GO:0051539

From wiki-pain
Jump to: navigation, search
Name 4 iron, 4 sulfur cluster binding
Categary Function
Go Slim No
Go Link GO:0051539
Unique Molecular Interactions 75
Total Molecular Interactions 96
Total Single Events 1652
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for 4 iron, 4 sulfur cluster binding. They are ordered first by their pain relevance and then by number of times they were reported for 4 iron, 4 sulfur cluster binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT266659 Binding of MMP9 and MOCS1 1 0.01 1.71 0.94
2 INT178576 CNTN2 Positive_regulation of DPYD 1 0.05 2.18 0.76
3 INT180961 Binding of MOCS1 and PLAU 1 0.00 0.61 0.67
4 INT153797 NUBPL Negative_regulation of PPARD 1 0.02 0.69 0.64
5 INT153796 NUBPL Negative_regulation of YWHAQ 1 0.02 0.69 0.64
6 INT83111 LIAS Negative_regulation of Binding of Chrna7 1 0.02 0 0.45
7 INT113992 Binding of HRH1 and LIAS 1 0.00 0.09 0.38
8 INT241742 Negative_regulation of Sdhb Regulation of Rapgef5 1 0.02 0.39 0.33
9 INT241740 Sdhb Regulation of Rapgef5 1 0.02 0.34 0.32
10 INT241739 Sdhb Regulation of Adora2b 1 0.04 0.63 0.31
11 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
12 INT69120 MOCS1 Regulation of PTGS2 1 0.00 0.39 0.26
13 INT156661 Binding of Pgls and Sdhb 1 0.01 1.43 0.25
14 INT287101 Binding of Bdnf and Mutyh 1 0.04 0.58 0.24
15 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17
16 INT85445 NUBPL Negative_regulation of Gene_expression of CD40LG 1 0.01 0.31 0.16
17 INT247851 Negative_regulation of Aqp4 Negative_regulation of Positive_regulation of Narfl 1 0.09 1.78 0.15
18 INT347806 Binding of MOCS1 and SMAP2 1 0.00 0.48 0.12
19 INT220240 IL1RN Negative_regulation of Gene_expression of MOCS1 1 0.01 0 0.12
20 INT281881 Binding of Aco1 and Ros1 1 0.01 1.93 0.1
21 INT335742 Binding of PDB1 and Dpyd 1 0.02 1.75 0.09
22 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 0.07 0.28 0.08
23 INT239186 H2 Negative_regulation of Aco1 1 0.00 1.96 0.05
24 INT255166 Binding of MOCS1 and MPO 1 0.00 0.7 0.05
25 INT247843 Narfl Regulation of Aqp4 1 0.04 1.07 0.04
26 INT247855 Positive_regulation of Narfl Regulation of Aqp4 1 0.04 2.93 0.04
27 INT220242 IL1B Positive_regulation of Gene_expression of MOCS1 1 0.01 0 0.04
28 INT220236 Positive_regulation of IL1RN Negative_regulation of Gene_expression of MOCS1 1 0.01 0 0.03
29 INT247856 Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 1 0.03
30 INT337066 Binding of DPYD and FRA1E 1 0.19 0.8 0
31 INT247847 Narfl Positive_regulation of Positive_regulation of Casp3 1 0.02 0.79 0
32 INT247853 Positive_regulation of Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 0.54 0
33 INT247846 Positive_regulation of Narfl Positive_regulation of Positive_regulation of Ube4a 1 0.00 0.82 0
34 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0
35 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0
36 INT312956 Regulation of Binding of MOCS1 and MTTP 1 0.00 0.21 0
37 INT286111 Binding of Rpa3 and Mutyh 1 0.30 0 0
38 INT241119 Binding of Sdhc and Sdhb 1 0.00 1.29 0
39 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0
40 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0
41 INT252791 Binding of IREB2 and TFRC 1 0.02 1.82 0
42 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0
43 INT322931 Binding of MOCS1 and Litaf 1 0.00 0.82 0
44 INT247848 Narfl Negative_regulation of Uchl1 1 0.03 0.74 0
