GO:0051216

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Name cartilage development
Categary Process
Go Slim No
Go Link GO:0051216
Unique Molecular Interactions 653
Total Molecular Interactions 836
Total Single Events 7665
Pain Genes Associated 67

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cartilage development. They are ordered first by their pain relevance and then by number of times they were reported for cartilage development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT87267 Binding of BMP8B and KRIT1 1 0.06 0.16 2.69
2 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
3 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
4 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
5 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
6 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
7 INT87266 Negative_regulation of Binding of BMP8B and KRIT1 1 0.05 0.07 1.37
8 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
9 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
10 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
11 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
12 INT45891 Tyms Positive_regulation of Localization of Acot1 1 0.02 0 1.23
13 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
14 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
15 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
16 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
17 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
18 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
19 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
20 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
21 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
22 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
23 INT139227 Icam1 Negative_regulation of Timp1 1 0.37 1.13 1.06
24 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
25 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 0.03 1.74 1.03
26 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
27 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
28 INT148327 Binding of Pkd1 and Trpv1 1 0.52 2.23 1.01
29 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
30 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
31 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
32 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
33 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
34 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
35 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
36 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
37 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
38 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
39 INT6975 Zeb1 Positive_regulation of St8sia1 1 0.03 0.17 0.91
40 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
41 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
42 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
43 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
44 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
45 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
46 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
47 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
48 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
49 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
50 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
51 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
52 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
53 INT162241 Binding of COL7A1 and MMP13 2 0.03 0.86 0.73
54 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
55 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
56 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
57 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
58 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
59 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
60 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
61 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
62 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
63 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
64 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
65 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
66 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
67 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
68 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
69 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
70 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
71 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
72 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
73 INT345303 MMP15 Positive_regulation of MMP13 1 0.00 1.18 0.58
74 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
75 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
76 INT176340 CHI3L1 Positive_regulation of Localization of CSF2 1 0.11 1.86 0.55
77 INT176343 CHI3L1 Positive_regulation of Localization of CSF1 1 0.23 1.86 0.55
78 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
79 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
80 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
81 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
82 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
83 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
84 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
85 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
86 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
87 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
88 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
89 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48
90 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48
91 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
92 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
93 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
94 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
95 INT135176 Myst2 Regulation of Gene_expression of Hif1a 1 0.24 0.47 0.47
96 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
97 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46
