GO:0051402

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Name neuron apoptosis
Categary Process
Go Slim No
Go Link GO:0051402
Unique Molecular Interactions 973
Total Molecular Interactions 1367
Total Single Events 14034
Pain Genes Associated 41

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neuron apoptosis. They are ordered first by their pain relevance and then by number of times they were reported for neuron apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT164362 Binding of NLRP1 and VTA1 1 0.15 2.37 4.67
2 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
3 INT85042 Binding of CCT6A and MAX 1 0.00 0 3.13
4 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
5 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
6 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
7 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
8 INT85041 Binding of IGHG3 and MAX 1 0.00 0 2.09
9 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
10 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
11 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71
12 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
13 INT114396 Positive_regulation of Vta1 Negative_regulation of Positive_regulation of Nlrp1a 1 0.03 0 1.63
14 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
15 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
16 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
17 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
18 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
19 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
20 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
21 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
22 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
23 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
24 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
25 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
26 INT139191 Binding of Fas and RFFL 1 0.00 0.61 1.22
27 INT164365 Positive_regulation of Binding of NLRP1 and VTA1 1 0.14 0.6 1.21
28 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
29 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
30 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
31 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
32 INT139188 Binding of Daxx and Fas 1 0.03 0.55 1.14
33 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
34 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
35 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
36 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
37 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
38 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
39 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
40 INT85040 Positive_regulation of Binding of CCT6A and MAX 1 0.00 0 1.06
41 INT85039 Binding of GPM6A and MAX 1 0.00 0 1.05
42 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
43 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
44 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99
45 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
46 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
47 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
48 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
49 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
50 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
51 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
52 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
53 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
54 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
55 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
56 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
57 INT130769 FASLG Negative_regulation of Binding of FAS 1 0.10 0.66 0.86
58 INT164363 Regulation of Binding of NLRP1 and VTA1 1 0.14 0.45 0.86
59 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
60 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
61 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
62 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
63 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
64 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
65 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
66 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
67 INT64067 Tp63 Negative_regulation of Localization of Gh1 1 0.08 0.07 0.76
68 INT117412 RYBP Negative_regulation of LIG4 1 0.00 0.42 0.76
69 INT142057 NLRP1 Regulation of Gene_expression of Fos 1 0.17 0 0.76
70 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
71 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
72 INT216668 Positive_regulation of NLRP1 Regulation of Vta1 1 0.00 0 0.73
73 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
74 INT228499 Binding of FAS and Fasl 1 0.15 2.75 0.73
75 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
76 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
77 INT16048 MAX Positive_regulation of SLC25A4 1 0.50 0 0.71
78 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
79 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
80 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
81 INT64068 Tp63 Regulation of Fdft1 1 0.00 0.06 0.69
82 INT81631 Selenbp2 Negative_regulation of Fas 1 0.03 0.77 0.67
83 INT81630 Selenbp2 Negative_regulation of Positive_regulation of Fas 1 0.03 0.77 0.67
84 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
85 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
86 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
87 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
88 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
89 INT197240 Grik2 Regulation of Gene_expression of Gabrg1 1 0.08 0.13 0.64
90 INT197236 Grik2 Regulation of Gabrg1 1 0.08 0.13 0.64
91 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
92 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
93 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
94 INT2700 Binding of App and Cpe 1 0.00 0 0.63
95 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
96 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
97 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
98 INT115592 IRF6 Positive_regulation of Gene_expression of FAS 1 0.34 0.34 0.62
99 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
100 INT139192 RFFL Positive_regulation of Fas 1 0.00 0.3 0.61
101 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
102 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
103 INT179203 NLRP1 Regulation of Gene_expression of TNF 1 0.31 1.73 0.6
104 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
105 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
106 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
107 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59
108 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
109 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
110 INT54942 Rb1 Regulation of Gab1 1 0.02 0.39 0.59
111 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
112 INT80030 Binding of FAS and TNF 3 0.27 2.54 0.56
113 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
114 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
115 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
116 INT160780 Cps1 Positive_regulation of Positive_regulation of FAS 1 0.01 1 0.55
117 INT221783 Nlrp1a Negative_regulation of Camk4 1 0.08 1.39 0.55
118 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
119 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
120 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
121 INT77098 Nlrp1a Negative_regulation of Positive_regulation of Ppig 1 0.47 0.68 0.53
122 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
123 INT292873 Binding of Fas and Fasl 5 0.26 15.74 0.49
124 INT158599 Tlr3 Positive_regulation of Binding of Fas 1 0.55 0.86 0.48
125 INT55262 Pigt Regulation of Calm2 1 0.07 0 0.47
126 INT11651 Nlrp1a Negative_regulation of Gpt 1 0.12 0.24 0.47
127 INT302839 MIR15A Negative_regulation of Bcl2 1 0.15 1.41 0.47
128 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
129 INT307048 Cnr1 Positive_regulation of Casp3 1 0.08 0 0.47
130 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
131 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46
132 INT238639 Cd86 Negative_regulation of Negative_regulation of Bcl2 1 0.01 0.97 0.46
133 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
134 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
135 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
136 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
137 INT297689 Atn1 Regulation of Gene_expression of Il6 1 0.02 1.13 0.44
138 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
139 INT55264 Pigt Regulation of Positive_regulation of Cckbr 1 0.03 0 0.44
140 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
141 INT116609 Lnpep Negative_regulation of Bcl2 1 0.05 0.62 0.43
142 INT116606 Lnpep Regulation of Gene_expression of Bcl2 1 0.07 0.62 0.43
143 INT116607 Lnpep Negative_regulation of Gene_expression of Bcl2 1 0.10 0.62 0.43
144 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
145 INT309143 Dlat Positive_regulation of Bcl2 1 0.06 1.04 0.42
146 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
147 INT309152 Dlat Positive_regulation of Gene_expression of Bcl2 1 0.04 1.05 0.42
148 INT55263 Binding of Cck and Pigt 1 0.05 0 0.41
149 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
150 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
151 INT121856 BID Regulation of ROS1 1 0.05 0.52 0.41
152 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
153 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
154 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
155 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
156 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
157 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
158 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
159 INT235878 Creb1 Positive_regulation of Gene_expression of Bcl2 1 0.05 0.17 0.38
160 INT355018 Binding of FAS and Faslg 1 0.12 1.34 0.37
161 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
162 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
163 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37
164 INT85782 Rb1 Regulation of PRKG1 1 0.00 0.38 0.37
165 INT179201 NLRP1 Regulation of Gene_expression of IL10 1 0.06 0.77 0.36
166 INT85778 Rb1 Regulation of Prkaca 1 0.00 0.38 0.36
167 INT85779 Rb1 Regulation of Prkcg 1 0.01 0.38 0.36
168 INT179202 NLRP1 Regulation of Gene_expression of IL6 1 0.07 0.77 0.36
169 INT155062 Csf2 Positive_regulation of Transcription of Bcl2 1 0.31 2.91 0.36
170 INT198970 GAPDH Negative_regulation of ADAMTS3 1 0.47 0 0.35
171 INT198971 GAPDH Negative_regulation of ADAMTS5 1 0.47 0 0.35
172 INT198969 GAPDH Negative_regulation of TIMP1 1 0.47 0 0.35
173 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
174 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
175 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34
176 INT269962 Bcl2 Negative_regulation of Bcl2l11 1 0.15 2.14 0.34
177 INT204080 HP Negative_regulation of Phosphorylation of Rb1 1 0.00 3.53 0.34
178 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33
179 INT155060 Stat3 Negative_regulation of Bcl2 1 0.21 3.7 0.33
180 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33
181 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32
182 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
183 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
184 INT332972 Fas Positive_regulation of Ppara 1 0.17 0.52 0.31
185 INT54943 Gab1 Regulation of Rb1 1 0.02 0.2 0.31
186 INT80029 Binding of FAS and Positive_regulation of NFKB1 1 0.34 0.92 0.3
187 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
188 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3
189 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
190 INT80031 FAS Positive_regulation of Positive_regulation of NFKB1 1 0.50 0.93 0.3
191 INT328407 Nlrp1a Negative_regulation of Gene_expression of Snca 1 0.07 0.31 0.29
192 INT328410 Nlrp1a Negative_regulation of Snca 1 0.07 0.31 0.29
