GO:0051389

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Name inactivation of MAPKK activity
Categary Process
Go Slim No
Go Link GO:0051389
Unique Molecular Interactions 16
Total Molecular Interactions 20
Total Single Events 185
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for inactivation of MAPKK activity. They are ordered first by their pain relevance and then by number of times they were reported for inactivation of MAPKK activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
2 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
3 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
4 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
5 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
6 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15
7 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05
8 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05
9 INT234620 Regulation of Binding of IGF1 and IGF1R 1 0.07 0.39 0.05
10 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 0.63 0.51 0
11 INT315065 IGF1R Regulation of Gene_expression of PAR4 1 0.37 0.53 0
12 INT315049 IGF1R Regulation of MT1X 1 0.29 0.52 0
13 INT319320 Binding of EGI and IGF1R 1 0.02 0.85 0
14 INT114713 Binding of IGF1R and SRC 1 0.33 0.6 0
15 INT307584 Binding of EGFR and IGF1R 1 0.03 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for inactivation of MAPKK activity. They are ordered first by their pain relevance and then by number of times they were reported in inactivation of MAPKK activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
2 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
3 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
4 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
5 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
6 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
7 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
8 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
9 INT145859 Regulation of Gene_expression of Igf1r 1 0.59 1.58 0.55
10 INT168940 Phosphorylation of Igf1r 1 0.77 2.18 0.38
11 INT210766 Gene_expression of Igf1r 6 0.65 2.15 0.31
12 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21
13 INT250517 Phosphorylation of Igf1r 5 0.79 1.21 0.21
14 INT213792 Positive_regulation of Igf1r 3 0.45 1 0.2
15 INT168938 Negative_regulation of Phosphorylation of Igf1r 1 0.40 1.1 0.19
16 INT168939 Negative_regulation of Igf1r 1 0.40 1.01 0.15
17 INT9320 Regulation of Transcription of Igf1r 1 0.04 0.36 0.13
18 INT9333 Regulation of Igf1r 1 0.07 0.36 0.13
19 INT92590 Positive_regulation of Gene_expression of IGF1R 3 0.57 2.31 0.12
20 INT92589 Positive_regulation of IGF1R 4 0.38 0.98 0.11
21 INT312954 Regulation of Binding of IGF1R 1 0.13 0 0.1
22 INT250519 Negative_regulation of Igf1r 5 0.42 2.7 0.09
23 INT92587 Positive_regulation of Positive_regulation of IGF1R 1 0.38 0.38 0.08
24 INT349623 Negative_regulation of Binding of Igf1r 1 0.39 0.51 0.08
25 INT250508 Negative_regulation of Gene_expression of Igf1r 1 0.42 2.01 0.08
26 INT349620 Binding of Igf1r 1 0.34 0.51 0.08
27 INT234462 Phosphorylation of IGF1R 2 0.42 0.99 0.06
28 INT315099 Localization of IGF1R 2 0.55 0.36 0.04
29 INT234471 Negative_regulation of Phosphorylation of IGF1R 1 0.04 0.76 0.03
30 INT334692 Localization of Igf1r 1 0.09 0.89 0.03
31 INT222308 Regulation of IGF1R 3 0.12 2.18 0
32 INT339214 Negative_regulation of Gene_expression of IGF1R 2 0.22 0.4 0
33 INT282728 Regulation of Igf1r 2 0.18 0.92 0
34 INT321694 Positive_regulation of Phosphorylation of Igf1r 1 0.27 0.2 0
35 INT338259 Positive_regulation of Binding of IGF1R 1 0.27 1.38 0
36 INT319333 Transcription of IGF1R 1 0.31 0.85 0
37 INT321704 Positive_regulation of Positive_regulation of Igf1r 1 0.18 0.17 0
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