GO:0051895

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Name negative regulation of focal adhesion assembly
Categary Process
Go Slim No
Go Link GO:0051895
Unique Molecular Interactions 115
Total Molecular Interactions 159
Total Single Events 783
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of focal adhesion assembly. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of focal adhesion assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
2 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
3 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
4 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
5 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
6 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
7 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
8 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
9 INT224678 Binding of Mmp14 and Mmp23 1 0.00 0.85 0.69
10 INT148452 Inhbe Regulation of Acvrl1 1 0.01 0.69 0.69
11 INT224683 Mmp14 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
12 INT224684 Binding of Mmp14 and Mmp9 1 0.01 0.81 0.64
13 INT113473 RETNLB Positive_regulation of MMP14 1 0.01 0.37 0.64
14 INT144071 TRPV1 Positive_regulation of Gene_expression of MMP14 1 0.21 0.5 0.58
15 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
16 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
17 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
18 INT150796 ZNF398 Positive_regulation of THBS1 1 0.06 0.5 0.52
19 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52
20 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
21 INT345306 Binding of MMP14 and TIMP2 1 0.04 0.21 0.48
22 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
23 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
24 INT345305 MMP14 Positive_regulation of MMP13 1 0.00 0.33 0.45
25 INT345304 MMP14 Positive_regulation of MMP2 1 0.08 0.2 0.45
26 INT113471 RETNLB Regulation of Localization of MMP14 1 0.01 0.24 0.43
27 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
28 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
29 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
30 INT342622 Binding of MMP14 and Mmp2 1 0.39 1.15 0.37
31 INT342606 Binding of MMP14 and VEGFA 1 0.08 1.16 0.37
32 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
33 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
34 INT113476 IL1A Positive_regulation of Localization of MMP14 1 0.10 0.22 0.34
35 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
36 INT113475 RETNLB Positive_regulation of Localization of MMP14 1 0.01 0.18 0.32
37 INT328223 Mmp14 Regulation of Positive_regulation of Mmp13 1 0.07 0.69 0.29
38 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
39 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
40 INT244687 Mmp14 Positive_regulation of Mmp2 1 0.23 0.48 0.25
41 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
42 INT252356 Binding of THBS1 and Cd47 1 0.00 0.44 0.24
43 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
44 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
45 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21
46 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
47 INT215944 Mmp14 Regulation of Eae1 1 0.03 0.95 0.2
48 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2
49 INT215942 Regulation of Mmp14 Regulation of Eae1 1 0.03 0.95 0.2
50 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
51 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
52 INT337260 ELL Positive_regulation of Gene_expression of THBS1 1 0.11 0.82 0.18
53 INT337263 ELL Regulation of Gene_expression of THBS1 1 0.10 0.82 0.18
54 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
55 INT231677 Binding of CD47 and THBS1 1 0.18 0 0.16
56 INT252352 Binding of THBS1 and Sirpa 1 0.00 0.26 0.15
57 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
58 INT264389 MMP14 Regulation of Positive_regulation of MMP13 1 0.31 0.06 0.12
59 INT264411 MMP14 Regulation of Positive_regulation of MMP1 1 0.20 0.06 0.12
60 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
61 INT264400 MMP9 Regulation of MMP14 1 0.08 0.06 0.11
62 INT264406 MMP3 Regulation of MMP14 1 0.09 0.06 0.11
63 INT264402 MMP2 Regulation of MMP14 1 0.10 0.06 0.11
64 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
65 INT294439 KLK4 Negative_regulation of THBS1 1 0.01 0 0.1
66 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 0.13 0.61 0.09
67 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
68 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
69 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
70 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
71 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
72 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
73 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03
74 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
75 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
76 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
77 INT250659 Negative_regulation of PTEN Positive_regulation of Positive_regulation of PIK3CB 1 0.02 1.18 0
