GO:0051425

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Name PTB domain binding
Categary Function
Go Slim No
Go Link GO:0051425
Unique Molecular Interactions 254
Total Molecular Interactions 380
Total Single Events 4461
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for PTB domain binding. They are ordered first by their pain relevance and then by number of times they were reported for PTB domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
8 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
9 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
10 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
11 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
12 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
13 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
14 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
15 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
16 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
17 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
18 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
19 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
20 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
21 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
22 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
23 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
24 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
25 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
26 INT2700 Binding of App and Cpe 1 0.00 0 0.63
27 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
28 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
29 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
30 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
31 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
32 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
33 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
34 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
35 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
36 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
37 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
38 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
39 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
40 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
41 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
42 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
43 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
44 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
45 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
46 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
47 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
48 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
49 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
50 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
51 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
52 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
53 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
54 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
55 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
56 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
57 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
58 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
59 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
60 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
61 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33
62 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33
63 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32
64 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
65 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3
66 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
67 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29
68 INT79592 Binding of APP and Reg1 1 0.01 0.16 0.27
69 INT25946 Regulation of Binding of Penk and App 1 0.18 0.19 0.27
70 INT25944 Binding of Penk and App 1 0.15 0.19 0.27
71 INT356094 Binding of App and Tg 1 0.08 0.12 0.26
72 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26
73 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26
74 INT39010 App Negative_regulation of Gene_expression of Gnrh1 1 0.05 0.07 0.26
75 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25
76 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
77 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
78 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
