GO:0051788

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Name response to misfolded protein
Categary Process
Go Slim No
Go Link GO:0051788
Unique Molecular Interactions 43
Total Molecular Interactions 82
Total Single Events 498
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to misfolded protein. They are ordered first by their pain relevance and then by number of times they were reported for response to misfolded protein. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
2 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
3 INT251159 Binding of Clu and Positive_regulation of Trpv1 1 0.16 0 0.87
4 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
5 INT251166 Clu Positive_regulation of Trpc3 1 0.09 0.75 0.67
6 INT251171 Clu Positive_regulation of C6 1 0.05 0.75 0.67
7 INT251188 Clu Positive_regulation of TRPV1 1 0.01 0.23 0.64
8 INT251167 Clu Positive_regulation of Trpc6 1 0.12 0.2 0.6
9 INT251168 Clu Positive_regulation of Trpc7 1 0.15 0.2 0.59
10 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
11 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 0.00 0.51 0.45
12 INT51341 Binding of Pomc and Clu 1 0.14 0 0.38
13 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
14 INT119717 Binding of ADRA1D and F12 1 0.35 0.23 0.23
15 INT332700 Binding of F12 and KNG1 1 0.15 1.05 0.21
16 INT251162 Clu Positive_regulation of Gene_expression of Trpv1 1 0.20 0.07 0.18
17 INT250550 Binding of F12 and CHDH 1 0.05 2.26 0.17
18 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
19 INT232015 SERPING1 Negative_regulation of F12 2 0.24 1.19 0.12
20 INT232017 F12 Positive_regulation of PLG 1 0.03 0.52 0.11
21 INT51344 Binding of Clu and Vtn 1 0.06 0 0.1
22 INT232019 F12 Positive_regulation of TRGC1 1 0.00 0.57 0.09
23 INT310201 Binding of F12 and Chdh 1 0.04 1.06 0.08
24 INT306510 INCENP Regulation of Gene_expression of Clu 1 0.00 1.92 0.05
25 INT232009 Positive_regulation of F12 Negative_regulation of Localization of KNG1 1 0.01 0.19 0.05
26 INT306505 Binding of Clu and Tnf 1 0.24 0.4 0.04
27 INT327162 Binding of SERPING1 and F12 1 0.05 0.29 0.04
28 INT306501 Negative_regulation of Binding of Clu and Tnf 1 0.29 0.4 0.04
29 INT306500 Clu Regulation of Esr1 1 0.22 0.13 0
30 INT306509 Binding of XRCC6 and Clu 1 0.37 0.27 0
31 INT310200 Binding of Serping1 and F12 1 0.21 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to misfolded protein. They are ordered first by their pain relevance and then by number of times they were reported in response to misfolded protein. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT58986 Gene_expression of Clu 17 0.77 8.35 9.61
2 INT51337 Binding of Clu 3 0.12 0.05 5.45
3 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06
4 INT35946 Positive_regulation of Clu 12 0.69 4.92 2.73
5 INT11481 Positive_regulation of F12 11 0.58 5.53 1.8
6 INT49347 Negative_regulation of Clu 4 0.58 1.63 1.79
7 INT77164 Binding of F12 8 0.47 2.66 1.48
8 INT35944 Regulation of Clu 4 0.20 0.15 1.3
9 INT11496 Negative_regulation of F12 6 0.59 3.41 1.27
10 INT10133 Negative_regulation of F12 16 0.49 5.21 1.26
11 INT251180 Phosphorylation of Clu 1 0.29 0.79 1.22
12 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21
13 INT27155 Binding of F12 8 0.36 1.61 1.21
14 INT233561 Gene_expression of Clu 14 0.66 45.63 1.07
15 INT100273 Localization of Clu 4 0.61 0.49 0.88
16 INT70666 Positive_regulation of CLU 16 0.45 12.95 0.74
17 INT44001 Negative_regulation of Positive_regulation of F12 5 0.59 2.53 0.73
18 INT94233 Positive_regulation of Gene_expression of Clu 3 0.69 2.64 0.71
19 INT90699 Regulation of F12 4 0.45 2.7 0.67
