GO:0051443

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Name positive regulation of ubiquitin-protein ligase activity
Categary Process
Go Slim No
Go Link GO:0051443
Unique Molecular Interactions 279
Total Molecular Interactions 347
Total Single Events 1924
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of ubiquitin-protein ligase activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of ubiquitin-protein ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
2 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
3 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
4 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
5 INT161191 CRX Regulation of Gene_expression of Trib3 1 0.00 2 1.38
6 INT50706 Phax Positive_regulation of Localization of Trib3 1 0.04 0.28 1.38
7 INT161185 NMS Regulation of Gene_expression of Trib3 1 0.03 2 1.38
8 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
9 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
10 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
11 INT228681 Fkbp4 Negative_regulation of Trib3 1 0.00 0.57 1.2
12 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
13 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
14 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14
15 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
16 INT186431 Trib3 Regulation of Creb1 1 0.03 0.23 0.92
17 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
18 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
19 INT261480 Negative_regulation of Trib3 Positive_regulation of Ephb1 1 0.04 0.8 0.84
20 INT186428 Trib3 Regulation of Prkcg 1 0.02 0.09 0.81
21 INT128041 Bdnf Positive_regulation of Trib3 1 0.10 0.29 0.79
22 INT50708 Phax Positive_regulation of Trib3 1 0.03 0.07 0.77
23 INT50707 Phax Positive_regulation of Positive_regulation of Trib3 1 0.04 0.16 0.74
24 INT161298 Ppp1r1b Negative_regulation of Trib3 1 0.05 0.16 0.7
25 INT82022 Binding of Trib3 and Ngf 1 0.08 0.31 0.68
26 INT249485 Trib3 Negative_regulation of Phosphorylation of Grin2b 1 0.02 0.64 0.68
27 INT82020 Negative_regulation of Binding of Trib3 and Ngf 1 0.07 0.31 0.68
28 INT134028 Olr696 Regulation of Trib3 1 0.00 0.15 0.68
29 INT112515 Binding of Ephb1 and Trib3 1 0.06 0.41 0.65
30 INT112516 Binding of Prkce and Trib3 1 0.01 0.4 0.64
31 INT165048 Trib3 Positive_regulation of Gene_expression of Tnf 1 0.08 0.8 0.63
32 INT249484 Trib3 Positive_regulation of Phosphorylation of Grin2b 1 0.01 0.57 0.61
33 INT186434 Trib3 Positive_regulation of Phosphorylation of Creb1 1 0.05 0.26 0.58
34 INT118003 Trib3 Regulation of Trpv1 1 0.03 0.09 0.58
35 INT282142 Grm1 Positive_regulation of Positive_regulation of Trib3 1 0.01 0.27 0.57
36 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
37 INT161250 Trib3 Regulation of Mapk14 1 0.04 0.81 0.54
38 INT149321 Amph Positive_regulation of Trib3 1 0.16 0 0.54
39 INT330545 Bcl2l11 Negative_regulation of Trib3 1 0.00 0.38 0.52
40 INT162993 Binding of Trib3 and Fadd 1 0.05 0.1 0.46
41 INT162990 Binding of Trib3 and Pea15a 1 0.04 0.09 0.46
42 INT128043 Positive_regulation of Ntrk2 Positive_regulation of Phosphorylation of Trib3 1 0.07 0.34 0.45
43 INT283731 Trib3 Positive_regulation of Creb1 2 0.01 0.16 0.44
