GO:0051098

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Name regulation of binding
Categary Process
Go Slim No
Go Link GO:0051098
Unique Molecular Interactions 238
Total Molecular Interactions 302
Total Single Events 1797
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of binding. They are ordered first by their pain relevance and then by number of times they were reported for regulation of binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
2 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
3 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
4 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
5 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
6 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
7 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
8 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95
9 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
10 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88
11 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88
12 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
13 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85
14 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
15 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
16 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
17 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
18 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
19 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 0.14 1.21 0.77
20 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
21 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
22 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
23 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67
24 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61
25 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57
26 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
27 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
28 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
29 INT89144 TGFB1 Regulation of Gene_expression of Tcstv1 1 0.00 0.53 0.53
30 INT92918 Atp6v0a2 Negative_regulation of Gene_expression of Tgfb1 1 0.01 0.83 0.52
31 INT138151 Tgfb1 Regulation of IL1B 1 0.01 0.29 0.49
32 INT89145 TGFB1 Positive_regulation of Tcstv1 1 0.00 0.49 0.49
33 INT138153 Tgfb1 Regulation of IL6 1 0.01 0.29 0.49
34 INT302643 ARSA Positive_regulation of Localization of TGFB1 1 0.08 0.12 0.49
35 INT138146 Tgfb1 Regulation of Mmp3 1 0.00 0.23 0.46
36 INT138149 Tgfb1 Regulation of Mmp2 1 0.00 0.23 0.46
37 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45
38 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
39 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
40 INT92690 Tgfb1 Positive_regulation of Transcription of Fgf2 1 0.32 1.8 0.4
41 INT165567 Tnf Regulation of Gene_expression of Tgfb1 1 0.41 1.15 0.39
42 INT336340 Glp2r Positive_regulation of Gene_expression of TGFB1 1 0.14 0.67 0.39
43 INT94853 TGFB1 Positive_regulation of Gene_expression of COL7A1 3 0.06 0.57 0.38
44 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
45 INT137018 Tgfb1 Positive_regulation of Pscs 1 0.01 0.43 0.34
46 INT137013 Tgfb1 Positive_regulation of Gene_expression of Pscs 1 0.01 0.43 0.34
47 INT225119 Foxm1 Regulation of Localization of TGFB1 1 0.01 0.63 0.34
48 INT333457 Binding of PPARA and TGFB1 1 0.04 0 0.34
49 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
50 INT299549 Binding of TGFB1 and Egf 1 0.02 0.32 0.32
51 INT102849 Tgfb1 Positive_regulation of Gene_expression of Col3a1 1 0.04 0.85 0.3
52 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
53 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
54 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
55 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
56 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29
57 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
58 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
59 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
60 INT137032 Il6 Positive_regulation of Localization of Tgfb1 1 0.04 0.51 0.27
61 INT83395 Binding of IL1RN and Tgfb1 1 0.01 0.17 0.26
62 INT139094 Csf2 Regulation of Tgfb1 1 0.42 0.58 0.26
63 INT271450 Thy1 Regulation of TGFB1 1 0.00 0.62 0.25
64 INT222981 TGFB1 Positive_regulation of Gene_expression of MMRN1 1 0.09 1.62 0.25
65 INT225098 ZNF630 Regulation of Localization of TGFB1 1 0.01 0.44 0.24
66 INT225105 ZNF630 Regulation of TGFB1 1 0.01 0.44 0.24
67 INT9720 Binding of TGFB1 and Egf 1 0.01 0 0.23
68 INT168710 Ifng Regulation of TGFB1 1 0.00 0.3 0.23
