9 1 0.03 1.37 0.14
69 INT94850 A2M Negative_regulation of Gene_expression of PIP 1 0.01 0.14 0.14
70 INT130920 HMHA1 Positive_regulation of CASP8 1 0.04 1.36 0.14
71 INT130919 HMHA1 Positive_regulation of Protein_catabolism of CASP9 1 0.03 1.37 0.14
72 INT304824 Binding of Rasa1 and Tnnc1 1 0.01 0 0.13
73 INT109410 RASGRP1 Regulation of Gene_expression of PPARG 1 0.03 0.76 0.13
74 INT269572 MAPKAP1 Positive_regulation of RHOA 1 0.06 0 0.13
75 INT269548 ARHGEF17 Positive_regulation of RHOA 1 0.01 0 0.12
76 INT279804 ATP6V0A2 Regulation of MCF2 1 0.00 1.76 0.12
77 INT191612 Nf1 Positive_regulation of ras 1 0.25 2.6 0.11
78 INT287267 EGF Positive_regulation of CDC42 1 0.12 0.16 0.11
79 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1
80 INT225743 Binding of SOS1 and RANBP9 1 0.00 0.09 0.1
81 INT132511 RASGRP1 Positive_regulation of OPCML 1 0.29 0.44 0.1
82 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1
83 INT132510 RASGRP1 Negative_regulation of OPCML 1 0.25 0.44 0.1
84 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1
85 INT96045 Capn1 Regulation of Rasgrp1 1 0.01 0.44 0.09
86 INT269593 MAPKAP1 Positive_regulation of Positive_regulation of RHOA 1 0.06 0 0.09
87 INT206054 RAC1 Positive_regulation of STAT3 1 0.07 0.11 0.09
88 INT311811 Binding of REN and RASGRP1 1 0.16 0.68 0.08
89 INT191617 Binding of Nf1 and Rtcd1 1 0.01 0.95 0.08
90 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08
91 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
92 INT250662 FNTA Positive_regulation of Positive_regulation of RASGRP1 1 0.00 0.79 0.07
93 INT231863 Binding of ARHGDIA and Akt1 1 0.02 0.23 0.07
94 INT159851 Positive_regulation of RHOA Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.06
95 INT132512 RASGRP1 Regulation of OPCML 1 0.16 0.32 0.06
96 INT263743 Rasgrf1 Positive_regulation of Positive_regulation of Mapk1 1 0.11 0 0.06
97 INT263770 Rasgrf1 Positive_regulation of Positive_regulation of Grin1 1 0.24 0 0.06
98 INT183863 RHOC Positive_regulation of Gene_expression of MAPK1 1 0.25 0.26 0.05
99 INT263727 Binding of Grin2b and Rasgrf1 1 0.18 0 0.05
100 INT206087 RAC1 Positive_regulation of Gene_expression of STAT3 1 0.08 0.05 0.05
101 INT263730 Binding of Grin2a and Rasgrf1 1 0.23 0 0.05
102 INT183851 RHOC Positive_regulation of MAPK1 1 0.34 0.26 0.05
103 INT183859 RHOC Positive_regulation of IFI44 1 0.18 0.26 0.05
104 INT183850 RHOC Positive_regulation of Gene_expression of IFI44 1 0.13 0.26 0.05
105 INT249170 Binding of AKT1 and ARHGDIA 1 0.00 0.15 0.04
106 INT231806 ARHGDIA Negative_regulation of ARHGEF1 1 0.02 0.11 0.04
107 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04
108 INT206073 Negative_regulation of RAC1 Positive_regulation of IL6 1 0.14 0.06 0.04
109 INT274585 Binding of PSTPIP1 and TRIP10 1 0.15 0.08 0.04
110 INT206067 Gene_expression of RAC1 Positive_regulation of Positive_regulation of IL6 1 0.16 0.07 0.04
111 INT246786 Ogg1 Regulation of Phosphorylation of Tsc2 1 0.20 0.42 0.04
