GO:0051896

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Name regulation of protein kinase B signaling cascade
Categary Process
Go Slim No
Go Link GO:0051896
Unique Molecular Interactions 106
Total Molecular Interactions 207
Total Single Events 989
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of protein kinase B signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported for regulation of protein kinase B signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
2 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
3 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
4 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
5 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
6 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
7 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
8 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
9 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
10 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34
11 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
12 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11
13 INT132610 Bdnf Positive_regulation of Ntrk2 4 0.46 1.09 0.93
14 INT298289 Runx1 Negative_regulation of Ntrk2 1 0.60 1.09 0.87
15 INT245564 Runx3 Negative_regulation of Ntrk2 3 0.61 1.61 0.79
16 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7
17 INT161186 Bdnf Regulation of Gene_expression of Ntrk2 1 0.44 1.05 0.68
18 INT142244 Positive_regulation of Ntrk2 Positive_regulation of Tcrg-C1 1 0.77 0 0.67
19 INT142243 Ntrk2 Positive_regulation of Tcrg-C1 1 0.77 0 0.67
20 INT161184 NMS Positive_regulation of Gene_expression of Ntrk2 1 0.55 1.3 0.67
21 INT90119 Ntrk2 Regulation of Gene_expression of Nfkb1 1 0.01 0.27 0.6
22 INT79740 Ntf3 Regulation of Positive_regulation of Ntrk2 1 0.28 0 0.6
23 INT90115 Ntrk2 Regulation of Jun 1 0.01 0.27 0.57
24 INT298271 Proc Negative_regulation of Gene_expression of Ntrk2 1 0.01 0.79 0.56
25 INT298278 Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.8 0.56
26 INT261481 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.02 0.21 0.56
27 INT193554 Ntrk2 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.73 0.52
28 INT134533 Binding of Ntrk2 and Psds1 1 0.01 0 0.5
29 INT128043 Positive_regulation of Ntrk2 Positive_regulation of Phosphorylation of Trib3 1 0.07 0.34 0.45
30 INT154592 Binding of Ntrk2 and Positive_regulation of Gene_expression of Kcna3 1 0.11 0.16 0.44
31 INT298296 Gene_expression of Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.33 0.39
32 INT201485 Ntrk2 Positive_regulation of Prkcg 1 0.01 0.73 0.38
33 INT53127 Binding of Ntrk2 and Ntf4 1 0.12 0 0.33
34 INT75989 Regulation of RICTOR Positive_regulation of IK 1 0.00 0.15 0.27
35 INT75988 RICTOR Positive_regulation of IK 1 0.00 0.15 0.27
36 INT298297 Pou4f1 Positive_regulation of Gene_expression of Ntrk2 1 0.50 0.36 0.24
37 INT287103 Binding of FL and Ntrk2 1 0.28 0.67 0.24
38 INT298290 Pou4f1 Regulation of Gene_expression of Ntrk2 1 0.29 0.48 0.23
39 INT154591 Binding of Ntrk2 and Positive_regulation of Kcna3 1 0.11 0.08 0.22
40 INT187486 Binding of Prkag1 and Stk11 1 0.01 0.95 0.22
41 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21
42 INT298275 Binding of Runx3 and Ntrk2 1 0.37 0.16 0.21
43 INT317394 Binding of Stk11 and Amp1 1 0.04 0.89 0.21
44 INT47694 sps Regulation of Ntrk2 1 0.00 0.98 0.2
45 INT287100 FL Positive_regulation of Ntrk2 1 0.30 0.61 0.2
46 INT298294 Gene_expression of Runx3 Negative_regulation of Ntrk2 1 0.39 0.16 0.19
47 INT154593 Ntrk2 Regulation of Kcna3 1 0.06 0.06 0.19
48 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19
49 INT280485 Ntrk2 Positive_regulation of Localization of Bdnf 1 0.55 0.45 0.19
50 INT280486 Binding of Ngfr and Ntrk2 2 0.18 1.21 0.17
51 INT320259 Binding of Ntrk2 and Atf3 1 0.01 0.38 0.17
52 INT320263 Binding of Ntrk2 and Atf4 1 0.01 0.38 0.17
53 INT298265 Runx3 Negative_regulation of Gene_expression of Ntrk2 1 0.61 0.25 0.17
