GO:0051291

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Name protein heterooligomerization
Categary Process
Go Slim No
Go Link GO:0051291
Unique Molecular Interactions 691
Total Molecular Interactions 962
Total Single Events 7024
Pain Genes Associated 84

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein heterooligomerization. They are ordered first by their pain relevance and then by number of times they were reported for protein heterooligomerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
3 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
4 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
5 INT297488 Itpr3 Regulation of Positive_regulation of Ltp 1 0.02 0.47 1.87
6 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
7 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
8 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71
9 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
10 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
11 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
12 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
13 INT149743 Ean5 Positive_regulation of Gene_expression of P2rx2 1 0.10 1.54 1.5
14 INT144122 Binding of Calca and P2rx6 1 0.10 0 1.4
15 INT144123 Binding of P2rx6 and Trpv1 1 0.11 0 1.4
16 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
17 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
18 INT160653 Binding of P2rx1 and Ptgfr 1 0.28 0.66 1.14
19 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
20 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
21 INT151768 Ngf Positive_regulation of P2rx6 1 0.00 0.81 1.01
22 INT151765 Ngf Positive_regulation of Positive_regulation of P2rx6 1 0.00 0.81 1.01
23 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
24 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
25 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
26 INT226128 Positive_regulation of Ghrl Regulation of Prkag1 1 0.06 0.28 0.97
27 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
28 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
29 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 0.21 0.98 0.95
30 INT215584 P2rx1 Regulation of Localization of Gabrg1 1 0.01 0 0.92
31 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
32 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
33 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
34 INT56500 Ide Regulation of Maoa 1 0.21 0 0.89
35 INT134993 P2rx6 Regulation of Ephb1 1 0.20 1.27 0.87
36 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
37 INT271511 Binding of Phb2 and Glrb 1 0.04 1.7 0.84
38 INT289658 Tnfrsf1a Positive_regulation of Mcpt1 1 0.02 0.76 0.81
39 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
40 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
41 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
42 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
43 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
44 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75
45 INT275285 Ros1 Positive_regulation of Tnfrsf1a 1 0.27 1.06 0.72
46 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
47 INT297490 Itpr3 Regulation of Ltp 1 0.02 0 0.7
48 INT144124 Binding of P2rx6 and Trpv2 1 0.09 0 0.7
49 INT148452 Inhbe Regulation of Acvrl1 1 0.01 0.69 0.69
50 INT155457 Tnfrsf1a Positive_regulation of Mapk14 1 0.20 1.17 0.67
51 INT232622 Magi2 Regulation of Cysltr1 1 0.01 0.58 0.67
52 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
53 INT151783 Regulation of Binding of Calca and P2rx1 1 0.42 0.51 0.64
54 INT151778 Binding of Calca and P2rx1 1 0.35 0.5 0.64
