GO:0051466

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Name positive regulation of corticotropin-releasing hormone secretion
Categary Process
Go Slim No
Go Link GO:0051466
Unique Molecular Interactions 125
Total Molecular Interactions 252
Total Single Events 1091
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of corticotropin-releasing hormone secretion. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of corticotropin-releasing hormone secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
2 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
3 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86
4 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
5 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
6 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77
7 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
8 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
9 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7
10 INT187220 Il11 Positive_regulation of Gene_expression of Tnfsf11 1 0.13 0.86 0.69
11 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55
12 INT254279 Il13 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
13 INT254280 Il4 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
14 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51
15 INT187227 Vip Negative_regulation of Gene_expression of Tnfsf11 1 0.35 1.23 0.51
16 INT207394 IL1B Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.95 0.51
17 INT207395 TNF Regulation of Gene_expression of Tnfsf11 1 0.11 0.91 0.49
18 INT231732 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
19 INT231733 Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
20 INT346130 Il17a Positive_regulation of Gene_expression of TNFSF11 1 0.08 0.61 0.41
21 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33
22 INT165764 Tnfsf11 Positive_regulation of Mapk3 1 0.17 1.08 0.33
23 INT165765 Tnfsf11 Positive_regulation of Nfkb1 1 0.01 1.07 0.33
24 INT165763 Tnfsf11 Positive_regulation of Phosphorylation of Mapk3 1 0.40 1.08 0.33
25 INT187223 Il1 Positive_regulation of Gene_expression of Tnfsf11 1 0.09 0.64 0.32
26 INT188804 S100a8 Positive_regulation of Gene_expression of Tnfsf11 1 0.00 0.7 0.31
27 INT144500 CCL3 Positive_regulation of Gene_expression of Tnfsf11 1 0.77 1.62 0.31
28 INT224422 Regulation of Binding of NFKB2 and TNFSF11 1 0.13 0.69 0.3
29 INT224418 Binding of NFKB2 and TNFSF11 1 0.11 0.68 0.3
30 INT301279 Tnfsf11 Regulation of Gene_expression of Mmp9 1 0.13 0.34 0.21
31 INT171973 Tnfsf11 Positive_regulation of Gene_expression of Il1 1 0.06 0.21 0.21
32 INT171972 Tnfsf11 Positive_regulation of Gene_expression of Il6 1 0.08 0.21 0.21
33 INT301281 Tnfsf11 Regulation of Gene_expression of Clec5a 1 0.22 0.34 0.21
34 INT188801 Il6 Positive_regulation of Positive_regulation of Tnfsf11 1 0.06 0.46 0.21
35 INT301290 Tnfsf11 Positive_regulation of Nfatc1 1 0.15 0.65 0.2
36 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
37 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19
38 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19
39 INT355365 CSF1 Positive_regulation of Tnfsf11 1 0.03 1.49 0.19
40 INT355366 Regulation of CSF1 Positive_regulation of Tnfsf11 1 0.02 1.5 0.19
41 INT148531 Binding of TNFRSF11A and Tnfsf11 2 0.08 1.77 0.17
42 INT148532 Binding of CCL3 and Tnfsf11 1 0.03 0.71 0.14
43 INT81992 IL1A Positive_regulation of Positive_regulation of Tnfsf11 1 0.05 0.27 0.13
