GO:0051085

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Name chaperone mediated protein folding requiring cofactor
Categary Process
Go Slim No
Go Link GO:0051085
Unique Molecular Interactions 60
Total Molecular Interactions 86
Total Single Events 485
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for chaperone mediated protein folding requiring cofactor. They are ordered first by their pain relevance and then by number of times they were reported for chaperone mediated protein folding requiring cofactor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
2 INT48101 RT1-DMb Positive_regulation of Penk 1 0.10 0 1.5
3 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16
4 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
5 INT346205 Binding of CD74 and TPPP 1 0.02 0.87 0.51
6 INT324816 Hspd1 Positive_regulation of Gene_expression of Ik 1 0.00 1.59 0.5
7 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
8 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43
9 INT93694 Binding of Hspa8 and Ptgs1 1 0.30 0.79 0.36
10 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
11 INT324830 Hspd1 Positive_regulation of IFNA1 1 0.04 0.46 0.3
12 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
13 INT324835 Hspd1 Positive_regulation of Gene_expression of IFNA1 1 0.15 0.31 0.23
14 INT269066 Binding of Hspa8 and Il6 1 0.00 0.74 0.23
15 INT224086 Binding of Agtr1a and Hspa8 1 0.00 0.1 0.19
16 INT353808 HLA-DMA Regulation of HLA-B 1 0.00 1.72 0.19
17 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
18 INT93693 Positive_regulation of Binding of Hspa8 and Ptgs1 1 0.31 0.38 0.17
19 INT165751 Hspa8 Positive_regulation of Protein_catabolism of Rgs9 1 0.50 0.17 0.17
20 INT224126 Binding of Hspa8 and Agtr1a 1 0.00 0.09 0.17
21 INT43495 Cd74 Regulation of Gene_expression of Ifng 1 0.47 0 0.14
22 INT298052 Binding of Cd74 and Vip 1 0.00 1.05 0.13
23 INT324804 Binding of Hspd1 and Tlr4 1 0.14 0.36 0.13
24 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
25 INT87839 Binding of Cd74 and Dcn 1 0.36 0.21 0.13
26 INT180345 Binding of HLA-DMA and HLA-DRB4 1 0.00 1.51 0.12
27 INT230065 Binding of TOR1A and HLA-DOA 1 0.00 1.65 0.09
28 INT337084 Negative_regulation of Binding of Cd74 and Mif 1 0.29 1.64 0.08
29 INT284448 Il11 Positive_regulation of Hspa8 1 0.04 0.42 0.05
30 INT276951 Hspd1 Positive_regulation of Il10 1 0.05 0.75 0.04
31 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
32 INT276949 Hspd1 Positive_regulation of Gene_expression of Socs3 1 0.15 0.71 0.04
33 INT276977 Hspd1 Positive_regulation of Gene_expression of Il13 1 0.07 0.75 0.04
34 INT276956 Hspd1 Positive_regulation of Il13 1 0.07 0.75 0.04
35 INT348820 Cd74 Regulation of Gene_expression of TFDP3 1 0.07 0.16 0.04
36 INT276954 Hspd1 Positive_regulation of Stat3 1 0.31 0.65 0.04
37 INT276967 Hspd1 Regulation of Gene_expression of Socs3 1 0.14 0.71 0.04
38 INT276970 Hspd1 Positive_regulation of Gene_expression of Il10 1 0.10 0.69 0.03
39 INT236078 Binding of AGER and HLA-DMA 1 0.08 0.81 0
40 INT350792 Binding of Hspd1 and Lsr1 1 0.00 0.25 0
41 INT320632 Ptger2 Regulation of Gene_expression of Hspd1 1 0.00 0.41 0
42 INT146131 Binding of Gnrh1 and Hspd1 1 0.02 0.88 0
43 INT350796 Binding of CEBPB and Hspd1 1 0.00 0.25 0
44 INT180350 Binding of HLA-DMA and ENAM 1 0.00 1.85 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for chaperone mediated protein folding requiring cofactor. They are ordered first by their pain relevance and then by number of times they were reported in chaperone mediated protein folding requiring cofactor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT253970 Positive_regulation of Cd74 3 0.48 8.16 4.09
2 INT73981 Gene_expression of Hspd1 18 0.75 5.69 3.72
3 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47
4 INT187168 Binding of Cd74 13 0.27 11.2 3.44
5 INT117121 Gene_expression of Hspa8 7 0.65 4.92 2.94
6 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84
7 INT79476 Gene_expression of HLA-DMA 23 0.38 9.5 2.76
