GO:0051481

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Name reduction of cytosolic calcium ion concentration
Categary Process
Go Slim No
Go Link GO:0051481
Unique Molecular Interactions 549
Total Molecular Interactions 777
Total Single Events 6751
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for reduction of cytosolic calcium ion concentration. They are ordered first by their pain relevance and then by number of times they were reported for reduction of cytosolic calcium ion concentration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
4 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
5 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
6 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
7 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
8 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
9 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
10 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
11 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
12 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
13 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
14 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
15 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
16 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
17 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
18 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
19 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
20 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
21 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
22 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
23 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
24 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
25 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
26 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
27 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
28 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
29 INT91860 Npy Regulation of Npy1r 2 0.28 1.13 2.24
30 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
31 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
32 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
33 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
34 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
35 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
36 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
37 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
38 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
39 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
40 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
41 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
42 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
43 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
44 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
45 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
46 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
47 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
48 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
49 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
50 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
51 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
52 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
53 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
54 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
55 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
56 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
57 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
58 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
59 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
60 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
61 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
62 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
63 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
64 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
65 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
66 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
67 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
68 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
69 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
70 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
71 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
72 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
73 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
74 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
75 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
76 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
77 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
78 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
79 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
80 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5
81 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
82 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
83 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
84 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
85 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46
86 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
87 INT141674 Oprm1 Positive_regulation of Ltp 1 0.13 0 1.46
88 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
89 INT131039 Binding of Oprm1 and Prf1 1 0.17 0 1.45
90 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45
91 INT131040 Binding of Oprm1 and S100a9 1 0.24 0 1.45
92 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
93 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
94 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43
95 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
96 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
97 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
98 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
99 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
100 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
101 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
102 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