193 INT298995 Il18 Positive_regulation of Gene_expression of Cdk5 1 0.12 1.65 0.29
194 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29
195 INT299008 Il18 Positive_regulation of Transcription of Cdk5 1 0.12 1.65 0.29
196 INT239336 Nr1h2 Positive_regulation of Gene_expression of Fas 1 0.07 0.84 0.29
197 INT228500 Fadd Positive_regulation of FAS 1 0.14 1.12 0.28
198 INT247949 Cdk5r1 Positive_regulation of Cdk5 1 0.26 1.12 0.28
199 INT166162 Ccr9 Negative_regulation of Positive_regulation of Casp3 1 0.18 1.49 0.28
200 INT218928 Cyp3a23/3a1 Regulation of Transcription of Bcl2 1 0.00 0.56 0.28

Single Events

The table below shows the top 100 pain related interactions that have been reported for neuron apoptosis. They are ordered first by their pain relevance and then by number of times they were reported in neuron apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
4 INT65500 Gene_expression of App 605 0.78 429.94 98.31
5 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
6 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
7 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
8 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
9 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
10 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
11 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
12 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
13 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
14 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
15 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
16 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
17 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
18 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
19 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
20 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
21 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
22 INT11625 Localization of App 98 0.78 55.46 20.86
23 INT16794 Binding of App 103 0.48 64.87 19.79
24 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
25 INT65502 Regulation of App 77 0.62 52.05 19.44
26 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01
27 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
28 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
29 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
30 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
31 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61
32 INT164366 Localization of NLRP1 26 0.71 5.9 16.54
33 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
34 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
35 INT114395 Positive_regulation of Nlrp1a 15 0.45 4.61 15.37
36 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36
37 INT54052 Gene_expression of App 33 0.78 25.08 14.7
38 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
39 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
40 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94
41 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
42 INT29745 Binding of APP 47 0.48 26.49 12.4
43 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
44 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
45 INT145425 Positive_regulation of NLRP1 19 0.47 6.93 12.09
46 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
47 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
48 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
49 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
50 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
51 INT88020 Positive_regulation of Fas 32 0.70 19.78 9.97
52 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
53 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4
54 INT41569 Regulation of APP 32 0.62 17.15 9.4
55 INT35707 Gene_expression of Nlrp1a 20 0.75 9.61 9.32
56 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
57 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
58 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
59 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
60 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51
61 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
62 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
63 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
64 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
65 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
66 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
67 INT98178 Localization of Casp3 32 0.65 21.01 7.77
68 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
69 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47
70 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
71 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
72 INT114394 Negative_regulation of Positive_regulation of Nlrp1a 4 0.42 1.09 7.37
73 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
74 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
75 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
76 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
77 INT206603 Localization of Nlrp1a 9 0.16 1.37 6.57
78 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
79 INT57232 Binding of Casp3 22 0.36 9.42 6.2
80 INT17641 Gene_expression of NLRP1 33 0.73 8.85 6.02
81 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95
82 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
83 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
84 INT80033 Binding of FAS 37 0.48 41.19 5.67
85 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
86 INT145929 Regulation of Bax 20 0.60 18.12 5.35
87 INT113516 Negative_regulation of Fas 16 0.51 8.37 5.32
88 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
89 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
90 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
91 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
92 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
93 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
94 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
95 INT113517 Binding of Fas 16 0.37 15.86 4.62
96 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
