GO:0051439

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Name regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Categary Process
Go Slim No
Go Link GO:0051439
Unique Molecular Interactions 63
Total Molecular Interactions 99
Total Single Events 705
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported for regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
3 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
4 INT144286 ACP1 Negative_regulation of Phosphorylation of PSMC6 1 0.45 0.39 0.78
5 INT72229 Binding of NFKBIL1 and BTRC 1 0.00 0 0.73
6 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
7 INT164264 TGM7 Negative_regulation of CCNB1 1 0.07 1.08 0.53
8 INT72230 Binding of BTRC and EMID1 1 0.00 0 0.49
9 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
10 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 0.11 0.77 0.46
11 INT177781 BUB1B Positive_regulation of ATF4 1 0.07 0.76 0.46
12 INT177780 BUB1B Positive_regulation of ASNS 1 0.05 0.76 0.46
13 INT177787 BUB1B Positive_regulation of MTHFD2 1 0.15 0.76 0.46
14 INT13879 Binding of PSMB9 and KCNAB2 1 0.03 0.19 0.41
15 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
16 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
17 INT35178 Binding of STT3A and PSME3 1 0.01 0.38 0.25
18 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 0.00 0 0.24
19 INT180503 Binding of SARS and PSMD6 1 0.22 2.44 0.16
20 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
21 INT57014 PSMB1 Regulation of SCN5A 1 0.02 0 0.1
22 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09
23 INT298351 PSMD1 Regulation of Gene_expression of HLA-DRA 1 0.01 0.42 0.08
24 INT298356 PSMD1 Regulation of Gene_expression of Cd14 1 0.04 0.42 0.08
25 INT320267 CCNA2 Positive_regulation of CDK1 1 0.12 1.08 0.08
26 INT166784 Binding of PSMD1 and Nkx6-2 1 0.21 0.5 0.08
27 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
28 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
29 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
30 INT231605 Binding of PSMD1 and SGCG 1 0.02 0.34 0.04
31 INT261728 PSMB6 Negative_regulation of Transcription of F2R 1 0.01 0.17 0.03
32 INT261731 PSMB6 Regulation of COL5A2 1 0.00 0.21 0.03
33 INT287479 PSMB10 Positive_regulation of TBK1 1 0.00 0.59 0.03
34 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
35 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
36 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
37 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
38 INT318081 Binding of RPL5 and UBC 1 0.02 0.52 0
39 INT182397 NFYA Regulation of CCNB1 1 0.00 0.09 0
40 INT209454 Binding of PSMD1 and PSMD2 1 0.15 0 0
41 INT165318 Binding of PSMD1 and CHPT1 1 0.23 0.57 0
42 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
43 INT182402 E2F2 Regulation of CCNB1 1 0.00 0.09 0
44 INT276607 Binding of DBT and PSMD1 1 0.00 0.08 0
45 INT209452 Binding of PSMD2 and PSMD3 1 0.07 0.2 0
46 INT318103 Binding of UBC and Hprt 1 0.10 0.52 0
47 INT182399 E2F2 Regulation of CDK1 1 0.00 0.09 0
48 INT182406 NFYA Regulation of CDK1 1 0.00 0.09 0
49 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
50 INT299698 Binding of CFB and PSMC2 1 0.00 0.14 0
51 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
52 INT209453 Binding of PSMD1 and PSMD3 1 0.08 0.2 0
53 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
54 INT175194 Binding of UBC and NUP62 1 0.01 0.05 0
55 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
56 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
57 INT299708 Binding of C3 and PSMC2 1 0.00 0.14 0
58 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0
59 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported in regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
2 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
3 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86
4 INT151748 Positive_regulation of Positive_regulation of PSMD2 4 0.49 4.45 5.35
5 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69
6 INT69591 Positive_regulation of Positive_regulation of PSMD1 2 0.50 3.06 3.99
7 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
