GO:0051298

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Name centrosome duplication
Categary Process
Go Slim No
Go Link GO:0051298
Unique Molecular Interactions 42
Total Molecular Interactions 75
Total Single Events 305
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for centrosome duplication. They are ordered first by their pain relevance and then by number of times they were reported for centrosome duplication. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
3 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
4 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
5 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
6 INT297316 Negative_regulation of Rock2 Positive_regulation of Cdh1 1 0.01 1.92 0.43
7 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
8 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
9 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21
10 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19
11 INT120552 Y-27632 Negative_regulation of Rock2 1 0.02 0.15 0.15
12 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
13 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
14 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
15 INT229500 Binding of Vim and Nde1 1 0.00 0.79 0.07
16 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
17 INT229499 Nde1 Regulation of Vim 1 0.00 0.35 0.04
18 INT159960 Rock2 Regulation of Phosphorylation of Tnf 1 0.04 0.55 0.03
19 INT303010 Ptgis Positive_regulation of Rock2 1 0.05 1.23 0.03
20 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
21 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
22 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
23 INT313597 Binding of BRCA2 and TOX3 1 0.11 0.7 0
24 INT314742 Binding of RAD51 and Brca2 1 0.06 1.05 0
25 INT234182 Binding of BRCA2 and PALB2 1 0.41 1.43 0
26 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
27 INT314743 Binding of RAD51 and Brca1 1 0.06 1.06 0
28 INT314740 Binding of ESR1 and Brca1 1 0.16 0.69 0
29 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0
30 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
31 INT159959 Gtf3a Positive_regulation of Phosphorylation of Rock2 1 0.01 0.5 0
32 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
33 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
34 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
35 INT314745 Binding of TP53 and Brca1 1 0.18 1.17 0
36 INT296162 Mcph1 Regulation of Brca1 1 0.26 0.19 0
37 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
38 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
39 INT260072 Binding of BRCA2 and FANCC 1 0.37 0.63 0
40 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0
41 INT159966 TNF Positive_regulation of Phosphorylation of Rock2 1 0.01 0.5 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for centrosome duplication. They are ordered first by their pain relevance and then by number of times they were reported in centrosome duplication. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
2 INT123564 Negative_regulation of Rock2 13 0.59 9.61 3.58
3 INT120551 Negative_regulation of Rock2 8 0.52 2.73 2.53
4 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
5 INT146553 Positive_regulation of Rock2 4 0.44 2.56 1.09
6 INT136044 Gene_expression of Rock2 7 0.78 0.19 1.06
7 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
8 INT147433 Gene_expression of BRCA2 7 0.62 7.02 0.79
9 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
10 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63
11 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
12 INT167608 Regulation of Rock2 2 0.33 2.47 0.59
13 INT136043 Negative_regulation of Gene_expression of Rock2 1 0.43 0 0.53
14 INT126628 Positive_regulation of Rock2 4 0.70 3.56 0.52
15 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
16 INT126627 Gene_expression of Rock2 9 0.60 3.33 0.32
17 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25
18 INT147486 Negative_regulation of Positive_regulation of Rock2 1 0.06 1.67 0.24
19 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
20 INT159956 Phosphorylation of Rock2 3 0.79 1.57 0.2
21 INT19359 Binding of BRCA2 5 0.47 2.63 0.19
22 INT89690 Binding of Brca2 2 0.37 1.8 0.18
23 INT89689 Binding of Brca1 2 0.37 2.55 0.18
24 INT263407 Binding of Rock2 1 0.02 0 0.18
25 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
26 INT89691 Regulation of Brca2 1 0.23 0.56 0.13
27 INT201462 Binding of CDK2 12 0.39 5.2 0.12
28 INT187590 Gene_expression of Brca1 12 0.65 4.94 0.11
29 INT208914 Regulation of Brca1 1 0.10 0.79 0.11
30 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
31 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
32 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
33 INT302272 Localization of CDK2 2 0.30 1.09 0.09
34 INT126625 Transcription of Rock2 1 0.67 0 0.09
35 INT306176 Localization of Rock2 1 0.73 0.41 0.09
36 INT126624 Negative_regulation of Transcription of Rock2 1 0.41 0 0.09
37 INT174155 Negative_regulation of Brca1 4 0.36 1.77 0.07
38 INT234186 Localization of BRCA2 2 0.69 1.48 0.07
39 INT286583 Localization of PKD2 1 0.35 0.17 0.06
40 INT261879 Binding of PKD2 3 0.13 2.59 0.05
41 INT187589 Positive_regulation of Gene_expression of Brca1 2 0.55 1.93 0.03
42 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
43 INT169427 Transcription of CDK2 2 0.09 0.42 0
44 INT167536 Positive_regulation of BRCA2 2 0.49 0.29 0
45 INT241245 Negative_regulation of PKD2 2 0.42 2.35 0
46 INT212457 Phosphorylation of Brca1 2 0.51 0.96 0
47 INT234191 Positive_regulation of Localization of BRCA2 1 0.46 0.68 0
48 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0
49 INT187580 Positive_regulation of Brca1 1 0.10 1.17 0
50 INT314708 Gene_expression of Brca2 1 0.41 1.75 0
51 INT314707 Regulation of Transcription of Brca2 1 0.27 0.56 0
52 INT341855 Positive_regulation of Positive_regulation of CDK2 1 0.06 0.51 0
53 INT314706 Transcription of Brca1 1 0.43 0.53 0
54 INT232493 Negative_regulation of Positive_regulation of PKD2 1 0.23 0.61 0
55 INT289620 Regulation of Binding of CDK2 1 0.28 0.22 0
56 INT261878 Negative_regulation of Binding of PKD2 1 0.14 0.6 0
57 INT314705 Transcription of Brca2 1 0.42 0.56 0
58 INT232491 Positive_regulation of PKD2 1 0.27 0.56 0
59 INT173224 Regulation of BRCA2 1 0.21 1.3 0
60 INT325169 Regulation of Negative_regulation of CDK2 1 0.34 0.05 0
61 INT306177 Regulation of Gene_expression of Rock2 1 0.26 0.84 0
62 INT225187 Positive_regulation of Binding of CDK2 1 0.56 0.87 0
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