GO:0051290

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Name protein heterotetramerization
Categary Process
Go Slim No
Go Link GO:0051290
Unique Molecular Interactions 99
Total Molecular Interactions 145
Total Single Events 1878
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein heterotetramerization. They are ordered first by their pain relevance and then by number of times they were reported for protein heterotetramerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
8 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
9 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
10 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
11 INT15221 RRM1 Regulation of Localization of VIP 1 0.12 0.08 0.74
12 INT15222 RRM1 Regulation of VIP 1 0.12 0.08 0.74
13 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
14 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
15 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
16 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
17 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
18 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
19 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
20 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
21 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
22 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
23 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
24 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
25 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
26 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
27 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
28 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
29 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
30 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
31 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
32 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
33 INT244022 Binding of Nrxn1 and Nlgn4l 1 0.00 0.21 0.07
34 INT107727 ASIP Negative_regulation of RRM2 1 0.29 0.43 0.07
35 INT17920 Penk Positive_regulation of Insr 1 0.05 0.14 0.06
36 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05
37 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
38 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05
39 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04
40 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04
41 INT248493 Pdss1 Positive_regulation of Gene_expression of Smn1 1 0.16 0.4 0.03
42 INT144761 Binding of INSR and Insr 1 0.05 0 0
43 INT329641 Rrm2 Regulation of Ear11 1 0.01 0.49 0
44 INT268095 Binding of IFNW1 and PDSS1 1 0.00 0.35 0
45 INT289672 Binding of GNRH1 and INSR 1 0.02 0 0
46 INT248497 Positive_regulation of Upf1 Positive_regulation of Pdss1 1 0.01 0.15 0
47 INT235623 Binding of INS and INSR 1 0.14 0.47 0
48 INT329642 Rrm2 Regulation of Eefsec 1 0.04 0.42 0
49 INT248494 Upf1 Positive_regulation of Pdss1 1 0.01 0.15 0
50 INT248501 Binding of Upf1 and Pdss1 1 0.01 0.21 0
51 INT144754 Negative_regulation of Binding of Insr and Slc2a2 1 0.01 0 0
52 INT329649 Binding of VEGFA and Rrm2 1 0.02 2.39 0
53 INT308132 Binding of RRM1 and F2 1 0.01 0 0
54 INT277315 Binding of Insr and Mbnl1 1 0.18 1.1 0
55 INT322607 Binding of RRM2 and TF 1 0.02 0.09 0
56 INT268096 Binding of CYP4F3 and PDSS1 1 0.00 0.35 0
57 INT283009 Binding of Bcl2 and Pdss2 1 0.03 0.56 0
58 INT235624 INS Regulation of Phosphorylation of INSR 1 0.08 0.26 0
59 INT248491 Binding of Smn1 and Pdss1 1 0.12 0.21 0
60 INT271281 Gene_expression of Stat1 Positive_regulation of Insr 1 0.19 0.51 0
61 INT248495 Pdss1 Positive_regulation of Smn1 1 0.13 0.25 0
62 INT271287 Gene_expression of IFNA1 Positive_regulation of Insr 1 0.03 0.51 0
63 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0
64 INT144760 Binding of ABCA1 and Insr 1 0.00 0 0
65 INT268098 Binding of FAS and PDSS1 1 0.03 0.34 0
66 INT283004 Binding of Becn1 and Pdss2 1 0.00 0.57 0
67 INT218307 Grb10 Positive_regulation of Protein_catabolism of INSR 1 0.03 0 0
68 INT144753 Binding of Insr and Slc2a2 1 0.01 0 0
69 INT311383 Mbnl1 Regulation of Insr 1 0.00 0.24 0
70 INT144762 Negative_regulation of Binding of INSR and Insr 1 0.06 0 0
71 INT311386 Celf1 Regulation of Insr 1 0.00 0.24 0
72 INT248498 Smn1 Positive_regulation of Pdss1 1 0.16 0.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein heterotetramerization. They are ordered first by their pain relevance and then by number of times they were reported in protein heterotetramerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
2 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
3 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
4 INT8691 Localization of Insr 85 0.80 9.27 30.32
5 INT5300 Regulation of Insr 54 0.60 11.33 29.26
6 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
7 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
8 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
9 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
10 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
11 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
12 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
13 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
14 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
15 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
16 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
17 INT51084 Binding of Insr 13 0.30 4.25 4.23
18 INT83035 Binding of INSR 16 0.47 9.29 4.11
19 INT10116 Localization of INSR 11 0.57 5.43 3.48
20 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
21 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
22 INT77339 Positive_regulation of RRM2 5 0.41 1.36 2.88
23 INT53707 Negative_regulation of RRM1 4 0.59 0.44 2.87
24 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
25 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
26 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
27 INT114059 Localization of Insr 10 0.46 3.49 1.87
28 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
29 INT232645 Transcription of INSR 2 0.09 1.19 1.71
30 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
31 INT19342 Regulation of Insr 12 0.24 6.11 1.54
32 INT64503 Negative_regulation of PDSS1 3 0.38 1.39 1.47
33 INT85378 Binding of Pdss1 6 0.28 3.81 1.35
34 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
35 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
36 INT88568 Positive_regulation of RRM1 4 0.41 1.81 1.14
37 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
38 INT153129 Positive_regulation of Pdss1 25 0.21 5.83 1.1
39 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
40 INT281849 Binding of RRM2 5 0.17 0.43 1.07
41 INT25071 Binding of PDSS1 5 0.32 2.42 0.97
42 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
43 INT37950 Regulation of PDSS1 3 0.44 1.24 0.91
44 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
45 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
46 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
47 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
48 INT85379 Gene_expression of Pdss1 19 0.55 3.42 0.72
49 INT117392 Binding of Insr 8 0.23 4.88 0.68
50 INT171366 Positive_regulation of Localization of Insr 3 0.18 0.63 0.66
51 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
52 INT18446 Transcription of Insr 2 0.18 0.84 0.62
53 INT217091 Positive_regulation of Rrm2 5 0.33 4.12 0.6
54 INT288644 Binding of Pdss2 2 0.25 1.37 0.55
55 INT308979 Regulation of Localization of Insr 1 0.24 0.44 0.53
56 INT77338 Negative_regulation of RRM2 2 0.38 0 0.49
57 INT217083 Gene_expression of Rrm2 10 0.47 4.16 0.47
58 INT114062 Negative_regulation of Localization of Insr 1 0.19 0.31 0.39
59 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
60 INT80543 Negative_regulation of Pdss1 4 0.42 0.95 0.36
61 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
62 INT278530 Regulation of Positive_regulation of Insr 1 0.01 1.96 0.28
63 INT37951 Positive_regulation of PDSS1 8 0.41 2.5 0.27
64 INT129470 Regulation of RRM2 4 0.22 0.36 0.27
65 INT274774 Regulation of RRM1 2 0.16 0.07 0.27
66 INT124735 Positive_regulation of Positive_regulation of Insr 1 0.08 0 0.25
67 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
68 INT308129 Positive_regulation of Positive_regulation of RRM1 2 0.04 0.82 0.24
69 INT184652 Binding of RRM1 5 0.22 0.55 0.23
70 INT171829 Localization of PDSS1 1 0.65 0.18 0.18
71 INT227749 Negative_regulation of Binding of Pdss1 1 0.04 0.95 0.16
72 INT184651 Gene_expression of RRM1 6 0.48 3.46 0.15
73 INT274773 Gene_expression of RRM2 1 0.08 0.21 0.15
74 INT184649 Localization of RRM1 3 0.07 1.08 0.13
75 INT92634 Negative_regulation of Binding of Insr 1 0.25 0.08 0.12
76 INT308981 Positive_regulation of Negative_regulation of Insr 1 0.27 0.95 0.11
77 INT323945 Positive_regulation of Binding of Insr 1 0.08 0.94 0.11
78 INT315821 Regulation of Transcription of RRM1 1 0.21 0.67 0.1
79 INT315817 Transcription of RRM1 2 0.42 0.67 0.09
80 INT184647 Regulation of Localization of RRM1 1 0.04 0.07 0.07
81 INT243988 Binding of Nrxn1 1 0.01 0.21 0.07
82 INT248484 Positive_regulation of Gene_expression of Pdss1 1 0.15 0.31 0.07
83 INT330353 Positive_regulation of Gene_expression of RRM1 1 0.04 1.01 0.06
84 INT330365 Positive_regulation of Localization of RRM1 1 0.04 1.01 0.06
85 INT243932 Gene_expression of Nrxn1 1 0.02 0.28 0.06
86 INT71164 Gene_expression of PDSS1 7 0.59 4.78 0.04
87 INT184013 Protein_catabolism of Insr 1 0.05 0.4 0.04
88 INT71163 Negative_regulation of Gene_expression of PDSS1 1 0.37 0.57 0.04
89 INT318720 Regulation of Binding of Pdss1 1 0.02 0.74 0.04
90 INT217104 Negative_regulation of Rrm2 2 0.28 1.46 0.03
91 INT117362 Positive_regulation of Positive_regulation of INSR 1 0.22 0.1 0.03
92 INT235634 Phosphorylation of INSR 24 0.70 3.64 0
93 INT278278 Positive_regulation of Gene_expression of Rrm2 3 0.33 1.9 0
94 INT215947 Positive_regulation of Gene_expression of INSR 2 0.14 0.25 0
95 INT217085 Binding of Rrm2 2 0.23 1.05 0
96 INT329627 Positive_regulation of Positive_regulation of Rrm2 1 0.24 0.57 0
97 INT248466 Regulation of Localization of Pdss1 1 0.14 0.57 0
98 INT248476 Localization of Pdss1 1 0.23 0.85 0
99 INT144758 Negative_regulation of Negative_regulation of INSR 1 0.41 0 0
100 INT235628 Negative_regulation of Phosphorylation of INSR 1 0.16 0.25 0
101 INT230481 Positive_regulation of Regulation of Insr 1 0.01 0.24 0
102 INT320323 Negative_regulation of Transcription of RRM1 1 0.25 0 0
103 INT144756 Positive_regulation of Negative_regulation of INSR 1 0.49 0 0
104 INT37952 Regulation of Positive_regulation of PDSS1 1 0.09 0.08 0
105 INT144757 Negative_regulation of Gene_expression of INSR 1 0.41 0 0
106 INT329628 Positive_regulation of Negative_regulation of Rrm2 1 0.24 0.54 0
107 INT176904 Negative_regulation of Transcription of PDSS1 1 0.02 0.37 0
108 INT248487 Negative_regulation of Gene_expression of Pdss1 1 0.13 0.14 0
109 INT176897 Transcription of PDSS1 1 0.03 0.36 0
110 INT329626 Localization of Rrm2 1 0.39 0.72 0
111 INT248467 Regulation of Pdss1 1 0.08 0.16 0
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