GO:0051482

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Name elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger
Categary Process
Go Slim No
Go Link GO:0051482
Unique Molecular Interactions 1167
Total Molecular Interactions 1802
Total Single Events 22767
Pain Genes Associated 33

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger. They are ordered first by their pain relevance and then by number of times they were reported for elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
2 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
3 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
4 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
5 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
6 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
7 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
8 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
9 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
10 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
11 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
12 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
13 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
14 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
15 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
16 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
17 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
18 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
19 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
20 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
21 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
22 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
23 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
24 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
25 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
26 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
27 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
28 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
29 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
30 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
31 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
32 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
33 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
34 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
35 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
36 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
37 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
38 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
39 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
40 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
41 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
42 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
43 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
44 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
45 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
46 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02
47 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
48 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
49 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
50 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
51 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
52 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
53 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
54 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
55 INT163514 Ngf Positive_regulation of Gene_expression of Calca 1 0.30 2.21 1.82
56 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
57 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
58 INT24934 Calca Regulation of Nka1 3 0.05 0.43 1.73
59 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
60 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7
61 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
62 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
63 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
64 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
65 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
66 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66
67 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
68 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
69 INT24157 Binding of CALCA and SFTPA1 2 0.07 0.96 1.64
70 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
71 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
72 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
73 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
74 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
75 INT13968 Calca Negative_regulation of Positive_regulation of Sst 1 0.34 0 1.55
76 INT13970 Positive_regulation of Calca Positive_regulation of Sst 1 0.37 0 1.53
77 INT13965 Calca Positive_regulation of Positive_regulation of Sst 1 0.37 0 1.53
78 INT96784 Binding of CALCA and Calca 3 0.23 0.27 1.47
79 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
80 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
81 INT276681 Calca Regulation of Nav1 1 0.07 0.74 1.45
82 INT276686 Calca Regulation of Nav1 1 0.26 0.74 1.45
83 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44
84 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
85 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
86 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
87 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
88 INT144122 Binding of Calca and P2rx6 1 0.10 0 1.4
89 INT169163 Binding of Calca and Ctbs 1 0.00 0.51 1.4
90 INT51213 Vip Regulation of Localization of Calca 1 0.38 0 1.39
91 INT8719 Npy Negative_regulation of Localization of Calca 1 0.06 0.26 1.39
92 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
93 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
94 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
95 INT180810 Gopc Positive_regulation of Calca 1 0.02 0.28 1.36
96 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
97 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
98 INT151771 Binding of P2RX3 and Calca 1 0.04 0.89 1.34