44 INT313377 Trib3 Regulation of Gene_expression of Gfap 1 0.01 0.37 0.44
45 INT313378 Trib3 Regulation of Phosphorylation of Mapk14 1 0.01 0.37 0.44
46 INT114599 Positive_regulation of Il1rap Positive_regulation of Trib3 1 0.03 0.07 0.43
47 INT95403 Ephb1 Regulation of Positive_regulation of Trib3 1 0.07 0.19 0.41
48 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
49 INT95402 Mapk14 Regulation of Positive_regulation of Trib3 1 0.06 0.19 0.41
50 INT114598 Positive_regulation of Il1b Positive_regulation of Trib3 1 0.08 0.08 0.4
51 INT114594 Il1b Positive_regulation of Positive_regulation of Trib3 1 0.08 0.08 0.4
52 INT114596 Il1b Positive_regulation of Trib3 1 0.08 0.08 0.4
53 INT114597 Positive_regulation of Trib3 Regulation of Gene_expression of Tac4 1 0.01 0.09 0.4
54 INT140869 Binding of Gdnf and Trib3 1 0.04 0.15 0.37
55 INT118000 Trpv1 Regulation of Phosphorylation of Trib3 1 0.01 0.08 0.36
56 INT117999 Trpv1 Positive_regulation of Phosphorylation of Trib3 1 0.02 0.08 0.36
57 INT202810 Pin1 Regulation of Csf2 1 0.03 0.82 0.36
58 INT224285 BDNF Positive_regulation of Trib3 1 0.06 0.22 0.36
59 INT122757 Helt Positive_regulation of Trib3 1 0.00 0.2 0.35
60 INT263383 Abl1 Regulation of Trib3 1 0.01 0.28 0.35
61 INT249492 Trib3 Regulation of Phosphorylation of Grin2b 1 0.01 0.23 0.35
62 INT304495 Trib3 Positive_regulation of Mapk1 1 0.02 1.4 0.35
63 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
64 INT309132 Edc4 Negative_regulation of Positive_regulation of Trib3 1 0.00 0.69 0.33
65 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
66 INT356288 Egf Positive_regulation of Trib3 1 0.00 0.17 0.3
67 INT186430 Creb1 Positive_regulation of Trib3 1 0.04 0.17 0.3
68 INT356283 Ngf Positive_regulation of Trib3 1 0.00 0.17 0.3
69 INT356282 Gdnf Positive_regulation of Trib3 1 0.00 0.17 0.3
70 INT283733 Trib3 Positive_regulation of Creb1 1 0.00 0 0.28
71 INT53951 Negative_regulation of Trib3 Negative_regulation of Gene_expression of Ptgs1 1 0.01 0.43 0.26
72 INT149357 Trib3 Negative_regulation of Raf1 1 0.01 0.08 0.25
73 INT51432 Gria1 Positive_regulation of Trib3 1 0.04 0 0.25
74 INT177661 Binding of Trib3 and Myo1f 1 0.00 0.54 0.24
75 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
76 INT171250 Binding of BMI1 and OAP 1 0.13 1.02 0.22
77 INT202808 Binding of Pin1 and Hnrpd 1 0.08 0.84 0.22
78 INT187485 Trib3 Positive_regulation of Prkag1 1 0.00 0.97 0.22
79 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
80 INT323884 BMI1 Regulation of Gene_expression of TIMP2 1 0.01 0.64 0.21
81 INT285979 Ros1 Positive_regulation of Trib3 2 0.02 2.18 0.2
82 INT179937 Trib3 Regulation of TNF 1 0.00 0.59 0.2
83 INT345209 Repin1 Positive_regulation of Positive_regulation of Trib3 1 0.00 0.88 0.18
84 INT140870 Binding of Trib3 and Gtf3a 1 0.00 0.07 0.18
85 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
86 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
87 INT164790 Cdk5r1 Positive_regulation of Trib3 1 0.02 0.25 0.17
88 INT146841 Tnf Positive_regulation of Trib3 1 0.03 0.77 0.16
89 INT309125 Trib3 Positive_regulation of Rorb 1 0.00 0.16 0.16
90 INT146845 Tnf Positive_regulation of Positive_regulation of Trib3 1 0.03 0.77 0.16
91 INT153185 Prok2 Regulation of Trib3 1 0.02 0 0.15
92 INT202813 Pin1 Positive_regulation of Regulation of TH1L 1 0.50 0 0.14
93 INT352450 Tnc Regulation of Trib3 1 0.00 0.22 0.13
94 INT133349 Positive_regulation of Trib3 Positive_regulation of Gene_expression of Qrfp 1 0.02 0 0.12
95 INT177675 Binding of CALM1 and Positive_regulation of Trib3 1 0.00 0.27 0.12
96 INT323886 BMI1 Regulation of Gene_expression of MMP13 1 0.01 1.13 0.12
97 INT177674 CALM1 Positive_regulation of Trib3 1 0.00 0.27 0.12
98 INT332685 Trib3 Positive_regulation of Binding of Ros1 1 0.01 0.74 0.12
99 INT285981 Ros1 Regulation of Positive_regulation of Trib3 1 0.01 0.95 0.12
100 INT323875 Binding of BMI1 and IGF1 1 0.01 1.2 0.11
101 INT323882 Binding of BMI1 and MMP13 1 0.01 1.26 0.11
102 INT323869 Binding of BMI1 and COL1A2 1 0.00 1.21 0.11
103 INT278156 Negative_regulation of Trib3 Negative_regulation of Akt1 1 0.00 0.45 0.1
104 INT350011 Binding of BMI1 and IL6 1 0.01 0.58 0.1
105 INT321299 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Nr0b2 1 0.02 0.31 0.1
106 INT248704 Trib3 Positive_regulation of Phosphorylation of Rxrb 1 0.00 0.49 0.08
107 INT285982 Ros1 Positive_regulation of Binding of Trib3 1 0.02 1.41 0.08
108 INT323881 BMI1 Regulation of Gene_expression of LEP 1 0.03 1.09 0.08
109 INT202807 Pin1 Regulation of Binding of Hnrpd 1 0.06 0.14 0.08
110 INT285602 Trib3 Regulation of Gene_expression of Nos2 1 0.00 0.48 0.07
111 INT263430 Binding of Wasf1 and Trib3 1 0.01 0.06 0.07
112 INT215693 Trib3 Regulation of Gene_expression of Ccnd1 1 0.00 0.09 0.07
113 INT300308 Positive_regulation of Mapk14 Positive_regulation of Trib3 1 0.03 1.42 0.07
114 INT292812 Zfp787 Negative_regulation of Trib3 1 0.00 0.48 0.06
115 INT213001 Hdl1 Positive_regulation of Trib3 1 0.00 2 0.06
116 INT179932 Trib3 Negative_regulation of Positive_regulation of Mmp9 1 0.01 0.41 0.05
117 INT308328 Hif1a Regulation of Positive_regulation of Trib3 1 0.02 0.89 0.05
118 INT179933 Trib3 Negative_regulation of Gene_expression of Mmp9 1 0.01 0.41 0.05
119 INT295263 Tlr4 Positive_regulation of Trib3 1 0.18 0.66 0.04
120 INT148095 Vasp Regulation of Trib3 1 0.00 0.12 0.04
121 INT263378 Trib3 Regulation of Bmx 1 0.00 0 0.04
122 INT263431 Trib3 Regulation of Pdgfra 1 0.00 0 0.04
123 INT263381 Trib3 Regulation of Src 1 0.01 0 0.04
124 INT263432 Trib3 Regulation of Abl1 1 0.00 0 0.04
125 INT213002 Binding of Scarb1 and Trib3 1 0.00 1.02 0.03
126 INT53100 Trib3 Regulation of Gene_expression of Penk 1 0.06 0 0.03
127 INT277745 Trib3 Regulation of Ccnd1 1 0.00 0.41 0.03
128 INT277223 Trib3 Regulation of Regulation of aicda 1 0.01 0.42 0.03
129 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
130 INT355435 Trib3 Positive_regulation of Eif2ak2 1 0.01 0.61 0
131 INT205985 Ptn Positive_regulation of Trib3 1 0.00 0.73 0
132 INT266533 Trib3 Positive_regulation of Phosphorylation of Olr447 1 0.00 0 0
133 INT214902 Binding of Pcna and Trib3 1 0.00 1.51 0
134 INT267261 GOPC Regulation of BMI1 1 0.06 0.75 0
135 INT234145 Fig4 Negative_regulation of Gene_expression of Trib3 1 0.01 0.31 0
136 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0
137 INT267257 BCL11B Regulation of Transcription of BMI1 1 0.28 0.74 0
138 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
139 INT257871 Binding of Ins1 and Positive_regulation of Trib3 1 0.01 0.49 0
140 INT225001 Binding of Mtpn and Trib3 1 0.00 0.15 0
141 INT330226 Positive_regulation of Prkaa2 Positive_regulation of Trib3 1 0.00 0.07 0
142 INT238624 Binding of Sdc2 and Trib3 1 0.00 0.08 0
143 INT234141 Fig4 Negative_regulation of Trib3 1 0.01 0.13 0
144 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0
145 INT326118 Binding of BMI1 and PCSK1 1 0.09 0 0
146 INT351977 Binding of Tp53 and Trib3 1 0.01 0.79 0
147 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
148 INT205986 Mapk8 Positive_regulation of Trib3 1 0.02 0.73 0
149 INT310240 INS Positive_regulation of Trib3 1 0.00 0.98 0
150 INT267259 BCL11B Regulation of BMI1 1 0.65 1.48 0
151 INT180673 Trib3 Regulation of Ecm1 1 0.02 0 0
152 INT249822 Foxm1 Positive_regulation of Transcription of Plk1 1 0.50 0.12 0
153 INT238620 Binding of Cadm1 and Trib3 1 0.00 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of ubiquitin-protein ligase activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of ubiquitin-protein ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01
2 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48
3 INT12681 Regulation of Trib3 76 0.53 23.92 26.58
4 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27
5 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58
6 INT38253 Localization of Trib3 35 0.63 10.28 15.42
7 INT171253 Positive_regulation of BMI1 23 0.53 39.41 11.23
8 INT33127 Positive_regulation of Phosphorylation of Trib3 26 0.17 14.04 10
9 INT10533 Positive_regulation of Positive_regulation of Trib3 24 0.42 6.59 9.2
10 INT165228 Binding of BMI1 13 0.47 25.36 7.97
11 INT38254 Positive_regulation of Localization of Trib3 14 0.45 6.14 6.99
12 INT50704 Binding of Trib3 13 0.31 6.33 5.46
13 INT51734 Negative_regulation of Localization of Trib3 10 0.19 2.53 4.97
14 INT24813 Negative_regulation of Positive_regulation of Trib3 10 0.16 1.3 4.48
15 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11
16 INT32205 Regulation of Positive_regulation of Trib3 9 0.11 2.82 4.1
17 INT10535 Positive_regulation of Gene_expression of Trib3 13 0.59 4.93 3.74
18 INT15327 Negative_regulation of Phosphorylation of Trib3 7 0.30 4.95 2.99
19 INT33492 Negative_regulation of Negative_regulation of Trib3 5 0.30 0.51 2.67
20 INT202792 Negative_regulation of Pin1 1 0.56 3.77 2.37
21 INT249563 Positive_regulation of Trib3 1 0.45 0.94 2.18
22 INT249555 Localization of Trib3 1 0.73 0.94 2.18
23 INT171251 Regulation of BMI1 8 0.20 10.46 2.01
24 INT32469 Regulation of Gene_expression of Trib3 5 0.07 2.33 1.7
25 INT48752 Regulation of Negative_regulation of Trib3 3 0.39 0.89 1.65
26 INT99639 Regulation of Phosphorylation of Trib3 6 0.14 0.44 1.36
27 INT263523 Regulation of Binding of BMI1 1 0.34 3.01 1.3
28 INT83061 Regulation of Localization of Trib3 2 0.07 0.11 1.17
29 INT207183 Binding of Bmi1 1 0.01 16.24 1.14
30 INT48931 Regulation of Regulation of Trib3 2 0.04 0.06 0.89
31 INT202790 Binding of Pin1 1 0.46 3.02 0.88
32 INT217683 Localization of BMI1 7 0.68 6.28 0.87
33 INT202786 Regulation of Pin1 1 0.43 2.16 0.83
34 INT217685 Negative_regulation of BMI1 7 0.18 6.01 0.82
35 INT161471 Gene_expression of Bmi1 9 0.76 11.47 0.72
36 INT202806 Gene_expression of Pin1 1 0.74 1.87 0.66
37 INT202801 Positive_regulation of Pin1 1 0.67 1.37 0.52
38 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
39 INT202805 Negative_regulation of Negative_regulation of Pin1 1 0.41 0.77 0.43
40 INT207182 Positive_regulation of Bmi1 1 0.02 6.81 0.41
41 INT202791 Phosphorylation of Pin1 1 0.78 0.61 0.28
42 INT161464 Regulation of Gene_expression of Bmi1 1 0.44 3.01 0.26
43 INT202789 Positive_regulation of Gene_expression of Pin1 1 0.67 0.62 0.22
44 INT310369 Protein_catabolism of Trib3 2 0.01 0.43 0.2
45 INT161469 Regulation of Bmi1 1 0.61 2.41 0.19
46 INT188059 Transcription of Trib3 3 0.05 1.07 0.18
47 INT323897 Positive_regulation of Gene_expression of BMI1 2 0.22 3.8 0.17
48 INT67625 Positive_regulation of Regulation of Trib3 1 0.10 0.24 0.17
49 INT210123 Localization of Axin1 1 0.04 0.84 0.17
50 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
51 INT202796 Regulation of Negative_regulation of Pin1 1 0.59 0.23 0.15
52 INT202797 Negative_regulation of Binding of Pin1 1 0.41 0.74 0.15
53 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
54 INT289345 Positive_regulation of Negative_regulation of Trib3 2 0.03 0.54 0.13
55 INT161470 Regulation of Negative_regulation of Bmi1 1 0.27 1.49 0.13
56 INT161473 Negative_regulation of Bmi1 1 0.42 1.49 0.13
57 INT188062 Regulation of Transcription of Trib3 1 0.02 0.25 0.12
58 INT202794 Negative_regulation of Protein_catabolism of Pin1 1 0.41 0.15 0.11
59 INT202793 Protein_catabolism of Pin1 1 0.63 0.15 0.11
60 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
61 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
62 INT245267 Negative_regulation of Trib3 1 0.21 0.64 0.08
63 INT69139 Gene_expression of Trib3 1 0.01 0.68 0.07
64 INT161472 Positive_regulation of Gene_expression of Bmi1 1 0.68 1.43 0.06
65 INT234134 Positive_regulation of Transcription of Trib3 1 0.03 0.12 0.06
66 INT304935 Transcription of Bmi1 1 0.08 0.65 0.05
67 INT244699 Positive_regulation of AXIN1 1 0.02 0 0.05
68 INT237226 Gene_expression of Plk1 3 0.59 0.78 0
69 INT267272 Transcription of BMI1 2 0.48 1.35 0
70 INT249774 Positive_regulation of Plk1 2 0.41 0.25 0
71 INT294025 Phosphorylation of AXIN1 2 0.38 0.47 0
72 INT287932 Negative_regulation of Binding of AXIN1 1 0.12 0 0
73 INT271928 Binding of Plk1 1 0.07 0.29 0
74 INT234133 Negative_regulation of Gene_expression of Trib3 1 0.03 0.13 0
75 INT332370 Regulation of Plk1 1 0.21 0.13 0
76 INT332346 Phosphorylation of Plk1 1 0.62 0 0
77 INT249761 Transcription of Plk1 1 0.60 0.12 0
78 INT249770 Positive_regulation of Gene_expression of Plk1 1 0.44 0.12 0
79 INT332343 Positive_regulation of Phosphorylation of Plk1 1 0.38 0 0
80 INT217687 Negative_regulation of Positive_regulation of BMI1 1 0.01 0.69 0
81 INT271923 Regulation of Binding of Plk1 1 0.09 0.29 0
82 INT267271 Regulation of Gene_expression of BMI1 1 0.25 0.7 0
83 INT237227 Negative_regulation of Gene_expression of Plk1 1 0.08 0.54 0
84 INT217690 Negative_regulation of Negative_regulation of BMI1 1 0.01 0.76 0
85 INT287935 Positive_regulation of Binding of AXIN1 1 0.14 0 0
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