GO:0051536

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Name iron-sulfur cluster binding
Categary Function
Go Slim No
Go Link GO:0051536
Unique Molecular Interactions 34
Total Molecular Interactions 46
Total Single Events 794
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for iron-sulfur cluster binding. They are ordered first by their pain relevance and then by number of times they were reported for iron-sulfur cluster binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
2 INT241742 Negative_regulation of Sdhb Regulation of Rapgef5 1 0.02 0.39 0.33
3 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32
4 INT241740 Sdhb Regulation of Rapgef5 1 0.02 0.34 0.32
5 INT241739 Sdhb Regulation of Adora2b 1 0.04 0.63 0.31
6 INT287101 Binding of Bdnf and Mutyh 1 0.04 0.58 0.24
7 INT316370 Ang Positive_regulation of Xdh 1 0.07 0.62 0.2
8 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
9 INT281881 Binding of Aco1 and Ros1 1 0.01 1.93 0.1
10 INT335742 Binding of PDB1 and Dpyd 1 0.02 1.75 0.09
11 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 0.07 0.28 0.08
12 INT239186 H2 Negative_regulation of Aco1 1 0.00 1.96 0.05
13 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03
14 INT240867 Binding of Ros1 and Xdh 1 0.02 0.07 0
15 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0
16 INT286111 Binding of Rpa3 and Mutyh 1 0.30 0 0
17 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0
18 INT303469 CDH3 Negative_regulation of Dpyd 1 0.01 0 0
19 INT149429 ERCC2 Negative_regulation of Localization of IL8 1 0.05 0.38 0
20 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0
21 INT149431 ERCC2 Negative_regulation of Localization of Il6 1 0.14 0.2 0
22 INT227831 Binding of ERCC2 and PGBD3 1 0.07 0.23 0
23 INT213751 Binding of FUT2 and ISCA1 1 0.00 0.16 0
24 INT163633 Col4a4 Regulation of Dpyd 1 0.04 0.06 0
25 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0
26 INT149432 ERCC2 Regulation of Localization of Il6 1 0.15 1.06 0
27 INT149428 ERCC2 Regulation of Localization of IL8 1 0.05 0.53 0
28 INT331117 EPO Positive_regulation of FXN 1 0.29 1.09 0
29 INT315532 Binding of NFS1 and ISCU 1 0.19 0.37 0
30 INT281880 Binding of Aco1 and Cish 1 0.00 0.16 0
31 INT315814 Tst Positive_regulation of Localization of RTEL1 1 0.02 2.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for iron-sulfur cluster binding. They are ordered first by their pain relevance and then by number of times they were reported in iron-sulfur cluster binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16720 Negative_regulation of Xdh 35 0.59 14 6.67
2 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
3 INT22223 Positive_regulation of Xdh 18 0.67 5.87 3.84
4 INT120201 Gene_expression of Aco1 54 0.35 26.29 2.95
5 INT22194 Gene_expression of Xdh 20 0.75 10.03 2.83
6 INT110038 Negative_regulation of Aco1 26 0.23 17.41 2.2
7 INT281878 Positive_regulation of Gene_expression of Aco1 35 0.31 17.15 1.98
8 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
9 INT19626 Regulation of Xdh 4 0.22 2.69 1.7
10 INT70781 Positive_regulation of Dpyd 6 0.54 2.51 1.26
11 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
12 INT202218 Positive_regulation of Aco1 4 0.27 12.31 1.06
13 INT22224 Positive_regulation of Positive_regulation of Xdh 3 0.42 0.87 0.92
14 INT117083 Localization of RTEL1 5 0.60 9.1 0.8
