GO:0051403

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Name stress-activated MAPK cascade
Categary Process
Go Slim No
Go Link GO:0051403
Unique Molecular Interactions 1004
Total Molecular Interactions 1249
Total Single Events 10062
Pain Genes Associated 39

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for stress-activated MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported for stress-activated MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
2 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
3 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
4 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
5 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
6 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
7 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
8 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
9 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72
10 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
11 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
12 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
13 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
14 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
15 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
16 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
17 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
18 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
19 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
20 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
21 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
22 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
23 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
24 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
25 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
26 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
27 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
28 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
29 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
30 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
31 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
32 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
33 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16
34 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
35 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
36 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
37 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
38 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
39 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
40 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
41 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
42 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09
43 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
44 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
45 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
46 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
47 INT105109 Cxcl12 Positive_regulation of JUN 1 0.01 1.07 1.05
48 INT154846 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Trpv1 1 0.23 0.07 1.05
49 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
50 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
51 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02
52 INT113453 Ngf Positive_regulation of JUN 1 0.27 0.6 1.01
53 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99
54 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
55 INT94206 SP5 Regulation of Gene_expression of FOS 1 0.22 0.7 0.98
56 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95
57 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
58 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
59 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
60 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
61 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
62 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
63 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
64 INT318461 Nnat Positive_regulation of Mapk14 1 0.05 0.97 0.92
65 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92
66 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
67 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
68 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91
69 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
70 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
71 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89
72 INT314207 Ngf Negative_regulation of Phosphorylation of Mapk14 1 0.33 0.4 0.88
73 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
74 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
75 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
76 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
77 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
78 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
79 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
80 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
81 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82
82 INT128590 Mapk14 Regulation of Nav1 1 0.21 0.25 0.82
83 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
84 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
85 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
86 INT341367 CRX Positive_regulation of Positive_regulation of FOS 1 0.04 0.83 0.8
87 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
88 INT168648 Positive_regulation of Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.35 1.51 0.8
89 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
90 INT168647 Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.52 1.51 0.79
91 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
92 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
93 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
94 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
95 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
96 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
97 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
98 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
99 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75
100 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
101 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
102 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74
103 INT186445 Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
104 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
105 INT186443 Phosphorylation of Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
106 INT186444 Creb1 Regulation of FOS 1 0.49 0.43 0.72
107 INT186442 Phosphorylation of Creb1 Regulation of FOS 1 0.49 0.43 0.72
108 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
109 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
110 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
111 INT66581 Binding of JUN and Rare2 1 0.00 0.07 0.69
112 INT66582 Binding of FOS and Rare2 1 0.00 0.07 0.69
113 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
114 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
115 INT164783 Positive_regulation of Mapk14 Regulation of Gene_expression of Cx3cr1 1 0.19 0.81 0.68
116 INT155457 Tnfrsf1a Positive_regulation of Mapk14 1 0.20 1.17 0.67
117 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67
118 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.46 0.98 0.66
119 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
120 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
121 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.64 0.98 0.66
122 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
123 INT166299 Binding of Mapk14 and Gpbar1 1 0.13 0.64 0.65
124 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
125 INT166302 Negative_regulation of Binding of Mapk14 and Gpbar1 1 0.12 0.64 0.65
126 INT288202 Negative_regulation of Cd14 Positive_regulation of Positive_regulation of Mapk14 1 0.09 1.08 0.64
127 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
128 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
129 INT165047 Mapk14 Positive_regulation of Gene_expression of Tnf 1 0.73 0.8 0.63
130 INT223155 Binding of Mapk14 and Stat4 1 0.36 0.84 0.63
131 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
132 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 0.46 1 0.63
133 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
134 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
135 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 0.06 0.35 0.61
136 INT219280 Mapk14 Positive_regulation of Pla2g2a 1 0.33 0.46 0.61
137 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61
138 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61
139 INT219282 Mapk14 Positive_regulation of Pla2g1b 1 0.18 0.46 0.61
140 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
141 INT81916 HSF1 Positive_regulation of FOS 1 0.76 0.66 0.59
142 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
143 INT81918 HSF1 Negative_regulation of FOS 1 0.64 0.66 0.59
144 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
145 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
146 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
147 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
148 INT314208 Trap1 Positive_regulation of Mapk14 1 0.10 0.66 0.57
149 INT110032 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il12a 1 0.36 0 0.57
150 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
151 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
152 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
153 INT196585 Mapk14 Regulation of TNF 1 0.02 0.36 0.55
154 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
155 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
156 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
157 INT328744 TNF Regulation of Positive_regulation of Mapk14 1 0.02 0.81 0.55
158 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
159 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
160 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54
161 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
162 INT161250 Trib3 Regulation of Mapk14 1 0.04 0.81 0.54
163 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
164 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
165 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
166 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
167 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
168 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
169 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
170 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
171 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
172 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
173 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
174 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
175 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
176 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
177 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
178 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
179 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
180 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
181 INT313376 Cnr1 Positive_regulation of Phosphorylation of Mapk14 1 0.20 0.38 0.5
182 INT104960 Ephb1 Regulation of Positive_regulation of Mapk14 1 0.15 0.42 0.5
183 INT313375 Cnr2 Positive_regulation of Phosphorylation of Mapk14 1 0.18 0.39 0.5
184 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
185 INT104961 Mapk14 Regulation of Positive_regulation of Ephb1 1 0.15 0.42 0.5
186 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
187 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
188 INT115184 Regulation of CASP1 Positive_regulation of MAPK9 1 0.09 0 0.49
189 INT110031 Positive_regulation of Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
190 INT115183 CASP1 Positive_regulation of Positive_regulation of MAPK9 1 0.16 0 0.48
191 INT39078 Binding of Agt and Penk 1 0.24 0.42 0.48
192 INT110030 Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
193 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
194 INT47144 Negative_regulation of Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
195 INT115185 CASP1 Positive_regulation of MAPK9 1 0.15 0 0.48
196 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
197 INT47146 Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
198 INT110034 Negative_regulation of Adra2c Positive_regulation of Mapk14 1 0.23 0 0.48
199 INT131504 Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.14 0.2 0.47
200 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47

Single Events

The table below shows the top 100 pain related interactions that have been reported for stress-activated MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported in stress-activated MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66
2 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
3 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
4 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38
5 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
6 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
7 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
8 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
9 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74
10 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
11 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
12 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
13 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
14 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
15 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
16 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
17 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
18 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
19 INT1158 Regulation of Agt 106 0.61 29.4 30.29
20 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
21 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
22 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03
23 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95
24 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
25 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
26 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
27 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
28 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
29 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
30 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
31 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
32 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
33 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
34 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
35 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
36 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
37 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
38 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
39 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
40 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
41 INT2066 Localization of Agt 56 0.80 9.95 16.25
42 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
43 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
44 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61
45 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
46 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
47 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
48 INT3962 Regulation of AGT 50 0.62 20.96 13.01
49 INT15246 Regulation of FOS 32 0.60 15.34 12.94
50 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
51 INT4199 Binding of Agt 76 0.48 21.06 12.66
52 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
53 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
54 INT398 Localization of AGT 45 0.78 16.97 11.54
55 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
56 INT8065 Binding of AGT 54 0.48 20.54 10.85
57 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
58 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
59 INT60198 Binding of JUN 54 0.48 11.56 10.27
60 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
61 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
62 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14
63 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
64 INT17333 Positive_regulation of Positive_regulation of FOS 17 0.67 6.06 8.4
65 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
66 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
67 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81