45 INT294880 DPYD Positive_regulation of Ephb1 1 0.00 0.53 0
46 INT252807 Binding of ACO1 and TFRC 1 0.01 1.83 0
47 INT303469 CDH3 Negative_regulation of Dpyd 1 0.01 0 0
48 INT247857 Narfl Positive_regulation of Gene_expression of Gfap 1 0.07 0.81 0
49 INT294828 DPYD Positive_regulation of PIK3CB 1 0.00 0.51 0
50 INT247888 Narfl Positive_regulation of CASP3 1 0.00 0.77 0
51 INT247850 Positive_regulation of Narfl Regulation of Ube4a 1 0.00 1.86 0
52 INT312955 Binding of MOCS1 and MTTP 1 0.00 0.21 0
53 INT273772 BCKDHA Positive_regulation of Positive_regulation of NARFL 1 0.03 1.21 0
54 INT163633 Col4a4 Regulation of Dpyd 1 0.04 0.06 0
55 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0
56 INT247852 Narfl Positive_regulation of Localization of Aqp4 1 0.08 0.81 0
57 INT294827 DPYD Positive_regulation of Gene_expression of REXO1 1 0.01 0.47 0
58 INT294831 DPYD Positive_regulation of Positive_regulation of RASGRP1 1 0.00 0.53 0
59 INT281880 Binding of Aco1 and Cish 1 0.00 0.16 0
60 INT247889 Positive_regulation of Narfl Positive_regulation of CASP3 1 0.00 0.84 0
61 INT354469 Binding of SDHC and Sdhb 1 0.08 1.82 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for 4 iron, 4 sulfur cluster binding. They are ordered first by their pain relevance and then by number of times they were reported in 4 iron, 4 sulfur cluster binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74
2 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41
3 INT1982 Regulation of NARFL 119 0.49 116.2 14.35
4 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47
5 INT24309 Binding of Sdhb 2 0.36 0.98 3.03
6 INT120201 Gene_expression of Aco1 54 0.35 26.29 2.95
7 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59
8 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4
9 INT110038 Negative_regulation of Aco1 26 0.23 17.41 2.2
10 INT134944 Gene_expression of MOCS1 37 0.06 10.76 2.17
11 INT24307 Transcription of Sdhb 1 0.26 0 2.11
12 INT281878 Positive_regulation of Gene_expression of Aco1 35 0.31 17.15 1.98
13 INT70781 Positive_regulation of Dpyd 6 0.54 2.51 1.26
14 INT121561 Negative_regulation of Binding of Sdhb 1 0.41 0.74 1.2
15 INT106261 Negative_regulation of DPYD 16 0.59 15.02 1.19
16 INT272274 Localization of NARFL 24 0.60 27.55 1.18
17 INT94690 Gene_expression of DPYD 12 0.75 4.6 1.07
18 INT202218 Positive_regulation of Aco1 4 0.27 12.31 1.06
19 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98
20 INT39369 Binding of NARFL 14 0.29 16.7 0.93
21 INT83109 Binding of LIAS 4 0.28 0 0.93
22 INT3776 Positive_regulation of Regulation of NARFL 2 0.37 2.44 0.93
23 INT272275 Regulation of Positive_regulation of NARFL 8 0.36 16.68 0.86
24 INT272414 Positive_regulation of Positive_regulation of NARFL 9 0.37 12.88 0.84
25 INT93908 Negative_regulation of Dpyd 9 0.45 3.19 0.78
26 INT131384 Binding of Mutyh 5 0.26 2.41 0.78
27 INT178587 Positive_regulation of DPYD 4 0.50 4.7 0.74
28 INT272415 Negative_regulation of Gene_expression of NARFL 14 0.34 17.62 0.73
29 INT280447 Negative_regulation of Positive_regulation of MOCS1 1 0.00 0.75 0.69
30 INT247868 Positive_regulation of Narfl 1 0.11 37.11 0.68
31 INT169779 Positive_regulation of Sdhb 4 0.67 1.2 0.64
32 INT100207 Negative_regulation of NUBPL 1 0.05 0.98 0.62
33 INT119633 Transcription of Dpyd 4 0.72 0.68 0.54