112 INT149751 Rapgef3 Regulation of Phosphorylation of Akt1 1 0.50 0.39 0.04
113 INT206068 RAC1 Positive_regulation of IL6 1 0.16 0.06 0.04
114 INT353317 Edn1 Positive_regulation of RHOA 1 0.19 0.16 0.04
115 INT231865 ARHGDIA Negative_regulation of Sergef 1 0.01 0.05 0.04
116 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
117 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03
118 INT183858 Negative_regulation of RHOC Positive_regulation of MAPK1 1 0.26 0.17 0.03
119 INT206061 RAC1 Positive_regulation of Positive_regulation of STAT3 1 0.07 0.43 0.03
120 INT194707 RAC1 Positive_regulation of PAK1 1 0.01 0 0.03
121 INT194738 Binding of PAK1 and RAC1 1 0.01 0 0.03
122 INT246791 Tsc2 Regulation of Ogg1 1 0.27 0.56 0.03
123 INT254511 RAC1 Positive_regulation of Positive_regulation of CYBB 1 0.14 0.39 0.03
124 INT291621 RAPGEF5 Regulation of CSTA 1 0.04 0.43 0.03
125 INT232900 Binding of ABR and Krt8 1 0.03 0.49 0.03
126 INT191613 Binding of Nf1 and Rasa1 1 0.06 0.88 0.03
127 INT302171 PTGER4 Positive_regulation of RASGRP1 1 0.01 1.03 0.03
128 INT225898 Positive_regulation of RAC1 Positive_regulation of PAK1 1 0.01 0.08 0
129 INT295710 PTGER2 Regulation of Positive_regulation of RAC1 1 0.01 1.62 0
130 INT96044 Rasgrp1 Positive_regulation of Gene_expression of Nos2 1 0.14 0.05 0
131 INT316500 INO80B Positive_regulation of RALBP1 1 0.00 0.31 0
132 INT295701 Positive_regulation of Binding of RAC1 and Racgap1 1 0.28 0.16 0
133 INT246784 Negative_regulation of Tsc2 Positive_regulation of Negative_regulation of Ogg1 1 0.20 0.43 0
134 INT225909 Binding of GRB2 and SOS1 1 0.01 0.11 0
135 INT284092 HNF1A Positive_regulation of FGD2 1 0.15 1.16 0
136 INT306257 Binding of MAPK8 and RAC2 1 0.24 0 0
137 INT246811 Ros1 Positive_regulation of Tsc2 1 0.02 0 0
138 INT325770 Binding of EPOR and PIK3R2 1 0.01 0.18 0
139 INT320959 Binding of HRAS and HMHA1 1 0.00 0.37 0
140 INT269586 Negative_regulation of TMPO Positive_regulation of RHOA 1 0.14 0 0
141 INT262731 Binding of CHN1 and TAF1A 1 0.00 0 0
142 INT225892 Binding of GAB1 and RASA1 1 0.01 0.06 0
143 INT235011 Ctnnd1 Positive_regulation of RAC1 1 0.00 0.07 0
144 INT72209 BCR Positive_regulation of Mapk13 1 0.00 0 0
145 INT295704 Positive_regulation of Binding of RHOA and Racgap1 1 0.15 0.16 0
146 INT246808 Tsc2 Regulation of Regulation of Tsc1 1 0.02 0.05 0
147 INT194716 Positive_regulation of Binding of VAV1 and ZAP70 1 0.04 0 0
148 INT246794 Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.03 0.66 0
149 INT115368 Binding of GDNF and RAPGEF5 1 0.32 0 0
150 INT217779 POLR2B Regulation of Gene_expression of RASGRP1 1 0.01 0.2 0
151 INT269547 PTGIR Regulation of Phosphorylation of RHOA 1 0.02 0 0
152 INT334320 EGFR Positive_regulation of RASGRP1 1 0.05 0.76 0
153 INT345287 Binding of SCN10A and RAPGEF5 1 0.01 0.67 0
154 INT295706 PTGER2 Regulation of Regulation of RHOA 1 0.01 0.61 0
155 INT218509 Binding of BCR and Cfb 1 0.00 0.18 0
156 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0
157 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0
