GO:0051428

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Name peptide hormone receptor binding
Categary Function
Go Slim No
Go Link GO:0051428
Unique Molecular Interactions 608
Total Molecular Interactions 887
Total Single Events 7621
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peptide hormone receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for peptide hormone receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
2 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
3 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
4 INT107812 Nppa Positive_regulation of Localization of Sst 1 0.48 0.54 2.51
5 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12
6 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
7 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
8 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
9 INT107815 Gene_expression of Sst Positive_regulation of Localization of Nppa 1 0.52 0.27 1.57
10 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
11 INT107813 Sst Negative_regulation of Localization of Nppa 1 0.44 0.2 1.46
12 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
13 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
14 INT142207 Adcyap1 Positive_regulation of Localization of Gh 1 0.07 0 1.3
15 INT31771 Penk Positive_regulation of Nppa 1 0.22 0.13 1.28
16 INT22501 Binding of Calca and Pth 1 0.21 0.07 1.28
17 INT31773 Pdyn Positive_regulation of Nppa 1 0.12 0.13 1.27
18 INT74467 Adcyap1 Positive_regulation of Localization of Gh1 1 0.37 0 1.25
19 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
20 INT147446 ADCYAP1 Regulation of Localization of CP 1 0.02 1.12 1.16
21 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
22 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
23 INT193288 CAP1 Positive_regulation of Pth 1 0.04 0.08 1.14
24 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
25 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
26 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
27 INT210015 Binding of Adcyap1 and Crh 1 0.47 0.88 1
28 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
29 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
30 INT28193 Nppb Positive_regulation of Positive_regulation of RYBP 1 0.29 0.05 0.88
31 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
32 INT186672 IL8 Positive_regulation of Transcription of PTH 1 0.01 1.83 0.85
33 INT193275 Phax Regulation of Pth 1 0.01 0.16 0.81
34 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
35 INT142208 Adcyap1 Positive_regulation of Transcription of Gh 1 0.05 0 0.77
36 INT166902 NPPB Positive_regulation of TRPA1 1 0.78 0.76 0.77
37 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
38 INT107810 Sst Positive_regulation of Localization of Nppa 1 0.42 0.14 0.77
39 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
40 INT142210 Adcyap1 Positive_regulation of Gh 1 0.05 0 0.77
41 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
42 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
43 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75
44 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
45 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
46 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
47 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
48 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
49 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
50 INT169603 Nppb Regulation of Npr1 1 0.26 0.95 0.69
51 INT74468 Adcyap1 Positive_regulation of Localization of Gnrhr 1 0.27 0 0.67
52 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
53 INT142209 Adcyap1 Positive_regulation of Gene_expression of Gh 1 0.05 0 0.63
54 INT16412 Nppa Negative_regulation of Localization of LH 2 0.41 0.29 0.62
55 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
56 INT147049 CB Positive_regulation of Nppa 1 0.02 1.01 0.6
57 INT193289 CAP1 Regulation of Pth 1 0.02 0 0.59
58 INT101216 Pnoc Positive_regulation of Localization of Nppa 1 0.68 0.09 0.57
59 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
60 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
61 INT59155 Binding of Adcyap1 and Vip 2 0.34 0.08 0.55
62 INT147040 Hmbs Negative_regulation of Nppa 1 0.07 0.95 0.55
63 INT107814 Nppa Positive_regulation of Positive_regulation of Sst 1 0.42 0.16 0.55
64 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
65 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
66 INT16643 Nppa Regulation of Rabep2 1 0.13 0.07 0.55
67 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
68 INT142206 Negative_regulation of Adcyap1 Positive_regulation of Gh 1 0.04 0 0.54
69 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
70 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
71 INT7120 Nppb Positive_regulation of Localization of Rab8a 1 0.08 0 0.51
72 INT97483 ADCYAP1 Positive_regulation of Localization of SST 1 0.04 0 0.5
73 INT106662 Adcyap1 Regulation of Penk 1 0.00 0 0.49
74 INT106664 Adcyap1 Regulation of Gene_expression of Vip 1 0.00 0 0.49
75 INT97482 ADCYAP1 Positive_regulation of Localization of VIP 1 0.50 0 0.49
76 INT106663 Adcyap1 Regulation of Vip 1 0.00 0 0.49
77 INT97484 Binding of ADCYAP1 and GRP 1 0.26 0 0.48
78 INT97487 ADCYAP1 Positive_regulation of Tac1 1 0.02 0 0.48
79 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
80 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
81 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
82 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
83 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
84 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
85 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
86 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
87 INT16413 Nppa Regulation of Localization of LH 1 0.43 0.76 0.45
88 INT25430 Gtf3a Regulation of Nppa 1 0.24 0.57 0.43
89 INT186673 IL8 Positive_regulation of Positive_regulation of PTH 1 0.01 0.92 0.42
90 INT170157 NPPC Regulation of CSF2 1 0.12 1.36 0.42
91 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
92 INT79486 Nppa Negative_regulation of NA 1 0.03 1.83 0.41
93 INT16411 Nppb Regulation of Localization of LH 1 0.34 0.49 0.41
94 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
95 INT131353 Binding of Npr1 and Nppb 1 0.27 1.73 0.4
96 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
97 INT131356 Binding of Nppa and Npr1 1 0.27 1.73 0.4
98 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
99 INT190739 Adcyap1 Regulation of Gene_expression of Scn2a1 1 0.13 0 0.39
100 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
101 INT71575 Negative_regulation of Nppb Positive_regulation of Gbf1 1 0.02 0.08 0.38
102 INT273045 Vip Regulation of Adcyap1 1 0.17 0.5 0.38
103 INT187230 Binding of Adcyap1 and Vipr1 1 0.11 0.92 0.38
104 INT71574 Nppb Positive_regulation of Gbf1 1 0.02 0.08 0.38
105 INT187228 Binding of Adcyap1 and Vipr2 1 0.11 0.91 0.38
106 INT16410 Nppb Negative_regulation of Localization of LH 1 0.37 0.21 0.38
107 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
108 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
109 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
110 INT169604 Nppb Positive_regulation of Npr1 2 0.52 2.52 0.37
111 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
112 INT190751 Adcyap1 Positive_regulation of Vipr2 2 0.16 1.02 0.36
113 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
114 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
115 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
116 INT99292 Pth Positive_regulation of Jun 1 0.10 0.13 0.36
117 INT154356 Binding of Nppc and ITS 1 0.00 0.85 0.35
118 INT32698 Nppa Regulation of Oxt 1 0.57 0.35 0.35
119 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
120 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
121 INT32699 Nppa Regulation of Avp 1 0.28 0.35 0.35
122 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
123 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
124 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
125 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
126 INT315385 Adcyap1 Positive_regulation of Phosphorylation of Bad 1 0.05 0.44 0.32
127 INT240129 Binding of Nppb and Crp 1 0.21 1.02 0.32
128 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
129 INT315387 Adcyap1 Positive_regulation of Phosphorylation of Gopc 1 0.03 0.44 0.32
130 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