97 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
98 INT89963 Regulation of Fas 15 0.59 8.25 4.32
99 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
100 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23
101 INT58003 Localization of APP 32 0.80 13.75 4.2
102 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
103 INT115889 Binding of Fas 27 0.36 28.87 4.08
104 INT123752 Regulation of Bax 19 0.60 16.45 4
105 INT112692 Localization of Bax 31 0.80 20.97 3.98
106 INT148495 Regulation of Cdk5 6 0.58 5.42 3.95
107 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
108 INT80681 Positive_regulation of Atn1 20 0.49 11.85 3.76
109 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
110 INT164540 Localization of Aifm1 15 0.46 13.87 3.65
111 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
112 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
113 INT125622 Regulation of NLRP1 7 0.44 1.84 3.62
114 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5
115 INT137634 Localization of Aifm1 17 0.80 11.8 3.45
116 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
117 INT104928 Positive_regulation of BID 10 0.67 6.9 3.41
118 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
119 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21
120 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19
121 INT156268 Regulation of Nlrp1a 4 0.08 1.95 3.18
122 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16
123 INT104930 Protein_catabolism of BID 12 0.86 10.82 3.15
124 INT29929 Gene_expression of Rb1 20 0.69 5.81 3.1
125 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
126 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03
127 INT105884 Binding of Bcl2 19 0.35 15.67 3
128 INT141180 Gene_expression of Apaf1 6 0.74 5.77 2.98
129 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
130 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
131 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82
132 INT178772 Transcription of App 17 0.70 10.79 2.79
133 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
134 INT54054 Binding of App 4 0.48 10.89 2.78
135 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
136 INT54938 Regulation of Rb1 6 0.44 4.41 2.69
137 INT196733 Gene_expression of Cdk5 25 0.76 18.25 2.64
138 INT138789 Gene_expression of Cdk5 6 0.76 5.19 2.62
139 INT257950 Regulation of Localization of NLRP1 3 0.08 0.27 2.6
140 INT164367 Negative_regulation of Localization of NLRP1 3 0.34 1.43 2.5
141 INT195005 Positive_regulation of Aifm1 11 0.29 7.92 2.46
142 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
143 INT163544 Binding of Psen1 40 0.36 15.28 2.42
144 INT57970 Positive_regulation of Rb1 17 0.67 7.03 2.36
145 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
146 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
147 INT151574 Gene_expression of Aifm1 5 0.62 3.63 2.34
148 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
149 INT170712 Gene_expression of Siah1a 1 0.77 2.33 2.33
150 INT56030 Regulation of App 8 0.62 4.06 2.32
151 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31
152 INT147349 Localization of Bcl2 13 0.65 7.83 2.31
153 INT148494 Binding of Cdk5 6 0.40 5.97 2.31
154 INT31118 Localization of Casp3 17 0.73 11.55 2.3
155 INT112905 Phosphorylation of Cdk5 15 0.82 2.78 2.3
156 INT88017 Regulation of Fas 12 0.62 8.27 2.29
157 INT142677 Negative_regulation of Positive_regulation of Bcl2 4 0.36 3.09 2.24
158 INT117415 Negative_regulation of LIG4 4 0.04 1.59 2.17
159 INT157579 Binding of Cdk5 3 0.35 0.47 2.13
160 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
161 INT154970 Localization of Bax 15 0.74 11.12 2.11
162 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
163 INT77621 Regulation of Gene_expression of Fas 10 0.56 7.62 2.08
164 INT98132 Regulation of FAS 16 0.42 20.57 2.06
165 INT39008 Localization of App 13 0.77 9.07 2.05
166 INT102176 Transcription of FAS 3 0.60 3.22 2.05
167 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
168 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03
169 INT142056 Binding of NLRP1 7 0.47 1.7 2.02
170 INT131920 Positive_regulation of Gene_expression of Nlrp1a 4 0.08 2.23 2.02
171 INT297674 Gene_expression of Atn1 11 0.29 6.69 2
172 INT98836 Transcription of Bax 6 0.69 5.04 1.96
173 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
174 INT113515 Positive_regulation of Positive_regulation of Fas 4 0.69 0.95 1.92
175 INT134442 Transcription of Bax 14 0.67 7.6 1.9
176 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
177 INT101108 Localization of Bcl2 16 0.72 11.68 1.86
178 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86
179 INT121784 Regulation of Gene_expression of Fas 7 0.38 5.68 1.86
180 INT148492 Positive_regulation of Binding of Cdk5 1 0.47 0.51 1.86
181 INT141191 Positive_regulation of Gene_expression of Apaf1 1 0.48 2.33 1.85
182 INT134443 Binding of Bax 10 0.47 5.62 1.84
183 INT158710 Negative_regulation of Binding of Cdk5 1 0.40 0 1.84
184 INT264622 Regulation of Positive_regulation of Nlrp1a 1 0.02 0 1.83
185 INT97750 Positive_regulation of Positive_regulation of FAS 4 0.49 4.9 1.8
186 INT139459 Negative_regulation of MAX 6 0.57 0.32 1.79
187 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
188 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
189 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76
190 INT206592 Negative_regulation of Localization of Nlrp1a 2 0.06 0.47 1.75
191 INT156005 Positive_regulation of Gene_expression of Aifm1 1 0.36 1.56 1.75
192 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
193 INT124667 Negative_regulation of Grik2 4 0.41 2.06 1.7
194 INT57971 Regulation of Rb1 5 0.41 2.36 1.66
195 INT101958 Positive_regulation of Transcription of Bcl2 4 0.50 2.22 1.65
196 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64
197 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62
198 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57
199 INT264620 Positive_regulation of Localization of Nlrp1a 1 0.04 0.59 1.54
200 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52
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