GO:0051898

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Name negative regulation of protein kinase B signaling cascade
Categary Process
Go Slim No
Go Link GO:0051898
Unique Molecular Interactions 387
Total Molecular Interactions 534
Total Single Events 3669
Pain Genes Associated 29

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein kinase B signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of protein kinase B signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
2 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
3 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
4 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
5 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
6 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
7 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
8 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
9 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
10 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
11 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
12 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
13 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
14 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
15 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
16 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
17 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
18 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
19 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
20 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
21 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
22 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
23 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
24 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
25 INT263236 DAG1 Positive_regulation of Prkcg 2 0.01 0.31 0.7
26 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
27 INT232622 Magi2 Regulation of Cysltr1 1 0.01 0.58 0.67
28 INT74729 Binding of Mpz and Ptprj 1 0.06 0.15 0.66
29 INT127056 Ddc Positive_regulation of Transcription of Drd3 1 0.10 0.06 0.63
30 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
31 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
32 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
33 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
34 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
35 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
36 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
37 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
38 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
39 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
40 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
41 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
42 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
43 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
44 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
45 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
46 INT130975 Binding of ASIC3 and Slc9a3r1 1 0.06 0.26 0.43
47 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
48 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
49 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
50 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
51 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
52 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
53 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
54 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
55 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
56 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
57 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
58 INT81506 Drd3 Regulation of Positive_regulation of Fos 1 0.28 0 0.37
59 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
60 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
61 INT138515 Drd3 Negative_regulation of Localization of Tnf 1 0.06 0.4 0.36
62 INT130974 Slc9a3r1 Positive_regulation of ASIC3 1 0.08 0.29 0.36
63 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
64 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
65 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
66 INT51629 Binding of DRD3 and OPRK1 1 0.15 0 0.33
67 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
68 INT51628 Binding of ACHE and DRD3 1 0.15 0 0.33
69 INT51631 Binding of DRD3 and PENK 1 0.08 0 0.33
70 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
71 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
72 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28
73 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28
74 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28
75 INT105004 Binding of DRD3 and PDYN 1 0.23 0.49 0.26
76 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25
77 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
78 INT189670 CHKB Negative_regulation of Gene_expression of DAG1 1 0.11 0 0.24