55 INT155458 Tnfrsf1a Regulation of Gene_expression of Il6 1 0.22 1.11 0.63
56 INT151766 Calca Regulation of P2rx6 1 0.00 0.56 0.58
57 INT151767 Ngf Regulation of P2rx6 1 0.00 0.56 0.58
58 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58
59 INT350716 Binding of CD58 and Casp8 1 0.03 1.81 0.58
60 INT148172 Mapk1 Positive_regulation of Phosphorylation of Kcnd2 1 0.49 0.55 0.57
61 INT139189 Binding of Daxx and Fadd 1 0.03 0.27 0.57
62 INT291386 Cntf Regulation of Gene_expression of Gria2 1 0.11 0.13 0.53
63 INT162991 Binding of Fadd and Ppm1e 1 0.03 0.09 0.52
64 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
65 INT8438 Cntf Regulation of TAC1 1 0.20 0.18 0.52
66 INT8439 Cntf Regulation of VIP 1 0.20 0.18 0.52
67 INT8440 Cntf Regulation of LIF 1 0.33 0.18 0.52
68 INT122107 Plbd2 Negative_regulation of Cdh2 1 0.03 0.42 0.5
69 INT228448 PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
70 INT56736 Cntf Positive_regulation of Chat 1 0.00 0.1 0.49
71 INT228447 Negative_regulation of PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
72 INT275286 Ros1 Regulation of Positive_regulation of Tnfrsf1a 1 0.16 0.55 0.49
73 INT152281 Binding of P2rx1 and Trpv1 1 0.15 0.42 0.49
74 INT34006 Binding of ITPR3 and YY1 1 0.22 0.33 0.48
75 INT252634 Binding of TNF and Tnfrsf1a 4 0.02 2.4 0.46
76 INT327995 Positive_regulation of TRPV1 Positive_regulation of Tnfrsf1a 1 0.16 0.63 0.46
77 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
78 INT162993 Binding of Trib3 and Fadd 1 0.05 0.1 0.46
79 INT237810 Itpr3 Positive_regulation of Localization of Car2 2 0.08 0.68 0.45
80 INT291384 Cntf Positive_regulation of Slc1a3 1 0.26 0.34 0.45
81 INT291387 Cntf Positive_regulation of Slc1a2 1 0.12 0.34 0.45
82 INT226126 Negative_regulation of Ghrl Regulation of Prkag1 1 0.06 0.17 0.45
83 INT151782 Phosphorylation of Creb1 Positive_regulation of Gene_expression of P2rx1 1 0.41 0.07 0.44
84 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
85 INT151781 Calca Positive_regulation of Gene_expression of P2rx1 1 0.50 0.07 0.44
86 INT253145 Il6 Positive_regulation of Prkag1 1 0.11 0.73 0.44
87 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
88 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
89 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
90 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
91 INT5531 Binding of Acot1 and Chrna2 1 0.12 0 0.42
92 INT217034 P2RX1 Regulation of Gene_expression of Ik 1 0.00 0.34 0.42
93 INT315333 Binding of Cflar and Fadd 1 0.01 0.49 0.42
94 INT226127 Regulation of Ghrl Regulation of Prkag1 1 0.05 0.07 0.42
95 INT291393 Cntf Regulation of GTS 1 0.05 0 0.42
96 INT201610 Binding of Mc1r and Braf 1 0.31 0.75 0.42
97 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
98 INT274781 Agrn Positive_regulation of Chrna2 1 0.08 0.18 0.41
99 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
100 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
101 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
102 INT158104 Binding of Trpv1 and P2rx2 1 0.03 0.27 0.4
103 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
104 INT226129 Ghrl Regulation of Localization of Prkag1 1 0.05 0.07 0.4
105 INT98535 Binding of P2rx6 and Spdya 1 0.00 0.1 0.4
106 INT33713 Binding of ITPR3 and Trh 1 0.00 0.86 0.39
107 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
108 INT346221 Positive_regulation of Braf Positive_regulation of Positive_regulation of Map2k2 1 0.11 0.67 0.39
109 INT346219 Positive_regulation of Braf Positive_regulation of Map2k2 1 0.11 0.67 0.39
110 INT187521 ATIC Positive_regulation of Prkag1 1 0.01 1.07 0.37