8 INT243350 Binding of CD74 2 0.11 4.86 2.72
9 INT44851 Gene_expression of RT1-DMb 3 0.52 2.2 2.1
10 INT253975 Binding of Cd74 4 0.27 4.57 1.88
11 INT271443 Regulation of Cd74 1 0.33 2.73 1.4
12 INT117122 Positive_regulation of Gene_expression of Hspa8 1 0.40 0.45 1.4
13 INT53775 Gene_expression of Hspd1 21 0.78 31.25 1.38
14 INT73180 Positive_regulation of Hspa8 7 0.37 3.41 1.37
15 INT53776 Positive_regulation of Hspd1 17 0.70 10.64 1.23
16 INT73176 Positive_regulation of Hspd1 5 0.35 3.96 1.22
17 INT116058 Gene_expression of Cd74 2 0.56 0.55 0.89
18 INT174420 Positive_regulation of Gene_expression of Cd74 3 0.20 1.92 0.81
19 INT188347 Localization of Hspd1 2 0.41 4.53 0.71
20 INT230087 Binding of TOR1A 6 0.35 2.84 0.68
21 INT139944 Transcription of RT1-DMb 1 0.11 0.87 0.68
22 INT116838 Regulation of Gene_expression of Hspd1 1 0.18 0.19 0.62
23 INT116060 Negative_regulation of Gene_expression of Cd74 1 0.12 0 0.61
24 INT53774 Positive_regulation of Gene_expression of Hspd1 7 0.70 6.99 0.6
25 INT53778 Regulation of Gene_expression of Hspd1 2 0.58 3.61 0.52
26 INT271439 Positive_regulation of Localization of Cd74 1 0.36 1.01 0.52
27 INT207614 Binding of Hspd1 4 0.18 1.16 0.5
28 INT271435 Localization of Cd74 1 0.54 0.95 0.49
29 INT174418 Regulation of Gene_expression of Cd74 1 0.04 0.9 0.46
30 INT229587 Positive_regulation of Gene_expression of RT1-DMb 1 0.06 1.7 0.45
31 INT254172 Negative_regulation of Gene_expression of Cd74 1 0.24 1.03 0.44
32 INT100082 Negative_regulation of Hspd1 3 0.54 1.91 0.42
33 INT239036 Positive_regulation of HLA-DMA 4 0.67 1.44 0.4
34 INT62874 Gene_expression of CD74 1 0.00 0.64 0.37
35 INT324772 Positive_regulation of Gene_expression of Hspd1 1 0.49 0.41 0.29
36 INT3912 Localization of HLA-DMA 2 0.35 1.09 0.27
37 INT230098 Positive_regulation of Binding of TOR1A 1 0.08 0.41 0.18
38 INT221116 Regulation of HLA-DMA 4 0.05 0.7 0.17
39 INT291908 Negative_regulation of HLA-DMA 1 0.08 0.14 0.17
40 INT230097 Gene_expression of TOR1A 1 0.12 2.93 0.17
41 INT230092 Positive_regulation of TOR1A 1 0.09 0.35 0.17
42 INT207611 Regulation of Hspd1 1 0.20 0.19 0.17
43 INT314810 Localization of Hspa8 1 0.17 0.1 0.15
44 INT140260 Positive_regulation of RT1-DMb 1 0.03 0 0.15
45 INT131015 Negative_regulation of Cd74 1 0.17 0.25 0.12
46 INT53777 Negative_regulation of Positive_regulation of Hspd1 1 0.59 0.58 0.12
47 INT230088 Negative_regulation of TOR1A 1 0.06 0.2 0.12
48 INT109025 Negative_regulation of Hspd1 2 0.55 1.48 0.1
49 INT109020 Positive_regulation of Negative_regulation of Hspd1 1 0.39 0.76 0.1
50 INT291910 Positive_regulation of Gene_expression of HLA-DMA 1 0.10 0.06 0.08
51 INT221986 Localization of Hspd1 1 0.52 1.8 0.06
52 INT258395 Positive_regulation of Positive_regulation of Hspd1 5 0.25 2.79 0.04
53 INT324127 Positive_regulation of Cd74 2 0.07 1.34 0.04
54 INT340886 Binding of Hspa8 1 0.34 0.23 0.04
55 INT269823 Transcription of Hspd1 1 0.30 1.66 0.04
56 INT314807 Positive_regulation of Hspa8 1 0.09 0.71 0.04
57 INT256851 Regulation of Hspa8 4 0.19 3.71 0.03
58 INT340902 Localization of Hspa8 1 0.64 0.14 0.03
59 INT194148 Positive_regulation of CD74 2 0.27 0.68 0
60 INT230477 Binding of Hspd1 2 0.34 1.09 0
61 INT348742 Gene_expression of Hspa8 1 0.38 0 0
62 INT324126 Negative_regulation of Binding of Cd74 1 0.08 0.31 0
63 INT314808 Binding of Hspa8 1 0.11 0.3 0
64 INT178216 Transcription of HLA-DMA 1 0.01 0.97 0
65 INT320629 Regulation of Hspd1 1 0.58 0.68 0
66 INT276945 Negative_regulation of Positive_regulation of Hspd1 1 0.22 0.9 0
67 INT249711 Regulation of Regulation of HLA-DMA 1 0.02 0 0
68 INT221120 Regulation of Gene_expression of HLA-DMA 1 0.00 0.62 0
69 INT320630 Negative_regulation of Gene_expression of Hspd1 1 0.55 1.3 0
70 INT324125 Positive_regulation of Binding of Cd74 1 0.09 0.62 0
71 INT314809 Negative_regulation of Binding of Hspa8 1 0.13 0.24 0
72 INT291903 Negative_regulation of Binding of HLA-DMA 1 0.08 0 0
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