79 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22
80 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21
81 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
82 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
83 INT25945 Plat Regulation of App 1 0.15 0.25 0.17
84 INT25947 Plat Regulation of Transcription of App 1 0.15 0.25 0.17
85 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16
86 INT204478 Fmr1 Regulation of Gene_expression of App 1 0.50 1.44 0.16
87 INT201744 Ngf Regulation of Transcription of App 1 0.06 0.39 0.15
88 INT201728 Ntrk1 Regulation of Transcription of App 1 0.03 0.39 0.15
89 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15
90 INT286476 Binding of App and Itm2b 1 0.47 5.24 0.14
91 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
92 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13
93 INT204489 Fmr1 Regulation of App 1 0.50 1.71 0.13
94 INT220622 App Positive_regulation of Rip 2 0.14 0.24 0.12
95 INT175196 Binding of NCOR1 and NUP62 1 0.02 0.84 0.12
96 INT308660 Binding of Ager and App 1 0.08 1.22 0.12
97 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11
98 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11
99 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11
100 INT204477 Binding of App and Scn10a 1 0.17 0.36 0.1
101 INT139847 Binding of App and Bace2 1 0.03 0.16 0.1
102 INT139850 Binding of MBTPS1 and App 1 0.00 0.16 0.1
103 INT217476 Nup62 Positive_regulation of Ngf 1 0.37 0.52 0.1
104 INT347647 Inpp5d Negative_regulation of Pik3r1 1 0.31 0.37 0.1
105 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
106 INT193963 App Regulation of Gene_expression of Ps 1 0.06 0.93 0.09
107 INT356112 Binding of App and Apba1 1 0.24 0.29 0.09
108 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
109 INT262701 App Positive_regulation of Aplp2 1 0.12 0.25 0.09
110 INT262705 App Positive_regulation of Aplp1 1 0.13 0.25 0.09
111 INT124036 Binding of App and Dnahc8 1 0.03 0.14 0.09
112 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
113 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
114 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
115 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
116 INT204487 Positive_regulation of Fmr1 Regulation of Gene_expression of App 1 0.30 0.8 0.08
117 INT175195 Binding of SH2B2 and NUP62 1 0.01 0 0.07
118 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
119 INT17920 Penk Positive_regulation of Insr 1 0.05 0.14 0.06
120 INT198934 Binding of App and Lrp1b 2 0.27 1.62 0.05
121 INT288099 Binding of APP and App 1 0.01 1.04 0.05
122 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05
123 INT356086 Negative_regulation of Binding of App and Lrp1b 1 0.30 1.42 0.05
124 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
125 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05
126 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05
127 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
128 INT356110 Binding of App and Slc5a7 1 0.02 0.25 0.05
129 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05
130 INT217467 Binding of Nup62 and Tnfrsf11a 1 0.31 0 0.05
131 INT236009 HIST2H2AA3 Positive_regulation of Protein_catabolism of APP 1 0.02 0.19 0.04
132 INT236015 HIST2H2AA3 Positive_regulation of Gene_expression of APP 1 0.02 0.95 0.04
133 INT162753 Binding of APP and Slc30a2 1 0.00 1.25 0.04
134 INT319973 App Regulation of Gene_expression of Mapk12 1 0.02 0.98 0.04
135 INT162754 Negative_regulation of Binding of APP and Slc30a2 1 0.00 1.26 0.04
136 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04
137 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
138 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04
139 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03
140 INT356102 Negative_regulation of Binding of App and Lrp1 1 0.32 0.71 0.03
141 INT237090 Binding of App and Bnip3l 1 0.18 1.66 0.03
142 INT322876 Binding of PDCD10 and Inpp5d 1 0.03 0.46 0.03
143 INT230137 OSBP Regulation of APP 1 0.59 0.15 0.03
144 INT356097 Binding of App and Apba3 1 0.12 0.12 0.03
145 INT270432 Lhb Positive_regulation of APP 1 0.03 0.51 0.03
146 INT356090 Binding of Apba2 and App 1 0.00 0.12 0.03
147 INT270431 Gnrh1 Positive_regulation of APP 1 0.06 0.51 0.03
148 INT220628 Gene_expression of Gga1 Positive_regulation of App 2 0.22 0 0
149 INT144761 Binding of INSR and Insr 1 0.05 0 0
150 INT220625 Negative_regulation of Binding of App and Bace1 1 0.44 0.09 0
151 INT289672 Binding of GNRH1 and INSR 1 0.02 0 0