111 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
112 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
113 INT289661 Tnfrsf1a Positive_regulation of TNF 1 0.01 1.2 0.37
114 INT77791 fut10 Regulation of Regulation of Tnfrsf1a 1 0.02 0.85 0.36
115 INT226120 Cnr1 Positive_regulation of Prkag1 1 0.09 0 0.35
116 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
117 INT352231 VEGFA Negative_regulation of Cntf 1 0.04 0.22 0.34
118 INT352230 VEGFA Negative_regulation of Gene_expression of Cntf 1 0.04 0.22 0.34
119 INT346226 Binding of TPPP and Braf 1 0.06 0.6 0.33
120 INT226124 Ghrl Positive_regulation of Prkag1 1 0.06 0.24 0.33
121 INT77792 fut10 Negative_regulation of Positive_regulation of Tnfrsf1a 1 0.04 0.82 0.32
122 INT275284 Tnfrsf1a Positive_regulation of Gene_expression of Trpv1 1 0.54 0.36 0.32
123 INT140537 RGD1563588 Negative_regulation of Gene_expression of KCND2 1 0.31 0.09 0.32
124 INT146248 Pcbd1 Positive_regulation of Trpv1 1 0.02 0 0.31
125 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
126 INT152061 Binding of SEPT9 and CD177 1 0.00 1.76 0.31
127 INT196883 Prkca Regulation of P2rx1 1 0.05 0.45 0.31
128 INT146247 Pcbd1 Positive_regulation of Trpa1 1 0.02 0 0.31
129 INT303105 CAMK4 Positive_regulation of Hras1 1 0.04 0.16 0.31
130 INT140474 Tnfrsf1a Positive_regulation of PECAM1 1 0.00 1.18 0.3
131 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
132 INT246690 exf Regulation of Localization of Ide 1 0.00 0.17 0.3
133 INT243151 P2ry4 Positive_regulation of P2rx6 1 0.00 0 0.3
134 INT258857 Binding of P2rx1 and P2ry2 1 0.22 0.81 0.29
135 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
136 INT291383 Fig4 Regulation of Gene_expression of Cntf 1 0.10 0 0.28
137 INT228500 Fadd Positive_regulation of FAS 1 0.14 1.12 0.28
138 INT346220 Binding of Kras and Braf 1 0.03 0.58 0.28
139 INT182347 Binding of Glrb and Cd163 1 0.24 0.98 0.28
140 INT63988 Cntf Regulation of Positive_regulation of Sds 1 0.22 0 0.28
141 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27
142 INT246689 Zglp1 Positive_regulation of Ide 1 0.06 0.28 0.27
143 INT246693 Zglp1 Positive_regulation of Localization of Ide 1 0.08 0.34 0.27
144 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
145 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
146 INT231797 Glrb Regulation of Negative_regulation of TNF 1 0.02 1.49 0.25
147 INT187518 Positive_regulation of ATIC Positive_regulation of Prkag1 1 0.01 0.99 0.25
148 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24
149 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
150 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
151 INT247475 P2RY6 Positive_regulation of ITPR3 1 0.01 0.45 0.23
152 INT97868 Binding of Chrna2 and Regulation of Acot1 1 0.09 0 0.23
153 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
154 INT346224 Braf Negative_regulation of Phosphorylation of Map2k1 1 0.14 0.62 0.22
155 INT246686 Ide Regulation of Ros1 1 0.03 0.41 0.22
156 INT187485 Trib3 Positive_regulation of Prkag1 1 0.00 0.97 0.22
157 INT277995 TNF Positive_regulation of Gene_expression of Tnfrsf1a 1 0.03 1.48 0.22
158 INT187486 Binding of Prkag1 and Stk11 1 0.01 0.95 0.22
159 INT277996 TNF Positive_regulation of Tnfrsf1a 1 0.03 1.48 0.22
160 INT283373 Pcbd1 Regulation of RYR1 1 0.00 1.45 0.21
161 INT33714 Positive_regulation of Binding of ITPR3 and Trh 1 0.00 0.46 0.21
162 INT317394 Binding of Stk11 and Amp1 1 0.04 0.89 0.21
163 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2
164 INT60347 COL2A1 Positive_regulation of Gene_expression of Hras 1 0.05 0.92 0.2
165 INT234992 Car2 Positive_regulation of Jup 1 0.02 0.27 0.2
