GO:0051899

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Name membrane depolarization
Categary Process
Go Slim No
Go Link GO:0051899
Unique Molecular Interactions 770
Total Molecular Interactions 1112
Total Single Events 8666
Pain Genes Associated 34

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for membrane depolarization. They are ordered first by their pain relevance and then by number of times they were reported for membrane depolarization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
2 INT17317 Binding of Jun and Fos 7 0.42 1.03 3.5
3 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
4 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
5 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
6 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
7 INT54489 Binding of Jun and Rabep2 4 0.16 1.48 2.3
8 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
9 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
10 INT54488 Npepo Regulation of Gene_expression of Jun 1 0.30 0 1.98
11 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
12 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
13 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
14 INT139640 Jun Regulation of Gene_expression of Npy 1 0.21 1.98 1.75
15 INT165183 Ifnb1 Positive_regulation of P2rx4 1 0.04 1.73 1.73
16 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
17 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
18 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
19 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
20 INT79021 Regulation of Binding of Jun and Fos 2 0.50 0.66 1.5
21 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
22 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
23 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
24 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
25 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
26 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
27 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
28 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
29 INT155663 Positive_regulation of P2rx4 Positive_regulation of Localization of Bdnf 1 0.42 0.84 1.25
30 INT86090 SCN5A Negative_regulation of Positive_regulation of Abat 1 0.00 0 1.25
31 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
32 INT197231 Grik1 Regulation of Gabrg1 1 0.19 0.13 1.22
33 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
34 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
35 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
36 INT105423 Jun Positive_regulation of Gene_expression of Penk 1 0.43 0 1.09
37 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
38 INT105109 Cxcl12 Positive_regulation of JUN 1 0.01 1.07 1.05
39 INT95378 Binding of Jun and Jund 5 0.20 2.06 1.02
40 INT74027 Creb1 Regulation of Jun 4 0.27 1.04 1.02
41 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02
42 INT139636 Jun Negative_regulation of Phosphorylation of Npy 1 0.33 1.07 1.01
43 INT113453 Ngf Positive_regulation of JUN 1 0.27 0.6 1.01
44 INT139639 Jun Negative_regulation of Positive_regulation of Vip 1 0.53 1.07 1
45 INT139643 Jun Negative_regulation of Positive_regulation of Npy 1 0.33 1.07 1
46 INT139641 Positive_regulation of Jun Positive_regulation of Positive_regulation of Vip 1 0.37 0.95 0.99
47 INT139642 Positive_regulation of Jun Regulation of Gene_expression of Npy 1 0.21 1.07 0.97
48 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
49 INT139638 Positive_regulation of Jun Positive_regulation of Positive_regulation of Npy 1 0.36 1.18 0.96
50 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
51 INT274899 Positive_regulation of P2rx4 Positive_regulation of Localization of Gtf3a 1 0.02 1.67 0.95
52 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
53 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
54 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
55 INT12373 SCN5A Negative_regulation of Cpe 1 0.00 0 0.94
56 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
57 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
58 INT151263 Jun Positive_regulation of S100a8 1 0.00 0.95 0.92
59 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
60 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
61 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89
62 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
63 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
64 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
65 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
66 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
67 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
68 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82
69 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
70 INT140281 Binding of Adora2a and Grina 1 0.19 0.64 0.82
71 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
72 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
73 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
74 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
75 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
76 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
77 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
78 INT200094 Negative_regulation of Jun Negative_regulation of Gene_expression of Ptgs2 1 0.01 2.87 0.78
79 INT72017 Binding of Adora2a and Ptprg 2 0.07 0 0.77
80 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
81 INT76498 Binding of Tacr1 and Adora2a 1 0.09 0 0.77
82 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77
83 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
84 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
85 INT90118 Jun Regulation of Gene_expression of Nfkb1 1 0.18 0.39 0.76
86 INT145646 Binding of Scn2a1 and Scn5a 1 0.36 0 0.76
87 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
88 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
89 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76
90 INT90123 Jun Positive_regulation of Gene_expression of Fos 1 0.47 0.39 0.76
91 INT82040 Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.11 0 0.75
92 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
93 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