78 INT245103 TNFRSF11B Negative_regulation of MMP14 1 0.02 1.15 0
79 INT337270 E2F1 Positive_regulation of Transcription of THBS1 1 0.67 0.19 0
80 INT337268 E2F1 Regulation of Transcription of THBS1 1 0.44 0 0
81 INT337274 E2F1 Regulation of THBS1 1 0.44 0 0
82 INT337269 Binding of E2F1 and Positive_regulation of Gene_expression of THBS1 1 0.45 0.21 0
83 INT337262 PRB1 Negative_regulation of THBS1 1 0.18 0.61 0
84 INT321718 Ins1 Regulation of Gene_expression of Pten 1 0.04 0.23 0
85 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0
86 INT99769 Thbs1 Regulation of THBS1 1 0.00 0 0
87 INT337264 Binding of E2F1 and THBS1 1 0.47 0.78 0
88 INT285908 AKT1 Regulation of Pten 1 0.01 0.53 0
89 INT268524 MYC Regulation of THBS1 1 0.02 1.85 0
90 INT337273 E2F1 Regulation of Gene_expression of THBS1 1 0.60 0 0
91 INT282880 MMP14 Regulation of MUC1 1 0.02 0.17 0
92 INT337266 E2F1 Positive_regulation of Gene_expression of THBS1 1 0.67 0.21 0
93 INT99772 Pgr Regulation of THBS1 1 0.00 0 0
94 INT348723 ED Positive_regulation of PTEN 1 0.04 1.3 0
95 INT282881 MUC1 Positive_regulation of Gene_expression of MMP14 1 0.04 0.17 0
96 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0
97 INT313885 XRCC1 Positive_regulation of Localization of PTEN 1 0.00 0.65 0
98 INT293802 PTEN Regulation of PIK3CG 1 0.03 0.07 0
99 INT351682 Fut1 Positive_regulation of PTEN 1 0.01 1.81 0
100 INT310187 Acvrl1 Regulation of Gene_expression of Bmpr2 1 0.04 0 0
101 INT337265 Negative_regulation of E2F1 Positive_regulation of THBS1 1 0.42 0 0
102 INT223574 PTEN Negative_regulation of AKT1 1 0.06 0.56 0
103 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0
104 INT337272 E2F1 Positive_regulation of THBS1 1 0.49 1.27 0
105 INT223579 PTEN Negative_regulation of PIK3CG 1 0.18 0.56 0
106 INT337267 THBS1 Positive_regulation of E2F1 1 0.49 0.05 0
107 INT285910 Pten Regulation of AKT1 1 0.00 0.53 0
108 INT99771 Oxtr Regulation of THBS1 1 0.01 0 0
109 INT310189 Binding of Acvrl1 and Gdf2 1 0.01 0 0
110 INT305350 Pten Regulation of Phosphorylation of Akt1 1 0.05 0.95 0
111 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0
112 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0
113 INT293804 PTEN Regulation of AKT1 1 0.04 0.07 0
114 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0
115 INT268511 MIR19B1 Regulation of THBS1 1 0.20 0.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of focal adhesion assembly. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of focal adhesion assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39
2 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
3 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
4 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49
5 INT113485 Localization of MMP14 11 0.77 3.44 4.19
6 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
7 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
8 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
9 INT215926 Regulation of Gene_expression of Mmp14 1 0.45 5.33 3.15
10 INT192676 Binding of PTEN 14 0.46 10.58 3.06
11 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
12 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
13 INT99895 Positive_regulation of Mmp14 10 0.58 6.64 2.72
14 INT99897 Positive_regulation of Gene_expression of Mmp14 7 0.36 6.33 2.51
15 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
16 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45
17 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
18 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
19 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
20 INT215914 Localization of Mmp14 4 0.59 2.26 1.98
21 INT107607 Negative_regulation of MMP14 10 0.37 6.05 1.83
22 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83
23 INT192152 Negative_regulation of Mmp14 3 0.24 1.69 1.72
24 INT113479 Transcription of MMP14 3 0.51 1.81 1.7
25 INT215921 Regulation of Mmp14 1 0.33 2.8 1.7
26 INT125245 Positive_regulation of Mmp14 4 0.44 4.38 1.67
27 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
28 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
29 INT176468 Transcription of Mmp14 3 0.52 2.47 1.51
30 INT228249 Binding of Pten 7 0.48 3.26 1.45
31 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
32 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
33 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
34 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4
35 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
36 INT288546 Regulation of Positive_regulation of THBS1 1 0.36 2.65 1.27
37 INT150805 Localization of THBS1 4 0.46 2.88 1.23
38 INT190014 Regulation of Pten 8 0.62 6.03 1.2
39 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
40 INT125248 Negative_regulation of Mmp14 1 0.06 3.06 1.07
41 INT99767 Regulation of THBS1 18 0.42 11.51 1.03
42 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03
43 INT192155 Negative_regulation of Negative_regulation of Mmp14 1 0.17 0.88 0.94
44 INT90370 Gene_expression of Mmp14 3 0.49 3.71 0.93