69 INT112596 Tgfb1 Negative_regulation of Negative_regulation of Mptp1 1 0.26 0.72 0.22
70 INT112595 Tgfb1 Negative_regulation of Gene_expression of Mptp1 1 0.27 0.72 0.22
71 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
72 INT346458 ROS1 Regulation of Localization of TGFB1 1 0.00 1.71 0.21
73 INT114905 TGFB1 Positive_regulation of Transcription of COL7A1 1 0.02 0.08 0.21
74 INT92691 Tgfb1 Positive_regulation of Ctgf 1 0.16 0.91 0.2
75 INT92692 Tgfb1 Positive_regulation of Gene_expression of Fn1 1 0.27 0.91 0.2
76 INT92693 Tgfb1 Positive_regulation of Fgf2 1 0.32 0.9 0.2
77 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19
78 INT280270 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.08 1.81 0.19
79 INT92694 Tgfb1 Positive_regulation of Positive_regulation of Col3a1 1 0.31 0.89 0.19
80 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19
81 INT153457 Tgfb1 Positive_regulation of Gene_expression of Ctgf 1 0.13 1.15 0.19
82 INT280268 Tgfb1 Positive_regulation of Gene_expression of Vegfa 1 0.06 1.81 0.19
83 INT280266 Tgfb1 Positive_regulation of Vegfa 1 0.09 1.8 0.19
84 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19
85 INT280267 Tgfb1 Positive_regulation of Cxcr4 1 0.11 2.45 0.19
86 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19
87 INT350718 Mir106b Regulation of TGFB1 1 0.00 0.42 0.18
88 INT350603 MIR25 Regulation of TGFB1 1 0.01 0.42 0.18
89 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18
90 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
91 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
92 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
93 INT296037 TGFB1 Positive_regulation of IL17A 1 0.02 0 0.17
94 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
95 INT160083 TGFB1 Positive_regulation of Gene_expression of L1CAM 1 0.16 1.53 0.16
96 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
97 INT239323 Binding of Nr1h2 and Positive_regulation of Positive_regulation of Tgfb1 1 0.00 3.71 0.14
98 INT299550 TGFB1 Negative_regulation of Glul 1 0.01 0.34 0.14
99 INT254855 Agt Positive_regulation of Tgfb1 1 0.03 0.18 0.13
100 INT296031 Negative_regulation of TGFB1 Regulation of IL10 1 0.01 1.01 0.13
101 INT296027 TGFB1 Regulation of TH1L 1 0.02 1 0.13
102 INT299547 Negative_regulation of Binding of TGFB1 and Egf 1 0.02 0.1 0.13
103 INT69687 Tgfb1 Positive_regulation of Gene_expression of Il4 1 0.23 0 0.12
104 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
105 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12
106 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
107 INT296028 TGFB1 Regulation of IL10 1 0.01 1 0.12
108 INT69688 Tgfb1 Positive_regulation of Rel 1 0.50 0 0.12
109 INT296038 TGFB1 Positive_regulation of Gene_expression of IL23R 1 0.02 0.05 0.11
110 INT299551 Regulation of Binding of TGFB1 and Egf 1 0.03 0.21 0.11
111 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11
112 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
113 INT269788 Binding of FN1 and TGFB1 1 0.00 0.29 0.1
114 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
115 INT116789 Bsg Positive_regulation of Gene_expression of Tgfb1 1 0.00 0.18 0.09
116 INT127143 Binding of IL6 and TGFB1 2 0.01 0.16 0.08
117 INT296041 Binding of TGFB1 and IL21 1 0.01 0.05 0.08
118 INT134832 TGFB1 Regulation of YAP1 1 0.16 0.68 0.08
119 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
120 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08
121 INT304330 TGFB1 Positive_regulation of ECM1 1 0.00 0.31 0.08
122 INT251232 Slc17a6 Positive_regulation of Tgfb1 1 0.03 0 0.08
123 INT134835 TGFB1 Regulation of Gene_expression of YAP1 1 0.49 0.69 0.08
124 INT134834 TGFB1 Positive_regulation of YAP1 1 0.55 0.81 0.08
125 INT134838 TGFB1 Positive_regulation of SMAD7 1 0.52 0.79 0.08
126 INT299548 Binding of TGFB1 and Lif 1 0.02 0 0.07
127 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07
128 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
129 INT311906 Binding of Smad4 and Insrr 1 0.00 0.18 0.06
130 INT94851 TGFB1 Regulation of Gene_expression of COL7A1 1 0.03 0.06 0.06
131 INT312228 INPP5K Regulation of TGFB1 1 0.06 0.08 0.05
132 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
133 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
134 INT232206 Binding of Tgfb1 and Tnfsf11 1 0.02 0.52 0.04
135 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
136 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
137 INT232207 Binding of Tgfb1 and Tnfrsf11a 1 0.02 0.51 0.04
138 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
139 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
140 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