166 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 0.06 0.2 0.2
167 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2
168 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2
169 INT203850 Binding of Tradd and Lna1 1 0.10 0.4 0.2
170 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2
171 INT280621 Il6 Negative_regulation of Transcription of Irs1 1 0.25 0.4 0.19
172 INT210551 Binding of KCNH2 and KCNE2 1 0.08 0 0.19
173 INT130740 Regulation of Binding of Tnnt2 and Mb 1 0.00 0.47 0.19
174 INT264189 HR Positive_regulation of Gene_expression of IL10 1 0.00 1.48 0.19
175 INT130741 Binding of Tnnt2 and Mb 1 0.01 0.47 0.19
176 INT254683 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Plaur 1 0.01 0.07 0.18
177 INT215167 Phosphorylation of Prkaca Positive_regulation of P2rx2 1 0.06 0.13 0.18
178 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
179 INT226123 Cnr1 Regulation of Prkag1 1 0.05 0.09 0.18
180 INT254698 Gopc Positive_regulation of Positive_regulation of Map2k1 1 0.06 0.07 0.18
181 INT337154 Binding of Iqgap1 and Braf 1 0.13 0.64 0.18
182 INT130932 Negative_regulation of Cpox Positive_regulation of Gene_expression of TSC1 1 0.00 0.42 0.18
183 INT349539 Smcp Positive_regulation of Positive_regulation of Casp8 1 0.04 0.68 0.18
184 INT228168 Adipoq Positive_regulation of Prkag1 2 0.05 1.08 0.17
185 INT304458 Binding of P2rx4 and P2rx6 1 0.14 0 0.17
186 INT264277 Binding of Car2 and P2rx1 1 0.10 0 0.16
187 INT304537 Map2k1 Positive_regulation of PRKG1 1 0.01 0.66 0.16
188 INT264276 Binding of Ednrb and P2rx1 1 0.00 0.17 0.16
189 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
190 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
191 INT246843 Positive_regulation of Binding of Irs1 and Ppp1r13b 1 0.18 0.28 0.16
192 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
193 INT216601 Itpr3 Positive_regulation of Localization of Ca2 1 0.00 0.05 0.15
194 INT34451 Binding of Itpr3 and Ptprg 1 0.03 0 0.15
195 INT349540 Tnfsf10 Positive_regulation of Positive_regulation of Casp8 1 0.05 0.65 0.15
196 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
197 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15
198 INT335459 ABCA1 Positive_regulation of ITPR3 1 0.00 0 0.15
199 INT251294 Binding of HR and MIR1249 1 0.00 0 0.15
200 INT139336 Il1b Regulation of Tnfrsf1a 1 0.27 1.3 0.14

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein heterooligomerization. They are ordered first by their pain relevance and then by number of times they were reported in protein heterooligomerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
2 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
3 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4
4 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75
5 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2
6 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
7 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09
8 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
9 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
10 INT86790 Gene_expression of P2rx6 34 0.74 14.04 15.92
11 INT91285 Negative_regulation of P2rx2 29 0.57 12.74 15.48
12 INT92839 Regulation of P2rx2 36 0.45 13.19 15.38
13 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69
14 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21
15 INT78234 Positive_regulation of Gene_expression of P2rx2 18 0.69 12.86 12.75
16 INT56494 Localization of Ide 73 0.68 22.9 11.26
17 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85
18 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
19 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