8 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33
9 INT51993 Gene_expression of PSMA5 5 0.75 2.59 2.92
10 INT140547 Negative_regulation of PSMB10 3 0.02 2.33 2.92
11 INT54749 Binding of BTRC 7 0.09 0.88 2.9
12 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77
13 INT60440 Localization of PSMD1 10 0.74 3.94 2.57
14 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29
15 INT69027 Binding of PSMA5 4 0.47 1.08 1.93
16 INT148721 Binding of PSMD1 13 0.31 4.78 1.76
17 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
18 INT159185 Positive_regulation of Gene_expression of PSMD2 3 0.40 1.4 1.63
19 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56
20 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
21 INT69513 Regulation of PSMA5 2 0.60 1.04 1.43
22 INT108587 Negative_regulation of PSMA5 1 0.57 1.73 1.42
23 INT6018 Positive_regulation of PSMB9 7 0.60 4.36 1.33
24 INT79660 Phosphorylation of PSMC6 3 0.80 0.45 1.28
25 INT67638 Positive_regulation of PSMA5 1 0.21 1.15 1.05
26 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
27 INT13882 Binding of PSMB9 3 0.15 2.84 1
28 INT78322 Positive_regulation of PSME1 2 0.44 1.8 0.95
29 INT144289 Negative_regulation of Positive_regulation of PSMC6 1 0.41 0.56 0.92
30 INT144287 Positive_regulation of PSMC6 1 0.49 0.56 0.92
31 INT113841 Gene_expression of CCNB1 11 0.75 3.46 0.86
32 INT78323 Negative_regulation of PSME1 1 0.37 0.5 0.78
33 INT108590 Negative_regulation of Negative_regulation of PSMA5 1 0.57 0.92 0.75
34 INT258791 Positive_regulation of CDK1 14 0.45 5.73 0.74
35 INT62273 Gene_expression of CDK1 19 0.75 8.43 0.68
36 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
37 INT108586 Positive_regulation of Negative_regulation of PSMA5 1 0.49 0.82 0.67
38 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
39 INT17109 Regulation of Gene_expression of PSMD1 3 0.44 0.86 0.58
40 INT16681 Positive_regulation of PSMC2 1 0.07 0 0.54
41 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
42 INT62272 Negative_regulation of CDK1 9 0.57 6.46 0.46
43 INT177869 Gene_expression of BUB1B 2 0.65 2.11 0.45
44 INT177866 Negative_regulation of BUB1B 1 0.32 1.23 0.45
45 INT177845 Negative_regulation of Gene_expression of BUB1B 1 0.23 0.75 0.45
46 INT350879 Negative_regulation of Localization of PSMD1 1 0.05 0.43 0.43
47 INT202762 Gene_expression of PSMD3 8 0.47 1.44 0.42
48 INT280564 Negative_regulation of Gene_expression of PSMB9 5 0.54 5.99 0.41
49 INT78324 Regulation of PSME1 1 0.61 0.49 0.41
50 INT280560 Positive_regulation of Gene_expression of PSMB9 7 0.64 6.44 0.36
51 INT335718 Regulation of Gene_expression of PSMD2 1 0.09 0.07 0.35
52 INT11689 Binding of PSMD2 16 0.36 2.77 0.34
53 INT57019 Gene_expression of PSMB1 1 0.38 0 0.34
54 INT11688 Binding of PSMD3 5 0.36 1.17 0.28
55 INT72235 Negative_regulation of BTRC 3 0.02 0 0.24
56 INT131823 Negative_regulation of PSMB6 2 0.01 0.09 0.24
57 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
58 INT322282 Localization of PSMD2 2 0.20 1.42 0.22
59 INT209076 Negative_regulation of PSME3 2 0.34 0.86 0.21
60 INT94166 Phosphorylation of CDK1 10 0.79 4.75 0.2
61 INT165973 Phosphorylation of PSMA5 1 0.79 0.07 0.2
62 INT165972 Positive_regulation of Phosphorylation of PSMA5 1 0.49 0.07 0.2
63 INT280553 Regulation of PSMB9 2 0.57 1.46 0.19
64 INT209077 Positive_regulation of Negative_regulation of PSME3 1 0.37 0.13 0.19
65 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
66 INT57020 Transcription of PSMB1 1 0.26 0 0.16
67 INT173184 Regulation of CDK1 4 0.30 2.97 0.15
68 INT90493 Negative_regulation of PSMB9 3 0.54 0.88 0.15
69 INT62271 Negative_regulation of Gene_expression of CDK1 2 0.42 1.32 0.14
70 INT201462 Binding of CDK2 12 0.39 5.2 0.12
71 INT15564 Regulation of PSMD2 1 0.00 0 0.12
72 INT165320 Protein_catabolism of PSMD1 1 0.61 1.37 0.11
73 INT165319 Regulation of Protein_catabolism of PSMD1 1 0.31 1.37 0.11
74 INT167436 Localization of CDK1 2 0.14 0.41 0.1
75 INT334958 Positive_regulation of Localization of PSMD1 1 0.10 0.87 0.1
76 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
77 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
78 INT186055 Binding of CDK1 3 0.35 1.43 0.09
79 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
80 INT302272 Localization of CDK2 2 0.30 1.09 0.09
81 INT306284 Binding of CCNB1 1 0.28 0.13 0.09
82 INT280554 Negative_regulation of Positive_regulation of PSMB9 1 0.40 0.9 0.09
83 INT189116 Gene_expression of PSMB10 1 0.18 0.3 0.08
84 INT285256 Positive_regulation of Negative_regulation of PSMD2 1 0.04 0 0.08
85 INT337665 Positive_regulation of PSME3 1 0.45 2.51 0.07
86 INT113842 Negative_regulation of CCNB1 1 0.40 0.53 0.06
87 INT166204 Gene_expression of PSME1 3 0.32 1.94 0.05
88 INT202765 Positive_regulation of PSMD3 1 0.12 0.51 0.05
89 INT263801 Localization of PSME1 2 0.07 1.72 0.04
90 INT318095 Gene_expression of UBC 1 0.16 1.24 0.04
91 INT337650 Positive_regulation of Positive_regulation of PSME3 1 0.32 1.33 0.04
92 INT337661 Positive_regulation of Positive_regulation of PSME1 1 0.05 1.31 0.04
93 INT337662 Localization of PSME3 1 0.52 1.26 0.04
94 INT94160 Positive_regulation of Phosphorylation of CDK1 2 0.49 0.93 0.03
95 INT186663 Protein_catabolism of PSMB9 2 0.60 0.39 0.03
96 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
97 INT94161 Negative_regulation of Phosphorylation of CDK1 1 0.41 0.93 0.03
98 INT214219 Regulation of PSMD6 1 0.01 0.05 0.03
99 INT329787 Regulation of CCNB1 1 0.08 1.21 0.03
100 INT214220 Gene_expression of PSMD6 3 0.65 0.83 0
101 INT169427 Transcription of CDK2 2 0.09 0.42 0
102 INT227884 Positive_regulation of Gene_expression of PSMD1 2 0.06 0.4 0
103 INT87528 Negative_regulation of PSMC6 2 0.41 0 0
104 INT155591 Binding of PSME1 2 0.07 0.49 0
105 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0
106 INT289866 Protein_catabolism of CDK1 1 0.46 0 0
107 INT230109 Positive_regulation of Gene_expression of BUB1B 1 0.42 0.65 0
108 INT289873 Negative_regulation of Gene_expression of CCNB1 1 0.15 0 0
109 INT248587 Positive_regulation of Gene_expression of PSMD3 1 0.04 0.16 0
110 INT166205 Negative_regulation of Gene_expression of PSME1 1 0.18 0.28 0
111 INT222070 Localization of PSMD3 1 0.04 0.09 0
112 INT302263 Regulation of Phosphorylation of PSMD6 1 0.09 0.84 0
113 INT209457 Negative_regulation of Gene_expression of PSMD1 1 0.27 0.2 0
114 INT175213 Negative_regulation of Binding of UBC 1 0.02 0.13 0
115 INT157670 Regulation of PSMC6 1 0.44 0.58 0
116 INT245611 Positive_regulation of Binding of PSMD2 1 0.43 0.1 0
117 INT289863 Negative_regulation of Positive_regulation of CDK1 1 0.31 0 0
118 INT156902 Positive_regulation of UBC 1 0.49 0 0
119 INT289864 Positive_regulation of CCNB1 1 0.25 0 0
120 INT341855 Positive_regulation of Positive_regulation of CDK2 1 0.06 0.51 0
121 INT289862 Positive_regulation of Gene_expression of CDK1 1 0.26 0 0
122 INT289859 Localization of CCNB1 1 0.24 0.27 0
123 INT302249 Positive_regulation of Phosphorylation of PSMD6 1 0.10 0.84 0
124 INT289620 Regulation of Binding of CDK2 1 0.28 0.22 0
125 INT186659 Regulation of Protein_catabolism of PSMB9 1 0.15 0.17 0
126 INT289869 Positive_regulation of Protein_catabolism of CDK1 1 0.26 0 0
127 INT177818 Positive_regulation of PSMB6 1 0.19 0.25 0
128 INT214218 Negative_regulation of PSMD6 1 0.01 0 0
129 INT302251 Phosphorylation of PSMD6 1 0.17 0.84 0
130 INT155592 Positive_regulation of Binding of PSME1 1 0.09 0.1 0
131 INT289860 Negative_regulation of Positive_regulation of CCNB1 1 0.15 0 0
132 INT280550 Regulation of Gene_expression of PSMB9 1 0.57 0.37 0
133 INT343564 Regulation of Gene_expression of PSMD6 1 0.44 0.35 0
134 INT287280 Positive_regulation of Negative_regulation of PSMD1 1 0.10 0 0
135 INT289871 Positive_regulation of Gene_expression of CCNB1 1 0.25 0.41 0
136 INT166206 Regulation of Gene_expression of PSME1 1 0.19 0.28 0
137 INT175222 Binding of UBC 1 0.02 0.54 0
138 INT325169 Regulation of Negative_regulation of CDK2 1 0.34 0.05 0
139 INT209458 Negative_regulation of Gene_expression of PSMD2 1 0.23 0.2 0
140 INT261736 Gene_expression of PSMB6 1 0.01 0 0
141 INT225187 Positive_regulation of Binding of CDK2 1 0.56 0.87 0
142 INT186626 Protein_catabolism of PSMB6 1 0.16 0.17 0
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