GO:0051897

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Name positive regulation of protein kinase B signaling cascade
Categary Process
Go Slim No
Go Link GO:0051897
Unique Molecular Interactions 3493
Total Molecular Interactions 5027
Total Single Events 47602
Pain Genes Associated 93

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of protein kinase B signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of protein kinase B signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
3 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
4 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
5 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
6 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
7 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
8 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
9 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
10 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
11 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
12 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
13 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
14 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
15 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
16 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
17 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
18 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
19 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
20 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
21 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
22 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
23 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
24 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
25 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
26 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
27 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
28 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
29 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
30 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
31 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
32 INT70946 Penk Positive_regulation of Hpse 1 0.34 0 2.65
33 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
34 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
35 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
36 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
37 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
38 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
39 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
40 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
41 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
42 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
43 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
44 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
45 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
46 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
47 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
48 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
49 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
50 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
51 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
52 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
53 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
54 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
55 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
56 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
57 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
58 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
59 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
60 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
61 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
62 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
63 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
64 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
65 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
66 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
67 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
68 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
69 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
70 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
71 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
72 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
73 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
74 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
75 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
76 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
77 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
78 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
79 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
80 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
81 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
82 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
83 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
84 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
85 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
86 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
87 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
88 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
89 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
90 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
91 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
92 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
93 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
94 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
95 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
96 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
97 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
98 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
99 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
100 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
101 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
102 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
103 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
104 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
105 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
106 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
107 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
108 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
109 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
110 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46
111 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
112 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
113 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
114 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
115 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
116 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
117 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
118 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
119 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
120 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
121 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
122 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
123 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
124 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
125 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
126 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
127 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
128 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
129 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
130 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
131 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
132 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
133 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
134 INT276282 Binding of Atrn and Mc1r 1 0.32 0.41 1.29
135 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
136 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27
137 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
138 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
139 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
140 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
141 INT271602 Binding of Pdgfa and Pdgfrl 1 0.02 0.86 1.25
142 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
143 INT151658 F3 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
144 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
145 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
146 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
147 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
148 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
149 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
150 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
151 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
152 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
153 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
154 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
155 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
156 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
157 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
158 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
159 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
160 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
161 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
162 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
163 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
164 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
165 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
166 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
167 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
168 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
169 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
170 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
171 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
172 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
173 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
174 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
175 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
176 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
177 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
178 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
179 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
180 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
181 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
182 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
183 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
184 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
185 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
186 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
187 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
188 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
189 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
190 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
191 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
192 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
193 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
194 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
195 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
196 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
197 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
198 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
199 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
200 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 0.05 0.5 1.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of protein kinase B signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of protein kinase B signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
5 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
6 INT6852 Localization of TNF 883 0.81 705.95 270.84
7 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
8 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
9 INT6481 Binding of TNF 624 0.48 510.2 214.82
10 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
11 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
12 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
13 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
14 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
15 INT812 Localization of INS 1026 0.81 515.6 145.31
16 INT9660 Regulation of TNF 363 0.62 312.94 139.99
17 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
18 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
19 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
20 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
21 INT12082 Localization of IL6 365 0.81 241.78 105.78
22 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
23 INT10166 Localization of Tnf 237 0.81 153.95 88.64
24 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
25 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
26 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
27 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
28 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
29 INT19511 Localization of Il6 212 0.81 118.17 67.67
30 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
31 INT11937 Localization of Il6 228 0.81 139.83 64.39
32 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
33 INT10706 Regulation of Il6 150 0.62 93.23 62.34
34 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
35 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
36 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
37 INT21737 Binding of MC1R 129 0.48 45.45 56.54
38 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
39 INT251 Regulation of INS 398 0.62 232.47 55.04
40 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
41 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
42 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
43 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
44 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
45 INT9210 Regulation of IL6 166 0.62 125.61 49.95
46 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
47 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
48 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
49 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
50 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
51 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
52 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
53 INT13354 Transcription of TNF 108 0.72 85.81 42.32
54 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
55 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
56 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
57 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
58 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
59 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
60 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
61 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
62 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
63 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
64 INT9655 Regulation of Il6 98 0.62 70.92 31.95
65 INT35406 Localization of Tnf 94 0.81 64.63 31.65
66 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
67 INT8691 Localization of Insr 85 0.80 9.27 30.32
68 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
69 INT86437 Binding of IL6 154 0.48 121.22 29.3
70 INT5300 Regulation of Insr 54 0.60 11.33 29.26
71 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8
72 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
73 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
74 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
75 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
76 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
77 INT13415 Positive_regulation of Hpse 58 0.70 24.9 25.53
78 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
79 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
80 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
81 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
82 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
83 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
84 INT51474 Binding of Il6 55 0.48 44.99 20.52
85 INT49985 Transcription of Il6 62 0.72 40.13 20.29
86 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8
87 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
88 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
89 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
90 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
91 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
92 INT12575 Regulation of Hpse 33 0.59 17.7 18.45
93 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
94 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
95 INT61626 Transcription of IL6 73 0.72 42.04 17.86
96 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
97 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
98 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
99 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
100 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
101 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
102 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
103 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
104 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
105 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46
106 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
107 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
108 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
109 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
110 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
111 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42
112 INT10173 Binding of Tnf 45 0.48 35.6 14.32
113 INT59870 Gene_expression of F3 51 0.65 51.83 14.01
114 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9
115 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
116 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
117 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
118 INT14572 Binding of INS 205 0.48 175.43 13.38
119 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
120 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
121 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
122 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91
123 INT54763 Binding of Il6 82 0.48 63.27 12.89
124 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
125 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
126 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
127 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
128 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
129 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
130 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
131 INT71030 Binding of Mc1r 39 0.48 10.27 12.02
132 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
133 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75
134 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
135 INT50933 Transcription of Il6 38 0.72 24.31 11.58
136 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
137 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
138 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
139 INT15305 Positive_regulation of Mtor 51 0.67 8.28 11
140 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76
141 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
142 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
143 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
144 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59
145 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
146 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
147 INT20166 Negative_regulation of Mtor 32 0.56 10.64 10.25
148 INT49474 Gene_expression of Hpse 24 0.55 20.11 10.03
149 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
150 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
151 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
152 INT15307 Regulation of Mtor 27 0.48 4.7 9.34
153 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
154 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83
155 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
156 INT34777 Localization of IGF1 82 0.80 42.68 8.62
157 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
158 INT75921 Negative_regulation of Ngfr 13 0.59 8.58 8.35
159 INT44003 Gene_expression of F3 40 0.75 27.92 8.29
160 INT48310 Binding of Ngfr 25 0.48 9.72 8.16
161 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01
162 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
163 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
164 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76
165 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
166 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
167 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
168 INT68299 Binding of Tnf 17 0.39 12.55 7.49
169 INT116717 Gene_expression of CCR7 37 0.76 34.1 7.48
170 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
171 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
172 INT61542 Positive_regulation of Ngfr 15 0.70 6.35 7.34
173 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
174 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
175 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
176 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
177 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
178 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
179 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9
180 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
181 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
182 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
183 INT78713 Negative_regulation of Ngfr 9 0.54 7.07 6.73
184 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51
185 INT85632 Regulation of Mc1r 14 0.61 3.22 6.5
186 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
187 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
188 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
189 INT11154 Binding of EGFR 149 0.48 96.23 6.29
190 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
191 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
192 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
193 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21
194 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
195 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
196 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
197 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96
198 INT62422 Regulation of Gene_expression of Mc1r 12 0.62 2.28 5.93
199 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
200 INT18677 Gene_expression of F3 50 0.65 30.86 5.86
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