158 INT306269 Binding of MAPK8 and RAC1 1 0.25 0 0
159 INT96046 Rasgrp1 Negative_regulation of Mpo 1 0.23 0.06 0
160 INT235181 IRF6 Positive_regulation of RASGRP1 1 0.00 0.2 0
161 INT234996 Ctnnd1 Positive_regulation of CDC42 1 0.01 0.07 0
162 INT246787 Akt2 Positive_regulation of Phosphorylation of Tsc2 1 0.10 0.16 0
163 INT232899 Krt18 Negative_regulation of Binding of ABR 1 0.05 0.68 0
164 INT101591 Binding of RAC1 and RAC3 1 0.13 0.52 0
165 INT203587 MCF2 Negative_regulation of Gene_expression of CPOX 1 0.00 0.6 0
166 INT225908 Binding of RAC1 and IQGAP1 1 0.00 0.09 0
167 INT225890 Binding of RAC1 and STAT3 1 0.01 0 0
168 INT246789 Pik3c3 Regulation of Tsc2 1 0.02 0.34 0
169 INT338194 Regulation of VAV3 Regulation of AR 1 0.31 0.49 0
170 INT24480 Binding of ERF and RASGEF1A 1 0.00 0 0
171 INT263248 Binding of ADD1 and RAPGEF5 1 0.01 0.84 0
172 INT246809 Negative_regulation of Tsc2 Positive_regulation of Positive_regulation of Ogg1 1 0.20 0.45 0
173 INT269549 Regulation of GOPC Positive_regulation of RHOA 1 0.09 0 0
174 INT218514 BCR Negative_regulation of Binding of Cfb 1 0.00 0.18 0
175 INT194711 LAT Positive_regulation of Binding of VAV1 1 0.03 0 0
176 INT246801 Negative_regulation of Akt1 Negative_regulation of Phosphorylation of Tsc2 1 0.17 0 0
177 INT217778 MAP3K3 Regulation of Gene_expression of RASGRP1 1 0.09 0.19 0
178 INT246792 Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.78 0
179 INT269581 PTGIR Regulation of RHOA 1 0.02 0 0
180 INT295714 PTGER2 Positive_regulation of RHOA 1 0.01 0.34 0
181 INT232893 Binding of ABR and Nup62 1 0.03 0.13 0
182 INT183857 CAV1 Positive_regulation of RHOC 1 0.46 0.21 0
183 INT321125 Binding of RHOB and IgG 1 0.01 0.31 0
184 INT303334 Binding of SOS1 and Grb2 1 0.00 0.11 0
185 INT232895 Krt18 Positive_regulation of Gene_expression of ABR 1 0.46 0.09 0
186 INT268595 Gene_expression of Mirlet7a-1 Negative_regulation of RASGRP1 1 0.00 0.59 0
187 INT262729 Binding of CHN1 and RN7SL2 1 0.02 0 0
188 INT269571 Positive_regulation of GOPC Positive_regulation of RHOA 1 0.10 0 0
189 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0
190 INT295700 Binding of RAC1 and Racgap1 1 0.21 0.16 0
191 INT183864 Gene_expression of CAV1 Negative_regulation of Positive_regulation of RHOC 1 0.39 0.95 0
192 INT246798 Akt1 Regulation of Tsc2 1 0.16 0.34 0
193 INT183897 Binding of RHOC and Racgap1 1 0.01 0.2 0
194 INT96043 Rasgrp1 Negative_regulation of Sdcbp 1 0.02 0.06 0
195 INT269771 Binding of ARHGDIB and NOVA2 1 0.05 0 0
196 INT217773 MIR208A Regulation of Gene_expression of RASGRP1 1 0.06 0.2 0
197 INT175400 RASGRP1 Positive_regulation of MAP3K5 1 0.00 1.2 0
198 INT183860 Binding of RHOC and CAV1 1 0.34 0.4 0
199 INT288827 Binding of Rasgrf2 and Vav1 1 0.40 0.37 0
200 INT269555 GOPC Positive_regulation of RHOA 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of small GTPase mediated signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in regulation of small GTPase mediated signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54
2 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47
3 INT128178 Positive_regulation of RHOA 59 0.68 9.3 4.7
4 INT68216 Binding of NF1 40 0.48 51.24 4.59
5 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55
6 INT34184 Localization of FGD1 7 0.65 2.68 4.21
7 INT58875 Positive_regulation of FGD1 20 0.60 3.88 4.19
8 INT151684 Gene_expression of MCF2L 7 0.54 6.25 3.76
9 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75
10 INT121967 Regulation of RAC1 9 0.45 6.14 3.41
11 INT128179 Gene_expression of RHOA 7 0.64 2.48 3.01
12 INT61714 Binding of FGD1 12 0.35 7.72 2.91
13 INT158083 Gene_expression of FGD1 24 0.67 6.82 2.83
14 INT10141 Gene_expression of A2M 11 0.35 9.37 2.75
15 INT17993 Negative_regulation of RASA1 8 0.41 7.34 2.62
16 INT169798 Positive_regulation of Rapgef3 1 0.45 1.7 2.56
17 INT699 Positive_regulation of A2M 16 0.66 10.49 2.5
18 INT262339 Positive_regulation of TRIP10 2 0.26 2.07 2.5
19 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
20 INT128174 Positive_regulation of Gene_expression of RHOA 7 0.36 1.5 2.36
21 INT249718 Binding of MCF2L 6 0.16 3.52 2.36
22 INT64700 Binding of Nf1 14 0.45 15.24 2.29
23 INT131850 Gene_expression of RHOC 17 0.72 29.06 2.28
24 INT23352 Negative_regulation of A2M 10 0.33 8.35 2.16
25 INT21611 Negative_regulation of RASGRP1 20 0.35 11.76 2.15
26 INT70987 Binding of RAC1 14 0.37 12.14 2.13
27 INT43900 Gene_expression of RASA1 13 0.58 12 2.03
28 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
29 INT68181 Binding of Nf1 6 0.48 8.14 1.88
30 INT240058 Gene_expression of RHOB 2 0.55 4.29 1.84
31 INT85348 Localization of RHOA 12 0.59 4.81 1.83
32 INT149441 Positive_regulation of MCF2L 5 0.61 3.96 1.82
33 INT59790 Binding of BCR 16 0.36 15.34 1.75
34 INT254045 Gene_expression of TRIP10 4 0.29 3.04 1.67
35 INT3249 Regulation of A2M 7 0.39 3.29 1.61
36 INT240059 Binding of RHOB 7 0.48 3.96 1.59
37 INT101859 Gene_expression of MCF2 34 0.49 19.45 1.51
38 INT37485 Regulation of RAPGEF5 10 0.44 6.64 1.51
39 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45
40 INT14916 Binding of RASA1 15 0.37 13.64 1.44
41 INT42391 Positive_regulation of BCR 7 0.49 4.93 1.44
42 INT169799 Binding of Rapgef3 1 0.30 1.04 1.43
43 INT47734 Positive_regulation of RAPGEF5 19 0.56 13.16 1.41
44 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4
45 INT8068 Gene_expression of RASGRP1 29 0.54 15.1 1.37
46 INT131848 Positive_regulation of Gene_expression of RHOC 9 0.64 15.43 1.36
47 INT96039 Regulation of Rasgrp1 1 0.37 0.44 1.36
48 INT8063 Regulation of RASGRP1 15 0.36 9.15 1.3
49 INT142992 Phosphorylation of RHOA 3 0.80 0.87 1.28
50 INT128176 Regulation of RHOA 13 0.44 4.35 1.26
51 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24
52 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23
53 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22
54 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19
55 INT188774 Binding of RAPGEF5 12 0.29 13.55 1.04
56 INT136817 Negative_regulation of Positive_regulation of RHOA 8 0.57 0 1.04
57 INT36517 Negative_regulation of MCF2 14 0.42 6.43 1.02
58 INT170818 Localization of RASGRP1 4 0.44 1.93 1.02
59 INT316159 Regulation of FGD1 1 0.01 0.59 0.99
60 INT17554 Regulation of ABR 6 0.54 2.21 0.98
61 INT262340 Binding of TRIP10 6 0.36 1.45 0.96
62 INT352919 Positive_regulation of Gene_expression of RHOB 1 0.35 2.21 0.96
63 INT20757 Binding of MCF2 4 0.07 0.71 0.95
64 INT4681 Localization of RAPGEF5 12 0.68 8.69 0.93
65 INT131824 Negative_regulation of RHOA 10 0.57 2.9 0.92
66 INT42390 Regulation of Positive_regulation of BCR 1 0.00 0 0.87
67 INT34188 Positive_regulation of Localization of FGD1 1 0.01 0 0.87
68 INT34185 Negative_regulation of Localization of FGD1 1 0.00 0 0.87
69 INT175904 Localization of RAC1 7 0.41 5.05 0.86
70 INT114176 Positive_regulation of SOS1 3 0.20 1.5 0.86
71 INT111943 Negative_regulation of Positive_regulation of RAC1 2 0.46 1.33 0.86
72 INT110208 Binding of ABR 2 0.35 10.49 0.81
73 INT241722 Gene_expression of Rapgef5 1 0.24 1.34 0.81
74 INT115757 Negative_regulation of ABR 3 0.57 0.53 0.8
75 INT111945 Protein_catabolism of RAC1 1 0.31 0.67 0.79
76 INT257400 Positive_regulation of Gene_expression of FGD1 3 0.50 0.79 0.78
77 INT304823 Negative_regulation of Rasa1 6 0.10 0.39 0.76
78 INT173338 Positive_regulation of Localization of RHOA 2 0.14 1.52 0.76
79 INT201253 Positive_regulation of GDI2 1 0.27 0 0.76
80 INT85347 Negative_regulation of Localization of RHOA 1 0.31 0 0.74
81 INT22096 Negative_regulation of SOS1 4 0.25 1.63 0.71
82 INT158084 Negative_regulation of FGD1 4 0.21 1.82 0.69
83 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68
84 INT179133 Localization of Nf1 2 0.80 2.18 0.68
85 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67
86 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67
87 INT282302 Regulation of TRIP10 1 0.23 0.39 0.67
88 INT189322 Binding of A2M 7 0.29 12.1 0.66
89 INT191194 Localization of MCF2 7 0.11 2.29 0.65
90 INT65016 Gene_expression of SOS1 4 0.61 0.47 0.65
91 INT211489 Gene_expression of ARHGAP4 6 0.65 2.88 0.61
92 INT8066 Binding of RASGRP1 10 0.36 4.65 0.58
93 INT50016 Positive_regulation of ARHGAP4 3 0.49 1.8 0.58
94 INT147734 Phosphorylation of RAC1 3 0.64 1.33 0.58
95 INT90416 Positive_regulation of RASA1 3 0.67 1.58 0.56
96 INT197117 Negative_regulation of Localization of MCF2 1 0.03 0.81 0.56
97 INT97956 Negative_regulation of CDC42 3 0.27 1.58 0.55
98 INT201255 Binding of GDI2 2 0.17 0.2 0.55
99 INT127736 Regulation of Gene_expression of RAC1 2 0.27 2 0.53
100 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51
101 INT69417 Positive_regulation of Positive_regulation of RASGRP1 4 0.29 3.92 0.49
102 INT65019 Regulation of SOS1 2 0.56 0.42 0.49
103 INT7248 Localization of RASA1 4 0.61 2.52 0.47
104 INT316933 Transcription of Nf1 1 0.18 0.49 0.47
105 INT316939 Positive_regulation of Transcription of Nf1 1 0.16 0.49 0.47
106 INT164267 Negative_regulation of Phosphorylation of RAC1 1 0.33 0.96 0.46
107 INT320452 Negative_regulation of MCF2L 1 0.13 0.5 0.46
108 INT232886 Regulation of Gene_expression of ABR 3 0.06 1.42 0.45
109 INT164266 Positive_regulation of Phosphorylation of RAC1 1 0.39 0.95 0.45
110 INT240033 Phosphorylation of PIK3R2 1 0.02 1.82 0.45
111 INT55893 Gene_expression of Rasa1 5 0.52 1.04 0.44
112 INT11118 Gene_expression of RAPGEF5 13 0.65 9.35 0.43
113 INT144907 Gene_expression of RAC3 2 0.53 0.57 0.43
114 INT131851 Positive_regulation of RHOC 3 0.57 9.44 0.41
115 INT282303 Positive_regulation of Gene_expression of TRIP10 1 0.17 0.46 0.39
116 INT60976 Positive_regulation of Gene_expression of CHN1 1 0.14 3.91 0.39
117 INT75496 Positive_regulation of MCF2 7 0.08 3.86 0.38
118 INT333516 Regulation of MCF2L 1 0.09 0.82 0.37
119 INT194779 Binding of VAV1 2 0.14 1.62 0.36
120 INT48772 Localization of A2M 3 0.78 2.83 0.35
121 INT60977 Localization of CHN1 2 0.57 1.9 0.35
122 INT340381 Transcription of FGD1 1 0.07 0.35 0.35
123 INT112334 Regulation of NF1 18 0.52 15.85 0.34
124 INT131849 Negative_regulation of RHOC 4 0.54 6.46 0.34
125 INT282301 Regulation of Gene_expression of TRIP10 1 0.23 0.3 0.34
126 INT221833 Positive_regulation of TSC2 2 0.23 0.39 0.33
127 INT136943 Positive_regulation of Rapgef3 2 0.67 1.25 0.33
128 INT50014 Negative_regulation of ARHGAP4 2 0.27 1.59 0.32
129 INT183879 Binding of RHOA 6 0.34 2.1 0.31
130 INT295683 Positive_regulation of RAC2 1 0.49 1.72 0.3
131 INT131822 Positive_regulation of Positive_regulation of RHOA 2 0.45 0.33 0.29
132 INT211491 Positive_regulation of Gene_expression of ARHGAP4 1 0.49 1.18 0.29
133 INT55894 Positive_regulation of Gene_expression of Rasa1 1 0.47 0.19 0.28
134 INT270743 Negative_regulation of Localization of RAPGEF5 1 0.11 1.6 0.27
135 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26
136 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25
137 INT234817 Gene_expression of GDI1 4 0.17 2.99 0.25
138 INT45351 Negative_regulation of ARHGDIB 1 0.47 0.56 0.25
139 INT183881 Localization of CDC42 3 0.49 1.92 0.23
140 INT46524 Negative_regulation of Gene_expression of A2M 2 0.02 1.45 0.23
141 INT129342 Positive_regulation of Positive_regulation of Nf1 1 0.50 0.79 0.23
142 INT65017 Negative_regulation of Gene_expression of SOS1 1 0.39 0.16 0.23
143 INT109415 Negative_regulation of Positive_regulation of RASGRP1 5 0.34 2.16 0.22
144 INT68180 Regulation of Nf1 2 0.27 2.02 0.22
145 INT8064 Negative_regulation of Binding of RASGRP1 2 0.28 0.83 0.22
146 INT154360 Localization of Tsc2 1 0.56 0.16 0.22
147 INT65022 Positive_regulation of Gene_expression of SOS1 1 0.45 0.16 0.22
148 INT231829 Negative_regulation of ARHGDIA 2 0.09 1.01 0.21
149 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2
150 INT129341 Negative_regulation of Gene_expression of Nf1 2 0.43 1.67 0.2
151 INT183876 Regulation of CDC42 3 0.30 1.94 0.19
152 INT60978 Gene_expression of CHN1 2 0.24 2.1 0.19
153 INT192748 Localization of BCR 4 0.68 2.4 0.18
154 INT132523 Positive_regulation of Gene_expression of RASGRP1 2 0.29 1.29 0.18