103 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
104 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
105 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
106 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
107 INT139987 Oprm1 Positive_regulation of Localization of Oprl1 1 0.16 0.17 1.35
108 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
109 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
110 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
111 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
112 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
113 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
114 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
115 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
116 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
117 INT130786 Positive_regulation of Oprm1 Positive_regulation of Arc 1 0.27 0.9 1.31
118 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
119 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3
120 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29
121 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
122 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
123 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
124 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27
125 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
126 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
127 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
128 INT207548 U Negative_regulation of Gene_expression of Oprm1 1 0.01 0.46 1.26
129 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
130 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
131 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
132 INT87375 Binding of Gabrg1 and Oprm1 1 0.00 0.83 1.25
133 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25
134 INT151444 Binding of Oprm1 and Pag1 1 0.00 1.5 1.24
135 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
136 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
137 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
138 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
139 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
140 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
141 INT76165 IGKV2-30 Positive_regulation of Phosphorylation of Oprm1 1 0.00 0.08 1.22
142 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
143 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
144 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
145 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
146 INT124157 Oprm1 Negative_regulation of Gnb5 1 0.25 0.4 1.19
147 INT133496 Binding of Oprm1 and Cckbr 1 0.15 0 1.19
148 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
149 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
150 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
151 INT153588 Binding of HINT1 and Oprm1 1 0.06 0 1.17
152 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
153 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
154 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
155 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
156 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
157 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
158 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12
159 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12
160 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
161 INT69338 Binding of Oprd1 and Oprm1 1 0.24 0.26 1.11
162 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
163 INT133497 Binding of Oprm1 and Cckbr 1 0.03 0 1.1
164 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
165 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1
166 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
167 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09
168 INT114007 Binding of Crygs and Oprm1 1 0.03 0 1.09
169 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08
170 INT317561 Binding of Grin1 and Oprm1 1 0.14 0.09 1.08
171 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06
172 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
173 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
174 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
175 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
176 INT133075 TFAM Positive_regulation of Transcription of OPRM1 1 0.03 0 1.04
177 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
178 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03
179 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02
180 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
181 INT106956 Oprm1 Positive_regulation of Positive_regulation of P9Ehs1 1 0.08 0.54 1.02
182 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
183 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 0.28 0.38 1.01
184 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
185 INT98002 Positive_regulation of Oprm1 Positive_regulation of P9Ehs1 1 0.10 0 1
186 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
187 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
188 INT317532 Grin1 Regulation of Negative_regulation of Oprm1 1 0.18 0.07 1
189 INT70105 SCD Positive_regulation of Oprm1 1 0.01 0 1
190 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
191 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
192 INT317544 Camk2a Regulation of Negative_regulation of Oprm1 1 0.20 0.07 1
193 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
194 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
195 INT169500 Negative_regulation of Mirlet7a-1 Regulation of Oprm1 1 0.37 0 0.99
196 INT200323 Binding of Oprm1 and Sp3 1 0.39 0 0.99
197 INT65631 Ufm1 Positive_regulation of Kcna5 1 0.02 0 0.99
198 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
199 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
200 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98

Single Events

The table below shows the top 100 pain related interactions that have been reported for reduction of cytosolic calcium ion concentration. They are ordered first by their pain relevance and then by number of times they were reported in reduction of cytosolic calcium ion concentration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