99 INT298455 Calca Positive_regulation of Gene_expression of Ceacam3 1 0.17 0.47 1.34
100 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
101 INT180786 Calca Regulation of Positive_regulation of Ngf 1 0.40 0 1.32
102 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
103 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
104 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
105 INT180771 Calca Regulation of Positive_regulation of Bdnf 1 0.18 0 1.32
106 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
107 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
108 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
109 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29
110 INT148775 Binding of Calca and Usf1 1 0.43 0.85 1.29
111 INT194408 Regulation of Binding of CALCA and DCLK3 1 0.15 0 1.29
112 INT138210 Mzb1 Regulation of Calca 1 0.25 0.41 1.29
113 INT22501 Binding of Calca and Pth 1 0.21 0.07 1.28
114 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
115 INT88635 Ptger3 Positive_regulation of Localization of Calca 2 0.05 0 1.24
116 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
117 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
118 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
119 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
120 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
121 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
122 INT87586 RPL7AP5 Negative_regulation of Gene_expression of Calca 1 0.00 0.05 1.21
123 INT79471 Mgat4a Regulation of Calca 1 0.06 1.09 1.21
124 INT87585 RPL7AP5 Negative_regulation of Calca 1 0.00 0.05 1.21
125 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
126 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
127 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
128 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
129 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
130 INT194403 Negative_regulation of Binding of CALCA and DCLK3 1 0.22 0 1.18
131 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
132 INT287749 Dmbx1 Positive_regulation of Gene_expression of Lpar1 1 0.41 0.82 1.16
133 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
134 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
135 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
136 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 0.25 0.15 1.15
137 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
138 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
139 INT22176 Calca Regulation of Localization of Prl 4 0.69 0.39 1.11
140 INT4752 Gal Negative_regulation of Localization of Calca 1 0.41 0.06 1.11
141 INT282065 Binding of Calca and Ngf 1 0.14 0.85 1.11
142 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
143 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
144 INT4753 Sst Negative_regulation of Localization of Calca 1 0.39 0.06 1.1
145 INT70495 CALCA Positive_regulation of CALCB 2 0.40 0 1.08
146 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
147 INT69889 Ngf Regulation of Localization of Calca 1 0.49 0.1 1.08
148 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
149 INT91395 MMP2 Positive_regulation of CALCA 1 0.36 0.17 1.07
150 INT79372 Calca Regulation of Pnoc 1 0.34 0 1.07
151 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
152 INT139225 Calca Negative_regulation of Icam1 1 0.44 1.13 1.06
153 INT139229 Calca Negative_regulation of Cmklr1 1 0.19 1.12 1.06
154 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
155 INT139226 Icam1 Negative_regulation of Calca 1 0.44 1.12 1.05
156 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
157 INT231391 Binding of Lpar1 and Rbm39 1 0.00 1.04 1.04
158 INT130167 Trpv1 Regulation of Localization of Calca 2 0.38 0.69 1.03
159 INT86073 Med15 Regulation of Calca 1 0.49 0.2 1.03
160 INT114555 Binding of Calca and St3gal3 1 0.01 0.44 1.03
161 INT114552 Binding of Calca and Col4a4 1 0.01 0.44 1.02
162 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
163 INT51260 Calca Negative_regulation of Nts 1 0.10 0.08 1.01
164 INT51261 Calca Negative_regulation of Sst 1 0.20 0.08 1.01
165 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
166 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 0.19 0.33 1
167 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
168 INT112163 Calca Positive_regulation of Mpo 1 0.49 1.23 1
169 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 0.19 0.33 1
170 INT162299 Negative_regulation of Adarb1 Negative_regulation of Gene_expression of Calca 1 0.01 0.93 1
171 INT49163 Binding of Pax3 and Calca 1 0.03 0.37 0.98
172 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
173 INT24395 Binding of CALCA and CLPP 1 0.03 0.17 0.96
174 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
175 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
176 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95
177 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
178 INT148772 Usf1 Regulation of Calca 1 0.40 0.69 0.95
179 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
180 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
181 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
182 INT352447 Gse1 Negative_regulation of Gene_expression of Calca 1 0.03 0.98 0.94
183 INT24938 TAC1 Regulation of Calca 1 0.22 0.35 0.94
184 INT24939 TAC3 Regulation of Calca 1 0.01 0.35 0.94
185 INT331109 Tpnr1 Regulation of Gene_expression of Calca 1 0.06 0.97 0.94
186 INT231392 Enpp2 Positive_regulation of Gene_expression of Lpar1 2 0.38 2.19 0.93
187 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
188 INT248186 Cxcl1 Positive_regulation of Localization of CALCA 1 0.39 0.88 0.93
189 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
190 INT207149 Binding of F2r and Par2 1 0.17 1.64 0.92
191 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
192 INT196591 Binding of Lpar1 and Pax3 1 0.05 1.1 0.92
193 INT28656 Calca Negative_regulation of Localization of Gnrhr 1 0.19 0 0.91
194 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91
195 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
196 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
197 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