141 INT271452 Binding of TGFB1 and Eln 1 0.00 0.38 0.04
142 INT271449 Binding of TGFB1 and Lox 1 0.01 0.38 0.04
143 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
144 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
145 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
146 INT280263 Binding of Smad4 and Proc 1 0.00 1.26 0.03
147 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
148 INT277927 WIF1 Negative_regulation of SMAD4 1 0.23 0.37 0
149 INT340086 Binding of Tgfb1 and Cndp2 1 0.04 0.38 0
150 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
151 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
152 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
153 INT157811 TGFB1 Positive_regulation of Timp2 1 0.02 0.06 0
154 INT314865 Binding of Ltbp3 and Tgfb1 1 0.24 0.51 0
155 INT312221 Binding of TGFB1 and INPP5K 1 0.09 0 0
156 INT280262 Binding of Tgfb1 and Positive_regulation of Cxcr4 1 0.07 1.27 0
157 INT280276 Binding of Tgfb1 and Positive_regulation of VEGFA 1 0.02 1.27 0
158 INT121314 Tgfb1 Positive_regulation of Egfr 1 0.08 0.16 0
159 INT180855 TGFB1 Regulation of S100A10 1 0.06 0.69 0
160 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
161 INT218669 Olr811 Negative_regulation of Phosphorylation of Smad2 1 0.01 0.18 0
162 INT121316 Tgfb1 Negative_regulation of Xrcc1 1 0.06 0.08 0
163 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
164 INT121318 Tgfb1 Negative_regulation of Ercc1 1 0.06 0.08 0
165 INT193308 Binding of PRNP and TGFB1 1 0.01 0 0
166 INT184955 EGR1 Regulation of Regulation of TGFB1 1 0.39 0.3 0
167 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
168 INT280265 Binding of Cxcr4 and Tgfb1 1 0.06 0.89 0
169 INT180860 TGFB1 Regulation of Transcription of NID2 1 0.23 0.77 0
170 INT212770 Binding of CTD and TGFB1 1 0.01 3.95 0
171 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0
172 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
173 INT254848 Tgfb1 Negative_regulation of Rhoa 1 0.02 0 0
174 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
175 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
176 INT248948 Binding of Klrd1 and Tgfb1 1 0.04 0.16 0
177 INT157813 TGFB1 Positive_regulation of Gene_expression of Tagln 1 0.11 0.06 0
178 INT121313 Tgfb1 Positive_regulation of Ercc1 1 0.07 0.08 0
179 INT269936 Smad2 Positive_regulation of Cdkn2b 1 0.15 0.07 0
180 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
181 INT248947 Binding of Cd8a and Tgfb1 1 0.05 0.16 0
182 INT81743 Tgfb1 Negative_regulation of Gene_expression of Atp9a 1 0.00 0.21 0
183 INT180849 TGFB1 Positive_regulation of COL4A2 1 0.10 1.28 0
184 INT147529 TGFB1 Negative_regulation of Gene_expression of Col2a1 1 0.05 0.32 0
185 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
186 INT71539 Tgfb1 Positive_regulation of Localization of Gnrh1 1 0.01 0 0
187 INT137933 TGFB3 Regulation of Tgfb1 1 0.00 0 0
188 INT180857 TGFB1 Regulation of VCAN 1 0.04 0.69 0
189 INT180865 TGFB1 Positive_regulation of S100A10 1 0.24 1.22 0
190 INT337914 sb Negative_regulation of Phosphorylation of Smad2 1 0.00 0.13 0
191 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
192 INT269957 Sox17 Negative_regulation of Gene_expression of TGFB1 1 0.04 0 0
193 INT180861 TGFB1 Positive_regulation of MT1E 1 0.17 1.22 0
194 INT137934 IGF1 Regulation of Tgfb1 1 0.00 0 0
195 INT280269 Tgfb1 Regulation of Cxcr4 1 0.04 0.88 0
196 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
197 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
198 INT180852 TGFB1 Regulation of Transcription of TM4SF1 1 0.24 0.77 0
199 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
200 INT157810 TGFB1 Positive_regulation of Tagln 1 0.05 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of binding. They are ordered first by their pain relevance and then by number of times they were reported in regulation of binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
2 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
3 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
4 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
5 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
6 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
7 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
8 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
9 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
10 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
11 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
12 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
13 INT89104 Binding of TGFB1 29 0.44 13.67 5.12