3 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
4 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
5 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
6 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
7 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
8 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
9 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
10 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
11 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
12 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
13 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
14 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
15 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
16 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
17 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
18 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
19 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
20 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
21 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
22 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
23 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
24 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
25 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
26 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
27 INT13501 Binding of Drd2 65 0.48 23.76 35.6
28 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
29 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
30 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
31 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
32 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
33 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
34 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
35 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
36 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
37 INT12484 Binding of Drd2 45 0.48 15.17 24.72
38 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
39 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
40 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
41 INT49774 Binding of DRD2 48 0.48 17.42 20.73
42 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
43 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29
44 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66
45 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78
46 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
47 INT33915 Regulation of Positive_regulation of Oprm1 22 0.60 2.44 16.43
48 INT48540 Gene_expression of Kcna5 37 0.77 14.04 16.07
49 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
50 INT68811 Regulation of Transcription of Oprm1 19 0.61 3.67 15.15
51 INT12658 Regulation of Binding of Oprm1 9 0.57 2.44 14.95
52 INT49147 Gene_expression of Npy1r 27 0.76 6.57 14.75
53 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
54 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
55 INT68814 Positive_regulation of Transcription of Oprm1 16 0.60 2.72 13.57
56 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
57 INT62523 Positive_regulation of Phosphorylation of Oprm1 11 0.53 0.75 12.51
58 INT6044 Regulation of Binding of Oprm1 16 0.61 3.01 11.11
59 INT59766 Positive_regulation of Negative_regulation of Oprm1 9 0.50 1.31 11.08
60 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
61 INT65627 Negative_regulation of Kcna5 19 0.59 7.82 10.79
62 INT71592 Negative_regulation of Gene_expression of Oprm1 11 0.58 4.03 10.37
63 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
64 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
65 INT49483 Regulation of Positive_regulation of Oprm1 8 0.61 2.34 9.4
66 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
67 INT20835 Negative_regulation of Negative_regulation of Oprm1 10 0.43 0.56 8.96
68 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95
69 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
70 INT76162 Positive_regulation of Phosphorylation of Oprm1 11 0.69 0.64 8.72
71 INT98835 Positive_regulation of Transcription of Oprm1 15 0.65 2.47 8.67
72 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38
73 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85
74 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75
75 INT101721 Positive_regulation of Transcription of OPRM1 8 0.48 1.22 7.74
76 INT62372 Positive_regulation of Localization of Oprm1 8 0.50 0.46 7.71
77 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
78 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
79 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36
80 INT65630 Regulation of Kcna5 11 0.62 6.61 7.22
81 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
82 INT16628 Negative_regulation of Positive_regulation of Oprm1 9 0.43 0.89 6.92
83 INT62524 Negative_regulation of Phosphorylation of Oprm1 7 0.59 0.08 6.92
84 INT75228 Positive_regulation of Negative_regulation of Oprm1 8 0.49 0.95 6.9
85 INT7665 Negative_regulation of Npy1r 10 0.45 2.87 6.73
86 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
87 INT72350 Positive_regulation of Npy1r 15 0.63 6.28 6.55
88 INT5932 Regulation of Regulation of Oprm1 7 0.61 0.44 6.47
89 INT24460 Localization of Drd2 12 0.73 2.96 6.46
90 INT48541 Positive_regulation of Kcna5 12 0.69 5.51 6.35
91 INT42832 Negative_regulation of Positive_regulation of OPRM1 6 0.36 0.96 6.35
92 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21
93 INT86772 Localization of Drd2 14 0.80 1.93 6.17
94 INT53135 Positive_regulation of Localization of Oprm1 2 0.50 0 6.12
95 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97
96 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
97 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
98 INT110545 Regulation of Regulation of OPRM1 7 0.42 1.68 5.67
99 INT112927 Negative_regulation of Localization of Oprm1 4 0.39 0.31 5.59
100 INT32979 Positive_regulation of Localization of OPRM1 5 0.50 0 5.54
101 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
102 INT42833 Positive_regulation of Negative_regulation of OPRM1 6 0.48 0.12 4.95