34 INT169780 Gene_expression of Sdhb 2 0.65 0.69 0.54
35 INT226985 Gene_expression of Lias 1 0.09 1.37 0.45
36 INT23650 Positive_regulation of Sdhb 2 0.17 1.34 0.43
37 INT178586 Localization of DPYD 1 0.36 0.76 0.42
38 INT147959 Localization of Dpyd 2 0.53 1.37 0.4
39 INT94691 Binding of DPYD 2 0.47 0 0.39
40 INT241723 Positive_regulation of Gene_expression of Sdhb 1 0.06 0.51 0.38
41 INT206440 Binding of MOCS1 13 0.01 3.76 0.35
42 INT134943 Localization of MOCS1 7 0.07 4.23 0.34
43 INT163630 Negative_regulation of Dpyd 3 0.58 0.52 0.34
44 INT272272 Positive_regulation of Gene_expression of NARFL 17 0.40 18.85 0.31
45 INT156656 Gene_expression of Sdhb 1 0.05 1.57 0.3
46 INT154137 Regulation of Dpyd 2 0.18 0.82 0.28
47 INT163628 Regulation of Transcription of Dpyd 1 0.27 0.25 0.27
48 INT220261 Negative_regulation of Gene_expression of MOCS1 2 0.01 0.35 0.26
49 INT95758 Negative_regulation of ACO1 2 0.51 1.25 0.26
50 INT169777 Positive_regulation of Positive_regulation of Sdhb 1 0.58 0.24 0.26
51 INT97149 Binding of Dpyd 3 0.14 1.73 0.25
52 INT320171 Positive_regulation of Gene_expression of MOCS1 2 0.01 0.87 0.25
53 INT281874 Localization of Aco1 1 0.32 3.67 0.23
54 INT173211 Regulation of MOCS1 4 0.01 1.94 0.22
55 INT281876 Regulation of Aco1 4 0.11 4 0.22
56 INT135644 Binding of Aco1 2 0.19 2.6 0.22
57 INT274271 Negative_regulation of Negative_regulation of NARFL 1 0.06 5.13 0.22
58 INT274273 Regulation of Gene_expression of NARFL 3 0.10 4.39 0.2
59 INT95760 Negative_regulation of Gene_expression of ACO1 1 0.00 0.93 0.2
60 INT274339 Negative_regulation of Binding of NARFL 1 0.06 0.58 0.17
61 INT226983 Localization of Lias 1 0.11 0.3 0.17
62 INT226982 Regulation of Lias 1 0.04 0.3 0.17
63 INT58816 Regulation of Regulation of NARFL 2 0.11 1.39 0.16
64 INT206971 Positive_regulation of Localization of MOCS1 2 0.01 0.71 0.16
65 INT247865 Gene_expression of Narfl 1 0.09 9.22 0.13
66 INT208551 Gene_expression of Mutyh 6 0.48 6.28 0.12
67 INT281872 Positive_regulation of Positive_regulation of Aco1 1 0.20 1.3 0.12
68 INT108344 Regulation of Sdhb 1 0.29 1.34 0.11
69 INT131139 Binding of ACO1 3 0.27 1.81 0.1
70 INT95756 Gene_expression of ACO1 3 0.27 2.49 0.1
71 INT131140 Negative_regulation of Negative_regulation of ACO1 1 0.37 0.58 0.09
72 INT247866 Localization of Narfl 1 0.10 1.98 0.09
73 INT335728 Positive_regulation of Dpyd 1 0.17 1.74 0.09
74 INT272530 Negative_regulation of Localization of NARFL 3 0.09 2.98 0.07
75 INT164225 Protein_catabolism of MOCS1 1 0.03 0 0.07
76 INT247873 Binding of Narfl 1 0.05 1.33 0.07
77 INT241727 Positive_regulation of Transcription of Sdhb 1 0.06 0.28 0.06
78 INT330979 Protein_catabolism of NARFL 1 0.02 0.84 0.06
79 INT239158 Negative_regulation of Positive_regulation of Aco1 2 0.17 1.26 0.05
80 INT275140 Negative_regulation of Regulation of MOCS1 1 0.00 0.49 0.05
81 INT252699 Gene_expression of IREB2 1 0.11 1.79 0.05
82 INT236519 Negative_regulation of Gene_expression of Mutyh 1 0.05 0 0.05
83 INT252720 Negative_regulation of IREB2 1 0.06 0.82 0.05
84 INT241732 Transcription of Sdhb 1 0.08 0.28 0.05
85 INT247867 Positive_regulation of Positive_regulation of Narfl 1 0.11 5.16 0.05
86 INT281875 Negative_regulation of Gene_expression of Aco1 1 0.17 0.48 0.05
87 INT252724 Negative_regulation of Gene_expression of IREB2 1 0.06 0.89 0.05
88 INT99965 Positive_regulation of Negative_regulation of NARFL 6 0.40 4.5 0.04