131 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
132 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
133 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
134 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31
135 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31
136 INT166901 NPPB Positive_regulation of Gene_expression of TRPA1 1 0.68 0.33 0.3
137 INT147041 Hmbs Negative_regulation of Negative_regulation of Nppa 1 0.05 0.51 0.3
138 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
139 INT30706 Nppa Positive_regulation of Localization of AVP 1 0.78 0.45 0.3
140 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
141 INT303983 Lep Positive_regulation of CXCL10 1 0.06 0.31 0.29
142 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
143 INT303998 Lep Positive_regulation of Localization of IL1RAPL1 1 0.04 0.31 0.29
144 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29
145 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
146 INT139125 Adcyap1 Regulation of Ier3 1 0.54 0.8 0.29
147 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
148 INT58898 Adcyap1 Regulation of Localization of Acot1 1 0.17 0 0.28
149 INT178578 Binding of PTHLH and CALCRL 1 0.01 0.68 0.27
150 INT63654 VIP Positive_regulation of Adcyap1 1 0.27 0.15 0.27
151 INT136245 Gucy1a2 Positive_regulation of Nppa 1 0.06 0.22 0.27
152 INT190998 ADCYAP1 Positive_regulation of Scn2a1 1 0.07 0.45 0.27
153 INT233780 Binding of ADCYAP1 and SCT 1 0.16 0 0.27
154 INT190996 ADCYAP1 Positive_regulation of Per1 1 0.06 0.45 0.27
155 INT233782 Binding of PTHLH and SCT 1 0.06 0 0.27
156 INT190997 ADCYAP1 Positive_regulation of Per2 1 0.07 0.45 0.27
157 INT100531 Cck Positive_regulation of Lep 1 0.70 0.15 0.26
158 INT136246 Gucy1a2 Negative_regulation of Nppa 1 0.05 0.22 0.26
159 INT20587 Nppa Positive_regulation of Gfra1 1 0.02 0.32 0.26
160 INT74118 Adcyap1 Positive_regulation of Localization of Avp 1 0.33 0 0.26
161 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
162 INT16163 Pth Regulation of Gene_expression of Plast4 1 0.00 0.65 0.25
163 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
164 INT106658 Adcyap1 Positive_regulation of Gene_expression of Npy 1 0.54 0.16 0.25
165 INT106660 Adcyap1 Positive_regulation of Gene_expression of Chga 1 0.54 0.16 0.25
166 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
167 INT71091 ADCYAP1 Positive_regulation of Localization of GHRH 1 0.26 0.26 0.24
168 INT71090 ADCYAP1 Positive_regulation of GHRH 1 0.12 0.26 0.24
169 INT190741 Adcyap1 Positive_regulation of Gria2 1 0.00 0 0.24
170 INT32636 Slc12a3 Regulation of Localization of Nppa 1 0.00 0.41 0.23
171 INT170158 NPPA Positive_regulation of Gene_expression of NPPB 1 0.13 0.91 0.23
172 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
173 INT303988 Lep Positive_regulation of Gene_expression of ISYNA1 1 0.06 0.55 0.23
174 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
175 INT69073 Adcyap1 Regulation of Localization of Gnrh1 2 0.66 0 0.22
176 INT102937 Gnrh1 Positive_regulation of Gene_expression of Lep 1 0.50 0 0.22
177 INT146993 Binding of NPPA and NPPC 1 0.27 0.82 0.22
178 INT32565 Nppa Regulation of Localization of CGA 1 0.00 0.07 0.22
179 INT63192 PTH Positive_regulation of ESR1 1 0.20 0.29 0.22
180 INT63201 PTH Positive_regulation of CD8A 1 0.45 0.29 0.22
181 INT63200 PTH Positive_regulation of IL2 1 0.24 0.29 0.22
182 INT131355 Npr1 Regulation of Nppb 1 0.39 0.88 0.22
183 INT131354 Npr1 Regulation of Nppa 1 0.40 0.88 0.22
184 INT110653 Lep Regulation of Localization of Cck 1 0.06 0.22 0.22
185 INT63194 PTH Positive_regulation of PGR 1 0.25 0.29 0.22
186 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
187 INT273046 Vip Negative_regulation of Gene_expression of Adcyap1 1 0.20 1.14 0.21
188 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21
189 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
190 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
191 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
192 INT190745 Adcyap1 Regulation of Car2 1 0.08 0 0.21
193 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2
194 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
195 INT304001 Lep Negative_regulation of ICAM3 1 0.07 0.35 0.2
196 INT315386 Adcyap1 Positive_regulation of Bad 1 0.03 0.52 0.2
197 INT80049 Adcyap1 Positive_regulation of Positive_regulation of Slc4a4 1 0.19 0 0.2
198 INT333889 Lep Regulation of Col7a1 1 0.04 0.41 0.2
199 INT303979 Lep Positive_regulation of ITGB2 1 0.11 0.35 0.2
200 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2

Single Events

The table below shows the top 100 pain related interactions that have been reported for peptide hormone receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in peptide hormone receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5617 Localization of Nppa 266 0.81 83.51 83.89
2 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33
3 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
4 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45
5 INT6196 Regulation of Nppa 83 0.62 30.31 30.18
6 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54
7 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26
8 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72
9 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31
10 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
11 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
12 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
13 INT5618 Regulation of Localization of Nppa 36 0.62 13.42 17.46
14 INT54077 Gene_expression of Adcyap1 62 0.78 23.17 16.75
15 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
16 INT75908 Regulation of LEP 77 0.60 60.16 15.19
17 INT58896 Localization of Adcyap1 35 0.81 4.57 14.77
18 INT48259 Positive_regulation of Adcyap1 33 0.67 10.94 14.39
19 INT65965 Gene_expression of Adcyap1 52 0.78 22.53 13.14
20 INT14764 Negative_regulation of Localization of Nppa 28 0.59 11.29 12.82
21 INT73641 Regulation of Lep 45 0.62 26.2 12.59
22 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19
23 INT11121 Positive_regulation of NPPA 64 0.70 34.09 11.96
24 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85
25 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7
26 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
27 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
28 INT7132 Localization of NPPA 53 0.81 19.79 10.86
29 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
30 INT16356 Regulation of NPPA 33 0.62 13.24 9.53
31 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
32 INT147452 Gene_expression of ADCYAP1 14 0.77 12.54 9.28
33 INT106199 Positive_regulation of Adcyap1 32 0.68 13.68 9.14
34 INT22083 Regulation of Pth 55 0.62 22.32 8.9
35 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85
36 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81
37 INT82082 Localization of Lep 63 0.81 26.41 8.56
38 INT75907 Binding of LEP 53 0.46 46.65 8.44
39 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24
40 INT52116 Regulation of Adcyap1 20 0.53 6.1 8.14
41 INT65964 Regulation of Adcyap1 13 0.45 10.1 7.54
42 INT6210 Binding of Nppa 39 0.47 14.35 7.21
43 INT15156 Positive_regulation of Localization of NPPA 21 0.70 8.61 6.97
44 INT6565 Positive_regulation of Positive_regulation of Nppa 14 0.70 4.04 6.76
45 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54
46 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33
47 INT43224 Negative_regulation of Adcyap1 17 0.54 3.69 6.19
48 INT12564 Localization of Pthlh 23 0.81 4.37 5.82
49 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
50 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
51 INT65356 Localization of LEP 46 0.79 41.17 5.43
52 INT91338 Binding of Lep 31 0.48 26.86 5.39
53 INT102935 Regulation of Lep 31 0.60 18.47 5.24
54 INT62570 Binding of Pth 48 0.48 26.45 4.85
55 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
56 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76
57 INT5624 Transcription of Nppa 19 0.69 8.52 4.72
58 INT66048 Positive_regulation of Gene_expression of Adcyap1 5 0.49 8.21 4.52
59 INT97391 Binding of Lep 18 0.48 8.97 4.47
60 INT45159 Regulation of Nppb 16 0.54 13.57 4.46
61 INT5619 Positive_regulation of Gene_expression of Nppa 21 0.70 11.95 4.41
62 INT4097 Localization of Pth 66 0.81 47.17 4.36
63 INT106548 Localization of Adcyap1 14 0.80 5.05 4.33
64 INT73434 Negative_regulation of Nppa 8 0.35 3.86 4.31
65 INT163581 Localization of Lep 27 0.79 18.99 4.08
66 INT138209 Positive_regulation of Localization of Adcyap1 2 0.41 2.07 4.08
67 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
68 INT229912 Phosphorylation of Fyn 5 0.42 2.57 3.78
69 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
70 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74
71 INT115877 Negative_regulation of Adcyap1 14 0.59 5.31 3.74
72 INT16408 Negative_regulation of Nppb 14 0.53 5.49 3.74
73 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
74 INT59154 Binding of Adcyap1 12 0.48 4.16 3.71
75 INT159472 Localization of NPPB 32 0.79 33.67 3.59
76 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
77 INT58897 Regulation of Localization of Adcyap1 4 0.45 1.82 3.48
78 INT9085 Localization of Nppb 32 0.81 15.1 3.47
79 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46
80 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39
81 INT240127 Binding of Nppb 19 0.37 22.42 3.3
82 INT120823 Positive_regulation of Gene_expression of Adcyap1 10 0.68 6.71 3.22
83 INT28094 Binding of PTH 29 0.37 13.57 3.09
84 INT16357 Negative_regulation of NPPA 23 0.58 12.37 2.98
85 INT6193 Regulation of Gene_expression of Nppa 6 0.45 2.02 2.93
86 INT37363 Localization of PTHLH 14 0.68 13.23 2.92
87 INT22500 Negative_regulation of Pth 6 0.43 3.41 2.83
88 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
89 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
90 INT59119 Positive_regulation of ADCYAP1 9 0.69 4.68 2.48
91 INT130476 Phosphorylation of Fyn 8 0.80 2.99 2.44
92 INT20498 Negative_regulation of Positive_regulation of Nppa 9 0.59 4.5 2.43
93 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
94 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
95 INT97485 Localization of ADCYAP1 4 0.78 0.24 2.35
96 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31
97 INT2544 Localization of PTH 39 0.81 30.55 2.22
98 INT120752 Positive_regulation of Gene_expression of NPPB 17 0.67 16.4 2.21
99 INT12565 Regulation of Localization of Pthlh 10 0.62 0.71 2.14
100 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
101 INT147453 Positive_regulation of Gene_expression of ADCYAP1 3 0.69 3.49 2.1
102 INT83392 Transcription of Lep 6 0.54 5.07 2.04
103 INT147451 Regulation of Gene_expression of ADCYAP1 3 0.61 1.88 2.04
104 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
105 INT54076 Transcription of Adcyap1 4 0.67 1.65 1.98
106 INT25461 Negative_regulation of Regulation of Nppa 2 0.43 0.22 1.97
107 INT84264 Regulation of NPPB 22 0.61 21.18 1.94
108 INT77300 Negative_regulation of Positive_regulation of Adcyap1 3 0.35 0 1.88
109 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87
110 INT26370 Positive_regulation of Positive_regulation of NPPA 4 0.60 0.67 1.87
111 INT66047 Regulation of Gene_expression of Adcyap1 2 0.58 3.36 1.84
112 INT13861 Negative_regulation of Localization of Pthlh 2 0.10 0.08 1.81
113 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
114 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73
115 INT46530 Gene_expression of Pthlh 15 0.78 11.23 1.7
116 INT15155 Regulation of Localization of NPPA 8 0.62 2.67 1.65
117 INT12566 Positive_regulation of Localization of Pthlh 4 0.70 0.13 1.65
118 INT3343 Regulation of PTH 24 0.62 11.18 1.62
119 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
120 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49
121 INT11057 Protein_catabolism of Nppa 11 0.94 3.34 1.47
122 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
123 INT73432 Gene_expression of Nppa 32 0.59 21.04 1.39
124 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37
125 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
126 INT59153 Positive_regulation of Binding of Adcyap1 3 0.43 0.56 1.37
127 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28
128 INT22498 Binding of Pth 2 0.48 2.81 1.24
129 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19
130 INT213465 Transcription of Lep 4 0.68 2.11 1.15
131 INT72749 Regulation of Pth 4 0.62 1.39 1.14
132 INT130477 Negative_regulation of Fyn 3 0.29 1.59 1.14
133 INT131351 Positive_regulation of Gene_expression of Nppb 2 0.50 13.72 1.14
134 INT253813 Regulation of Negative_regulation of Lep 2 0.45 1.01 1.12