94 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74
95 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
96 INT186436 Phosphorylation of Creb1 Regulation of Transcription of Jun 1 0.21 0.44 0.73
97 INT186438 Creb1 Regulation of Transcription of Jun 1 0.21 0.44 0.73
98 INT82041 Positive_regulation of Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.12 0 0.72
99 INT186440 Phosphorylation of Creb1 Regulation of Jun 1 0.21 0.43 0.72
100 INT197234 Grik1 Positive_regulation of Localization of Gabrg1 1 0.15 0.82 0.71
101 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
102 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
103 INT281241 Positive_regulation of P2RX7 Negative_regulation of Gene_expression of P2rx3 1 0.03 0.79 0.71
104 INT67887 SCN5A Negative_regulation of INA 1 0.02 0.13 0.71
105 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
106 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
107 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
108 INT282139 Grm1 Regulation of Grip2 1 0.00 0.62 0.69
109 INT66581 Binding of JUN and Rare2 1 0.00 0.07 0.69
110 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69
111 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
112 INT124257 Plat Positive_regulation of Jun 5 0.12 3.33 0.67
113 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
114 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
115 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
116 INT92025 Egr1 Positive_regulation of Jun 1 0.15 0.61 0.67
117 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
118 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
119 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
120 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
121 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
122 INT197238 Grik1 Regulation of Gene_expression of Gabrg1 1 0.17 0.13 0.64
123 INT239501 Binding of Adora2a and Mtx1 1 0.24 0.95 0.64
124 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
125 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
126 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
127 INT128869 Gabrg1 Positive_regulation of Transcription of Jun 1 0.09 0.55 0.62
128 INT54487 Rabep2 Regulation of Gene_expression of Jun 1 0.06 0 0.61
129 INT197239 Grik1 Regulation of Localization of Gabrg1 1 0.10 0.56 0.61
130 INT201294 Negative_regulation of Grik1 Negative_regulation of Gabrg1 1 0.30 0 0.6
131 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
132 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
133 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
134 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
135 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
136 INT73654 Binding of Jun and Pim3 1 0.02 0.99 0.58
137 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
138 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
139 INT93063 Binding of gr and Jun 3 0.14 0.79 0.57
140 INT90115 Ntrk2 Regulation of Jun 1 0.01 0.27 0.57
141 INT282142 Grm1 Positive_regulation of Positive_regulation of Trib3 1 0.01 0.27 0.57
142 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
143 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
144 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
145 INT282821 TACR1 Regulation of P2RX7 1 0.01 2.06 0.54
146 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
147 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
148 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
149 INT271902 Binding of KCNK1 and Jun 1 0.12 0.08 0.53
150 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
151 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
152 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
153 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
154 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
155 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
156 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
157 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
158 INT111244 Binding of BRS3 and SCN5A 1 0.00 0.72 0.48
159 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
160 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
161 INT117703 OPRK1 Positive_regulation of Positive_regulation of JUN 1 0.01 0.08 0.47
162 INT88080 Binding of Chrna4 and Psmb6 1 0.03 0.56 0.46
163 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
164 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
165 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
166 INT116929 OPRK1 Positive_regulation of JUN 1 0.28 0.15 0.46
167 INT69637 Binding of CAV1 and Zfp354a 1 0.00 0 0.46
168 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
169 INT349853 Binding of Hspb1 and Jun 1 0.14 2.3 0.45
170 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
171 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
172 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
173 INT247639 Binding of Jun and Atf3 2 0.09 3.06 0.44
174 INT103132 Positive_regulation of DCSTAMP Positive_regulation of JUN 1 0.03 0.73 0.43
175 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43
176 INT146276 Binding of P2RX4 and P2RX7 1 0.38 0.38 0.43
177 INT127074 Gdnf Regulation of Gene_expression of Jun 1 0.10 0.28 0.43
178 INT127075 Bdnf Regulation of Gene_expression of Jun 1 0.11 0.28 0.43
179 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
180 INT103129 DCSTAMP Positive_regulation of JUN 1 0.03 0.72 0.43
181 INT296477 Binding of Cacng2 and Dlg4 1 0.04 0.22 0.42
182 INT155752 Binding of CACNA1A and ATCAY 1 0.04 0.86 0.42
183 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
184 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
185 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
186 INT60456 SCN5A Regulation of Scn2a1 1 0.00 0 0.41
187 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
188 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
189 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
190 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
191 INT223474 Binding of Grik1 and P2rx3 1 0.03 0.36 0.4
192 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
193 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
194 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4
