GO:0051346

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Name negative regulation of hydrolase activity
Categary Process
Go Slim No
Go Link GO:0051346
Unique Molecular Interactions 250
Total Molecular Interactions 345
Total Single Events 3919
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of hydrolase activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of hydrolase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
2 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
3 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
4 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
5 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
6 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
7 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
8 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
9 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
10 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
11 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
12 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
13 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
14 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
15 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
16 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
17 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
18 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
19 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
20 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
21 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
22 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
23 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
24 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
25 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
26 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
27 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
28 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
29 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
30 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
31 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
32 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
33 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
34 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
35 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
36 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
37 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73
38 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
39 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
40 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67
41 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
42 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
43 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
44 INT118824 OPA1 Positive_regulation of Gene_expression of Nos1 2 0.03 0.24 0.65
45 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
46 INT175700 Nos3 Negative_regulation of smc 1 0.01 1.05 0.59
47 INT142571 Pnoc Positive_regulation of Nos1 1 0.52 0.06 0.57
48 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
49 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53
50 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
51 INT317537 Oprm1 Positive_regulation of Phosphorylation of Nos1 1 0.16 0 0.5
52 INT90121 Nos1 Regulation of Fos 1 0.27 0.25 0.49
53 INT257220 Binding of Nos1 and Flvcr2 1 0.00 0.17 0.47
54 INT103025 Calca Positive_regulation of Nos3 1 0.25 0.41 0.46
55 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
56 INT95276 Obfc2a Negative_regulation of Nos3 1 0.02 1.02 0.46
57 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 0.26 0.41 0.46