152 INT235623 Binding of INS and INSR 1 0.14 0.47 0
153 INT356108 App Positive_regulation of Positive_regulation of Lrp1 1 0.43 0.52 0
154 INT333770 Bace1 Regulation of Gene_expression of App 1 0.57 0 0
155 INT217473 Nup62 Regulation of Tnfrsf11a 1 0.38 0.66 0
156 INT204493 App Negative_regulation of Scn10a 1 0.20 0.74 0
157 INT144754 Negative_regulation of Binding of Insr and Slc2a2 1 0.01 0 0
158 INT236013 HIST2H2AA3 Regulation of Gene_expression of APP 1 0.01 0 0
159 INT204499 App Regulation of Fmr1 1 0.50 0.59 0
160 INT204492 Negative_regulation of Binding of App and Fmr1 1 0.42 0.28 0
161 INT356083 Binding of App and Notch1 1 0.02 0.2 0
162 INT277315 Binding of Insr and Mbnl1 1 0.18 1.1 0
163 INT356095 Lrp1 Positive_regulation of App 1 0.37 0.53 0
164 INT204502 Binding of App and RNPC3 1 0.01 0.09 0
165 INT356091 Lrp1 Positive_regulation of Positive_regulation of App 1 0.43 0.52 0
166 INT204481 App Negative_regulation of Positive_regulation of Scn10a 1 0.20 0.74 0
167 INT356100 Binding of Apbb1 and App 1 0.14 0.43 0
168 INT235624 INS Regulation of Phosphorylation of INSR 1 0.08 0.26 0
169 INT232893 Binding of ABR and Nup62 1 0.03 0.13 0
170 INT356087 Binding of App and Ncstn 1 0.17 0.07 0
171 INT271281 Gene_expression of Stat1 Positive_regulation of Insr 1 0.19 0.51 0
172 INT230140 Gene_expression of OSBP Regulation of Localization of APP 1 0.30 0.06 0
173 INT271287 Gene_expression of IFNA1 Positive_regulation of Insr 1 0.03 0.51 0
174 INT198933 Binding of Apoe and App 1 0.33 0.19 0
175 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0
176 INT175192 Binding of NUP62 and GOPC 1 0.03 0 0
177 INT144760 Binding of ABCA1 and Insr 1 0.00 0 0
178 INT198927 Lrp1 Regulation of App 1 0.14 0.42 0
179 INT204482 Fmr1 Negative_regulation of App 1 0.42 0.74 0
180 INT334643 Binding of APP and HM13 1 0.02 0 0
181 INT356118 Binding of SORL1 and App 1 0.41 0.43 0
182 INT230146 Binding of APP and SORL1 1 0.20 0.17 0
183 INT356109 Rab6a Regulation of App 1 0.14 0.05 0
184 INT180123 Egfl7 Positive_regulation of App 1 0.02 0.07 0
185 INT356106 Gene_expression of Pld1 Positive_regulation of App 1 0.29 0.21 0
186 INT188436 Negative_regulation of NUP62 Positive_regulation of TNFRSF11A 1 0.39 1.6 0
187 INT225629 APP Positive_regulation of Positive_regulation of nr 1 0.01 0.08 0
188 INT217396 Binding of Abca1 and App 1 0.26 0.83 0
189 INT262708 Bace1 Positive_regulation of Gene_expression of App 1 0.44 2.82 0
190 INT198915 Binding of App and Lrp8 1 0.24 0.17 0
191 INT230139 OSBP Regulation of Phosphorylation of APP 1 0.50 0 0
192 INT142955 Positive_regulation of Binding of APP and BACE1 1 0.48 0.5 0
193 INT218307 Grb10 Positive_regulation of Protein_catabolism of INSR 1 0.03 0 0
194 INT262713 App Regulation of Transcription of Bace1 1 0.45 0.31 0
195 INT198925 Binding of App and Ldlr 1 0.14 0.15 0
196 INT175194 Binding of UBC and NUP62 1 0.01 0.05 0
197 INT144753 Binding of Insr and Slc2a2 1 0.01 0 0
198 INT311383 Mbnl1 Regulation of Insr 1 0.00 0.24 0
199 INT175193 NUP62 Regulation of Binding of TRAF6 1 0.07 0.06 0
200 INT333773 Bace1 Regulation of App 1 0.25 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for PTB domain binding. They are ordered first by their pain relevance and then by number of times they were reported in PTB domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
3 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
4 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
5 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
6 INT8691 Localization of Insr 85 0.80 9.27 30.32
7 INT5300 Regulation of Insr 54 0.60 11.33 29.26
8 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
9 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
10 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
11 INT11625 Localization of App 98 0.78 55.46 20.86
12 INT16794 Binding of App 103 0.48 64.87 19.79
13 INT65502 Regulation of App 77 0.62 52.05 19.44
14 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
15 INT54052 Gene_expression of App 33 0.78 25.08 14.7
16 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
17 INT29745 Binding of APP 47 0.48 26.49 12.4
18 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
19 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
20 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
21 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
22 INT41569 Regulation of APP 32 0.62 17.15 9.4
23 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
24 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
