GO:0051100

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Name negative regulation of binding
Categary Process
Go Slim No
Go Link GO:0051100
Unique Molecular Interactions 46
Total Molecular Interactions 48
Total Single Events 853
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of binding. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
2 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
3 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
4 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
5 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
6 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
7 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
8 INT216644 Binding of P2ry1 and P2ry2 1 0.24 0.55 0.64
9 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
10 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
11 INT308894 Adp Regulation of P2ry1 1 0.05 0.49 0.53
12 INT330796 P2ry1 Positive_regulation of Ca2 1 0.05 0.06 0.5
13 INT308892 Adp Positive_regulation of P2ry1 1 0.11 0.44 0.47
14 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
15 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
16 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
17 INT308893 P2ry1 Positive_regulation of Adp 1 0.12 0 0.25
18 INT109845 Binding of P2RX3 and P2RY1 1 0.38 0 0.24
19 INT242245 Binding of P2ry1 and Adp 1 0.00 0.31 0.21
20 INT167113 Binding of P2ry1 and Trpv1 1 0.40 0 0.21
21 INT242250 Binding of P2ry1 and P2ry12 1 0.01 0.3 0.21
22 INT216705 Binding of MARS and P2RY1 1 0.06 0 0.2
23 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
24 INT104379 Gh1 Regulation of CYP2D6 1 0.07 0 0.17
25 INT352290 Binding of Agtr1a and P2ry1 1 0.00 0 0.16
26 INT216711 P2RY1 Negative_regulation of P2RY12 1 0.28 0.09 0.16
27 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
28 INT224040 Mtpn Positive_regulation of P2RY1 1 0.00 0.85 0.12
29 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
30 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
31 INT252421 Gja1 Regulation of P2ry1 1 0.00 0.28 0.09
32 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
33 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
34 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
35 INT215767 Binding of P2ry1 and Ca2 1 0.02 0.2 0.08
36 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05
37 INT351915 P2ry1 Regulation of Gfm1 1 0.01 0.86 0.03
38 INT351914 P2ry1 Regulation of Gene_expression of Gfm1 1 0.01 0.86 0.03
39 INT215765 Binding of P2ry1 and P2ry2 1 0.07 0.46 0.03
40 INT199717 2610029G23Rik Regulation of CYP2D6 1 0.02 0.44 0
41 INT233500 Tlr4 Negative_regulation of P2ry1 1 0.06 0.18 0
42 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0
43 INT20325 Binding of CYP2D6 and CYP21A2 1 0.00 0 0
44 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
45 INT169147 Binding of CYP2D6 and CYP3A 1 0.17 0 0
46 INT210416 ITGA4 Negative_regulation of CYP2D6 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of binding. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
2 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
3 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
4 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
5 INT69166 Positive_regulation of P2ry1 35 0.67 8.41 13.63
6 INT93122 Gene_expression of P2ry1 32 0.75 11.82 11.42
7 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
8 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
9 INT95170 Localization of P2ry1 10 0.78 5.08 5.63
10 INT111683 Gene_expression of P2ry1 22 0.74 7.96 5.59
11 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
12 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
13 INT139238 Positive_regulation of P2ry1 19 0.60 9.22 5.15
14 INT109848 Gene_expression of P2RY1 26 0.62 6.71 4.98
15 INT65509 Regulation of P2ry1 13 0.60 2.38 4.96