44 INT301284 Tnfsf11 Positive_regulation of Localization of Nfatc1 1 0.16 0.32 0.11
45 INT93535 PTH Negative_regulation of Gene_expression of Tnfsf11 1 0.19 0.22 0.11
46 INT107909 Binding of Tnfsf11 and Tnfrsf22 1 0.01 2.12 0.11
47 INT254284 Binding of TNF and Tnfsf11 1 0.04 0.44 0.1
48 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09
49 INT210595 Binding of TNF and TNFSF11 1 0.10 5.13 0.09
50 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08
51 INT210600 IL1B Regulation of TNFSF11 1 0.04 1.45 0.08
52 INT338999 Binding of BTF3P11 and Tnfsf11 1 0.01 0.35 0.08
53 INT210601 IL8 Positive_regulation of TNFSF11 1 0.06 1.46 0.08
54 INT321867 TNFRSF11B Negative_regulation of TNFSF11 1 0.00 0.85 0.08
55 INT205158 Gene_expression of SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 1.08 0.08
56 INT334061 Negative_regulation of Binding of TNFRSF11A and Tnfsf11 1 0.01 0.52 0.08
57 INT321868 Binding of TNFRSF11B and Negative_regulation of TNFSF11 1 0.00 0.91 0.08
58 INT210599 IL8 Regulation of TNFSF11 1 0.05 1.44 0.08
59 INT254277 Binding of Hand1 and Tnfsf11 1 0.02 0.08 0.08
60 INT127722 CSF1 Positive_regulation of TNFSF11 1 0.08 0.26 0.06
61 INT314369 Tnfsf11 Negative_regulation of Gene_expression of Tnfrsf11b 1 0.08 2.2 0.05
62 INT224421 TNFRSF11B Regulation of TNFSF11 1 0.27 0 0.05
63 INT210596 TNFRSF11B Negative_regulation of Binding of TNFSF11 2 0.11 1.62 0.04
64 INT232206 Binding of Tgfb1 and Tnfsf11 1 0.02 0.52 0.04
65 INT210598 PTHLH Positive_regulation of Gene_expression of TNFSF11 1 0.23 0.98 0.04
66 INT217474 Tnfrsf11a Regulation of Gene_expression of Tnfsf11 1 0.41 1.2 0.04
67 INT340276 Tnfsf11 Positive_regulation of Localization of RELA 1 0.02 0.58 0.03
68 INT165988 PTGER1 Positive_regulation of TNFSF11 1 0.05 0.13 0
69 INT340270 Negative_regulation of Tnfsf11 Positive_regulation of TRAP 1 0.03 0.37 0
70 INT205159 SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 0.8 0
71 INT298585 TNFSF11 Positive_regulation of ACP5 1 0.16 0.09 0
72 INT165986 PTGER1 Regulation of Positive_regulation of TNFSF11 1 0.04 0.12 0
73 INT210581 Binding of AMELX and Tnfsf11 1 0.01 0.15 0
74 INT298586 PTGER2 Regulation of Gene_expression of TNFSF11 1 0.06 0 0
75 INT217480 Tnfsf11 Negative_regulation of Tnfrsf11a 1 0.39 0.75 0
76 INT298587 TNFSF11 Regulation of IL1B 1 0.18 0 0
77 INT270778 Binding of TNFSF11 and CALCRL 1 0.00 0.44 0
78 INT210580 Negative_regulation of Binding of TNFRSF11A and Tnfsf11 1 0.07 0.19 0
79 INT135179 DCSTAMP Positive_regulation of Gene_expression of TNFSF11 1 0.06 0 0
80 INT340277 Tnfsf11 Positive_regulation of TRAP 1 0.03 0.76 0
81 INT340272 Tnfsf11 Positive_regulation of Gene_expression of NFATC1 1 0.09 0.56 0
82 INT165987 PTGER1 Regulation of Gene_expression of TNFSF11 1 0.06 0.16 0
83 INT298582 IL1B Regulation of Gene_expression of TNFSF11 1 0.46 0 0
84 INT340238 Tnfsf11 Positive_regulation of Gene_expression of Fig4 1 0.02 0.4 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of corticotropin-releasing hormone secretion. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of corticotropin-releasing hormone secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
2 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
3 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
4 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
5 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
6 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