25 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
26 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
27 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
28 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
29 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
30 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
31 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
32 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
33 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
34 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
35 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
36 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
37 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
38 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
39 INT51084 Binding of Insr 13 0.30 4.25 4.23
40 INT58003 Localization of APP 32 0.80 13.75 4.2
41 INT83035 Binding of INSR 16 0.47 9.29 4.11
42 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
43 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
44 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
45 INT10116 Localization of INSR 11 0.57 5.43 3.48
46 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
47 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
48 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
49 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
50 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
51 INT178772 Transcription of App 17 0.70 10.79 2.79
52 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
53 INT54054 Binding of App 4 0.48 10.89 2.78
54 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
55 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
56 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
57 INT56030 Regulation of App 8 0.62 4.06 2.32
58 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
59 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
60 INT39008 Localization of App 13 0.77 9.07 2.05
61 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
62 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
63 INT114059 Localization of Insr 10 0.46 3.49 1.87
64 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
65 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76
66 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
67 INT232645 Transcription of INSR 2 0.09 1.19 1.71
68 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
69 INT19342 Regulation of Insr 12 0.24 6.11 1.54
70 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52
71 INT58004 Positive_regulation of Localization of APP 5 0.46 2.1 1.5
72 INT25943 Transcription of App 5 0.53 1.79 1.44
73 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41
74 INT129700 Regulation of Positive_regulation of App 3 0.43 1.86 1.41
75 INT141529 Regulation of Positive_regulation of APP 3 0.44 0.31 1.34
76 INT103488 Positive_regulation of Localization of App 5 0.50 3.05 1.28
77 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
78 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
79 INT100137 Positive_regulation of Negative_regulation of App 2 0.41 1.26 1.16
80 INT135899 Regulation of Binding of APP 3 0.45 1.22 1.14
81 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
82 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
83 INT39009 Negative_regulation of App 6 0.38 3.37 1.07
84 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
85 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
86 INT167607 Positive_regulation of Binding of App 8 0.50 2.97 0.86
87 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
88 INT162514 Positive_regulation of Regulation of APP 1 0.41 0.37 0.86
89 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
90 INT99375 Positive_regulation of Binding of APP 3 0.61 1.63 0.83
91 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
92 INT118078 Phosphorylation of APP 10 0.79 2.5 0.76
93 INT99820 Negative_regulation of Localization of APP 2 0.37 0.75 0.76
94 INT127432 Gene_expression of Nup62 20 0.71 11.01 0.71
95 INT117392 Binding of Insr 8 0.23 4.88 0.68
96 INT112208 Negative_regulation of Gene_expression of App 4 0.59 1.88 0.68
97 INT25942 Regulation of Transcription of App 3 0.27 0.95 0.68
98 INT141528 Regulation of Localization of APP 2 0.52 0.4 0.67
99 INT171366 Positive_regulation of Localization of Insr 3 0.18 0.63 0.66
100 INT61147 Protein_catabolism of App 3 0.60 3.76 0.63
101 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
102 INT18446 Transcription of Insr 2 0.18 0.84 0.62