16 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
17 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
18 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
19 INT38030 Positive_regulation of P2RY1 15 0.67 5.54 3.17
20 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
21 INT215521 Negative_regulation of P2ry1 10 0.56 2.68 2.72
22 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
23 INT115401 Negative_regulation of P2ry1 6 0.42 1.27 2.25
24 INT99844 Localization of P2ry1 7 0.74 4.05 2.19
25 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
26 INT103236 Positive_regulation of Positive_regulation of P2ry1 5 0.54 2.39 1.92
27 INT111682 Transcription of P2ry1 4 0.52 1.26 1.71
28 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48
29 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44
30 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38
31 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19
32 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18
33 INT111681 Regulation of P2ry1 8 0.45 2.64 1.11
34 INT103235 Regulation of Localization of P2ry1 2 0.44 0.09 0.97
35 INT95468 Transcription of P2ry1 4 0.60 0 0.86
36 INT95537 Transcription of CYP2D6 4 0.68 0.2 0.85
37 INT167317 Negative_regulation of P2RY1 5 0.34 1.35 0.83
38 INT148302 Regulation of Regulation of P2ry1 1 0.44 0.09 0.74
39 INT111406 Binding of P2ry1 2 0.36 0.31 0.7
40 INT216662 Regulation of Gene_expression of P2ry1 1 0.24 0.2 0.63
41 INT331002 Negative_regulation of Localization of CYP2D6 1 0.40 0.17 0.6
42 INT93647 Regulation of P2RY1 7 0.36 2.13 0.55
43 INT215572 Negative_regulation of Localization of P2ry1 1 0.15 0.08 0.55
44 INT259774 Negative_regulation of Positive_regulation of P2ry1 1 0.33 1.11 0.54
45 INT142624 Regulation of Negative_regulation of CYP2D6 1 0.27 0 0.51
46 INT233484 Positive_regulation of Gene_expression of P2ry1 4 0.43 0.95 0.5
47 INT308880 Positive_regulation of Negative_regulation of P2ry1 1 0.48 0.13 0.49
48 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47
49 INT144386 Positive_regulation of Negative_regulation of CYP2D6 3 0.49 1.01 0.4
50 INT185697 Positive_regulation of Positive_regulation of P2RY1 1 0.40 0.36 0.36
51 INT217014 Transcription of P2RY1 1 0.23 0.26 0.35
52 INT109852 Binding of P2RY1 3 0.35 1.04 0.33
53 INT141814 Regulation of Positive_regulation of P2ry1 1 0.44 0.15 0.33
54 INT95464 Regulation of Transcription of P2ry1 1 0.25 0 0.28
55 INT347186 Regulation of Negative_regulation of Cyp2d4 1 0.45 0.21 0.25
56 INT308883 Negative_regulation of Positive_regulation of P2ry1 1 0.41 0.05 0.2
57 INT351912 Binding of P2ry1 1 0.09 2.15 0.19
58 INT137622 Protein_catabolism of CYP2D6 2 0.38 0 0.17
59 INT344065 Negative_regulation of Binding of CYP2D6 1 0.15 0.05 0.17
60 INT216718 Positive_regulation of Gene_expression of P2RY1 1 0.55 0.15 0.15
61 INT261231 Negative_regulation of Gene_expression of Cyp2d4 2 0.42 0.36 0.14
62 INT113802 Transcription of Cyp2d4 1 0.69 0 0.11
63 INT216716 Localization of P2RY1 1 0.60 0.33 0.1
64 INT216520 Regulation of Gene_expression of P2ry1 2 0.45 0.43 0.09
65 INT216730 Negative_regulation of Gene_expression of P2RY1 1 0.34 0 0.09
66 INT216522 Negative_regulation of Localization of P2ry1 1 0.42 0.13 0.07
67 INT180329 Positive_regulation of Binding of Cyp2d4 1 0.33 1.97 0.05
68 INT264053 Positive_regulation of Negative_regulation of Cyp2d4 1 0.25 0.18 0.03
69 INT216722 Regulation of Positive_regulation of P2RY1 1 0.49 0.16 0.03
70 INT351911 Positive_regulation of Positive_regulation of P2ry1 1 0.13 1.47 0.03
71 INT216615 Positive_regulation of Gene_expression of P2ry1 1 0.25 0.22 0
72 INT330999 Negative_regulation of Positive_regulation of CYP2D6 1 0.40 0 0
73 INT169150 Regulation of Binding of CYP2D6 1 0.41 0 0
74 INT180326 Regulation of Gene_expression of Cyp2d4 1 0.18 0.77 0
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