54 INT298293 Runx1 Positive_regulation of Negative_regulation of Ntrk2 1 0.52 0.54 0.16
55 INT300861 Ngf Positive_regulation of Ntrk2 1 0.29 0.27 0.15
56 INT223475 Binding of Ntrk1 and Ntrk2 2 0.22 0.25 0.14
57 INT321181 Binding of Ntrk2 and Ntf5 1 0.09 0.08 0.14
58 INT320261 Binding of Myc and Ntrk2 1 0.01 0.36 0.13
59 INT351974 Agt Positive_regulation of Gene_expression of Stk11 1 0.51 11.1 0.12
60 INT189559 STK11 Positive_regulation of SNRK 1 0.03 0.36 0.11
61 INT349858 Binding of Ngfr and Ntrk2 1 0.09 0.32 0.11
62 INT317392 Negative_regulation of Binding of Stk11 and Amp1 1 0.05 0.34 0.1
63 INT340318 Gopc Regulation of Ntrk2 1 0.24 0.1 0.08
64 INT300869 Ntrk2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.16 0.08
65 INT317398 Amp1 Positive_regulation of Phosphorylation of Stk11 1 0.05 0.22 0.07
66 INT215188 Binding of Ntrk2 and Nnat 1 0.00 0.15 0.07
67 INT317391 Amp1 Positive_regulation of Stk11 1 0.05 0.22 0.07
68 INT253139 Il6 Positive_regulation of Phosphorylation of Stk11 1 0.26 0.34 0.07
69 INT317389 Binding of Prkag1 and Stk11 1 0.16 0.2 0.06
70 INT317397 Negative_regulation of Binding of Prkag1 and Stk11 1 0.19 0.2 0.06
71 INT270705 Negative_regulation of Bdnf Positive_regulation of Ntrk2 1 0.22 0 0.05
72 INT257878 Ins1 Positive_regulation of Gene_expression of Ntrk2 1 0.00 0.65 0.04
73 INT307462 Gsk3a Regulation of Ntrk2 1 0.04 0.09 0.04
74 INT257877 Ins1 Positive_regulation of Phosphorylation of Ntrk2 1 0.00 0.66 0.04
75 INT307456 Bdnf Positive_regulation of Transcription of Ntrk2 1 0.14 0.25 0.04
76 INT307461 Bdnf Positive_regulation of Ntrk2 1 0.19 0.25 0.04
77 INT321178 Binding of Ntrk2 and Mgst1 1 0.07 0 0.03
78 INT317388 Stk11 Regulation of Positive_regulation of Prkag1 1 0.23 0.11 0.03
79 INT85473 Ntrk2 Regulation of Gene_expression of Pdyn 1 0.01 0.38 0.03
80 INT317404 Acc Positive_regulation of Stk11 1 0.41 0.06 0.03
81 INT351972 Binding of Agt and Stk11 1 0.27 0.74 0
82 INT307458 Ntrk2 Positive_regulation of Phosphorylation of Gsk3a 1 0.05 0 0
83 INT321180 Ntrk2 Regulation of Ntrk1 1 0.16 0 0
84 INT351975 Agt Positive_regulation of Stk11 1 0.34 0.39 0
85 INT321179 Negative_regulation of Binding of Bdnf and Ntrk2 1 0.38 0 0
86 INT299306 Binding of QPCT and RICTOR 1 0.02 0 0
87 INT351984 Gene_expression of Stk11 Positive_regulation of Gene_expression of Dcc 1 0.01 1.8 0
88 INT299284 RICTOR Negative_regulation of PI3 1 0.18 0 0
89 INT351982 Smarca4 Positive_regulation of Stk11 1 0.05 0.58 0
90 INT351985 Stk11 Positive_regulation of Gene_expression of Dcc 1 0.01 1.79 0
91 INT223479 Binding of Ntrk2 and Dok5 1 0.26 0.17 0
92 INT299290 Binding of VEGFA and RICTOR 1 0.16 0 0
93 INT210873 Binding of Ntrk2 and Adarb1 1 0.00 0 0
94 INT351976 Binding of Tp53 and Stk11 1 0.13 2.3 0
95 INT151589 Stk11 Positive_regulation of Prkag1 1 0.41 0.17 0
96 INT65173 Negative_regulation of Ntrk2 Negative_regulation of Bdnf 1 0.37 0 0
97 INT259094 STK11 Positive_regulation of Gene_expression of TCEAL1 1 0.18 5.5 0
98 INT340319 Ntrk2 Regulation of Gopc 1 0.24 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of protein kinase B signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported in regulation of protein kinase B signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68
2 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
3 INT47689 Positive_regulation of Ntrk2 44 0.68 16.84 19.59
4 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23
5 INT65172 Negative_regulation of Ntrk2 35 0.59 9.89 13.08
6 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75
7 INT47682 Transcription of Ntrk2 19 0.69 6.32 8.6
8 INT47691 Positive_regulation of Gene_expression of Ntrk2 17 0.62 13.64 6.96
9 INT47681 Regulation of Ntrk2 17 0.62 3.61 6.31
10 INT106552 Positive_regulation of Gene_expression of Ntrk2 19 0.68 9.72 5.51
11 INT107103 Negative_regulation of Ntrk2 21 0.59 10.38 5.28
12 INT106555 Binding of Ntrk2 15 0.48 6.31 5.05
13 INT65056 Binding of Ntrk2 20 0.36 3.72 4.42
14 INT122882 Regulation of Ntrk2 13 0.62 9.7 4.3
15 INT47686 Regulation of Gene_expression of Ntrk2 5 0.44 5.24 4.14
16 INT200047 Negative_regulation of Gene_expression of Ntrk2 8 0.56 10.78 3.95
17 INT134527 Phosphorylation of Ntrk2 7 0.69 3.72 3.65
18 INT142237 Phosphorylation of Ntrk2 8 0.82 2.24 2.82
19 INT280459 Regulation of Gene_expression of Ntrk2 13 0.62 8.48 2.71
20 INT67621 Negative_regulation of Gene_expression of Ntrk2 7 0.41 2.71 2.52
21 INT47687 Positive_regulation of Transcription of Ntrk2 5 0.45 2.42 2.24
22 INT107102 Negative_regulation of Positive_regulation of Ntrk2 6 0.54 1.61 2.21
23 INT12965 Negative_regulation of RICTOR 3 0.37 0.32 2
24 INT26579 Regulation of RICTOR 2 0.23 0.09 1.51
25 INT326192 Negative_regulation of Binding of Ntrk2 1 0.10 1 1.47
26 INT142241 Positive_regulation of Positive_regulation of Ntrk2 3 0.66 0.87 1.43
27 INT245544 Localization of Ntrk2 7 0.77 4.52 1.32
28 INT214113 Transcription of Ntrk2 2 0.72 1.84 0.96
29 INT138941 Regulation of Transcription of Ntrk2 2 0.47 0.76 0.95
30 INT228443 Regulation of Positive_regulation of Ntrk2 3 0.22 0.81 0.84
31 INT107101 Positive_regulation of Negative_regulation of Ntrk2 1 0.46 0.56 0.77
32 INT228439 Positive_regulation of Regulation of Ntrk2 1 0.01 0.28 0.76
33 INT142239 Regulation of Phosphorylation of Ntrk2 1 0.45 0 0.74
34 INT60503 Positive_regulation of RICTOR 4 0.36 0.14 0.71
35 INT253108 Phosphorylation of Stk11 4 0.65 2.13 0.52
36 INT150459 Positive_regulation of Phosphorylation of Ntrk2 2 0.42 0.24 0.52
37 INT69892 Regulation of Regulation of Ntrk2 1 0.62 0.14 0.49
38 INT45338 Gene_expression of RICTOR 4 0.52 0.89 0.48
39 INT47688 Negative_regulation of Positive_regulation of Ntrk2 2 0.41 1.79 0.47
40 INT228438 Negative_regulation of Regulation of Ntrk2 1 0.00 0.05 0.42
41 INT126389 Binding of RICTOR 1 0.01 0.08 0.38
42 INT126390 Positive_regulation of Binding of RICTOR 1 0.01 0.08 0.38
43 INT128040 Positive_regulation of Binding of Ntrk2 1 0.49 0.32 0.37
44 INT351970 Gene_expression of Stk11 1 0.75 33.89 0.35
45 INT69891 Positive_regulation of Negative_regulation of Ntrk2 1 0.50 0.08 0.26
46 INT206803 Positive_regulation of Positive_regulation of Ntrk2 4 0.15 1.78 0.24
47 INT235325 Positive_regulation of Localization of Ntrk2 2 0.23 0.2 0.19
48 INT351969 Positive_regulation of Gene_expression of Stk11 1 0.67 21.03 0.19
49 INT196603 Gene_expression of STK11 5 0.55 6.75 0.15
50 INT189633 Regulation of STK11 3 0.41 3.57 0.14
51 INT280469 Regulation of Localization of Ntrk2 1 0.43 1.74 0.14
52 INT106227 Binding of STK11 3 0.42 3.13 0.13
53 INT189583 Transcription of STK11 2 0.49 4.43 0.13
54 INT330233 Positive_regulation of Stk11 2 0.67 8.15 0.13
55 INT151587 Positive_regulation of Stk11 2 0.38 0.44 0.12
56 INT299328 Localization of RICTOR 1 0.57 0 0.09
57 INT167518 Regulation of Localization of Ntrk2 1 0.01 0.1 0.08
58 INT253107 Regulation of Stk11 2 0.33 0.3 0.07
59 INT307478 Negative_regulation of Transcription of Ntrk2 1 0.18 0.13 0.07
60 INT253102 Negative_regulation of Stk11 1 0.31 0.22 0.07
61 INT321173 Positive_regulation of Phosphorylation of Ntrk2 1 0.50 0.19 0.06
62 INT299322 Positive_regulation of Gene_expression of RICTOR 1 0.38 0 0.05
63 INT330228 Phosphorylation of Stk11 1 0.18 0.27 0.05
64 INT330227 Positive_regulation of Positive_regulation of Stk11 1 0.11 0.06 0.05
65 INT351967 Negative_regulation of Gene_expression of Stk11 1 0.57 0.89 0.04
66 INT351966 Binding of Stk11 1 0.36 2.15 0.04
67 INT253104 Gene_expression of Stk11 2 0.53 0.07 0.03
68 INT317354 Regulation of Phosphorylation of Stk11 1 0.36 0.12 0.03
69 INT259109 Negative_regulation of STK11 2 0.54 2.11 0
70 INT223679 Protein_catabolism of RICTOR 1 0.02 0.92 0
71 INT351968 Negative_regulation of Stk11 1 0.42 4.84 0
72 INT351971 Regulation of Stk11 1 0.26 0.43 0
73 INT317352 Positive_regulation of Phosphorylation of Stk11 1 0.32 0 0
74 INT242091 Phosphorylation of STK11 1 0.30 1.93 0
75 INT301374 Localization of Stk11 1 0.23 1.58 0
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