58 INT307781 Apoa1 Positive_regulation of LCAT 1 0.76 1.19 0.45
59 INT213027 Binding of Apoa1 and Scarb1 6 0.09 7.52 0.43
60 INT159349 Zfp956 Negative_regulation of Nos1 1 0.03 0.61 0.43
61 INT307780 Apoa1 Positive_regulation of Soat1 1 0.04 1.14 0.42
62 INT111410 Nos1 Regulation of Vip 1 0.00 0 0.41
63 INT146273 Binding of Nos1 and Rasd1 1 0.34 0.18 0.41
64 INT111409 Nos1 Regulation of Gene_expression of Vip 1 0.01 0 0.41
65 INT146272 Binding of Nos1 and Nos1ap 1 0.28 0.2 0.39
66 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38
67 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
68 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36
69 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
70 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
71 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
72 INT333158 asa Positive_regulation of Nos3 1 0.11 0.18 0.32
73 INT333166 Tlx2 Positive_regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
74 INT333155 Tlx2 Regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
75 INT333152 Tlx2 Positive_regulation of Nos3 1 0.08 0.18 0.32
76 INT333169 asa Positive_regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
77 INT78664 Negative_regulation of Nos1 Negative_regulation of Cebpz 1 0.30 0.43 0.32
78 INT333164 asa Regulation of Nos3 1 0.11 0.18 0.32
79 INT333149 asa Regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
80 INT333167 Tlx2 Regulation of Nos3 1 0.08 0.18 0.32
81 INT304497 Mknk1 Positive_regulation of Nos1 1 0.19 0.53 0.3
82 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3
83 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
84 INT303949 LEPR Positive_regulation of SOAT1 1 0.01 0.22 0.28
85 INT141871 Binding of Nos3 and Slc2a4 1 0.25 0.51 0.28
86 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
87 INT303948 LEPR Positive_regulation of PIK3CG 1 0.02 0.22 0.28
88 INT240807 Arc Regulation of Gene_expression of Lepr 1 0.05 0.72 0.28
89 INT213029 Positive_regulation of Binding of Apoa1 and Scarb1 1 0.09 3.38 0.27
90 INT242763 Olr1746 Negative_regulation of Nos1 1 0.02 0.97 0.26
91 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25
92 INT328707 Trat1 Negative_regulation of Nos1 1 0.02 2.32 0.24
93 INT257223 Ltp Positive_regulation of Gene_expression of Nos1 1 0.03 0.07 0.24
94 INT305798 Binding of APOA1 and OxP-11D 1 0.02 0.45 0.23
95 INT201273 Nos2 Regulation of Nos1 1 0.17 0.99 0.23
96 INT159351 Negative_regulation of Binding of Nos1 and Nos2 1 0.27 0.34 0.22
97 INT281901 Binding of KNG1 and NOS3 1 0.05 0.17 0.22
98 INT159348 Binding of Nos1 and Nos2 1 0.23 0.29 0.22
99 INT122576 Pik3cd Positive_regulation of Phosphorylation of Nos3 1 0.28 0.45 0.21
100 INT189321 Binding of Apoa1 and Hdlcl1 1 0.00 0.68 0.2
101 INT239227 Prkca Regulation of Nos3 1 0.02 0.97 0.2
102 INT257218 Camk1 Negative_regulation of Nos1 1 0.04 0.09 0.19
103 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19
104 INT137417 MAPK7 Regulation of Gene_expression of NOS3 1 0.00 0.5 0.19
105 INT300193 Binding of APOA1 and INSL4 1 0.01 2.17 0.18
106 INT222661 IFNA1 Positive_regulation of Gene_expression of Nos1 1 0.01 0.25 0.18
107 INT269333 Binding of BDKRB2 and NOS3 1 0.02 0 0.17
108 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
109 INT71383 Vip Positive_regulation of Nos1 1 0.01 0.09 0.16
110 INT257230 Binding of CALM1 and Nos1 1 0.00 0 0.15
111 INT304496 Mknk1 Positive_regulation of Gene_expression of Nos1 1 0.19 0.18 0.15
112 INT78662 Dlst Positive_regulation of Gene_expression of Nos1 1 0.20 0.17 0.14
113 INT214141 Binding of Lep and Lepr 1 0.32 0.82 0.12
114 INT269332 Binding of NOS3 and TMPO 1 0.01 0 0.12
115 INT195896 Egf Positive_regulation of Nos1 1 0.10 0.57 0.12
116 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12