68 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
69 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
70 INT47848 Negative_regulation of Positive_regulation of FOS 14 0.57 3.78 7.63
71 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
72 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
73 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14
74 INT75497 Regulation of JUN 28 0.61 11.04 7.09
75 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
76 INT60196 Binding of FOS 33 0.47 13.11 6.95
77 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56
78 INT5847 Transcription of FOS 31 0.69 11.11 6.41
79 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
80 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
81 INT128587 Localization of Mapk14 15 0.81 8.41 6.1
82 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
83 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
84 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
85 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
86 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
87 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
88 INT176524 Binding of Mapk14 19 0.43 12.54 5.21
89 INT126047 Regulation of Phosphorylation of Mapk14 7 0.60 5.05 5.03
90 INT171472 Binding of Mapk14 10 0.36 6.79 4.83
91 INT54911 Localization of FOS 20 0.78 3.27 4.56
92 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
93 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39
94 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
95 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
96 INT110024 Negative_regulation of Gene_expression of Mapk14 19 0.42 7.83 4.21
97 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
98 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
99 INT67936 Transcription of JUN 18 0.52 9.52 4.13
100 INT12772 Positive_regulation of Positive_regulation of IKBKG 9 0.69 0.84 4.12
101 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
102 INT131782 Regulation of Positive_regulation of Mapk14 7 0.43 2.68 4.02
103 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
104 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
105 INT110021 Positive_regulation of Gene_expression of Mapk14 29 0.46 19.06 3.86
106 INT110180 Phosphorylation of JUN 23 0.80 11.21 3.83
107 INT264972 Positive_regulation of MAP2K3 4 0.65 6.92 3.68
108 INT119420 Phosphorylation of MAP2K6 8 0.79 4.89 3.52
109 INT109914 Positive_regulation of MAPK9 16 0.56 7.64 3.27
110 INT133086 Positive_regulation of Phosphorylation of Map2k7 1 0.05 4.34 3.27
111 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23
112 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
113 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
114 INT133082 Phosphorylation of Map2k7 5 0.15 4.27 3.05
115 INT68651 Negative_regulation of Positive_regulation of JUN 11 0.58 4.28 3.04
116 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
117 INT12770 Negative_regulation of Positive_regulation of IKBKG 7 0.56 0.34 3.02
118 INT103910 Binding of NOD2 19 0.47 12.24 2.93
119 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
120 INT155453 Protein_catabolism of Mapk14 6 0.36 4.24 2.85
121 INT102565 Positive_regulation of Phosphorylation of RPS6KA1 1 0.25 2.77 2.85
122 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
123 INT108358 Phosphorylation of FOS 12 0.80 6.33 2.79
124 INT96901 Regulation of Negative_regulation of Mapk14 3 0.45 4.07 2.79
125 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
126 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71
127 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71
128 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
129 INT98919 Negative_regulation of Phosphorylation of CREB1 8 0.58 2.4 2.63
130 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
131 INT102646 Positive_regulation of MAP2K6 3 0.63 4.37 2.44
132 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
133 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
134 INT12769 Localization of IKBKG 6 0.15 1.66 2.43
135 INT110179 Negative_regulation of Phosphorylation of MAPK14 11 0.36 5.25 2.38
136 INT123682 Localization of JUN 8 0.50 4.15 2.38
137 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
138 INT48980 Positive_regulation of Transcription of FOS 10 0.67 3.07 2.34
139 INT60199 Positive_regulation of Binding of JUN 5 0.49 1.3 2.34
140 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
141 INT117924 Gene_expression of MAP2K3 2 0.72 5.82 2.32
142 INT128926 Gene_expression of Map2k7 5 0.23 3.01 2.31
143 INT150547 Phosphorylation of MAP2K3 2 0.79 4.92 2.3
144 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
145 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21
146 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
147 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13
148 INT12005 Negative_regulation of Localization of Agt 6 0.57 1.49 2.06
149 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05
150 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
151 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
152 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98
153 INT79915 Positive_regulation of Agt 27 0.56 12.97 1.96
154 INT12801 Negative_regulation of Regulation of Agt 4 0.43 1.2 1.96
155 INT43944 Negative_regulation of Positive_regulation of Agt 4 0.42 1.44 1.93
156 INT130208 Positive_regulation of Phosphorylation of JUN 4 0.38 3.07 1.92
157 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
158 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
159 INT109921 Phosphorylation of MAPK9 9 0.67 5.07 1.81
160 INT133084 Positive_regulation of Gene_expression of Map2k7 3 0.17 2.56 1.8
161 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
162 INT118907 Negative_regulation of Negative_regulation of Mapk14 2 0.57 2.09 1.77
163 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76
164 INT119422 Negative_regulation of Phosphorylation of MAP2K6 3 0.38 2.09 1.76
165 INT152894 Regulation of Positive_regulation of Mapk14 9 0.45 6.01 1.74
166 INT3152 Transcription of Agt 7 0.72 5.09 1.68
167 INT168686 Transcription of Mapk14 6 0.52 2.96 1.67
168 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
169 INT173173 Regulation of Positive_regulation of MAPK14 6 0.38 2.59 1.64
170 INT69917 Negative_regulation of CREB1 8 0.58 2.28 1.59
171 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53
172 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
173 INT171029 Positive_regulation of Transcription of JUN 4 0.14 2.87 1.48
174 INT109916 Positive_regulation of Positive_regulation of MAP2K6 2 0.45 2.28 1.45
175 INT157362 Negative_regulation of MAPK9 7 0.35 4.27 1.44
176 INT173654 Localization of MAPK14 12 0.62 3.16 1.43
177 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42
178 INT34912 Regulation of IKBKG 5 0.08 2.41 1.42
179 INT102561 Positive_regulation of Phosphorylation of ELK1 1 0.12 1.39 1.42
180 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
181 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39
182 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
183 INT239215 Binding of Agt 9 0.38 6.75 1.35
184 INT104027 Negative_regulation of Negative_regulation of MAPK1 6 0.56 2.87 1.35
185 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31
186 INT11306 Regulation of Gene_expression of Agt 7 0.45 3.29 1.31
187 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
188 INT11241 Transcription of AGT 4 0.52 1.83 1.27
189 INT202365 Regulation of Gene_expression of Mapk14 6 0.45 4.89 1.26
190 INT68652 Regulation of Positive_regulation of JUN 4 0.54 4.95 1.26
191 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
192 INT130207 Phosphorylation of ATF2 5 0.60 1.34 1.25
193 INT19319 Negative_regulation of Binding of Agt 9 0.42 3.42 1.24
194 INT222843 Positive_regulation of Map3k7 4 0.24 3.04 1.24
195 INT120764 Negative_regulation of Binding of JUN 7 0.25 2.65 1.23
196 INT79916 Negative_regulation of Agt 14 0.47 6 1.22
197 INT112823 Negative_regulation of Positive_regulation of MAPK14 5 0.36 1.49 1.22
198 INT47644 Positive_regulation of Localization of AGT 4 0.45 1.24 1.2
199 INT157364 Positive_regulation of Phosphorylation of MAPK9 3 0.56 2.33 1.15
200 INT28594 Positive_regulation of Transcription of Agt 2 0.47 1.3 1.15
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