7 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16
8 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99
9 INT93531 Negative_regulation of Gene_expression of Tnfsf11 15 0.43 7.74 2.84
10 INT132846 Localization of Tnfsf11 17 0.69 10.28 2.78
11 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4
12 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39
13 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39
14 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82
15 INT182643 Binding of TNFSF11 15 0.35 13.12 1.61
16 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46
17 INT105551 Transcription of Tnfsf11 6 0.69 4.21 1.38
18 INT135181 Regulation of Gene_expression of TNFSF11 5 0.61 6.98 1.27
19 INT135186 Negative_regulation of Gene_expression of TNFSF11 10 0.58 2.69 1.25
20 INT105552 Positive_regulation of Transcription of Tnfsf11 3 0.31 2.94 1.17
21 INT224429 Regulation of TNFSF11 8 0.61 4.35 1.13
22 INT210586 Negative_regulation of Positive_regulation of Tnfsf11 3 0.41 1.4 1.02
23 INT132847 Negative_regulation of Localization of Tnfsf11 1 0.32 0.16 1.01
24 INT171963 Positive_regulation of Positive_regulation of Tnfsf11 3 0.42 2.44 0.93
25 INT294998 Positive_regulation of Gene_expression of Tnfsf11 5 0.62 2.98 0.79
26 INT298598 Positive_regulation of Positive_regulation of TNFSF11 2 0.38 1.26 0.72
27 INT165760 Positive_regulation of Binding of Tnfsf11 2 0.36 1.83 0.71
28 INT185729 Negative_regulation of Gene_expression of Tnfsf11 3 0.52 2.07 0.69
29 INT205171 Localization of TNFSF11 4 0.74 3.94 0.66
30 INT264991 Positive_regulation of Localization of Tnfsf11 5 0.24 3.22 0.59
31 INT207379 Regulation of Negative_regulation of Tnfsf11 2 0.28 1.7 0.5
32 INT340265 Localization of Tnfsf11 2 0.30 1.65 0.44
33 INT341289 Positive_regulation of Localization of Tnfsf11 1 0.13 1.26 0.44
34 INT137846 Regulation of Tnfsf11 5 0.48 1.62 0.42
35 INT165761 Phosphorylation of Tnfsf11 3 0.75 2.76 0.4
36 INT187214 Negative_regulation of Binding of Tnfsf11 1 0.25 1.01 0.38
37 INT135188 Transcription of TNFSF11 4 0.59 0.72 0.36
38 INT295000 Binding of Tnfsf11 5 0.32 2.27 0.32
39 INT137847 Negative_regulation of Tnfsf11 4 0.42 1.31 0.24
40 INT210588 Protein_catabolism of Tnfsf11 1 0.72 1.43 0.23
41 INT294997 Regulation of Gene_expression of Tnfsf11 1 0.35 0.81 0.13
42 INT210605 Negative_regulation of Negative_regulation of TNFSF11 2 0.42 1.65 0.1
43 INT224430 Positive_regulation of Transcription of TNFSF11 1 0.43 0.06 0.07
44 INT144491 Negative_regulation of Transcription of Tnfsf11 1 0.42 0.82 0.07
45 INT210608 Negative_regulation of Binding of TNFSF11 2 0.25 2.31 0.04
46 INT232197 Positive_regulation of Phosphorylation of Tnfsf11 1 0.46 0.6 0.04
47 INT232196 Negative_regulation of Negative_regulation of Tnfsf11 1 0.39 1.5 0.04
48 INT210609 Positive_regulation of Localization of TNFSF11 1 0.41 1.12 0.04
49 INT210591 Positive_regulation of Negative_regulation of Tnfsf11 1 0.47 1.46 0.03
50 INT221486 Positive_regulation of Binding of TNFSF11 1 0.15 0.98 0
51 INT274022 Regulation of Positive_regulation of TNFSF11 1 0.05 0.29 0
52 INT205176 Protein_catabolism of TNFSF11 1 0.29 0.25 0
53 INT185731 Negative_regulation of Regulation of Tnfsf11 1 0.34 0.89 0
54 INT329484 Regulation of Regulation of TNFSF11 1 0.23 0.71 0
55 INT185728 Positive_regulation of Positive_regulation of Tnfsf11 1 0.36 0.25 0
56 INT340267 Negative_regulation of Localization of Tnfsf11 1 0.19 0.45 0
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