20 INT105304 Negative_regulation of Gene_expression of P2rx2 11 0.28 11.07 9.53
21 INT116705 Positive_regulation of Positive_regulation of P2rx2 13 0.49 9.44 9.47
22 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5
23 INT70775 Positive_regulation of Positive_regulation of P2rx1 15 0.49 8.65 8.49
24 INT8423 Gene_expression of Cntf 29 0.69 11.69 8.4
25 INT31761 Positive_regulation of Itpr3 32 0.58 5.95 8.22
26 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
27 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
28 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94
29 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
30 INT95172 Localization of P2rx1 14 0.78 6.77 7.81
31 INT36040 Localization of Itpr3 21 0.70 4.87 7.77
32 INT152347 Binding of GCH1 8 0.37 6.13 7.36
33 INT90943 Negative_regulation of P2rx1 13 0.42 8.21 7.22
34 INT114014 Positive_regulation of Gene_expression of P2rx1 13 0.69 7.77 7.15
35 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97
36 INT91351 Gene_expression of P2rx1 28 0.75 5.89 6.78
37 INT120261 Binding of P2rx2 19 0.28 5.8 6.72
38 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
39 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
40 INT275265 Negative_regulation of Positive_regulation of Tnfrsf1a 1 0.56 4.41 6.35
41 INT163776 Regulation of GCH1 7 0.27 4.58 6.16
42 INT71758 Gene_expression of P2RX1 40 0.75 9.01 6.14
43 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14
44 INT275272 Positive_regulation of Positive_regulation of Tnfrsf1a 8 0.48 6.44 5.97
45 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81
46 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79
47 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
48 INT105538 Negative_regulation of Tnfrsf1a 16 0.56 12.51 5.61
49 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
50 INT63957 Positive_regulation of Tnnt2 33 0.69 18.56 5.41
51 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41
52 INT105306 Regulation of Gene_expression of P2rx2 7 0.21 6.92 5.22
53 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
54 INT182338 Gene_expression of Glrb 11 0.51 14.26 5.1
55 INT26334 Localization of ITPR3 39 0.49 2.53 5.07
56 INT115270 Positive_regulation of P2rx6 9 0.48 6.37 5.06
57 INT56495 Positive_regulation of Localization of Ide 20 0.53 3.53 4.92
58 INT71759 Positive_regulation of P2RX1 13 0.67 3.53 4.9
59 INT199560 Binding of Braf 4 0.30 8.83 4.8
60 INT148649 Transcription of P2rx2 8 0.43 8.11 4.79
61 INT121608 Positive_regulation of Prkag1 23 0.15 9.35 4.64
62 INT26546 Positive_regulation of Gene_expression of Hras1 35 0.70 16.59 4.54
63 INT23045 Positive_regulation of Hbb 31 0.64 19.35 4.54
64 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47
65 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 11 0.66 11.17 4.44
66 INT118230 Binding of Tnfrsf1a 15 0.42 7.63 4.39
67 INT106778 Regulation of Gene_expression of P2rx6 5 0.34 4.3 4.38
68 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33
69 INT144396 Positive_regulation of P2rx1 11 0.49 3.25 4.23
70 INT44578 Binding of Hbb 19 0.48 3.12 4.2
71 INT155512 Positive_regulation of Braf 2 0.49 7.88 4.2
72 INT105974 Positive_regulation of PRKAB1 43 0.67 23.47 4.16
73 INT31762 Gene_expression of Itpr3 22 0.74 1.6 4.15
74 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
75 INT133602 Positive_regulation of Fadd 2 0.54 0.38 4.02
76 INT5527 Binding of Chrna2 11 0.47 1.42 4.01
77 INT95171 Binding of P2rx1 12 0.36 4.69 3.92
78 INT56493 Regulation of Localization of Ide 15 0.47 3.53 3.82
79 INT26191 Positive_regulation of ITPR3 24 0.44 1.9 3.74