15 INT93908 Negative_regulation of Dpyd 9 0.45 3.19 0.78
16 INT131384 Binding of Mutyh 5 0.26 2.41 0.78
17 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74
18 INT169779 Positive_regulation of Sdhb 4 0.67 1.2 0.64
19 INT104632 Negative_regulation of Positive_regulation of Xdh 2 0.14 0.9 0.61
20 INT236981 Negative_regulation of ISCA1 1 0.05 2.45 0.55
21 INT119633 Transcription of Dpyd 4 0.72 0.68 0.54
22 INT169780 Gene_expression of Sdhb 2 0.65 0.69 0.54
23 INT134070 Binding of ERCC2 3 0.27 0.76 0.51
24 INT186882 Gene_expression of RTEL1 13 0.27 13.45 0.49
25 INT227331 Binding of Xdh 5 0.29 1.83 0.49
26 INT148087 Positive_regulation of RTEL1 9 0.17 5.13 0.41
27 INT226818 Negative_regulation of RTEL1 1 0.06 1.17 0.41
28 INT147959 Localization of Dpyd 2 0.53 1.37 0.4
29 INT103901 Regulation of ERCC2 1 0.23 0.51 0.4
30 INT241723 Positive_regulation of Gene_expression of Sdhb 1 0.06 0.51 0.38
31 INT111388 Negative_regulation of Gene_expression of Xdh 1 0.13 0.51 0.38
32 INT163630 Negative_regulation of Dpyd 3 0.58 0.52 0.34
33 INT154137 Regulation of Dpyd 2 0.18 0.82 0.28
34 INT163628 Regulation of Transcription of Dpyd 1 0.27 0.25 0.27
35 INT169777 Positive_regulation of Positive_regulation of Sdhb 1 0.58 0.24 0.26
36 INT97149 Binding of Dpyd 3 0.14 1.73 0.25
37 INT221496 Localization of ISCA1 4 0.73 2.12 0.23
38 INT281874 Localization of Aco1 1 0.32 3.67 0.23
39 INT281876 Regulation of Aco1 4 0.11 4 0.22
40 INT135644 Binding of Aco1 2 0.19 2.6 0.22
41 INT236980 Gene_expression of ISCA1 9 0.53 2.43 0.19
42 INT113024 Regulation of Gene_expression of Xdh 1 0.03 0.1 0.16
43 INT255793 Positive_regulation of Gene_expression of Xdh 1 0.12 0.27 0.16
44 INT324856 Localization of Xdh 1 0.04 0.61 0.15
45 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14
46 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14
47 INT208551 Gene_expression of Mutyh 6 0.48 6.28 0.12
48 INT281872 Positive_regulation of Positive_regulation of Aco1 1 0.20 1.3 0.12
49 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11
50 INT335728 Positive_regulation of Dpyd 1 0.17 1.74 0.09
51 INT199646 Transcription of Fxn 2 0.67 4.78 0.08
52 INT174848 Gene_expression of ISCU 2 0.59 2.79 0.08
53 INT199643 Phosphorylation of Fxn 1 0.40 1.04 0.08
54 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07
55 INT121075 Positive_regulation of Negative_regulation of Xdh 1 0.11 0 0.07
56 INT236982 Positive_regulation of ISCA1 1 0.06 0.5 0.07
57 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07
58 INT315598 Localization of FXN 1 0.43 1.04 0.07
59 INT241727 Positive_regulation of Transcription of Sdhb 1 0.06 0.28 0.06
60 INT315630 Gene_expression of FXN 8 0.64 20.05 0.05
61 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05
62 INT239158 Negative_regulation of Positive_regulation of Aco1 2 0.17 1.26 0.05
63 INT236519 Negative_regulation of Gene_expression of Mutyh 1 0.05 0 0.05
64 INT241732 Transcription of Sdhb 1 0.08 0.28 0.05
65 INT281875 Negative_regulation of Gene_expression of Aco1 1 0.17 0.48 0.05
66 INT281877 Regulation of Localization of Aco1 1 0.18 1.36 0.04
67 INT281871 Positive_regulation of Localization of Aco1 1 0.20 1.37 0.04
68 INT241718 Binding of Sdhb 1 0.05 0 0.04
69 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04
70 INT241731 Localization of Sdhb 1 0.09 0 0.04
71 INT241729 Positive_regulation of Localization of Sdhb 1 0.06 0 0.04
72 INT269499 Regulation of Negative_regulation of Xdh 1 0.32 0.38 0.04
73 INT199648 Regulation of Fxn 1 0.29 2.14 0.04
74 INT286105 Positive_regulation of Mutyh 1 0.36 1.94 0.04
75 INT199651 Binding of Fxn 3 0.30 1.45 0.03
76 INT315806 Phosphorylation of RTEL1 1 0.04 0.68 0.03
77 INT315624 Positive_regulation of Gene_expression of ISCU 1 0.38 0.23 0.03
78 INT291518 Positive_regulation of Negative_regulation of Fxn 1 0.47 1.1 0.03
79 INT291906 Positive_regulation of Negative_regulation of ERCC2 1 0.40 0 0.03
80 INT186878 Binding of RTEL1 7 0.12 4.75 0
81 INT70782 Gene_expression of Dpyd 5 0.53 2.44 0
82 INT315563 Positive_regulation of Gene_expression of FXN 4 0.41 5.05 0
83 INT119632 Gene_expression of Dpyd 4 0.77 0.4 0
84 INT315635 Positive_regulation of FXN 2 0.41 5.76 0
85 INT174850 Binding of ISCU 2 0.33 0.51 0
86 INT315628 Negative_regulation of Gene_expression of FXN 2 0.36 2.37 0
87 INT315561 Regulation of ISCU 2 0.35 1.1 0
88 INT315808 Positive_regulation of Protein_catabolism of RTEL1 1 0.03 0.98 0
89 INT315810 Positive_regulation of Gene_expression of RTEL1 1 0.03 1.77 0
90 INT315581 Positive_regulation of Phosphorylation of ISCU 1 0.44 0.33 0
91 INT291511 Positive_regulation of Transcription of Fxn 1 0.47 0.09 0
92 INT186880 Regulation of RTEL1 1 0.11 0.54 0
93 INT315614 Negative_regulation of Transcription of FXN 1 0.25 0.82 0
94 INT315811 Negative_regulation of Binding of RTEL1 1 0.02 0.86 0
95 INT315602 Binding of ISCA1 1 0.30 0 0
96 INT286106 Positive_regulation of Gene_expression of Mutyh 1 0.36 0.66 0
97 INT258773 Negative_regulation of Binding of Dpyd 1 0.11 0.6 0
98 INT331131 Regulation of Gene_expression of FXN 1 0.37 1.49 0
99 INT291516 Negative_regulation of Transcription of Fxn 1 0.54 0.77 0
100 INT315637 Transcription of FXN 1 0.40 1.44 0
101 INT315634 Negative_regulation of Binding of ISCU 1 0.33 0.28 0
102 INT315597 Negative_regulation of ISCU 1 0.51 0.22 0
103 INT174845 Protein_catabolism of ISCU 1 0.04 0.25 0
104 INT162118 Regulation of Transcription of Dpyd 1 0.18 0.1 0
105 INT163631 Regulation of Dpyd 1 0.45 0.06 0
106 INT315555 Binding of FXN 1 0.28 1.29 0
107 INT315970 Regulation of Gene_expression of RTEL1 1 0.03 1.35 0
108 INT286104 Negative_regulation of Mutyh 1 0.35 2.24 0
109 INT186879 Positive_regulation of Positive_regulation of RTEL1 1 0.12 0.29 0
110 INT149430 Localization of ERCC2 1 0.43 0.76 0
111 INT315807 Protein_catabolism of RTEL1 1 0.05 0.84 0
112 INT154142 Regulation of Gene_expression of Dpyd 1 0.03 0.26 0
113 INT315615 Positive_regulation of ISCU 1 0.44 0.11 0
114 INT323587 Transcription of Aco1 1 0.03 0.1 0
115 INT315639 Localization of ISCU 1 0.66 0 0
116 INT315629 Phosphorylation of ISCU 1 0.71 0.33 0
117 INT291507 Regulation of Negative_regulation of Fxn 1 0.37 0.87 0
118 INT162119 Transcription of Dpyd 1 0.36 0.1 0
119 INT315809 Regulation of Protein_catabolism of RTEL1 1 0.03 0.97 0
120 INT315971 Transcription of RTEL1 1 0.04 1.28 0
121 INT291512 Regulation of Gene_expression of Fxn 1 0.37 0.06 0
122 INT323585 Regulation of Transcription of Aco1 1 0.02 0.1 0
123 INT281622 Regulation of Mutyh 1 0.04 0.83 0
124 INT186881 Positive_regulation of Binding of RTEL1 1 0.12 0.5 0
125 INT331130 Negative_regulation of FXN 1 0.48 4.93 0
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