117 INT213042 Apoa1 Positive_regulation of Nos3 1 0.10 2.17 0.11
118 INT288616 EPO Positive_regulation of Nos3 1 0.08 0.69 0.11
119 INT304502 Mknk1 Positive_regulation of Phosphorylation of Nos1 1 0.19 0.16 0.11
120 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
121 INT302511 Binding of OPA1 and Nos3 1 0.02 1.57 0.1
122 INT172816 Crp Positive_regulation of Transcription of Nos3 1 0.06 0.91 0.1
123 INT172817 Crp Positive_regulation of Regulation of Nos3 1 0.09 0.84 0.1
124 INT184814 NOS3 Positive_regulation of Gene_expression of NOS1 1 0.09 0.54 0.1
125 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1
126 INT252790 Binding of NOS1 and NOS3 1 0.03 0.37 0.1
127 INT305780 Binding of APOA1 and LRCH2 1 0.00 0.19 0.1
128 INT249848 Fgf2 Positive_regulation of Gene_expression of Nos3 1 0.33 0.44 0.1
129 INT172819 Crp Positive_regulation of Gene_expression of Nos3 1 0.06 0.91 0.1
130 INT249851 VEGFA Positive_regulation of Gene_expression of Nos3 1 0.05 0.44 0.1
131 INT172821 Crp Positive_regulation of Negative_regulation of Nos3 1 0.06 0.84 0.1
132 INT213023 Hdl1 Regulation of Nos3 2 0.09 4.06 0.09
133 INT192249 Angpt1 Positive_regulation of Localization of NOS3 1 0.01 0.46 0.09
134 INT252803 Binding of NOS3 and ISYNA1 1 0.02 0.32 0.09
135 INT192248 Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
136 INT192250 Positive_regulation of Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
137 INT301144 Nos1 Regulation of Gene_expression of TNF 1 0.11 0.55 0.09
138 INT300192 Gene_expression of APOA1 Positive_regulation of HSD11B1 1 0.16 1.08 0.08
139 INT309390 Gene_expression of Sod2 Negative_regulation of Nos3 1 0.31 0.2 0.08
140 INT279652 PPARA Positive_regulation of Gene_expression of Apoa1 1 0.00 0.75 0.07
141 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
142 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07
143 INT267998 Binding of XDH and Nos1 1 0.02 0.46 0.06
144 INT250015 Binding of FLNA and Nos3 1 0.05 1.09 0.06
145 INT269501 Nos1 Regulation of Lta 1 0.28 0.26 0.05
146 INT246691 Ide Positive_regulation of Gene_expression of Nos3 1 0.03 0.26 0.05
147 INT335047 PPARA Positive_regulation of Gene_expression of APOA1 1 0.20 0.42 0.05
148 INT239348 Binding of Apoa1 and Hdl1 1 0.03 3.34 0.05
149 INT296023 Positive_regulation of Apoa2 Negative_regulation of APOA1 1 0.50 0.35 0.05
150 INT249954 Cpa1 Positive_regulation of Nos3 1 0.04 0.36 0.05
151 INT296025 Apoa2 Negative_regulation of APOA1 1 0.47 0.35 0.05
152 INT236722 Ppara Positive_regulation of Binding of Apoa1 1 0.10 0.18 0.04
153 INT213047 Hdl1 Positive_regulation of Gene_expression of Nos3 1 0.14 0.94 0.04
154 INT213031 Positive_regulation of Pik3r1 Positive_regulation of Gene_expression of Nos3 1 0.10 0.8 0.04
155 INT348881 Atpif1 Positive_regulation of If3 1 0.01 0.08 0.04
156 INT348885 Atpif1 Positive_regulation of EIF5B 1 0.01 0.08 0.04
157 INT290877 Binding of Bcl2a1c and Lepr 1 0.00 0.87 0.04
158 INT288908 Apoa1 Positive_regulation of Gene_expression of HSD11B1 1 0.03 0.53 0.04
159 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03
160 INT214149 Binding of Lepr and Pomc 1 0.33 0.21 0.03
161 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03
162 INT238035 Binding of LEPR and OPLL 1 0.01 0.43 0.03
163 INT353865 Binding of CHI3L1 and Lepr 1 0.00 1.88 0.03
164 INT181618 NOS3 Positive_regulation of INS 1 0.02 0.59 0.03
165 INT239345 Apoa1 Positive_regulation of RCT 1 0.02 1.15 0.03
166 INT214148 Binding of Lepr and Cartpt 1 0.09 0.21 0.03
167 INT281908 VEGFA Positive_regulation of NOS3 1 0.14 0.14 0
168 INT249953 Cpa1 Regulation of Nos3 1 0.03 0.08 0
169 INT183248 LPA Positive_regulation of NOS3 1 0.02 0 0
170 INT239332 Hdl1 Positive_regulation of Gene_expression of Apoa1 1 0.04 0.84 0