198 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
199 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
200 INT53153 fut10 Positive_regulation of Gene_expression of Calca 1 0.01 0 0.88

Single Events

The table below shows the top 100 pain related interactions that have been reported for elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger. They are ordered first by their pain relevance and then by number of times they were reported in elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84
3 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08
4 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04
5 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
6 INT2649 Regulation of Calca 433 0.62 146.05 330.95
7 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
8 INT626 Localization of CALCA 289 0.81 125.39 221.15
9 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57
10 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2
11 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47
12 INT2541 Binding of Calca 200 0.48 67.14 134.62
13 INT5008 Localization of Calca 204 0.81 80.35 125.16
14 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75
15 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61
16 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03
17 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
18 INT6761 Binding of CALCA 100 0.48 26.71 62.05
19 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
20 INT4241 Regulation of CALCA 87 0.62 28.19 55.29
21 INT4891 Transcription of Calca 81 0.72 35.27 53.75
22 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66
23 INT97674 Positive_regulation of Localization of Calca 70 0.69 27.71 51.79
24 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
25 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
26 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
27 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8
28 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17
29 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
30 INT13501 Binding of Drd2 65 0.48 23.76 35.6
31 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
32 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
33 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45
34 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
35 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
36 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76
37 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
38 INT22499 Regulation of Calca 42 0.62 17.32 28.02
39 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
40 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99
41 INT12484 Binding of Drd2 45 0.48 15.17 24.72
42 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
43 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
44 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
45 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
46 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
47 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45
48 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
49 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51
50 INT49774 Binding of DRD2 48 0.48 17.42 20.73
51 INT166115 Positive_regulation of Gene_expression of Lpar1 42 0.61 31 20.71
52 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
53 INT5048 Binding of Edn1 55 0.47 18.86 19.16
54 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
55 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
56 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
57 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
58 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
59 INT48055 Gene_expression of Grm1 27 0.78 14.29 17.01
60 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98
61 INT6150 Positive_regulation of Negative_regulation of Calca 20 0.68 4.06 16.26
62 INT153913 Positive_regulation of Lpar1 31 0.70 33.5 16.14
63 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
64 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
65 INT9191 Localization of EDN1 94 0.81 57.01 14.78
66 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
67 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
68 INT6365 Localization of Edn1 56 0.81 18.84 13.83
69 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
70 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
71 INT65109 Negative_regulation of Transcription of Calca 16 0.59 8.63 12.84
72 INT26217 Binding of Calca 22 0.48 5.22 12.57
73 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
74 INT11244 Transcription of CALCA 21 0.69 3.61 12.27
75 INT15136 Regulation of Positive_regulation of Calca 12 0.62 3.02 12.16
76 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
77 INT6151 Negative_regulation of Negative_regulation of Calca 14 0.58 4.86 11.81
78 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
79 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
80 INT100919 Positive_regulation of Grm1 21 0.70 7.82 11.55
81 INT107522 Regulation of Grm5 9 0.44 6.42 11.46
82 INT5779 Positive_regulation of Transcription of Calca 15 0.62 5.61 10.86
83 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
84 INT101203 Negative_regulation of Gene_expression of Calca 12 0.59 7.06 10.72
85 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
86 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
87 INT6361 Localization of Edn1 30 0.81 19.09 9.7
88 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
89 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
90 INT78570 Negative_regulation of Grm5 15 0.57 5.45 9.17
91 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
92 INT107657 Positive_regulation of Positive_regulation of Grm5 6 0.69 1.83 8.92
93 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
94 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86
95 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
96 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
97 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77
98 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
99 INT166119 Negative_regulation of Gene_expression of Lpar1 17 0.51 13.86 8.7
100 INT10237 Binding of EDN1 40 0.48 16 8.48
101 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
102 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
103 INT8761 Negative_regulation of Binding of Calca 12 0.43 3.59 8.32
104 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
105 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
106 INT205203 Gene_expression of Lpar1 6 0.39 11.83 8.08
107 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
108 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
109 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
110 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
111 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
112 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
113 INT25220 Positive_regulation of Binding of Calca 7 0.69 3.78 7.34
114 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27
115 INT116163 Gene_expression of S1pr1 29 0.78 14.11 7.27
116 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
117 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
118 INT124264 Regulation of Localization of Calca 10 0.33 1.39 7.14
119 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
120 INT167049 Binding of Ednra 3 0.07 3.47 6.84
121 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
122 INT24460 Localization of Drd2 12 0.73 2.96 6.46
123 INT205198 Positive_regulation of Lpar1 2 0.35 7.35 6.37
124 INT86772 Localization of Drd2 14 0.80 1.93 6.17
125 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
126 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
127 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89
128 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
129 INT86982 Transcription of Calca 9 0.69 2.98 5.74
130 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
131 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
132 INT113153 Regulation of Grm1 6 0.44 4.11 5.41
133 INT5778 Regulation of Transcription of Calca 4 0.45 2.47 5.37
134 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
135 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29
136 INT14715 Negative_regulation of Positive_regulation of CALCA 5 0.43 2.22 5.2
137 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
138 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15
139 INT27261 Regulation of Regulation of Calca 7 0.45 2.8 5.08
140 INT107655 Positive_regulation of Gene_expression of Grm5 6 0.67 5.09 5.06
141 INT165490 Regulation of Lpar1 8 0.45 15.31 5.05
142 INT351354 Localization of Lpar1 1 0.40 6.93 5.05
143 INT37148 Negative_regulation of Gene_expression of CALCA 7 0.43 1.91 4.98
144 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
145 INT100920 Positive_regulation of Gene_expression of Grm1 7 0.70 5.88 4.87
146 INT91055 Negative_regulation of Grm1 7 0.45 5.14 4.87
147 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
148 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
149 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
150 INT52251 Negative_regulation of Binding of CALCA 3 0.41 0.57 4.71
151 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66
152 INT246315 Localization of Ednra 22 0.15 2.73 4.64
153 INT54987 Regulation of Gene_expression of Calca 6 0.62 3.44 4.59
154 INT21953 Binding of Ednra 12 0.33 4.72 4.56
155 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
156 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
157 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
158 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
159 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
160 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
161 INT74815 Binding of Grm5 11 0.36 3.62 4.25
162 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
163 INT287726 Gene_expression of Lpar3 10 0.76 3.89 4.13
164 INT74814 Binding of Grm1 5 0.45 2.69 4.1
165 INT24677 Regulation of Negative_regulation of Calca 6 0.44 0.73 3.9
166 INT142984 Positive_regulation of S1pr1 13 0.70 7.9 3.84
167 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
168 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
169 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32
170 INT46754 Localization of F2r 7 0.78 2.36 3.24
171 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
172 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
173 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
174 INT231377 Regulation of Gene_expression of Lpar1 7 0.53 5.55 3.12
175 INT58433 Negative_regulation of F2r 9 0.59 2.77 3.08
176 INT51151 Positive_regulation of Regulation of Calca 8 0.50 1.77 3.08
177 INT49971 Regulation of Ednra 10 0.35 2.4 3.06
178 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
179 INT53374 Binding of Edn1 17 0.43 11.66 2.98
180 INT27146 Negative_regulation of Regulation of Calca 4 0.43 1.18 2.9
181 INT93058 Positive_regulation of Gene_expression of Ednra 8 0.28 4.11 2.88
182 INT351355 Positive_regulation of Localization of Lpar1 1 0.25 3.94 2.87
183 INT113077 Positive_regulation of Phosphorylation of Drd1a 1 0.11 0.15 2.87
184 INT60672 Regulation of Gene_expression of CALCA 3 0.61 1.76 2.85
185 INT95720 Phosphorylation of Calca 2 0.80 2.04 2.8
186 INT57354 Positive_regulation of Positive_regulation of Calca 3 0.60 1.42 2.78
187 INT8840 Positive_regulation of Positive_regulation of CALCA 8 0.50 1.8 2.74
188 INT76836 Positive_regulation of Ednra 6 0.55 2.65 2.72
189 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
190 INT82653 Regulation of F2r 8 0.36 3.78 2.62
191 INT64248 Positive_regulation of Positive_regulation of Drd1a 6 0.45 1.97 2.62
192 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
193 INT89992 Positive_regulation of Gene_expression of Drd1a 5 0.39 2.11 2.54
194 INT19292 Protein_catabolism of CALCA 7 0.76 0.8 2.53
195 INT150339 Gene_expression of F2R 10 0.73 3.59 2.46
196 INT63418 Regulation of Agtr1a 8 0.44 3.67 2.43
197 INT116164 Positive_regulation of Gene_expression of S1pr1 5 0.66 4.72 2.42
198 INT107656 Regulation of Gene_expression of Grm5 4 0.26 0.84 2.38
199 INT79281 Gene_expression of Tgm2 14 0.76 7.46 2.37
200 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36
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