135 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
136 INT82214 Transcription of PTH 6 0.54 3.33 1.11
137 INT106549 Binding of Adcyap1 3 0.35 1.83 1.08
138 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
139 INT32760 Regulation of Gene_expression of PTHLH 4 0.51 6.32 1
140 INT133846 Binding of NPPB 14 0.42 11.52 0.98
141 INT23030 Positive_regulation of Pth 13 0.61 9.24 0.97
142 INT16371 Positive_regulation of Gene_expression of NPPA 7 0.45 3.62 0.96
143 INT4096 Regulation of Localization of Pth 7 0.58 3.97 0.95
144 INT169336 Binding of Jak2 2 0.42 1.31 0.93
145 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
146 INT23921 Negative_regulation of NPPB 13 0.58 16.19 0.9
147 INT114824 Binding of PTHLH 12 0.42 9.5 0.9
148 INT29759 Negative_regulation of Negative_regulation of Nppa 3 0.58 1.5 0.9
149 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
150 INT72715 Positive_regulation of Nppc 4 0.39 1.55 0.87
151 INT15587 Protein_catabolism of NPPA 4 0.71 1.55 0.87
152 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
153 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
154 INT62072 Negative_regulation of Gene_expression of PTHLH 3 0.43 4.45 0.85
155 INT43221 Negative_regulation of Negative_regulation of Adcyap1 1 0.18 0 0.85
156 INT333883 Positive_regulation of Positive_regulation of Lep 2 0.46 1.06 0.83
157 INT146940 Gene_expression of Fyn 2 0.52 2.76 0.83
158 INT16587 Regulation of Negative_regulation of Nppa 3 0.53 0.84 0.82
159 INT7297 Binding of NPPA 8 0.45 5.33 0.79
160 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
161 INT80118 Gene_expression of NPPC 2 0.68 4.14 0.77
162 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
163 INT16537 Regulation of Positive_regulation of Nppa 2 0.45 1.44 0.76
164 INT156533 Transcription of LEP 9 0.69 4.35 0.74
165 INT5621 Positive_regulation of Transcription of Nppa 5 0.50 4.97 0.74
166 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74
167 INT19316 Positive_regulation of Localization of Nppb 2 0.50 3.15 0.73
168 INT210014 Regulation of Binding of Adcyap1 1 0.38 0.25 0.73
169 INT42722 Negative_regulation of Ptpn11 1 0.21 0 0.71
170 INT210012 Regulation of Transcription of Adcyap1 1 0.44 0.48 0.7
171 INT210011 Negative_regulation of Gene_expression of Adcyap1 1 0.36 1.22 0.69
172 INT54167 Negative_regulation of Positive_regulation of NPPA 4 0.42 1.26 0.63
173 INT80452 Positive_regulation of Gene_expression of Pthlh 4 0.40 3.77 0.62
174 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61
175 INT109081 Localization of Nppa 9 0.59 2.72 0.61
176 INT101484 Regulation of Positive_regulation of Lep 3 0.45 1.68 0.61
177 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6
178 INT83391 Negative_regulation of Transcription of Lep 1 0.43 0.34 0.6
179 INT254132 Positive_regulation of Localization of NPPB 2 0.40 2.9 0.58
180 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58
181 INT137580 Negative_regulation of Gene_expression of Adcyap1 3 0.43 0.15 0.57
182 INT51718 Positive_regulation of Negative_regulation of Nppa 3 0.47 0.79 0.57
183 INT30943 Negative_regulation of Pthlh 3 0.20 2.75 0.56
184 INT249509 Gene_expression of Fyn 2 0.35 1.79 0.56
185 INT19395 Negative_regulation of Localization of Pth 11 0.58 10.16 0.55
186 INT7293 Negative_regulation of Binding of Nppa 5 0.43 1.4 0.55
187 INT93520 Negative_regulation of ADCYAP1 3 0.42 0.32 0.53
188 INT50555 Regulation of Pthlh 3 0.16 2.07 0.52
189 INT183375 Binding of Nppa 14 0.38 8.95 0.51
190 INT81175 Localization of Pthlh 4 0.70 7.64 0.5
191 INT68358 Regulation of Positive_regulation of Adcyap1 1 0.44 0 0.5
192 INT40572 Regulation of Localization of PTHLH 1 0.04 0 0.49
193 INT184062 Binding of Jak2 5 0.37 3.13 0.47
194 INT19315 Phosphorylation of Nppb 2 0.55 0.23 0.47
195 INT203480 Negative_regulation of Transcription of Adcyap1 1 0.41 0.81 0.47
196 INT97486 Positive_regulation of Localization of ADCYAP1 1 0.67 0 0.47
197 INT203479 Transcription of Adcyap1 1 0.67 0.81 0.47
198 INT36770 Positive_regulation of Localization of Pth 14 0.70 10.42 0.46
199 INT82819 Negative_regulation of Negative_regulation of LEP 3 0.56 2.22 0.46
200 INT5625 Regulation of Transcription of Nppa 2 0.26 0.29 0.46
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