171 INT98710 Pdyn Negative_regulation of Nos3 1 0.02 0 0
172 INT249935 Nos3 Regulation of Nos2 1 0.25 0.19 0
173 INT117647 Agt Regulation of Nos1 1 0.19 0.13 0
174 INT133825 TNF Negative_regulation of NOS3 1 0.28 0.06 0
175 INT247444 Binding of APOA1 and APOC3 1 0.28 0.39 0
176 INT176535 Ass1 Positive_regulation of Lepr 1 0.00 0 0
177 INT305265 Obsty1 Negative_regulation of Phosphorylation of Nos3 1 0.05 0.78 0
178 INT315669 Binding of Nes and Nos1 1 0.20 0 0
179 INT213017 Apoa1 Negative_regulation of Positive_regulation of Gtf3a 1 0.00 1.16 0
180 INT247436 Binding of APOA1 and SACM1L 1 0.27 0.39 0
181 INT249937 Nos1 Regulation of Nos3 1 0.23 0.19 0
182 INT290193 Binding of APOA1 and Hdl1 1 0.01 1 0
183 INT309834 Binding of Lepr and Zfp366 1 0.00 0.28 0
184 INT268013 Binding of Nos3 and Acot1 1 0.02 1.48 0
185 INT340178 Car2 Positive_regulation of Positive_regulation of Nos3 1 0.01 0.26 0
186 INT305254 Obsty1 Regulation of Gene_expression of Nos3 1 0.03 0.97 0
187 INT239353 CETP Regulation of Apoa1 1 0.16 0.65 0
188 INT98711 Regulation of Pdyn Negative_regulation of Nos3 1 0.02 0 0
189 INT351165 Binding of CAV1 and Nos3 1 0.09 1.46 0
190 INT239342 Lcat Regulation of Apoa1 1 0.16 0.65 0
191 INT260134 CGA Positive_regulation of Gene_expression of Nos3 1 0.16 0.13 0
192 INT334102 Nos3 Positive_regulation of Gene_expression of ISYNA1 1 0.01 0.59 0
193 INT133824 IL1B Negative_regulation of NOS3 1 0.48 0.06 0
194 INT231168 Binding of Dmd and Nos1 1 0.11 0.06 0
195 INT326060 Binding of ABCA1 and APOA1 1 0.39 1.5 0
196 INT323279 Binding of Nos3 and Arg2 1 0.01 0.67 0
197 INT333560 NOS3 Regulation of HCK 1 0.01 0.2 0
198 INT326058 Negative_regulation of PRKCA Negative_regulation of APOA1 1 0.15 0.32 0
199 INT326059 APOA1 Positive_regulation of Gene_expression of APOE 1 0.61 0.38 0
200 INT326064 APOA1 Positive_regulation of HMGCR 1 0.16 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of hydrolase activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of hydrolase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
2 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
3 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
4 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
5 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
6 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
7 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
8 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
9 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
10 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
11 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
12 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
13 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
14 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
15 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
16 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
17 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
18 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
19 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
20 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
21 INT80251 Binding of Nos1 21 0.30 8.24 11.31
22 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
23 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
24 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71
25 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
26 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06
27 INT71381 Localization of Nos1 33 0.79 11.46 8.05
28 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
29 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86
30 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62
31 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21