98 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
99 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
100 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
101 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
102 INT345305 MMP14 Positive_regulation of MMP13 1 0.00 0.33 0.45
103 INT224686 S100a4 Positive_regulation of Gene_expression of Mmp13 1 0.05 0.85 0.45
104 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
105 INT135178 Myst2 Regulation of Hif1a 1 0.24 0.44 0.44
106 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42
107 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
108 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
109 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
110 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
111 INT275089 Pde4a Negative_regulation of stm 1 0.02 0.51 0.42
112 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
113 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
114 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
115 INT160245 Binding of Col11a1 and Crygs 1 0.00 0.17 0.4
116 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
117 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
118 INT13715 PDYN Positive_regulation of TYMS 1 0.27 0 0.39
119 INT278944 ZEB1 Negative_regulation of IL1B 1 0.00 1.09 0.39
120 INT303444 Timp1 Regulation of Fig4 1 0.15 0.43 0.39
121 INT183924 Binding of CHI3L1 and HLA-E 1 0.08 0.9 0.39
122 INT275093 Pde9a Negative_regulation of stm 1 0.00 0.51 0.39
123 INT312086 ELANE Positive_regulation of MMP13 1 0.13 0.64 0.39
124 INT278960 ZEB1 Negative_regulation of MMP3 1 0.00 1.05 0.38
125 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
126 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
127 INT278943 ZEB1 Negative_regulation of Gene_expression of MMP3 1 0.00 1.05 0.38
128 INT249090 FOXL1 Regulation of Regulation of ICAM1 1 0.12 1.03 0.37
129 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
130 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
131 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
132 INT336339 Glp2r Positive_regulation of Timp1 1 0.16 1.82 0.36
133 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
134 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
135 INT288164 Jun Regulation of Gene_expression of Mmp13 1 0.02 0.41 0.35
136 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
137 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
138 INT288167 Ugcg Negative_regulation of Gene_expression of Mmp13 1 0.06 0.46 0.35
139 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
140 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35
141 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
142 INT97328 Ptger2 Regulation of Transcription of Timp1 1 0.00 0.48 0.34
143 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34
144 INT97357 IL1A Positive_regulation of Transcription of Timp1 1 0.06 0.47 0.34
145 INT194859 IL1B Positive_regulation of Gene_expression of MMP13 2 0.52 0.86 0.33
146 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
147 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
148 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33
149 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
150 INT165764 Tnfsf11 Positive_regulation of Mapk3 1 0.17 1.08 0.33
151 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
152 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33
153 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33
154 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
155 INT165763 Tnfsf11 Positive_regulation of Phosphorylation of Mapk3 1 0.40 1.08 0.33
156 INT149902 Ihh Positive_regulation of SGCG 1 0.45 0.76 0.32
157 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
158 INT100028 TNF Positive_regulation of Mapk3 1 0.22 0.79 0.32
159 INT280926 Hoxa3 Positive_regulation of Gene_expression of Ccl2 1 0.53 2.61 0.32
160 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
161 INT303446 Timp1 Negative_regulation of Mmp2 1 0.19 0.33 0.31
162 INT97327 Ptger2 Positive_regulation of Gene_expression of Timp1 1 0.00 0.46 0.31
163 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
164 INT97358 IL1A Regulation of Timp1 1 0.04 0.51 0.31
165 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
166 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
167 INT97326 Ptger2 Positive_regulation of Transcription of Timp1 1 0.00 0.49 0.31
168 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
169 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
170 INT162045 F2 Positive_regulation of Phosphorylation of MAPK3 1 0.30 0.99 0.3
171 INT220194 PTGER2 Negative_regulation of COL2A1 1 0.26 0.55 0.29
172 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 0.04 0.8 0.29
173 INT328223 Mmp14 Regulation of Positive_regulation of Mmp13 1 0.07 0.69 0.29
174 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
175 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
176 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
177 INT179423 Fig4 Regulation of Mapk3 1 0.02 0.32 0.28
178 INT218660 Mmp1a Negative_regulation of Timp1 1 0.02 1.84 0.28
179 INT336335 Glp2r Regulation of Mmp13 1 0.06 0.68 0.28
180 INT166156 Ccr9 Positive_regulation of Mapk3 1 0.49 1.47 0.28
181 INT328222 Mmp2 Regulation of Positive_regulation of Mmp13 1 0.05 0.69 0.28
182 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
183 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
184 INT249831 Binding of CHI3L1 and IL6 1 0.30 2.81 0.26
185 INT191876 Pbsn Positive_regulation of Mapk3 1 0.01 0.33 0.25
186 INT180964 PLG Positive_regulation of MMP13 1 0.24 0.45 0.25
187 INT191894 Prkca Positive_regulation of Mapk3 1 0.05 0.33 0.25
188 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
189 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
190 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
191 INT314045 THL Negative_regulation of Phosphorylation of Mapk3 1 0.13 0.7 0.25
192 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
193 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
194 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
195 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