103 INT118077 Negative_regulation of Phosphorylation of APP 1 0.07 0.74 0.61
104 INT142112 Regulation of Regulation of App 3 0.39 2.46 0.59
105 INT225462 Positive_regulation of Positive_regulation of APP 3 0.44 1.41 0.55
106 INT175219 Binding of NUP62 31 0.27 4.51 0.53
107 INT308979 Regulation of Localization of Insr 1 0.24 0.44 0.53
108 INT78117 Positive_regulation of Positive_regulation of App 4 0.48 2.6 0.51
109 INT167614 Positive_regulation of Protein_catabolism of App 1 0.30 0.88 0.44
110 INT217452 Binding of Nup62 1 0.38 2.7 0.44
111 INT114062 Negative_regulation of Localization of Insr 1 0.19 0.31 0.39
112 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
113 INT303286 Localization of Nup62 1 0.08 0 0.35
114 INT330616 Positive_regulation of Gene_expression of Inpp5d 2 0.49 0.89 0.34
115 INT54056 Negative_regulation of Binding of App 2 0.37 0.99 0.32
116 INT178773 Positive_regulation of Regulation of App 2 0.49 1.01 0.32
117 INT330615 Gene_expression of Inpp5d 2 0.66 0.78 0.31
118 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
119 INT178774 Positive_regulation of Transcription of App 2 0.49 1.17 0.31
120 INT278530 Regulation of Positive_regulation of Insr 1 0.01 1.96 0.28
121 INT217446 Negative_regulation of Binding of Nup62 1 0.33 1.54 0.25
122 INT124735 Positive_regulation of Positive_regulation of Insr 1 0.08 0 0.25
123 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
124 INT330612 Positive_regulation of Localization of Inpp5d 1 0.02 0.35 0.22
125 INT330610 Localization of Inpp5d 1 0.02 0.3 0.22
126 INT347641 Regulation of Positive_regulation of Inpp5d 1 0.27 0.33 0.19
127 INT347643 Positive_regulation of Inpp5d 1 0.46 0.33 0.18
128 INT217463 Positive_regulation of Nup62 5 0.39 1.79 0.17
129 INT180104 Positive_regulation of Phosphorylation of App 2 0.54 0.87 0.16
130 INT286326 Regulation of Transcription of App 3 0.45 0.26 0.15
131 INT232830 Positive_regulation of Protein_catabolism of Nup62 3 0.39 0.75 0.15
132 INT69045 Negative_regulation of Positive_regulation of App 1 0.05 0.28 0.13
133 INT92634 Negative_regulation of Binding of Insr 1 0.25 0.08 0.12
134 INT217454 Positive_regulation of Gene_expression of Nup62 2 0.39 1.56 0.11
135 INT308981 Positive_regulation of Negative_regulation of Insr 1 0.27 0.95 0.11
136 INT323945 Positive_regulation of Binding of Insr 1 0.08 0.94 0.11
137 INT142958 Positive_regulation of Protein_catabolism of APP 3 0.55 2.04 0.1
138 INT39007 Negative_regulation of Localization of App 3 0.10 0.94 0.08
139 INT127433 Negative_regulation of Gene_expression of Nup62 2 0.53 2.36 0.08
140 INT232834 Protein_catabolism of Nup62 3 0.56 0.8 0.07
141 INT217461 Negative_regulation of Positive_regulation of Nup62 1 0.33 0.41 0.07
142 INT175226 Gene_expression of NUP62 4 0.52 1.26 0.05
143 INT217443 Regulation of Nup62 1 0.48 1.47 0.05
144 INT188456 Negative_regulation of Gene_expression of NUP62 1 0.33 0.99 0.05
145 INT184013 Protein_catabolism of Insr 1 0.05 0.4 0.04
146 INT180116 Negative_regulation of Transcription of App 1 0.38 0 0.04
147 INT182830 Negative_regulation of Protein_catabolism of APP 2 0.35 2.09 0.03
148 INT117362 Positive_regulation of Positive_regulation of INSR 1 0.22 0.1 0.03
149 INT255657 Negative_regulation of Protein_catabolism of App 1 0.20 1.07 0.03
150 INT351386 Negative_regulation of Phosphorylation of App 1 0.42 0.82 0.03
151 INT235634 Phosphorylation of INSR 24 0.70 3.64 0
152 INT50103 Regulation of Localization of App 2 0.26 0.2 0
153 INT215947 Positive_regulation of Gene_expression of INSR 2 0.14 0.25 0
154 INT234255 Transcription of APP 2 0.49 0.98 0
155 INT217457 Negative_regulation of Nup62 2 0.33 0.94 0
156 INT286323 Negative_regulation of Protein_catabolism of App 1 0.11 0.54 0
157 INT188443 Negative_regulation of NUP62 1 0.33 1.53 0
158 INT144758 Negative_regulation of Negative_regulation of INSR 1 0.41 0 0
159 INT235628 Negative_regulation of Phosphorylation of INSR 1 0.16 0.25 0
160 INT175215 Negative_regulation of Binding of NUP62 1 0.19 0.13 0
161 INT230481 Positive_regulation of Regulation of Insr 1 0.01 0.24 0
162 INT350662 Regulation of Inpp5d 1 0.06 0.16 0
163 INT144756 Positive_regulation of Negative_regulation of INSR 1 0.49 0 0
164 INT144757 Negative_regulation of Gene_expression of INSR 1 0.41 0 0
165 INT188454 Positive_regulation of NUP62 1 0.36 0.92 0
166 INT217459 Regulation of Gene_expression of Nup62 1 0.35 0.35 0
167 INT236037 Positive_regulation of Phosphorylation of APP 1 0.48 0.14 0
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