14 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37
15 INT36335 Localization of Tgfb1 19 0.79 7.06 4.17
16 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4
17 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6
18 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53
19 INT56300 Negative_regulation of Gene_expression of TGFB1 13 0.41 4.87 3.5
20 INT69216 Positive_regulation of Tgfb1 14 0.49 5.84 3.29
21 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24
22 INT85149 Negative_regulation of Gene_expression of Tgfb1 11 0.42 4.73 3.19
23 INT112667 Negative_regulation of Tgfb1 9 0.58 2.72 2.97
24 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92
25 INT48199 Regulation of Tgfb1 17 0.54 9.57 2.74
26 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
27 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46
28 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
29 INT12086 Regulation of Localization of TGFB1 4 0.43 1.65 2.09
30 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
31 INT74824 Positive_regulation of Transcription of TGFB1 6 0.67 2.58 1.84
32 INT86712 Regulation of Gene_expression of Tgfb1 2 0.15 2.03 1.65
33 INT84310 Regulation of Gene_expression of Tgfb1 7 0.29 6.6 1.63
34 INT120071 Negative_regulation of Positive_regulation of Tgfb1 4 0.16 4.06 1.55
35 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
36 INT110992 Positive_regulation of Positive_regulation of TGFB1 4 0.50 3.01 1.51
37 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
38 INT228040 Negative_regulation of Transcription of Tgfb1 1 0.04 0.49 1.42
39 INT12085 Positive_regulation of Localization of TGFB1 7 0.42 4.9 1.4
40 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
41 INT173892 Phosphorylation of TGFB1 8 0.79 2.63 1.3
42 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
43 INT120858 Positive_regulation of Localization of Tgfb1 7 0.68 1.46 1.03
44 INT128717 Regulation of Tgfb1 6 0.61 1.94 0.94
45 INT123852 Negative_regulation of Positive_regulation of Tgfb1 3 0.28 1.69 0.94
46 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
47 INT139322 Negative_regulation of Negative_regulation of Tgfb1 1 0.53 0 0.86
48 INT85148 Transcription of Tgfb1 5 0.52 1.91 0.84
49 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
50 INT102848 Negative_regulation of Localization of Tgfb1 3 0.10 1.81 0.83
51 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
52 INT139323 Positive_regulation of Negative_regulation of Tgfb1 1 0.45 0 0.79
53 INT291617 Negative_regulation of Transcription of TGFB1 2 0.15 0.61 0.76
54 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
55 INT90790 Regulation of Localization of Tgfb1 2 0.29 0.46 0.75
56 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
57 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
58 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
59 INT337046 Positive_regulation of Binding of Tgfb1 1 0.30 1.1 0.69
60 INT121302 Positive_regulation of Localization of Tgfb1 5 0.07 1.91 0.67
61 INT114909 Negative_regulation of Localization of TGFB1 5 0.36 1.37 0.66
62 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
63 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
64 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
65 INT111891 Regulation of Transcription of Tgfb1 1 0.04 0.68 0.64
66 INT114910 Negative_regulation of Positive_regulation of TGFB1 3 0.34 0.92 0.6
67 INT173891 Positive_regulation of Phosphorylation of TGFB1 4 0.49 2 0.59
68 INT138140 Protein_catabolism of Tgfb1 2 0.09 0.87 0.59
69 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
70 INT69683 Positive_regulation of Transcription of Tgfb1 1 0.67 0 0.53
71 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
72 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
73 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
74 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
75 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
76 INT69680 Positive_regulation of Positive_regulation of Tgfb1 3 0.67 1.04 0.35
77 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
78 INT92100 Binding of Smad4 5 0.31 2.23 0.3
79 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
80 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
81 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
82 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
83 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
84 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
85 INT251228 Phosphorylation of Tgfb1 4 0.15 1.18 0.24
86 INT129907 Regulation of Smad2 1 0.40 0.87 0.23
87 INT299545 Positive_regulation of Binding of TGFB1 2 0.06 1.08 0.22