155 INT96038 Positive_regulation of Rasgrp1 2 0.30 0.55 0.17
156 INT155285 Positive_regulation of Nf1 1 0.16 0.55 0.17
157 INT3248 Positive_regulation of Positive_regulation of A2M 1 0.46 0.25 0.17
158 INT23708 Regulation of Regulation of A2M 1 0.02 0.68 0.17
159 INT269466 Positive_regulation of Localization of GDI1 1 0.01 0 0.16
160 INT201013 Regulation of Gene_expression of RASA1 1 0.05 0.16 0.16
161 INT103196 Negative_regulation of Gene_expression of Nf1 1 0.57 1.21 0.16
162 INT269482 Localization of GDI1 1 0.02 0 0.16
163 INT119070 Phosphorylation of SOS1 2 0.79 0.94 0.15
164 INT55892 Negative_regulation of Gene_expression of Rasa1 1 0.29 0.1 0.15
165 INT316515 Positive_regulation of RALBP1 28 0.25 10.37 0.14
166 INT191179 Regulation of MCF2 12 0.06 8.54 0.14
167 INT170468 Regulation of Gene_expression of RASGRP1 2 0.17 1.68 0.14
168 INT119145 Binding of RAC2 2 0.13 0.47 0.14
169 INT149302 Regulation of ARHGEF3 1 0.14 1.02 0.14
170 INT149301 Binding of ARHGEF3 1 0.20 1.02 0.14
171 INT232877 Negative_regulation of Binding of ABR 1 0.06 1.88 0.14
172 INT304822 Regulation of Negative_regulation of Rasa1 1 0.05 0 0.14
173 INT119228 Gene_expression of TSC2 3 0.75 4.43 0.13
174 INT75168 Binding of CHN1 2 0.19 1.73 0.13
175 INT282160 Regulation of Binding of RAC1 1 0.18 0.45 0.13
176 INT50015 Negative_regulation of Positive_regulation of ARHGAP4 1 0.27 0.37 0.13
177 INT232880 Phosphorylation of ABR 1 0.79 0.76 0.13
178 INT232875 Negative_regulation of Phosphorylation of ABR 1 0.41 0.76 0.13
179 INT246776 Negative_regulation of Tsc2 18 0.48 6.82 0.12
180 INT246749 Negative_regulation of Phosphorylation of Tsc2 11 0.35 3.4 0.12
181 INT206133 Binding of CDC42 3 0.25 0.8 0.12
182 INT131847 Negative_regulation of Gene_expression of RHOC 2 0.39 1.38 0.12
183 INT304820 Transcription of Rasa1 1 0.10 0 0.12
184 INT269636 Phosphorylation of ARHGEF17 1 0.02 0 0.12
185 INT131852 Positive_regulation of Negative_regulation of RHOC 1 0.46 1.12 0.12
186 INT201009 Transcription of RASA1 1 0.07 0.14 0.12
187 INT349974 Positive_regulation of Rasa1 1 0.04 0.92 0.11
188 INT223764 Gene_expression of ARHGDIB 1 0.07 0.36 0.11
189 INT171092 Positive_regulation of Gene_expression of MCF2 6 0.05 1.57 0.1
190 INT316511 Gene_expression of RALBP1 5 0.28 5.24 0.1
191 INT25530 Positive_regulation of ABR 3 0.33 0.34 0.1
192 INT172526 Regulation of RHOC 2 0.51 4.7 0.1
193 INT58594 Regulation of ARHGAP4 1 0.21 0.65 0.1
194 INT149303 Positive_regulation of ARHGEF3 1 0.37 0.77 0.1
195 INT269666 Regulation of Gene_expression of RHOA 1 0.32 0.38 0.1
196 INT279950 Positive_regulation of Positive_regulation of RAPGEF5 1 0.24 1.56 0.1
197 INT316168 Negative_regulation of Negative_regulation of FGD1 1 0.01 0 0.1
198 INT154184 Positive_regulation of SIPA1 1 0.20 0.81 0.1
199 INT149306 Negative_regulation of ARHGEF3 1 0.23 0.8 0.1
200 INT328094 Positive_regulation of Gene_expression of ABR 1 0.33 0 0.09
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