20 INT94232 Negative_regulation of Gene_expression of Clu 2 0.43 1.17 0.63
21 INT312882 Negative_regulation of Hdac6 1 0.52 1.86 0.63
22 INT135294 Negative_regulation of Positive_regulation of Clu 1 0.37 0.35 0.59
23 INT251182 Regulation of Phosphorylation of Clu 1 0.16 0.13 0.52
24 INT221932 Gene_expression of F12 4 0.66 2.61 0.5
25 INT233552 Positive_regulation of Gene_expression of Clu 3 0.59 9.31 0.45
26 INT10129 Gene_expression of F12 4 0.65 3.4 0.37
27 INT312879 Regulation of Hdac6 1 0.55 0.76 0.29
28 INT77162 Regulation of Binding of F12 2 0.33 0.52 0.28
29 INT122985 Negative_regulation of Gene_expression of CLU 4 0.57 4.58 0.27
30 INT145259 Binding of CLU 1 0.03 0.84 0.27
31 INT312887 Gene_expression of Hdac6 1 0.60 1.28 0.25
32 INT312883 Regulation of Regulation of Hdac6 1 0.40 0.38 0.24
33 INT77165 Regulation of Positive_regulation of F12 1 0.38 0.28 0.23
34 INT77160 Positive_regulation of Binding of F12 1 0.42 0.28 0.23
35 INT77156 Regulation of Binding of F12 1 0.13 0.25 0.23
36 INT77153 Positive_regulation of Binding of F12 1 0.14 0.26 0.22
37 INT122987 Negative_regulation of CLU 5 0.42 4.58 0.21
38 INT35945 Positive_regulation of Regulation of Clu 1 0.35 0 0.2
39 INT119715 Localization of F12 3 0.67 1.24 0.17
40 INT58589 Regulation of F12 3 0.39 1.9 0.16
41 INT122984 Localization of CLU 2 0.78 2.46 0.16
42 INT122989 Positive_regulation of Localization of CLU 2 0.45 1.81 0.16
43 INT96541 Negative_regulation of Binding of F12 2 0.41 0.32 0.16
44 INT312881 Positive_regulation of Hdac6 1 0.45 0.67 0.15
45 INT122986 Positive_regulation of Gene_expression of CLU 3 0.67 2.37 0.14
46 INT119714 Protein_catabolism of F12 1 0.84 0.14 0.14
47 INT10128 Negative_regulation of Gene_expression of F12 2 0.01 0.33 0.12
48 INT316316 Negative_regulation of Binding of F12 1 0.18 1.1 0.12
49 INT232026 Positive_regulation of Gene_expression of F12 1 0.03 0.58 0.11
50 INT233567 Positive_regulation of Clu 3 0.59 2.91 0.09
51 INT310198 Positive_regulation of Positive_regulation of F12 1 0.38 1.63 0.09
52 INT123574 Localization of F12 1 0.15 0.25 0.09
53 INT233554 Negative_regulation of Gene_expression of Clu 2 0.39 1.96 0.05
54 INT233550 Localization of Clu 2 0.69 4.52 0.05
55 INT312877 Positive_regulation of Negative_regulation of Hdac6 1 0.45 0 0.05
56 INT161524 Regulation of Clu 4 0.38 3.18 0.03
57 INT312888 Phosphorylation of Hdac6 1 0.73 0 0.03
58 INT233556 Regulation of Gene_expression of Clu 2 0.33 1.45 0
59 INT312873 Negative_regulation of Gene_expression of Hdac6 1 0.38 0 0
60 INT49344 Negative_regulation of Transcription of Clu 1 0.35 0.07 0
61 INT49345 Transcription of Clu 1 0.58 0.2 0
62 INT312885 Binding of Hdac6 1 0.43 0 0
63 INT326466 Regulation of Gene_expression of F12 1 0.03 0.6 0
64 INT312874 Regulation of Phosphorylation of Hdac6 1 0.40 0 0
65 INT233564 Regulation of Positive_regulation of Clu 1 0.38 0.98 0
66 INT206738 Regulation of CLU 1 0.44 1.15 0
67 INT312876 Negative_regulation of Transcription of Hdac6 1 0.38 0 0
68 INT326467 Regulation of Gene_expression of F12 1 0.44 0.6 0
69 INT354842 Protein_catabolism of CLU 1 0.28 1.6 0
70 INT306487 Binding of Clu 1 0.24 0.27 0
71 INT49348 Regulation of Transcription of Clu 1 0.50 0.13 0
72 INT318803 Regulation of Gene_expression of CLU 1 0.21 0.9 0
73 INT250579 Transcription of F12 1 0.62 0.77 0
74 INT312875 Transcription of Hdac6 1 0.61 0 0
75 INT233557 Transcription of Clu 1 0.45 0.77 0
76 INT318804 Negative_regulation of Localization of CLU 1 0.18 1.33 0
77 INT312878 Protein_catabolism of Hdac6 1 0.88 0 0
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