79 INT46400 Negative_regulation of Drd3 Positive_regulation of Localization of Prl 1 0.15 0.09 0.22
80 INT46399 Negative_regulation of Drd3 Positive_regulation of Prl 1 0.15 0.09 0.22
81 INT164136 Binding of DRD2 and Prl 1 0.09 0 0.22
82 INT335464 Binding of DAG1 and PRKCA 1 0.03 0 0.22
83 INT164135 Binding of Drd2 and Prl 1 0.04 0 0.22
84 INT148345 Binding of Drd3 and Adra1a 1 0.18 0.12 0.21
85 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
86 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
87 INT69254 Drd2 Regulation of Gene_expression of Pomc 1 0.01 0 0.2
88 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2
89 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
90 INT299113 Binding of INPP5K and GOPC 1 0.18 2.69 0.19
91 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
92 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
93 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
94 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
95 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17
96 INT256987 Binding of Cd81 and Slc9a3r1 1 0.43 0.06 0.17
97 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
98 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17
99 INT157097 Ddc Positive_regulation of Drd3 1 0.30 0.88 0.16
100 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
101 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
102 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
103 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15
104 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
105 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
106 INT227956 Drd2 Regulation of Chrm2 1 0.07 0.38 0.13
107 INT227957 Chrm4 Regulation of Localization of Drd2 1 0.19 0.38 0.13
108 INT227960 Drd2 Regulation of Chrm5 1 0.26 0.38 0.13
109 INT227958 Chrm2 Regulation of Localization of Drd2 1 0.17 0.38 0.13
110 INT227959 Drd2 Regulation of Chrm4 1 0.08 0.38 0.13
111 INT67619 Inpp5k Negative_regulation of Ptgs1 1 0.03 0.5 0.13
112 INT202255 Binding of DRD2 and TCN1 1 0.16 0 0.12
113 INT312218 INPP5K Positive_regulation of Protein_catabolism of IGFBP3 1 0.17 0.39 0.11
114 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
115 INT258767 Binding of Drd2 and ADHD1 1 0.11 1.14 0.11
116 INT312212 Binding of ADAM12 and INPP5K 1 0.16 0.46 0.11
117 INT352763 Sms Regulation of Gene_expression of DAG1 1 0.08 0.64 0.11
118 INT243996 Binding of Dag1 and Dmd 1 0.04 0.08 0.11
119 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
120 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1
121 INT8046 SORT1 Negative_regulation of Drd2 1 0.00 0 0.09
122 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 0.13 0.61 0.09
123 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
124 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
125 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
126 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
127 INT244027 Binding of Dag1 and Helt 1 0.00 0.05 0.08
128 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
129 INT258768 Drd2 Regulation of ADHD1 1 0.14 0.79 0.07
130 INT283126 Dag1 Positive_regulation of Localization of Aqp4 1 0.47 0.2 0.07
131 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
132 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
133 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
134 INT352766 DAG1 Positive_regulation of Prkd1 1 0.15 0.38 0.07
135 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
136 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07
137 INT244092 Binding of C2 and Drd2 1 0.01 0.06 0.07
138 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
139 INT312228 INPP5K Regulation of TGFB1 1 0.06 0.08 0.05
140 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05
141 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05
142 INT234620 Regulation of Binding of IGF1 and IGF1R 1 0.07 0.39 0.05
143 INT352762 DAG1 Regulation of Sms 1 0.03 0.37 0.05
144 INT312226 INPP5K Positive_regulation of IGFBP5 1 0.12 0.07 0.05
145 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
146 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
147 INT327711 Binding of Drd2 and Uts2r 1 0.07 0.41 0.04
148 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04
149 INT246786 Ogg1 Regulation of Phosphorylation of Tsc2 1 0.20 0.42 0.04
150 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
151 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
152 INT352764 DAG1 Positive_regulation of Sms 1 0.06 0.11 0.03
153 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
154 INT246791 Tsc2 Regulation of Ogg1 1 0.27 0.56 0.03
155 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
156 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
157 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
158 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03
159 INT115609 Binding of ERBB2 and SFRP5 3 0.15 1.83 0
160 INT312224 INPP5K Regulation of Negative_regulation of COL1A1 1 0.08 0 0
161 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
162 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
163 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
164 INT246784 Negative_regulation of Tsc2 Positive_regulation of Negative_regulation of Ogg1 1 0.20 0.43 0
165 INT246811 Ros1 Positive_regulation of Tsc2 1 0.02 0 0
166 INT250659 Negative_regulation of PTEN Positive_regulation of Positive_regulation of PIK3CB 1 0.02 1.18 0
167 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
168 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
169 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
170 INT312221 Binding of TGFB1 and INPP5K 1 0.09 0 0
171 INT256997 Binding of RLBP1 and Slc9a3r1 1 0.44 0 0
172 INT246808 Tsc2 Regulation of Regulation of Tsc1 1 0.02 0.05 0
173 INT312220 IL4 Positive_regulation of Regulation of INPP5K 1 0.05 0.24 0
174 INT246794 Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.03 0.66 0
175 INT312222 IFNA1 Positive_regulation of Regulation of INPP5K 1 0.05 0.24 0
176 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
177 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0
178 INT202571 Binding of DRD2 and DRD4 1 0.41 0.76 0
179 INT267255 Bcl2 Positive_regulation of Gene_expression of Ptprj 1 0.04 0.63 0
180 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0
181 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0
182 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 0.63 0.51 0
183 INT235648 Binding of EFNA1 and EPHA2 1 0.23 1.3 0
184 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
185 INT315065 IGF1R Regulation of Gene_expression of PAR4 1 0.37 0.53 0
186 INT246787 Akt2 Positive_regulation of Phosphorylation of Tsc2 1 0.10 0.16 0
187 INT312230 INPP5K Regulation of Gene_expression of COL2A1 1 0.06 0 0
188 INT321718 Ins1 Regulation of Gene_expression of Pten 1 0.04 0.23 0
189 INT312225 Positive_regulation of INPP5K Positive_regulation of CD44 1 0.15 0.1 0
190 INT246789 Pik3c3 Regulation of Tsc2 1 0.02 0.34 0
191 INT235647 TP63 Regulation of EPHA2 1 0.15 0.97 0
192 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0
193 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
194 INT230762 Binding of DAG1 and Tbx15 1 0.00 0.21 0
195 INT315049 IGF1R Regulation of MT1X 1 0.29 0.52 0
196 INT246809 Negative_regulation of Tsc2 Positive_regulation of Positive_regulation of Ogg1 1 0.20 0.45 0
197 INT337408 Binding of TCF4 and KLF4 1 0.09 0 0
198 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
199 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
200 INT312214 INPP5K Regulation of Gene_expression of COL1A1 1 0.08 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein kinase B signaling cascade. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of protein kinase B signaling cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
2 INT13501 Binding of Drd2 65 0.48 23.76 35.6
3 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
4 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
5 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
6 INT12484 Binding of Drd2 45 0.48 15.17 24.72
7 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
8 INT49774 Binding of DRD2 48 0.48 17.42 20.73
9 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
10 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
11 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
12 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
13 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07
14 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
15 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
16 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
17 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
18 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
19 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
20 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
21 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
22 INT64215 Gene_expression of Drd3 16 0.78 5.27 6.71
23 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
24 INT24460 Localization of Drd2 12 0.73 2.96 6.46
25 INT86772 Localization of Drd2 14 0.80 1.93 6.17
26 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
27 INT42799 Positive_regulation of Drd3 11 0.69 1.1 5.92
28 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
29 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
30 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
31 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
32 INT50330 Positive_regulation of Drd3 7 0.70 0.76 5.08
33 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
34 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
35 INT24011 Binding of Drd3 13 0.47 3.03 4.64
36 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
37 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