89 INT281877 Regulation of Localization of Aco1 1 0.18 1.36 0.04
90 INT341617 Positive_regulation of Positive_regulation of MOCS1 1 0.01 0.07 0.04
91 INT281871 Positive_regulation of Localization of Aco1 1 0.20 1.37 0.04
92 INT241718 Binding of Sdhb 1 0.05 0 0.04
93 INT241731 Localization of Sdhb 1 0.09 0 0.04
94 INT348071 Localization of NUBPL 1 0.03 0 0.04
95 INT241729 Positive_regulation of Localization of Sdhb 1 0.06 0 0.04
96 INT286105 Positive_regulation of Mutyh 1 0.36 1.94 0.04
97 INT274269 Transcription of NARFL 1 0.09 1.13 0.03
98 INT220253 Regulation of Gene_expression of MOCS1 1 0.00 0.08 0.03
99 INT247878 Negative_regulation of Positive_regulation of Narfl 1 0.06 2.14 0.03
100 INT274274 Positive_regulation of Transcription of NARFL 1 0.06 1.13 0.03
101 INT70782 Gene_expression of Dpyd 5 0.53 2.44 0
102 INT119632 Gene_expression of Dpyd 4 0.77 0.4 0
103 INT181315 Regulation of DPYD 2 0.54 3.64 0
104 INT252722 Binding of IREB2 2 0.16 1.31 0
105 INT325463 Positive_regulation of Binding of NARFL 2 0.15 0.76 0
106 INT274340 Regulation of Localization of NARFL 1 0.06 0.63 0
107 INT315631 Protein_catabolism of IREB2 1 0.44 0.4 0
108 INT220264 Positive_regulation of Negative_regulation of MOCS1 1 0.01 0 0
109 INT188130 Negative_regulation of Gene_expression of NUBPL 1 0.57 0.08 0
110 INT286106 Positive_regulation of Gene_expression of Mutyh 1 0.36 0.66 0
111 INT258773 Negative_regulation of Binding of Dpyd 1 0.11 0.6 0
112 INT178545 Regulation of Transcription of MOCS1 1 0.00 0.11 0
113 INT223288 Protein_catabolism of DPYD 1 0.46 0.11 0
114 INT337068 Transcription of DPYD 1 0.60 0 0
115 INT325466 Positive_regulation of Localization of NARFL 1 0.04 0.53 0
116 INT247872 Positive_regulation of Gene_expression of Narfl 1 0.07 0.44 0
117 INT247862 Regulation of Narfl 1 0.06 0.67 0
118 INT247869 Regulation of Positive_regulation of Narfl 1 0.06 1.85 0
119 INT162118 Regulation of Transcription of Dpyd 1 0.18 0.1 0
120 INT163631 Regulation of Dpyd 1 0.45 0.06 0
121 INT315623 Positive_regulation of Localization of ACO1 1 0.20 0.79 0
122 INT286104 Negative_regulation of Mutyh 1 0.35 2.24 0
123 INT247877 Negative_regulation of Gene_expression of Narfl 1 0.06 1.05 0
124 INT315588 Regulation of ACO1 1 0.18 0.57 0
125 INT178541 Transcription of MOCS1 1 0.01 0.06 0
126 INT341614 Positive_regulation of Binding of MOCS1 1 0.01 0 0
127 INT154142 Regulation of Gene_expression of Dpyd 1 0.03 0.26 0
128 INT323587 Transcription of Aco1 1 0.03 0.1 0
129 INT259719 Negative_regulation of Regulation of NARFL 1 0.01 1.67 0
130 INT247876 Negative_regulation of Localization of Narfl 1 0.06 0.94 0
131 INT162119 Transcription of Dpyd 1 0.36 0.1 0
132 INT252749 Regulation of Gene_expression of ACO1 1 0.02 0.9 0
133 INT158113 Positive_regulation of LIAS 1 0.39 0.06 0
134 INT247879 Regulation of Gene_expression of Narfl 1 0.04 0.66 0
135 INT315574 Localization of ACO1 1 0.30 0.79 0
136 INT315616 Positive_regulation of Gene_expression of ACO1 1 0.20 0.79 0
137 INT315572 Positive_regulation of ACO1 1 0.20 0.94 0
138 INT323585 Regulation of Transcription of Aco1 1 0.02 0.1 0
139 INT281622 Regulation of Mutyh 1 0.04 0.83 0
140 INT315632 Positive_regulation of Protein_catabolism of IREB2 1 0.22 0.4 0
141 INT188129 Gene_expression of NUBPL 1 0.75 1.05 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox