GO:0051444

From wiki-pain
Jump to: navigation, search
Name negative regulation of ubiquitin-protein ligase activity
Categary Process
Go Slim No
Go Link GO:0051444
Unique Molecular Interactions 102
Total Molecular Interactions 144
Total Single Events 1666
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of ubiquitin-protein ligase activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of ubiquitin-protein ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
3 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
4 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
5 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
6 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
7 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
8 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
9 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
10 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
11 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
12 INT251347 Binding of Bmpr2 and Limk1 1 0.18 1.51 0.16
13 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
14 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
15 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
16 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
17 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
18 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
19 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
20 INT228808 Smad7 Regulation of Rgs1 1 0.19 0.24 0.09
21 INT228812 Smad7 Regulation of Stap1 1 0.00 0.24 0.09
22 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
23 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
24 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
25 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
26 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08
27 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
28 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
29 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
30 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
31 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
32 INT134838 TGFB1 Positive_regulation of SMAD7 1 0.52 0.79 0.08
33 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
34 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
35 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
36 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
37 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
38 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
39 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
40 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
41 INT353287 Prdx2 Positive_regulation of Phosphorylation of Smad7 1 0.22 0.06 0.03
42 INT353291 Prdx2 Positive_regulation of Smad7 1 0.31 0.06 0.03
43 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
44 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
45 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
46 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03
47 INT120077 Gene_expression of Smad7 Negative_regulation of Positive_regulation of Itk 1 0.02 0.27 0
48 INT192227 VEGFA Positive_regulation of Phosphorylation of LIMK1 1 0.03 0.05 0
49 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
50 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
51 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
52 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
53 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
54 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
55 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
56 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
57 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
58 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
59 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0
60 INT218663 Olr811 Positive_regulation of Gene_expression of Smad7 1 0.01 0.45 0
61 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
62 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
63 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
64 INT134836 Binding of SMAD7 and YAP1 1 0.53 0.89 0
65 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
66 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0
67 INT310188 Binding of Adcyap1r1 and Smad7 1 0.00 0 0
68 INT347155 Mirlet7a-1 Negative_regulation of Smad7 1 0.10 0 0
69 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
70 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
71 INT184956 ID1 Negative_regulation of CDKN2A 1 0.42 0.21 0
72 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
73 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0
74 INT215699 Cdkn2a Negative_regulation of Cdkn1c 1 0.01 0 0
75 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
76 INT215696 Cdkn2a Negative_regulation of Kras 1 0.00 0 0
77 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
78 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
79 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
80 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
81 INT329677 CDKN2A Regulation of CBX7 1 0.31 2.23 0
82 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0
83 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
84 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
85 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
86 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
87 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
88 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
89 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
90 INT314685 TBX2 Negative_regulation of CDKN2A 1 0.32 1.16 0
91 INT329679 CBX7 Regulation of CDKN2A 1 0.31 4.18 0
92 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
93 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 0.34 1.16 0
94 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0
95 INT311403 CDKN2A Regulation of Celf1 1 0.41 0.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of ubiquitin-protein ligase activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of ubiquitin-protein ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
2 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
3 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
4 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
5 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
6 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
7 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
8 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
9 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
10 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
11 INT251332 Negative_regulation of Limk1 1 0.59 16.43 4.66
12 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
13 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69
14 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
15 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
16 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
17 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
18 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
19 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
20 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
21 INT163544 Binding of Psen1 40 0.36 15.28 2.42
22 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
23 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
24 INT60723 Localization of Psen2 5 0.68 2.11 2.02
25 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
26 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
27 INT174924 Gene_expression of Smad7 6 0.41 3.59 1.76
28 INT174923 Positive_regulation of Gene_expression of Smad7 3 0.37 2.3 1.73
29 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
30 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
31 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
32 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
33 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25
34 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
35 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
36 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
37 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
38 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
39 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
40 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
41 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
42 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
43 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
44 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
45 INT78649 Binding of Psen2 7 0.36 5.9 0.73
46 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
47 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72
48 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
49 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
50 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
51 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
52 INT251322 Positive_regulation of Limk1 1 0.50 2.05 0.55
53 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
54 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
55 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
56 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
57 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
58 INT120074 Regulation of Gene_expression of Smad7 1 0.58 2.05 0.5
59 INT251323 Negative_regulation of Gene_expression of Limk1 1 0.43 1.26 0.5
60 INT251326 Gene_expression of Limk1 1 0.67 1.87 0.47
61 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
62 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
63 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
64 INT224538 Negative_regulation of Gene_expression of Smad7 1 0.09 0.25 0.43
65 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
66 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
67 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
68 INT193856 Localization of Psen1 19 0.73 9.79 0.41
69 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
70 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
71 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
72 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
73 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
74 INT134840 Gene_expression of SMAD7 1 0.74 2.74 0.31
75 INT184716 Binding of Smad7 2 0.34 0.91 0.29
76 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
77 INT251325 Regulation of Negative_regulation of Limk1 1 0.62 2.3 0.29
78 INT272890 Regulation of Negative_regulation of Smad7 1 0.19 1.33 0.29
79 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
80 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
81 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
82 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
83 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
84 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
85 INT228793 Negative_regulation of Gene_expression of Smad7 5 0.25 2.33 0.23
86 INT251317 Binding of Limk1 1 0.37 1.69 0.23
87 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
88 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
89 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
90 INT251318 Localization of Limk1 1 0.71 0.46 0.16
91 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
92 INT228790 Positive_regulation of Smad7 4 0.41 0.58 0.15
93 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
94 INT149305 Regulation of LIMK1 1 0.21 1 0.14
95 INT149304 Binding of LIMK1 1 0.13 1.05 0.14
96 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
97 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
98 INT251330 Regulation of Binding of Limk1 1 0.45 1.06 0.13
99 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
100 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
101 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
102 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
103 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
104 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
105 INT109131 Regulation of PSEN2 3 0.44 0.55 0.08
106 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
107 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
108 INT353267 Negative_regulation of Positive_regulation of Smad7 1 0.25 0.32 0.08
109 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
110 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
111 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
112 INT176592 Transcription of PSEN2 5 0.33 0.41 0.05
113 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
114 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
115 INT347149 Localization of Smad7 1 0.67 0 0.05
116 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
117 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
118 INT192242 Phosphorylation of LIMK1 4 0.61 0.34 0.04
119 INT343552 Gene_expression of LIMK1 1 0.65 0.15 0.04
120 INT350515 Transcription of SMAD7 1 0.07 0.38 0.03
121 INT353280 Phosphorylation of Smad7 1 0.48 0.06 0.03
122 INT224302 Negative_regulation of Transcription of PSEN2 3 0.26 0.08 0
123 INT94773 Negative_regulation of Gene_expression of Cdkn2a 3 0.41 0.65 0
124 INT282090 Regulation of Cdkn2a 2 0.33 2.02 0
125 INT265229 Binding of PSEN2 2 0.16 1.37 0
126 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0
127 INT147151 Positive_regulation of Negative_regulation of CDKN2A 2 0.47 1.74 0
128 INT286327 Regulation of Binding of Psen1 1 0.33 0.16 0
129 INT234250 Positive_regulation of Negative_regulation of PSEN1 1 0.41 0 0
130 INT347148 Regulation of Smad7 1 0.26 0 0
131 INT308400 Negative_regulation of Regulation of CDKN2A 1 0.40 0.87 0
132 INT193886 Regulation of Protein_catabolism of Psen1 1 0.44 0.06 0
133 INT172979 Regulation of Negative_regulation of CDKN2A 1 0.44 0.57 0
134 INT193934 Positive_regulation of Binding of PSEN1 1 0.49 0.92 0
135 INT224297 Regulation of Transcription of PSEN2 1 0.20 0.06 0
136 INT281254 Negative_regulation of Negative_regulation of CDKN2A 1 0.08 1.44 0
137 INT147147 Positive_regulation of Transcription of CDKN2A 1 0.49 0 0
138 INT218701 Negative_regulation of Binding of Smad7 1 0.14 0.15 0
139 INT331407 Negative_regulation of Transcription of Psen1 1 0.04 0.08 0
140 INT251333 Regulation of Limk1 1 0.45 0 0
141 INT166121 Binding of SMAD7 1 0.30 0.39 0
142 INT353273 Negative_regulation of Phosphorylation of Smad7 1 0.25 0 0
143 INT177774 Transcription of PSEN1 1 0.33 0.09 0
144 INT192240 Positive_regulation of Phosphorylation of LIMK1 1 0.22 0.17 0
145 INT185285 Negative_regulation of Transcription of CDKN2A 1 0.43 1.12 0
146 INT347145 Transcription of Smad7 1 0.68 0 0
147 INT184623 Positive_regulation of Localization of CDKN2A 1 0.04 0.86 0
148 INT192241 Negative_regulation of Phosphorylation of LIMK1 1 0.14 0.06 0
149 INT247424 Transcription of Cdkn2a 1 0.47 0.82 0
150 INT354892 Negative_regulation of Psen2 1 0.37 0.95 0
151 INT355162 Regulation of Localization of CDKN2A 1 0.40 1.13 0
152 INT193844 Positive_regulation of Protein_catabolism of Psen1 1 0.49 0.05 0
153 INT331463 Regulation of Gene_expression of PSEN2 1 0.04 0 0
154 INT218685 Binding of Smad7 1 0.13 0.15 0
155 INT234258 Negative_regulation of Phosphorylation of PSEN1 1 0.35 0.49 0
156 INT247425 Regulation of Transcription of Cdkn2a 1 0.18 0.82 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox