GO:0051453

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Name regulation of intracellular pH
Categary Process
Go Slim No
Go Link GO:0051453
Unique Molecular Interactions 91
Total Molecular Interactions 110
Total Single Events 996
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of intracellular pH. They are ordered first by their pain relevance and then by number of times they were reported for regulation of intracellular pH. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
2 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
3 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
4 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
5 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
6 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
7 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
8 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
9 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
10 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
11 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
12 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
13 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
14 INT298448 Binding of SLC4A1 and Slc4a3 1 0.39 1.89 0.15
15 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
16 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
17 INT212139 Slc4a3 Positive_regulation of Cl 1 0.07 0 0.12
18 INT212138 Slc4a3 Positive_regulation of Gene_expression of Cl 1 0.07 0 0.12
19 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
20 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
21 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
22 INT350106 Binding of SLC4A3 and SLC4A1 1 0.13 2.78 0.09
23 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
24 INT137255 BCL2L11 Regulation of SLC4A3 1 0.10 0.99 0.08
25 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
26 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
27 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
28 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
29 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
30 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
31 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
32 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
33 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
34 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
35 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
36 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
37 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
38 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
39 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
40 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
41 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
42 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
43 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
44 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
45 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0
46 INT315395 Regulation of Binding of IFNA1 and Tp53 1 0.00 0.46 0
47 INT315221 Tpt1 Regulation of Positive_regulation of Trp53 1 0.33 1.04 0
48 INT232006 Binding of Trp53 and Tsp1 1 0.06 0.75 0
49 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
50 INT333688 Trp53 Positive_regulation of Bcl2 1 0.45 2.51 0
51 INT333690 Hr Negative_regulation of Transcription of Trp53 1 0.23 0.51 0
52 INT342007 Mta1 Regulation of Trp53 1 0.15 0.15 0
53 INT179095 Myc Positive_regulation of Gene_expression of Trp53 1 0.43 0.83 0
54 INT315397 Binding of IFNA1 and Tp53 1 0.00 0.43 0
55 INT333689 Hr Positive_regulation of Protein_catabolism of Trp53 1 0.25 1.71 0
56 INT286044 Wwox Positive_regulation of Tp53 1 0.05 0.63 0
57 INT305542 Binding of Rb1 and Trp53 1 0.00 0.9 0
58 INT352625 Trp53 Regulation of CEL 1 0.00 0.71 0
59 INT337708 Naf1 Regulation of Gene_expression of Tp53 1 0.09 0.22 0
60 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
61 INT193118 Trp53 Regulation of Gene_expression of Birc5 1 0.19 0.86 0
62 INT225564 Ncoa6 Regulation of Trp53 1 0.04 0.93 0
63 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0
64 INT276380 Binding of PIM1 and Trp53 1 0.01 0.66 0
65 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0
66 INT305540 Binding of Trp53 and Tpt1 1 0.07 0.9 0
67 INT333697 Binding of Hr and Trp53 1 0.19 0.56 0
68 INT179090 Positive_regulation of Myc Regulation of Gene_expression of Trp53 1 0.23 0.69 0
69 INT301466 Smyd2 Negative_regulation of Binding of Trp53 1 0.20 0.3 0
70 INT301468 Smyd2 Negative_regulation of Trp53 1 0.20 0.31 0
71 INT351977 Binding of Tp53 and Trib3 1 0.01 0.79 0
72 INT333695 Trp53 Positive_regulation of Localization of Bcl2l1 1 0.23 1.33 0
73 INT333693 Hr Negative_regulation of Gene_expression of Trp53 1 0.27 0.9 0
74 INT333681 Trp53 Regulation of Negative_regulation of Bax 1 0.15 1.17 0
75 INT333691 Trp53 Positive_regulation of Bcl2l1 1 0.23 1.33 0
76 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
77 INT305541 Binding of Bcl2 and Trp53 1 0.05 0.9 0
78 INT351976 Binding of Tp53 and Stk11 1 0.13 2.3 0
79 INT286029 Binding of Tp53 and Atf2 1 0.03 0.33 0
80 INT305539 Binding of Mki67 and Trp53 1 0.20 0.91 0
81 INT352614 Negative_regulation of Binding of Mdm2 and Trp53 1 0.19 1.16 0
82 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
83 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
84 INT342251 Binding of Trp53 and Tymp 1 0.21 1.01 0
85 INT305543 Binding of Top2a and Trp53 1 0.37 0.91 0
86 INT333687 Trp53 Positive_regulation of Localization of Bcl2 1 0.45 1.24 0
87 INT301465 Mdm4 Negative_regulation of Trp53 1 0.13 0.35 0
88 INT333686 Gene_expression of Hr Negative_regulation of Gene_expression of Trp53 1 0.23 1.02 0
89 INT253022 PTTG1 Negative_regulation of Negative_regulation of Trp53 1 0.03 1.34 0
90 INT265547 Positive_regulation of Tp53 Positive_regulation of Gene_expression of Kras 1 0.01 0.93 0
91 INT193119 Trp53 Regulation of Birc5 1 0.19 0.55 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of intracellular pH. They are ordered first by their pain relevance and then by number of times they were reported in regulation of intracellular pH. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
2 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
3 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
4 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
5 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
6 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
7 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
8 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
9 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
10 INT149125 Gene_expression of Slc4a3 25 0.78 3.45 2.41
11 INT48217 Gene_expression of SLC4A3 22 0.75 21.12 2.17
12 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
13 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
14 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
15 INT172953 Binding of Trp53 33 0.37 20.76 1.41
16 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
17 INT145221 Binding of Tp53 10 0.37 8.59 1.37
18 INT174156 Localization of Trp53 16 0.72 13.52 1.18
19 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
20 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
21 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
22 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
23 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
24 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
25 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
26 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
27 INT113859 Positive_regulation of SLC4A3 3 0.21 2.6 0.39
28 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
29 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
30 INT149126 Regulation of Gene_expression of Slc4a3 1 0.62 0.16 0.3
31 INT212132 Negative_regulation of Slc4a3 1 0.43 1.17 0.3
32 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
33 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
34 INT212127 Positive_regulation of Gene_expression of Slc4a3 1 0.50 0.93 0.23
35 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
36 INT212136 Positive_regulation of Slc4a3 1 0.70 0.54 0.17
37 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
38 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
39 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
40 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
41 INT212135 Localization of Slc4a3 2 0.73 0.35 0.13
42 INT212129 Transcription of Slc4a3 1 0.69 0.07 0.13
43 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
44 INT95691 Negative_regulation of SLC4A3 1 0.18 0.92 0.12
45 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
46 INT111139 Localization of Tp53 4 0.45 2.4 0.09
47 INT188168 Binding of Slc4a3 4 0.47 1.06 0.07
48 INT352605 Regulation of Negative_regulation of Trp53 1 0.45 0.72 0.07
49 INT156738 Binding of SLC4A3 1 0.36 0.83 0.07
50 INT315213 Negative_regulation of Binding of Trp53 1 0.32 0.11 0.05
51 INT305536 Positive_regulation of Binding of Trp53 1 0.35 0.32 0.04
52 INT178927 Regulation of Gene_expression of Tp53 6 0.26 2.23 0
53 INT333669 Positive_regulation of Transcription of Trp53 3 0.45 2.33 0
54 INT214913 Positive_regulation of Positive_regulation of Tp53 2 0.08 2.47 0
55 INT204059 Positive_regulation of Phosphorylation of Tp53 1 0.07 0.76 0
56 INT333668 Regulation of Protein_catabolism of Trp53 1 0.24 1.58 0
57 INT333671 Regulation of Transcription of Trp53 1 0.24 0.83 0
58 INT212134 Regulation of Slc4a3 1 0.62 0.34 0
59 INT179076 Negative_regulation of Protein_catabolism of Trp53 1 0.32 0.43 0
60 INT179957 Positive_regulation of Binding of Tp53 1 0.08 0.48 0
61 INT333663 Positive_regulation of Protein_catabolism of Trp53 1 0.45 0.84 0
62 INT333662 Negative_regulation of Transcription of Trp53 1 0.53 1.15 0
63 INT223765 Negative_regulation of Positive_regulation of Tp53 1 0.07 1.69 0
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