32 INT92741 Positive_regulation of Positive_regulation of Nos1 8 0.47 1.44 6.58
33 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
34 INT83712 Transcription of Nos3 19 0.69 13.09 6.31
35 INT69499 Binding of Nos1 15 0.36 2.56 6.23
36 INT93658 Transcription of Nos1 16 0.72 6.85 6.16
37 INT64111 Negative_regulation of Gene_expression of Nos1 22 0.57 8.96 6.02
38 INT257199 Positive_regulation of Phosphorylation of Nos1 2 0.45 0.68 5.78
39 INT84673 Localization of Nos1 19 0.80 5.01 5.62
40 INT74614 Positive_regulation of Apoa1 16 0.68 23.95 5.04
41 INT181886 Gene_expression of Apoa1 40 0.64 40.53 4.56
42 INT83991 Regulation of Nos3 25 0.44 9.89 4.06
43 INT102515 Binding of Nos3 19 0.45 9.41 4.01
44 INT134875 Phosphorylation of Nos1 5 0.70 1.21 3.44
45 INT142568 Negative_regulation of Positive_regulation of Nos1 2 0.37 0.25 3.3
46 INT70958 Binding of NOS3 19 0.37 11.84 3.29
47 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07
48 INT10830 Regulation of Apoa1 11 0.44 15.1 3.04
49 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
50 INT91869 Transcription of NOS3 13 0.67 6.81 2.86
51 INT170557 Gene_expression of Lepr 16 0.67 17.26 2.78
52 INT101883 Regulation of Gene_expression of Nos3 11 0.52 6.71 2.73
53 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7
54 INT49169 Regulation of Negative_regulation of Nos1 3 0.45 4.67 2.7
55 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64
56 INT108608 Positive_regulation of Positive_regulation of Nos1 8 0.49 1.66 2.58
57 INT145101 Transcription of Nos3 8 0.70 6.04 2.47
58 INT181880 Positive_regulation of Apoa1 19 0.66 21.19 2.43
59 INT73809 Regulation of Nos3 18 0.45 10.05 2.27
60 INT144792 Negative_regulation of Transcription of Nos1 2 0.43 1.74 2.27
61 INT141299 Negative_regulation of Gene_expression of Nos3 9 0.55 5.38 2.17
62 INT110016 Negative_regulation of Phosphorylation of Nos1 3 0.28 0.47 2.16
63 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15
64 INT82166 Regulation of NOS3 14 0.54 7.57 2.08
65 INT91594 Localization of NOS3 12 0.78 5.39 2.02
66 INT49313 Positive_regulation of Gene_expression of Apoa1 3 0.68 9.55 2.01
67 INT76532 Binding of Nos3 13 0.37 9.32 1.87
68 INT22863 Negative_regulation of Apoa1 10 0.57 10.68 1.86
69 INT60999 Localization of Nos3 12 0.74 5.28 1.75
70 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73
71 INT64559 Positive_regulation of Negative_regulation of Nos1 2 0.41 1.58 1.68
72 INT97418 Regulation of Regulation of Nos1 2 0.41 0.94 1.68
73 INT72676 Gene_expression of APOA1 34 0.75 34.15 1.67
74 INT89008 Gene_expression of Lepr 2 0.65 5.39 1.66
75 INT156484 Binding of Apoa1 4 0.47 6.78 1.63
76 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
77 INT93350 Binding of Lepr 17 0.05 27.21 1.5
78 INT181881 Positive_regulation of Gene_expression of Apoa1 13 0.48 14.31 1.45
79 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
80 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41
81 INT83713 Positive_regulation of Transcription of Nos3 3 0.67 2.92 1.38
82 INT181882 Localization of Apoa1 8 0.71 7.94 1.37
83 INT89785 Regulation of Transcription of Nos3 1 0.32 0.85 1.36
84 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34
85 INT115938 Negative_regulation of Negative_regulation of Nos1 2 0.36 0.27 1.31
86 INT136612 Positive_regulation of Positive_regulation of Nos3 5 0.43 4.22 1.26
87 INT212983 Positive_regulation of Positive_regulation of Nos3 9 0.51 7.08 1.23
88 INT144393 Negative_regulation of Negative_regulation of Nos1 2 0.32 0.96 1.15
89 INT181879 Negative_regulation of Apoa1 8 0.55 8.18 1.11
90 INT159477 Phosphorylation of NOS3 14 0.72 1.54 1.08
91 INT54794 Binding of Lepr 1 0.01 0 1.07
92 INT108609 Regulation of Localization of Nos1 3 0.45 0 1.06
93 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04
94 INT89847 Positive_regulation of Localization of Nos1 10 0.49 2.45 1.01
95 INT134879 Negative_regulation of Phosphorylation of Nos1 1 0.50 0.27 0.93
96 INT72672 Positive_regulation of Gene_expression of APOA1 4 0.67 3.81 0.89
97 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
98 INT181885 Binding of Apoa1 7 0.35 5.66 0.84
99 INT191926 Negative_regulation of Lepr 13 0.48 17.68 0.8
100 INT122572 Phosphorylation of Nos3 37 0.65 25.23 0.75
101 INT216258 Positive_regulation of Regulation of Nos1 2 0.40 1.45 0.74
102 INT152562 Regulation of Transcription of NOS3 1 0.23 0.34 0.71
103 INT92547 Regulation of Localization of Nos1 2 0.43 0.61 0.7
104 INT278977 Gene_expression of LEPR 5 0.75 1.99 0.69
105 INT193486 Negative_regulation of Negative_regulation of Nos3 3 0.34 2.21 0.68
106 INT97192 Regulation of Transcription of Nos1 1 0.55 1.94 0.68
107 INT201270 Regulation of Positive_regulation of Nos1 2 0.38 2.27 0.63
108 INT181576 Phosphorylation of Nos3 7 0.59 1.35 0.6
109 INT181888 Regulation of Apoa1 5 0.26 5.07 0.6
110 INT213118 Negative_regulation of Gene_expression of Apoa1 2 0.42 2.86 0.6
111 INT144447 Regulation of Regulation of Nos1 1 0.43 0.1 0.59
112 INT159476 Positive_regulation of Phosphorylation of NOS3 6 0.44 1.43 0.58
113 INT141864 Negative_regulation of Binding of Nos3 3 0.39 2.27 0.56
114 INT112279 Regulation of Positive_regulation of Nos1 3 0.39 1.07 0.54
115 INT145099 Regulation of Transcription of Nos1 3 0.44 1.24 0.53
116 INT20239 Regulation of APOA1 10 0.60 10.98 0.51
117 INT92549 Negative_regulation of Localization of Nos1 1 0.37 0.26 0.5
118 INT91864 Negative_regulation of Transcription of NOS3 4 0.54 1.41 0.48
119 INT145100 Regulation of Transcription of Nos3 4 0.44 2.05 0.46
120 INT144095 Localization of Nos3 8 0.57 4.5 0.43
121 INT190882 Regulation of Gene_expression of Apoa1 4 0.23 3.67 0.43
122 INT159479 Positive_regulation of Binding of NOS3 2 0.50 0.63 0.41
123 INT193491 Negative_regulation of Positive_regulation of Nos3 2 0.36 1.67 0.4
124 INT190691 Negative_regulation of APOA1 12 0.42 15.9 0.39
125 INT181883 Negative_regulation of Negative_regulation of Apoa1 1 0.40 1.24 0.39
126 INT104414 Negative_regulation of Transcription of Nos1 1 0.42 0.96 0.38
127 INT95273 Regulation of Negative_regulation of Nos3 2 0.20 0.85 0.37
128 INT72673 Transcription of APOA1 2 0.52 1.2 0.36
129 INT261209 Localization of Apoa1 4 0.73 2.61 0.33
130 INT307779 Positive_regulation of Localization of Apoa1 1 0.49 0.88 0.31
131 INT189968 Binding of APOA1 12 0.47 10.1 0.3
132 INT120320 Positive_regulation of Transcription of Nos1 3 0.46 0.58 0.29
133 INT107757 Regulation of Negative_regulation of Nos1 2 0.39 0 0.27
134 INT112278 Positive_regulation of Regulation of Nos1 4 0.38 0.99 0.25
135 INT212933 Regulation of Binding of Nos3 2 0.34 0.88 0.24
136 INT214119 Regulation of Lepr 2 0.23 3.17 0.23
137 INT172796 Regulation of Negative_regulation of Nos3 1 0.16 1.4 0.23
138 INT105900 Regulation of Binding of Nos1 1 0.35 0.52 0.22
139 INT214103 Transcription of Lepr 1 0.57 0.36 0.22
140 INT316565 Negative_regulation of Regulation of Nos3 1 0.32 1.01 0.22
141 INT133762 Gene_expression of Atpif1 3 0.17 0.34 0.21
142 INT73810 Negative_regulation of Regulation of Nos3 2 0.36 1.01 0.21
143 INT118276 Regulation of Positive_regulation of Nos3 1 0.09 0 0.21
144 INT133634 Positive_regulation of Negative_regulation of Nos1 1 0.47 0.57 0.2
145 INT269409 Regulation of Phosphorylation of NOS3 1 0.18 0 0.2
146 INT190874 Negative_regulation of Gene_expression of Apoa1 1 0.15 0.9 0.2
147 INT163997 Positive_regulation of Negative_regulation of Nos3 1 0.49 1.15 0.2
148 INT92815 Positive_regulation of Negative_regulation of NOS3 1 0.12 1.03 0.2