45 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87
46 INT276177 Regulation of Gene_expression of Pten 1 0.34 1.51 0.84
47 INT311884 Negative_regulation of Acvrl1 1 0.30 2.16 0.81
48 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78
49 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75
50 INT144073 Positive_regulation of Gene_expression of MMP14 4 0.24 6.13 0.72
51 INT224633 Binding of Mmp14 1 0.06 0.83 0.69
52 INT276199 Binding of Pten 2 0.30 0.4 0.67
53 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63
54 INT276179 Regulation of Pten 1 0.46 0.81 0.63
55 INT149889 Localization of Mmp14 5 0.47 2.58 0.61
56 INT113484 Positive_regulation of Localization of MMP14 1 0.58 0.34 0.6
57 INT252993 Negative_regulation of THBS1 8 0.55 6.93 0.59
58 INT196352 Positive_regulation of Transcription of MMP14 1 0.06 0.91 0.58
59 INT161322 Localization of PTEN 9 0.73 5.65 0.57
60 INT215918 Negative_regulation of Positive_regulation of Mmp14 1 0.31 0.45 0.56
61 INT150808 Negative_regulation of Localization of THBS1 1 0.25 0.5 0.53
62 INT138125 Positive_regulation of MMP14 5 0.49 4.04 0.52
63 INT192153 Protein_catabolism of Mmp14 1 0.31 1.01 0.52
64 INT282919 Regulation of MMP14 1 0.12 1.53 0.52
65 INT176146 Positive_regulation of Localization of PTEN 3 0.36 1.69 0.5
66 INT345323 Protein_catabolism of MMP14 1 0.33 0.12 0.49
67 INT130732 Binding of MMP14 4 0.36 2.58 0.47
68 INT268576 Positive_regulation of Gene_expression of THBS1 2 0.64 2.26 0.47
69 INT276174 Regulation of Negative_regulation of Pten 1 0.34 0.63 0.47
70 INT276180 Positive_regulation of Negative_regulation of Pten 1 0.35 0.89 0.43
71 INT276202 Negative_regulation of Protein_catabolism of Pten 1 0.32 0.78 0.42
72 INT113481 Regulation of Localization of MMP14 1 0.43 0.24 0.42
73 INT276204 Protein_catabolism of Pten 1 0.75 0.77 0.41
74 INT203816 Localization of Pten 4 0.75 1.37 0.4
75 INT311889 Negative_regulation of Gene_expression of Acvrl1 1 0.22 1.27 0.37
76 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35
77 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35
78 INT107608 Regulation of Negative_regulation of MMP14 1 0.17 0.4 0.34
79 INT281469 Transcription of Pten 2 0.72 1.12 0.32
80 INT281474 Regulation of Transcription of Pten 1 0.62 0.35 0.32
81 INT263819 Regulation of Gene_expression of PTEN 1 0.25 0.63 0.32
82 INT311895 Regulation of Positive_regulation of Acvrl1 1 0.23 0.97 0.29
83 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28
84 INT133488 Negative_regulation of Phosphorylation of PTEN 4 0.41 1.88 0.26
85 INT220857 Negative_regulation of Transcription of Mmp14 1 0.05 1.04 0.2
86 INT215917 Regulation of Regulation of Mmp14 1 0.33 0.95 0.2
87 INT178504 Positive_regulation of Localization of THBS1 2 0.05 1.9 0.19
88 INT224616 Regulation of Negative_regulation of Pten 1 0.13 1.21 0.18
89 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16
90 INT231474 Binding of THBS1 4 0.34 2.04 0.16
91 INT189590 Positive_regulation of ACVRL1 3 0.08 1.3 0.16
92 INT239373 Positive_regulation of Positive_regulation of PTEN 3 0.25 4.98 0.12
93 INT210224 Localization of Acvrl1 1 0.03 0.33 0.12
94 INT236108 Positive_regulation of Positive_regulation of Pten 3 0.39 2.3 0.04
95 INT176144 Positive_regulation of Phosphorylation of PTEN 1 0.36 0.29 0.04
96 INT233844 Negative_regulation of Positive_regulation of Pten 1 0.17 0.73 0.04
97 INT294469 Transcription of THBS1 2 0.66 0.46 0.03
98 INT231690 Negative_regulation of Binding of THBS1 1 0.16 0.37 0.03
99 INT265340 Binding of Acvrl1 3 0.30 0.46 0
100 INT315882 Regulation of Negative_regulation of PTEN 2 0.44 1.39 0
101 INT305346 Positive_regulation of Negative_regulation of Pten 2 0.41 0.91 0
102 INT321706 Negative_regulation of Phosphorylation of Pten 1 0.38 0.16 0
103 INT310166 Regulation of Acvrl1 1 0.07 0 0
104 INT337281 Regulation of Gene_expression of THBS1 1 0.57 0.48 0
105 INT252974 Positive_regulation of Negative_regulation of THBS1 1 0.03 0.09 0
106 INT304062 Regulation of Localization of PTEN 1 0.43 1.29 0
107 INT310163 Positive_regulation of Positive_regulation of Acvrl1 1 0.08 0 0
108 INT351091 Negative_regulation of Binding of PTEN 1 0.09 0.23 0
109 INT189611 Negative_regulation of Gene_expression of ACVRL1 1 0.06 0.29 0
110 INT334324 Positive_regulation of Negative_regulation of PTEN 1 0.41 0.81 0
111 INT297259 Regulation of ACVRL1 1 0.18 0.55 0
112 INT252970 Negative_regulation of Positive_regulation of THBS1 1 0.04 0.2 0
113 INT176158 Regulation of Positive_regulation of PTEN 1 0.32 0.23 0
114 INT244680 Positive_regulation of Gene_expression of Mmp14 1 0.44 0 0
115 INT244684 Binding of Mmp14 1 0.23 0.1 0
116 INT207312 Phosphorylation of THBS1 1 0.43 0.28 0
117 INT337279 Positive_regulation of Binding of THBS1 1 0.46 0 0
118 INT320827 Negative_regulation of Gene_expression of THBS1 1 0.03 1.52 0
119 INT245109 Negative_regulation of Binding of MMP14 1 0.12 1.14 0
120 INT228244 Negative_regulation of Binding of Pten 1 0.16 0.72 0
121 INT337283 Positive_regulation of Regulation of THBS1 1 0.46 0 0
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