196 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
197 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
198 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
199 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
200 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24

Single Events

The table below shows the top 100 pain related interactions that have been reported for cartilage development. They are ordered first by their pain relevance and then by number of times they were reported in cartilage development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
3 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
4 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
5 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
6 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
7 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98
8 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
9 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
10 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
11 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
12 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18
13 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
14 INT5048 Binding of Edn1 55 0.47 18.86 19.16
15 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
16 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91
17 INT9191 Localization of EDN1 94 0.81 57.01 14.78
18 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
19 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
20 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9
21 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
22 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85
23 INT6365 Localization of Edn1 56 0.81 18.84 13.83
24 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
25 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
26 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
27 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45
28 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
29 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
30 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
31 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
32 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71
33 INT6361 Localization of Edn1 30 0.81 19.09 9.7
34 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
35 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41
36 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
37 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
38 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
39 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
40 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57
41 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54
42 INT10237 Binding of EDN1 40 0.48 16 8.48
43 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
44 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
45 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
46 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
47 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
48 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
49 INT81608 Gene_expression of Col11a1 13 0.15 1.58 6.87
50 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
51 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
52 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27
53 INT185252 Gene_expression of Dlx2 7 0.71 8.8 6.24
54 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
55 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
56 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07
57 INT254269 Gene_expression of Il17f 12 0.48 13.29 6.02
58 INT141146 Gene_expression of Mmp13 18 0.38 8.61 5.54
59 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45
60 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44
61 INT183119 Gene_expression of SULF1 1 0.75 46.71 5.44
62 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
63 INT88784 Negative_regulation of stm 11 0.56 0.51 5.33
64 INT1285 Localization of Mmp13 12 0.78 8.98 4.93
65 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
66 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
67 INT87268 Positive_regulation of BMP8B 5 0.19 0.53 4.6
68 INT125884 Positive_regulation of CHI3L1 15 0.62 34.04 4.43
69 INT98357 Binding of Gnas 11 0.41 1.87 4.35
70 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
71 INT111535 Negative_regulation of Phosphorylation of Mapk3 9 0.57 6.39 4.31
72 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23
73 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
74 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21
75 INT97334 Positive_regulation of Gene_expression of Timp1 11 0.49 7.44 4.14
76 INT55741 Negative_regulation of Timp1 15 0.51 8.12 4.09
77 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
78 INT112782 Localization of Mapk3 8 0.78 1.87 3.98
79 INT124815 Binding of Col2a1 9 0.37 10.27 3.93
80 INT123827 Positive_regulation of Phosphorylation of Mapk3 10 0.67 5.22 3.82
81 INT94291 Regulation of Gene_expression of Mapk3 4 0.40 3.05 3.8
82 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
83 INT149614 Localization of MMP13 13 0.81 6.12 3.65
84 INT32464 Regulation of Mmp13 12 0.44 6.46 3.61
85 INT87269 Localization of BMP8B 1 0.07 0.24 3.58
86 INT129960 Negative_regulation of Gene_expression of MMP13 19 0.53 7.17 3.55
87 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
88 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
89 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
90 INT116281 Negative_regulation of Gene_expression of Mmp13 15 0.41 9.96 3.41
91 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
92 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35
93 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
94 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3
95 INT230060 Binding of Timp1 7 0.47 5.61 3.2
96 INT39867 Binding of Col2a1 9 0.35 7.65 3.18
97 INT54832 Negative_regulation of Gene_expression of Col2a1 6 0.50 2.53 3.16
98 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05
99 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
100 INT39990 Negative_regulation of BMP6 1 0.59 0 3.05
101 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
102 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02
103 INT55739 Transcription of Timp1 7 0.67 4.72 3
104 INT53374 Binding of Edn1 17 0.43 11.66 2.98
105 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88
106 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87
107 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
108 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68
109 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
110 INT52911 Gene_expression of Tyms 10 0.42 2.24 2.66
111 INT151037 Gene_expression of Col10a1 13 0.68 4.47 2.64
112 INT125885 Positive_regulation of Gene_expression of CHI3L1 8 0.49 10.8 2.64
113 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
114 INT3123 Localization of Tyms 6 0.78 0.85 2.6
115 INT213681 Gene_expression of TYMS 9 0.33 8.96 2.45
116 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42
117 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
118 INT30202 Positive_regulation of GHRL 5 0.44 3.04 2.22
119 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
120 INT55090 Positive_regulation of Wnt7a 13 0.37 2.25 2.2
121 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17
122 INT302340 Positive_regulation of Gene_expression of Dlx2 2 0.64 3.43 2.15
123 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13
124 INT120106 Negative_regulation of Mmp13 8 0.51 2.25 2.08
125 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
126 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
127 INT116280 Transcription of Mmp13 11 0.67 6.52 2.06
128 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
129 INT145235 Protein_catabolism of Mmp13 3 0.89 2.46 2.03
130 INT184676 Transcription of Prrx2 1 0.37 3.64 2.02
131 INT121781 Regulation of Mapk3 5 0.44 1.96 1.98
132 INT88783 Positive_regulation of stm 4 0.39 0 1.98
133 INT350632 Positive_regulation of Il17f 2 0.29 6.22 1.96
134 INT158022 Binding of CHI3L1 10 0.43 14.18 1.94
135 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
136 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
137 INT148326 Gene_expression of Pkd1 7 0.76 5.38 1.85
138 INT213676 Negative_regulation of Gene_expression of TYMS 2 0.08 1.95 1.83
139 INT174240 Negative_regulation of TYMS 12 0.57 6.35 1.82
140 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
141 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
142 INT82760 Negative_regulation of Positive_regulation of Mapk3 7 0.57 3.18 1.78
143 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78
144 INT182295 Regulation of MMP13 6 0.27 3.33 1.77
145 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
146 INT4786 Gene_expression of GHRL 7 0.78 7.94 1.76
147 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
148 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
149 INT97333 Regulation of Gene_expression of Timp1 6 0.54 4.8 1.71
150 INT98469 Positive_regulation of Transcription of Timp1 4 0.45 3.2 1.68
151 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
152 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
153 INT220992 Protein_catabolism of Col2a1 8 0.40 5.55 1.64
154 INT337100 Gene_expression of Mgp 3 0.71 45.04 1.64
155 INT248321 Regulation of Gene_expression of CHI3L1 2 0.44 10.73 1.64
156 INT122597 Transcription of Hif1a 5 0.69 5.56 1.63
157 INT149994 Gene_expression of Mapk3 16 0.65 3.45 1.62
158 INT141147 Negative_regulation of Gene_expression of Mmp13 5 0.12 1.37 1.59
159 INT153723 Negative_regulation of Gene_expression of Hif1a 2 0.41 1.25 1.58
160 INT164410 Negative_regulation of Col2a1 4 0.39 3.75 1.53
161 INT82761 Regulation of Positive_regulation of Mapk3 3 0.40 1.34 1.52
162 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51
163 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
164 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
165 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5
166 INT184683 Gene_expression of Prrx2 1 0.37 7.9 1.5
167 INT143443 Localization of HIF1A 14 0.78 10.93 1.49
168 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
169 INT132886 Negative_regulation of Positive_regulation of Mapk3 2 0.30 1.27 1.49
170 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
171 INT120111 Regulation of Mmp13 4 0.29 2.65 1.48
172 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
173 INT121347 Binding of GNAS 8 0.13 3.99 1.47
174 INT250114 Gene_expression of Hoxa3 36 0.77 23.04 1.46
175 INT32184 Negative_regulation of Col2a1 9 0.42 3.05 1.43
176 INT113268 Positive_regulation of Positive_regulation of Timp1 3 0.15 3.23 1.43
177 INT145809 Gene_expression of stm 9 0.65 3.66 1.4
178 INT124212 Protein_catabolism of CHI3L1 3 0.21 3.48 1.4
179 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
180 INT129963 Regulation of Gene_expression of MMP13 8 0.42 2.84 1.39
181 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
182 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
183 INT97332 Regulation of Timp1 4 0.44 3.6 1.38
184 INT148740 Regulation of Gene_expression of Mmp13 1 0.03 2.58 1.37
185 INT123778 Positive_regulation of Positive_regulation of MMP13 4 0.25 2.51 1.34
186 INT232785 Localization of Hif1a 8 0.46 10.37 1.33
187 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
188 INT54831 Regulation of Gene_expression of Col2a1 4 0.39 2.3 1.31
189 INT117232 Localization of COL2A1 11 0.72 7.34 1.3
190 INT52212 Gene_expression of Bmp6 6 0.64 2.38 1.27
191 INT300541 Negative_regulation of Gene_expression of Il17f 3 0.26 2.6 1.27
192 INT145312 Localization of CHI3L1 8 0.78 12.71 1.26
193 INT170294 Regulation of Gene_expression of Mmp13 5 0.44 4.25 1.26
194 INT254179 Localization of Il17f 3 0.49 3.29 1.25
195 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24
196 INT39991 Negative_regulation of Negative_regulation of BMP6 1 0.43 0 1.24
197 INT120108 Transcription of Mmp13 3 0.51 0.22 1.22
198 INT317972 Positive_regulation of Transcription of Mmp13 5 0.41 3.83 1.21
199 INT338411 Positive_regulation of Gene_expression of Il17f 5 0.29 4.58 1.21
200 INT148321 Positive_regulation of Gene_expression of Pkd1 5 0.68 2.93 1.21
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