88 INT265311 Localization of Smad2 5 0.50 1.57 0.21
89 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2
90 INT277935 Binding of SMAD4 4 0.28 1.12 0.17
91 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
92 INT268365 Binding of SMAD2 2 0.47 0.56 0.17
93 INT85330 Positive_regulation of Regulation of Tgfb1 1 0.41 0.67 0.17
94 INT122201 Binding of Tgfb1 1 0.16 0.17 0.17
95 INT133100 Negative_regulation of Localization of Tgfb1 2 0.28 1.48 0.15
96 INT139977 Regulation of Smad4 1 0.16 1.41 0.15
97 INT135490 Localization of Smad2 1 0.51 0.08 0.14
98 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
99 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
100 INT158893 Negative_regulation of Gene_expression of Smad2 1 0.30 0.13 0.13
101 INT129616 Negative_regulation of Phosphorylation of Smad2 4 0.38 0.78 0.12
102 INT311892 Regulation of Positive_regulation of Smad2 1 0.23 0.24 0.12
103 INT14738 Negative_regulation of Regulation of TGFB1 2 0.41 0.81 0.09
104 INT286183 Regulation of Blm 1 0.36 1.3 0.09
105 INT325505 Transcription of Smad2 1 0.67 0.16 0.09
106 INT286184 Gene_expression of Blm 1 0.39 2.16 0.09
107 INT325510 Transcription of Smad4 1 0.67 0.16 0.09
108 INT331623 Negative_regulation of Binding of TGFB1 1 0.02 1.02 0.08
109 INT254790 Localization of Smad4 2 0.37 0.54 0.06
110 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
111 INT139093 Regulation of Negative_regulation of Tgfb1 1 0.27 0.44 0.06
112 INT251230 Positive_regulation of Negative_regulation of Tgfb1 1 0.09 0 0.05
113 INT136115 Positive_regulation of Regulation of TGFB1 1 0.11 0.16 0.05
114 INT254814 Positive_regulation of Phosphorylation of Smad2 7 0.33 3.74 0.04
115 INT262799 Localization of Smad3 6 0.56 2.09 0.04
116 INT337908 Binding of Smad2 3 0.24 1.06 0.04
117 INT353261 Negative_regulation of Localization of Smad2 1 0.33 0 0.04
118 INT334291 Positive_regulation of Gene_expression of SMAD4 1 0.18 0 0.04
119 INT353263 Positive_regulation of Localization of Smad2 1 0.33 0.15 0.04
120 INT185020 Positive_regulation of Negative_regulation of TGFB1 1 0.43 0.44 0.04
121 INT268360 Positive_regulation of SMAD4 3 0.55 1.55 0.03
122 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
123 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
124 INT180881 Regulation of Positive_regulation of TGFB1 2 0.32 1.32 0.03
125 INT254799 Transcription of Smad2 1 0.19 0.52 0.03
126 INT353266 Negative_regulation of Negative_regulation of Smad2 1 0.28 0 0.03
127 INT296618 Negative_regulation of Smad2 1 0.37 1.42 0.03
128 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
129 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
130 INT117563 Negative_regulation of Gene_expression of SMAD4 6 0.54 3.87 0
131 INT268378 Positive_regulation of Phosphorylation of SMAD2 3 0.67 1.22 0
132 INT271411 Positive_regulation of Positive_regulation of Smad2 2 0.45 0.9 0
133 INT334327 Regulation of SMAD4 2 0.35 1.73 0
134 INT265337 Binding of Smad3 2 0.35 1 0
135 INT269913 Positive_regulation of Binding of Smad3 1 0.34 0.3 0
136 INT218693 Negative_regulation of Phosphorylation of Smad3 1 0.19 0.32 0
137 INT268368 Transcription of SMAD4 1 0.54 1.7 0
138 INT329784 Gene_expression of SMAD3 1 0.31 0.41 0
139 INT133097 Positive_regulation of Phosphorylation of Tgfb1 1 0.05 0.07 0
140 INT268384 Positive_regulation of Phosphorylation of SMAD3 1 0.29 1.22 0
141 INT296615 Positive_regulation of Smad2 1 0.50 1.51 0
142 INT173000 Negative_regulation of Localization of SMAD4 1 0.22 0.98 0
143 INT173008 Localization of SMAD4 1 0.38 0.97 0
144 INT254788 Negative_regulation of Regulation of Tgfb1 1 0.06 0.61 0
145 INT269873 Positive_regulation of Negative_regulation of Smad3 1 0.34 0.31 0
146 INT254800 Positive_regulation of Phosphorylation of Tgfb1 1 0.04 0.24 0
147 INT268382 Phosphorylation of SMAD3 1 0.34 0.6 0
148 INT133099 Negative_regulation of Phosphorylation of Tgfb1 1 0.04 0.08 0
149 INT334289 Regulation of Binding of SMAD4 1 0.16 0 0
150 INT286182 Positive_regulation of Gene_expression of Blm 1 0.29 0.53 0
151 INT334288 Regulation of Negative_regulation of SMAD4 1 0.16 0 0
152 INT133098 Phosphorylation of Tgfb1 1 0.06 0.07 0
153 INT128712 Positive_regulation of Regulation of Tgfb1 1 0.15 0 0
154 INT228250 Positive_regulation of Smad4 1 0.45 1.93 0
155 INT254809 Positive_regulation of Transcription of Smad3 1 0.25 0.24 0
156 INT295579 Negative_regulation of Phosphorylation of SMAD2 1 0.42 0.08 0
157 INT228247 Regulation of Positive_regulation of Smad4 1 0.26 0.97 0
158 INT268363 Binding of SMAD3 1 0.20 0.56 0
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