149 INT141866 Regulation of Localization of Nos3 1 0.42 0.24 0.18
150 INT257201 Positive_regulation of Negative_regulation of Nos3 1 0.12 0 0.18
151 INT239275 Regulation of Localization of Apoa1 1 0.19 1.62 0.18
152 INT269403 Regulation of Positive_regulation of NOS3 1 0.18 0 0.17
153 INT257203 Regulation of Phosphorylation of Nos1 1 0.15 0 0.17
154 INT297577 Localization of APOA1 12 0.65 4.58 0.15
155 INT252219 Negative_regulation of Binding of Apoa1 1 0.16 0.95 0.15
156 INT145102 Positive_regulation of Transcription of Nos3 1 0.45 0.46 0.14
157 INT290701 Protein_catabolism of Nos3 1 0.54 0.42 0.13
158 INT212996 Negative_regulation of Positive_regulation of Nos3 3 0.35 2.11 0.12
159 INT269395 Regulation of Binding of NOS3 2 0.39 1.84 0.12
160 INT323261 Positive_regulation of Binding of Nos3 1 0.18 0.25 0.12
161 INT190693 Negative_regulation of Regulation of APOA1 1 0.09 1.94 0.11
162 INT186558 Negative_regulation of Positive_regulation of NOS3 2 0.37 0.26 0.1
163 INT172791 Negative_regulation of Transcription of Nos3 1 0.17 0.9 0.1
164 INT309385 Positive_regulation of Phosphorylation of Nos3 5 0.48 2.98 0.09
165 INT305235 Negative_regulation of Phosphorylation of Nos3 5 0.41 4.17 0.09
166 INT192238 Positive_regulation of Localization of NOS3 2 0.21 0.76 0.09
167 INT303975 Positive_regulation of Gene_expression of LEPR 1 0.13 0 0.07
168 INT175698 Positive_regulation of Localization of Nos3 2 0.27 1.19 0.04
169 INT100487 Negative_regulation of Binding of Nos1 1 0.28 0 0.04
170 INT335114 Negative_regulation of Transcription of APOA1 1 0.16 0.46 0.04
171 INT176521 Positive_regulation of Lepr 8 0.07 6.6 0.03
172 INT255452 Negative_regulation of Gene_expression of APOA1 1 0.41 2.46 0.03
173 INT335848 Positive_regulation of Gene_expression of Lepr 1 0.05 1.25 0.03
174 INT343710 Positive_regulation of Localization of Nos3 1 0.38 0.22 0.03
175 INT112277 Negative_regulation of Regulation of Nos1 1 0.35 0.33 0.03
176 INT269496 Regulation of Binding of Nos3 3 0.25 0.46 0
177 INT109984 Positive_regulation of Localization of Nos1 2 0.39 0.86 0
178 INT259197 Negative_regulation of Lepr 2 0.11 0.33 0
179 INT267959 Negative_regulation of Positive_regulation of APOA1 2 0.41 1.4 0
180 INT309830 Positive_regulation of Positive_regulation of Lepr 1 0.07 0.6 0
181 INT75 Positive_regulation of Atpif1 1 0.26 0 0
182 INT326078 Positive_regulation of Negative_regulation of APOA1 1 0.40 0.32 0
183 INT355212 Positive_regulation of Phosphorylation of Nos3 1 0.23 0.18 0
184 INT336827 Regulation of Regulation of NOS3 1 0.23 0.51 0
185 INT309384 Regulation of Phosphorylation of Nos3 1 0.31 0.39 0
186 INT332953 Regulation of Gene_expression of Lepr 1 0.52 2.43 0
187 INT326072 Negative_regulation of Localization of APOA1 1 0.34 0.38 0
188 INT290862 Regulation of Regulation of Lepr 1 0.00 1 0
189 INT249944 Positive_regulation of Regulation of Nos3 1 0.35 0.07 0
190 INT255448 Positive_regulation of Binding of APOA1 1 0.48 2.88 0
191 INT255449 Positive_regulation of Positive_regulation of APOA1 1 0.48 1.44 0
192 INT139479 Protein_catabolism of Nos1 1 0.58 0.05 0
193 INT174535 Negative_regulation of Negative_regulation of NOS3 1 0.11 0.32 0
194 INT326079 Regulation of Localization of APOA1 1 0.36 0.24 0
195 INT269497 Protein_catabolism of Nos1 1 0.57 0.64 0
196 INT213117 Negative_regulation of Positive_regulation of Apoa1 1 0.07 0.54 0
197 INT348873 Negative_regulation of Gene_expression of Atpif1 1 0.07 0.07 0
198 INT326068 Positive_regulation of Localization of APOA1 1 0.40 1.76 0
199 INT343712 Regulation of Positive_regulation of Nos3 1 0.50 0.93 0
200 INT288894 Regulation of Localization of Apoa1 1 0.14 0.42 0
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