38 INT76714 Binding of Drd3 9 0.37 2.33 4.09
39 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
40 INT89329 Regulation of Gene_expression of Drd3 4 0.61 0.72 3.56
41 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
42 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
43 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
44 INT192676 Binding of PTEN 14 0.46 10.58 3.06
45 INT82992 Gene_expression of DRD3 3 0.50 2.12 2.88
46 INT15157 Gene_expression of INPP5K 30 0.67 15.49 2.85
47 INT99419 Regulation of Drd3 7 0.48 1.89 2.81
48 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
49 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
50 INT89327 Positive_regulation of Gene_expression of Drd3 4 0.54 0.32 2.64
51 INT67618 Positive_regulation of Inpp5k 3 0.45 0.77 2.64
52 INT89326 Transcription of Drd3 4 0.37 0.67 2.58
53 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
54 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
55 INT51047 Regulation of Drd3 4 0.53 2 2.2
56 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
57 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
58 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
59 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
60 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
61 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
62 INT105008 Binding of DRD3 5 0.36 3.15 2.05
63 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
64 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
65 INT89330 Positive_regulation of Binding of Drd3 1 0.31 0.16 1.81
66 INT267108 Negative_regulation of Gene_expression of DRD3 2 0.26 1.53 1.69
67 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
68 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
69 INT141455 Negative_regulation of Inpp5k 2 0.36 1.09 1.51
70 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
71 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
72 INT228249 Binding of Pten 7 0.48 3.26 1.45
73 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
74 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
75 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
76 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
77 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
78 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
79 INT173328 Positive_regulation of DAG1 6 0.31 1.74 1.36
80 INT125296 Regulation of Inpp5k 1 0.22 0 1.32
81 INT112063 Regulation of Gene_expression of Drd3 2 0.09 1.84 1.31
82 INT202817 Gene_expression of Dag1 16 0.75 7.82 1.3
83 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
84 INT82991 Regulation of Gene_expression of DRD3 1 0.23 0.59 1.26
85 INT82988 Regulation of Transcription of DRD3 1 0.38 0.59 1.26
86 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
87 INT82987 Transcription of DRD3 1 0.58 0.59 1.25
88 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
89 INT89328 Regulation of Transcription of Drd3 2 0.22 0.51 1.21
90 INT190014 Regulation of Pten 8 0.62 6.03 1.2
91 INT4570 Negative_regulation of Drd3 4 0.39 0.09 1.2
92 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
93 INT77216 Localization of DRD2 3 0.75 0 1.19
94 INT143846 Positive_regulation of INPP5K 5 0.40 6.4 1.17
95 INT189771 Gene_expression of DAG1 5 0.27 4.14 1.12
96 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
97 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
98 INT211095 Negative_regulation of Dag1 14 0.57 7.18 1.07
99 INT60441 Positive_regulation of Positive_regulation of Drd3 1 0.21 0 1.07
100 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
101 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
102 INT88083 Negative_regulation of Drd3 3 0.58 0.88 1.01
103 INT127052 Transcription of Drd3 2 0.37 0.06 1
104 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
105 INT82989 Regulation of DRD3 1 0.23 0.45 0.99
106 INT64044 Localization of DAG1 3 0.59 0.27 0.87
107 INT89331 Positive_regulation of Transcription of Drd3 1 0.21 0.09 0.85
108 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
109 INT276177 Regulation of Gene_expression of Pten 1 0.34 1.51 0.84
110 INT119491 Positive_regulation of Positive_regulation of Drd3 1 0.46 0.17 0.83
111 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
112 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
113 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
114 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
115 INT16434 Regulation of Positive_regulation of Drd2 1 0.30 0 0.78
116 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75
117 INT12885 Negative_regulation of Binding of Drd2 2 0.53 0.26 0.71
118 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69
119 INT15662 Positive_regulation of Transcription of Drd2 3 0.39 0 0.68
120 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67
121 INT276199 Binding of Pten 2 0.30 0.4 0.67
122 INT283119 Regulation of Dag1 4 0.44 1.98 0.65
123 INT184840 Positive_regulation of Transcription of Drd2 2 0.35 1.03 0.65
124 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63
125 INT276179 Regulation of Pten 1 0.46 0.81 0.63
126 INT127050 Positive_regulation of Transcription of Drd3 1 0.26 0.06 0.62
127 INT283110 Localization of Dag1 5 0.73 3.14 0.61
128 INT131421 Localization of INPP5K 9 0.74 4.3 0.59
129 INT299115 Regulation of INPP5K 6 0.39 4.11 0.59
130 INT130971 Binding of Slc9a3r1 2 0.39 0.32 0.59
131 INT161322 Localization of PTEN 9 0.73 5.65 0.57
132 INT12483 Regulation of Binding of Drd2 1 0.38 0 0.57
133 INT47933 Positive_regulation of Localization of Drd2 1 0.10 0.23 0.56
134 INT47934 Negative_regulation of Localization of Drd2 1 0.10 0.22 0.56
135 INT145859 Regulation of Gene_expression of Igf1r 1 0.59 1.58 0.55
136 INT89285 Positive_regulation of Gene_expression of Drd3 2 0.60 0.09 0.52
137 INT74724 Regulation of Ptprj 2 0.05 0.35 0.51
138 INT176146 Positive_regulation of Localization of PTEN 3 0.36 1.69 0.5
139 INT74725 Localization of Ptprj 1 0.14 0.15 0.5
140 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
141 INT202581 Positive_regulation of Gene_expression of DRD2 2 0.49 0.81 0.47
142 INT276174 Regulation of Negative_regulation of Pten 1 0.34 0.63 0.47
143 INT66984 Regulation of Binding of Drd2 1 0.60 0 0.47
144 INT186593 Gene_expression of SFRP5 1 0.16 3.94 0.46
145 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
146 INT276180 Positive_regulation of Negative_regulation of Pten 1 0.35 0.89 0.43
147 INT130969 Positive_regulation of Binding of Slc9a3r1 1 0.09 0.26 0.43
148 INT119492 Positive_regulation of Negative_regulation of Drd3 1 0.69 0.07 0.43
149 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
150 INT276202 Negative_regulation of Protein_catabolism of Pten 1 0.32 0.78 0.42
151 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
152 INT276204 Protein_catabolism of Pten 1 0.75 0.77 0.41
153 INT124636 Negative_regulation of Positive_regulation of Drd3 1 0.43 0.09 0.41
154 INT235660 Gene_expression of EPHA2 27 0.75 23.46 0.4
155 INT203816 Localization of Pten 4 0.75 1.37 0.4
156 INT124635 Localization of Drd3 1 0.75 0.08 0.39
157 INT283120 Regulation of Gene_expression of Dag1 4 0.52 1.32 0.38
158 INT168940 Phosphorylation of Igf1r 1 0.77 2.18 0.38
159 INT130972 Gene_expression of Slc9a3r1 2 0.63 0.36 0.37
160 INT284325 Positive_regulation of Gene_expression of DAG1 3 0.13 1.08 0.36
161 INT317624 Regulation of Phosphorylation of Drd3 1 0.05 0.46 0.36
162 INT317616 Phosphorylation of Drd3 1 0.12 0.46 0.36
163 INT235655 Positive_regulation of Gene_expression of EPHA2 14 0.67 13.48 0.35
164 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35
165 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35
166 INT261442 Negative_regulation of Gene_expression of Drd3 1 0.04 0.7 0.35
167 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
168 INT132881 Binding of INPP5K 7 0.48 4.35 0.33
169 INT221833 Positive_regulation of TSC2 2 0.23 0.39 0.33
170 INT235658 Positive_regulation of EPHA2 4 0.67 3.42 0.32
171 INT119907 Binding of Inpp5k 3 0.33 0.6 0.32
172 INT281469 Transcription of Pten 2 0.72 1.12 0.32
173 INT281474 Regulation of Transcription of Pten 1 0.62 0.35 0.32
174 INT263819 Regulation of Gene_expression of PTEN 1 0.25 0.63 0.32
175 INT210766 Gene_expression of Igf1r 6 0.65 2.15 0.31
176 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
177 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
178 INT105005 Positive_regulation of Positive_regulation of DRD3 1 0.48 0.5 0.28
179 INT105006 Positive_regulation of DRD3 1 0.48 0.5 0.27
180 INT24010 Negative_regulation of Binding of Drd3 1 0.39 0 0.27
181 INT133488 Negative_regulation of Phosphorylation of PTEN 4 0.41 1.88 0.26
182 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26
183 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25
184 INT173164 Negative_regulation of INPP5K 4 0.51 2.01 0.24
185 INT326600 Negative_regulation of Gene_expression of DRD2 1 0.53 0.35 0.23
186 INT89286 Positive_regulation of Binding of Drd3 1 0.69 0 0.23
187 INT286203 Protein_catabolism of Dag1 2 0.26 1.56 0.22
188 INT154360 Localization of Tsc2 1 0.56 0.16 0.22
189 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21
190 INT250517 Phosphorylation of Igf1r 5 0.79 1.21 0.21
191 INT316917 Negative_regulation of Protein_catabolism of Dag1 1 0.12 0.44 0.21
192 INT186598 Binding of SFRP5 1 0.07 0.92 0.21
193 INT283102 Positive_regulation of Dag1 1 0.49 1.31 0.21
194 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
195 INT213792 Positive_regulation of Igf1r 3 0.45 1 0.2
196 INT352913 Regulation of EPHA2 1 0.05 0.74 0.2
197 INT89284 Regulation of Binding of Drd3 1 0.45 0 0.2
198 INT344112 Regulation of Transcription of Drd3 1 0.04 0 0.2
199 INT243937 Binding of Dag1 1 0.05 0.13 0.19
200 INT168938 Negative_regulation of Phosphorylation of Igf1r 1 0.40 1.1 0.19
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