103 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
104 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
105 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
106 INT47894 Regulation of Npy1r 5 0.33 3.08 4.27
107 INT105998 Protein_catabolism of Oprm1 5 0.95 0.88 4.08
108 INT73114 Gene_expression of Kcnk3 32 0.77 1.57 4.03
109 INT116181 Localization of Npy1r 10 0.79 2.17 3.94
110 INT168736 Binding of Npy1r 4 0.35 0.24 3.89
111 INT80882 Negative_regulation of Phosphorylation of OPRM1 4 0.45 0.21 3.68
112 INT76373 Positive_regulation of Gene_expression of Npy1r 6 0.38 1.84 3.64
113 INT5929 Positive_regulation of Regulation of Oprm1 4 0.50 0.56 3.48
114 INT8731 Regulation of Localization of Oprm1 3 0.43 0.25 3.4
115 INT13347 Regulation of Negative_regulation of OPRM1 5 0.45 0.64 3.38
116 INT68812 Regulation of Regulation of Oprm1 5 0.40 0.16 3.28
117 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
118 INT89986 Gene_expression of Il6st 5 0.56 2.35 3.15
119 INT108728 Regulation of ATP1A2 4 0.45 3.65 3.04
120 INT186507 Localization of ATP1A2 2 0.74 3.35 3.04
121 INT109496 Gene_expression of KCNK3 9 0.78 0.59 3.02
122 INT65628 Regulation of Gene_expression of Kcna5 4 0.61 1.66 2.98
123 INT72349 Transcription of Npy1r 3 0.41 1.76 2.93
124 INT77325 Regulation of Gene_expression of Npy1r 5 0.41 1.62 2.89
125 INT70377 Regulation of Transcription of Oprm1 3 0.47 0.93 2.78
126 INT85142 Gene_expression of Gtf2i 5 0.26 2.3 2.76
127 INT65629 Positive_regulation of Gene_expression of Kcna5 5 0.69 2.48 2.76
128 INT116215 Transcription of Kcna5 6 0.53 3.62 2.75
129 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
130 INT116216 Negative_regulation of Gene_expression of Kcna5 4 0.43 3.11 2.64
131 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
132 INT99800 Binding of Kcna5 4 0.47 0.96 2.55
133 INT64062 Negative_regulation of Regulation of OPRM1 2 0.41 0.3 2.48
134 INT114011 Negative_regulation of ATP1A2 5 0.45 6.12 2.41
135 INT60156 Regulation of Kcnk3 7 0.42 2.47 2.4
136 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
137 INT71952 Regulation of Negative_regulation of Oprm1 3 0.43 0.09 2.18
138 INT145539 Negative_regulation of KCNK3 3 0.59 0 2.07
139 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
140 INT32980 Positive_regulation of Regulation of OPRM1 2 0.45 0 1.98
141 INT62522 Regulation of Phosphorylation of Oprm1 3 0.13 0 1.96
142 INT142684 Protein_catabolism of OPRM1 2 0.66 0.48 1.81
143 INT131751 Localization of Kcna5 1 0.71 0 1.7
144 INT103959 Gene_expression of ATP1A2 3 0.67 2.47 1.68
145 INT134617 Gene_expression of Npy1r 2 0.57 1.3 1.63
146 INT132677 Regulation of Kcnk3 3 0.45 1.32 1.57
147 INT73112 Negative_regulation of Kcnk3 7 0.58 1.2 1.55
148 INT81828 Positive_regulation of Kcnk3 7 0.45 1.43 1.54
149 INT253403 Positive_regulation of Il6st 2 0.28 2.07 1.54
150 INT130552 Negative_regulation of Localization of Oprm1 2 0.31 0.37 1.53
151 INT75871 Negative_regulation of Positive_regulation of Npy1r 2 0.53 1.34 1.51
152 INT77322 Negative_regulation of Transcription of Npy1r 1 0.33 0.86 1.51
153 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
154 INT114013 Binding of ATP1A2 3 0.47 3.51 1.46
155 INT105997 Positive_regulation of Protein_catabolism of Oprm1 2 0.66 0.41 1.45
156 INT21106 Regulation of Phosphorylation of Oprm1 3 0.61 0 1.43
157 INT159009 Regulation of Il6st 2 0.18 2 1.41
158 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
159 INT118581 Positive_regulation of ATP1A2 3 0.21 1.81 1.4
160 INT115804 Regulation of Localization of OPRM1 2 0.33 0.12 1.33
161 INT85667 Negative_regulation of Negative_regulation of Oprm1 3 0.37 0.54 1.31
162 INT39503 Positive_regulation of KCNK3 3 0.47 0.09 1.29
163 INT90397 Positive_regulation of Kcnk3 3 0.68 1.31 1.29
164 INT67450 Negative_regulation of Localization of OPRM1 2 0.06 0.24 1.26
165 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
166 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
167 INT14138 Regulation of Localization of Oprm1 1 0.28 0 1.23
168 INT145919 Regulation of KCNK3 5 0.62 0.09 1.22
169 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
170 INT120576 Negative_regulation of Negative_regulation of Npy1r 1 0.20 0.29 1.2
171 INT77216 Localization of DRD2 3 0.75 0 1.19
172 INT129374 Negative_regulation of Regulation of Oprm1 3 0.43 0.58 1.18
173 INT122474 Negative_regulation of Npy1r 3 0.42 1.71 1.1
174 INT35786 Negative_regulation of Negative_regulation of OPRM1 2 0.33 0.91 1.1
175 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
176 INT177392 Binding of Npy1r 2 0.47 1.14 0.98
177 INT21108 Negative_regulation of Phosphorylation of Oprm1 2 0.43 0 0.98
178 INT134618 Regulation of Gene_expression of Npy1r 1 0.38 1.03 0.97
179 INT116179 Negative_regulation of Localization of Npy1r 1 0.38 0.32 0.96
180 INT116180 Positive_regulation of Localization of Npy1r 1 0.45 0.32 0.95
181 INT11273 Positive_regulation of Gtf2i 4 0.20 0.71 0.9
182 INT99801 Regulation of Binding of Kcna5 1 0.26 0.14 0.9
183 INT77324 Negative_regulation of Gene_expression of Npy1r 3 0.42 0.45 0.85
184 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
185 INT109570 Gene_expression of Kcnk3 3 0.75 2.18 0.81
186 INT109568 Negative_regulation of Kcnk3 2 0.37 0.86 0.8
187 INT123412 Negative_regulation of Transcription of Oprm1 2 0.56 0.06 0.79
188 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
189 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
190 INT16434 Regulation of Positive_regulation of Drd2 1 0.30 0 0.78
191 INT55921 Negative_regulation of Transcription of Oprm1 1 0.43 0 0.76
192 INT12885 Negative_regulation of Binding of Drd2 2 0.53 0.26 0.71
193 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69
194 INT15662 Positive_regulation of Transcription of Drd2 3 0.39 0 0.68
195 INT129375 Negative_regulation of Regulation of Oprm1 1 0.28 0.49 0.68
196 INT184840 Positive_regulation of Transcription of Drd2 2 0.35 1.03 0.65
197 INT333965 Binding of Il6st 1 0.08 0.9 0.65
198 INT77323 Regulation of Transcription of Npy1r 1 0.21 0.39 0.59
199 INT12483 Regulation of Binding of Drd2 1 0.38 0 0.57
200 INT47933 Positive_regulation of Localization of Drd2 1 0.10 0.23 0.56
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