80 INT215163 Phosphorylation of P2rx2 19 0.60 1.43 3.62
81 INT77786 Negative_regulation of Tnfrsf1a 5 0.56 5.03 3.58
82 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53
83 INT77788 Regulation of Tnfrsf1a 14 0.57 11.24 3.53
84 INT133604 Negative_regulation of Fadd 4 0.57 0.81 3.5
85 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45
86 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
87 INT96700 Positive_regulation of Positive_regulation of Tnfrsf1a 6 0.69 3.93 3.42
88 INT151586 Positive_regulation of Prkag1 51 0.54 18.7 3.34
89 INT139807 Gene_expression of Braf 7 0.51 8.78 3.34
90 INT135815 Transcription of Gch1 1 0.60 0 3.32
91 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
92 INT37180 Negative_regulation of Itpr3 6 0.51 1.43 3.27
93 INT137049 Positive_regulation of Glrb 7 0.46 9.24 3.22
94 INT12273 Regulation of Chrna2 8 0.59 0.4 3.21
95 INT115790 Negative_regulation of P2rx6 8 0.47 4.13 3.19
96 INT81458 Positive_regulation of Cntf 11 0.47 4.18 3.18
97 INT81830 Localization of P2rx2 14 0.73 5.42 3.16
98 INT54999 Regulation of Itpr3 6 0.24 0.18 3.11
99 INT23044 Gene_expression of Hbb 13 0.43 5.77 3.1
100 INT12270 Gene_expression of Chrna2 11 0.67 5.47 3.06
101 INT134470 Positive_regulation of Map2k1 74 0.49 46.07 3.02
102 INT36039 Gene_expression of Itpr3 19 0.72 3.75 2.93
103 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9
104 INT26833 Negative_regulation of P2rx1 9 0.41 1.5 2.89
105 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
106 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
107 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
108 INT134228 Positive_regulation of Gene_expression of P2rx6 5 0.38 3.48 2.85
109 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77
110 INT346210 Phosphorylation of Braf 1 0.44 5.3 2.77
111 INT4647 Regulation of Hbb 10 0.60 5.28 2.66
112 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
113 INT100743 Regulation of KCNH2 6 0.54 2.37 2.61
114 INT86602 Binding of KCNH2 14 0.36 4.65 2.58
115 INT17039 Regulation of Hr 11 0.27 5.22 2.58
116 INT39367 Negative_regulation of Chrna2 5 0.42 0.53 2.57
117 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57
118 INT196919 Regulation of Braf 3 0.32 6.14 2.55
119 INT191974 Regulation of Ide 16 0.38 9.54 2.52
120 INT168097 Transcription of Tnnt2 1 0.07 2.12 2.47
121 INT17037 Negative_regulation of Hr 11 0.22 11.81 2.46
122 INT26918 Positive_regulation of Gene_expression of ITPR3 14 0.27 2.31 2.41
123 INT81247 Gene_expression of Tnnt2 9 0.31 2.06 2.37
124 INT283973 Transcription of GCH1 1 0.61 1.99 2.33
125 INT37347 Positive_regulation of Itpr3 6 0.34 1.3 2.31
126 INT31763 Positive_regulation of Gene_expression of Itpr3 10 0.30 0.83 2.28
127 INT26335 Binding of ITPR3 22 0.18 3.3 2.27
128 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27
129 INT127104 Regulation of P2rx6 4 0.23 2.71 2.22
130 INT121435 Negative_regulation of Gene_expression of P2rx1 3 0.43 1.82 2.21
131 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
132 INT135827 Positive_regulation of Transcription of Gch1 1 0.58 0 2.2
133 INT109970 Negative_regulation of Casp8 5 0.52 9.34 2.19
134 INT275279 Positive_regulation of Localization of Tnfrsf1a 3 0.48 1.13 2.17
135 INT116194 Gene_expression of Casp8 14 0.75 14.61 2.13
136 INT63081 Localization of Itpr3 13 0.67 1.08 2.12
137 INT228442 Localization of Cntf 8 0.63 4.2 2.12
138 INT286801 Positive_regulation of Gene_expression of Cntf 4 0.62 3.01 2.12
139 INT162669 Regulation of Prkag1 4 0.09 3.77 2.1
140 INT118896 Regulation of Tnnt2 4 0.44 2.94 2.09
141 INT55000 Positive_regulation of Regulation of Itpr3 1 0.41 0 2.08
142 INT13243 Gene_expression of Sqstm1 4 0.30 2.07 2.06
143 INT127756 Negative_regulation of Map2k1 10 0.41 6.69 2.04
144 INT133607 Regulation of Fadd 1 0.60 0.41 2.04
145 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02
146 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
147 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
148 INT215166 Binding of P2rx1 5 0.35 0.41 1.97
149 INT37181 Negative_regulation of Localization of Itpr3 3 0.37 0.83 1.97
150 INT133605 Positive_regulation of Negative_regulation of Fadd 1 0.46 0.28 1.96
151 INT148648 Negative_regulation of Transcription of P2rx2 3 0.29 3.54 1.94
152 INT139174 Positive_regulation of Fadd 1 0.59 0.83 1.94
153 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
154 INT139185 Phosphorylation of Fadd 1 0.69 0.59 1.92
155 INT133609 Negative_regulation of Positive_regulation of Fadd 2 0.46 0.24 1.9
156 INT288630 Gene_expression of Cntf 6 0.75 3.99 1.89
157 INT135820 Regulation of Gch1 1 0.59 0 1.88
158 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87
159 INT183381 Transcription of Tnfrsf1a 3 0.46 2.08 1.83
160 INT100742 Regulation of Gene_expression of KCNH2 1 0.62 0.57 1.83
161 INT101476 Binding of P2rx6 4 0.24 1.04 1.78
162 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77
163 INT106984 Regulation of P2RX1 12 0.60 2.05 1.75
164 INT146948 Negative_regulation of Positive_regulation of P2rx1 2 0.34 2.23 1.74
165 INT162670 Gene_expression of Prkag1 5 0.22 4.45 1.73
166 INT8422 Binding of Cntf 8 0.37 4.54 1.72
167 INT182334 Binding of Glrb 3 0.28 4.81 1.71
168 INT100375 Gene_expression of Vhl 14 0.15 22.3 1.69
169 INT139177 Regulation of Fadd 1 0.60 0.78 1.69
170 INT120505 Negative_regulation of ITPR3 6 0.27 1.46 1.68
171 INT8421 Regulation of Cntf 6 0.44 1.46 1.67
172 INT149435 Regulation of Positive_regulation of P2rx1 2 0.30 1.55 1.67
173 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
174 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
175 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
176 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
177 INT31760 Negative_regulation of Itpr3 5 0.23 0.84 1.61
178 INT25240 Negative_regulation of Pcbd1 11 0.43 3.1 1.59
179 INT37346 Positive_regulation of Localization of Itpr3 3 0.47 0.45 1.59
180 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
181 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
182 INT151777 Regulation of Gene_expression of P2rx1 3 0.60 1.97 1.48
183 INT100376 Positive_regulation of Gene_expression of Vhl 4 0.10 6.47 1.47
184 INT168726 Negative_regulation of Positive_regulation of P2rx2 1 0.07 0.09 1.44
185 INT168727 Negative_regulation of Negative_regulation of P2rx2 1 0.07 0.09 1.43
186 INT56497 Negative_regulation of Localization of Ide 12 0.44 5.34 1.42
187 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
188 INT191970 Positive_regulation of Ide 29 0.51 12.94 1.4
189 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4
190 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
191 INT151588 Phosphorylation of Prkag1 48 0.73 15.62 1.38
192 INT72458 Positive_regulation of Tnnt2 5 0.69 5.59 1.38
193 INT47434 Gene_expression of Tnnt2 14 0.60 10.4 1.37
194 INT175525 Positive_regulation of Phosphorylation of Map2k1 8 0.33 7.02 1.37
195 INT107924 Localization of Tnfrsf1a 5 0.70 3.86 1.37
196 INT77785 Negative_regulation of Gene_expression of Tnfrsf1a 4 0.56 3.1 1.35
197 INT135822 Gene_expression of Gch1 2 0.50 0.77 1.35
198 INT214073 Binding of TSC1 9 0.37 22 1.34
199 INT215162 Phosphorylation of P2rx1 2 0.43 0.12 1.34
200 INT130998 Regulation of PRKAB1 11 0.45 5.7 1.33
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