195 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
196 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
197 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
198 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
199 INT97404 Nfkb1 Positive_regulation of Transcription of JUN 1 0.00 1.03 0.38
200 INT97403 JUN Positive_regulation of Transcription of Nfkb1 1 0.00 1.03 0.38

Single Events

The table below shows the top 100 pain related interactions that have been reported for membrane depolarization. They are ordered first by their pain relevance and then by number of times they were reported in membrane depolarization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54
2 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64
3 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
4 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
5 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
6 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
7 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
8 INT666 Gene_expression of Jun 124 0.78 54.61 33.67
9 INT47764 Binding of Jun 106 0.48 22.62 31.39
10 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73
11 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
12 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03
13 INT86789 Gene_expression of P2rx4 46 0.77 30.66 25.68
14 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
15 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
16 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
17 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
18 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73
19 INT112427 Positive_regulation of P2rx4 27 0.68 26.29 21.31
20 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
21 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
22 INT5048 Binding of Edn1 55 0.47 18.86 19.16
23 INT124670 Gene_expression of Grik1 53 0.77 4.83 19.13
24 INT9482 Positive_regulation of Gene_expression of Jun 60 0.69 9.95 18.61
25 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88
26 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
27 INT48055 Gene_expression of Grm1 27 0.78 14.29 17.01
28 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
29 INT197210 Positive_regulation of Grik1 24 0.69 3.15 16.24
30 INT9191 Localization of EDN1 94 0.81 57.01 14.78
31 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76
32 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61
33 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
34 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
35 INT17593 Regulation of Jun 37 0.60 5.5 14.35
36 INT15042 Gene_expression of Adora2a 37 0.77 3.77 14.24
37 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
38 INT6365 Localization of Edn1 56 0.81 18.84 13.83
39 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78
40 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
41 INT6794 Negative_regulation of Jun 37 0.53 8.04 13.37
42 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75
43 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
44 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
45 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06
46 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
47 INT122053 Positive_regulation of P2rx4 16 0.69 13.02 11.98
48 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
49 INT100919 Positive_regulation of Grm1 21 0.70 7.82 11.55
50 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47
51 INT52233 Transcription of Jun 37 0.66 6.39 11.15
52 INT15597 Negative_regulation of Gene_expression of Jun 20 0.48 6.04 11.08
53 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
54 INT60198 Binding of JUN 54 0.48 11.56 10.27
55 INT98329 Gene_expression of P2RX4 23 0.75 13.13 10.25
56 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
57 INT137980 Positive_regulation of P2RX7 30 0.67 22.49 10
58 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
59 INT6361 Localization of Edn1 30 0.81 19.09 9.7
60 INT112428 Positive_regulation of Gene_expression of P2rx4 12 0.68 12.67 9.57
61 INT168991 Negative_regulation of P2rx4 9 0.43 12.77 9.39
62 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
63 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
64 INT61264 Regulation of Jun 36 0.61 18.42 8.71
65 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
66 INT64815 Binding of Jun 49 0.48 21.47 8.59
67 INT10237 Binding of EDN1 40 0.48 16 8.48
68 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
69 INT23209 Binding of Adora2a 17 0.38 2.04 8.35
70 INT53975 Positive_regulation of Binding of Jun 28 0.70 4.67 8.16
71 INT136177 Gene_expression of P2rx4 8 0.75 6.74 8.05
72 INT54755 Negative_regulation of Adora2a 17 0.58 2.7 7.75
73 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
74 INT64816 Transcription of Jun 31 0.69 16.01 7.64
75 INT9476 Regulation of Gene_expression of Jun 14 0.43 4.25 7.61
76 INT10344 Localization of Jun 23 0.73 6.36 7.46
77 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3
78 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
79 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
80 INT75497 Regulation of JUN 28 0.61 11.04 7.09
81 INT88079 Gene_expression of Chrna4 20 0.76 8.52 6.98
82 INT53491 Negative_regulation of Jun 28 0.57 14.2 6.9
83 INT47817 Positive_regulation of Positive_regulation of Jun 21 0.66 3.7 6.83
84 INT197216 Localization of Grik1 9 0.80 0.39 6.78
85 INT112430 Negative_regulation of P2rx4 9 0.57 8.4 6.63
86 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56
87 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
88 INT47765 Negative_regulation of Binding of Jun 21 0.43 5.05 6.38
89 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
90 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
91 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
92 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
93 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
94 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
95 INT101008 Gene_expression of Scn5a 5 0.75 26.93 6.06
96 INT73649 Phosphorylation of Jun 28 0.80 11.01 5.87
97 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
98 INT113153 Regulation of Grm1 6 0.44 4.11 5.41
99 INT23598 Binding of SCN5A 32 0.40 16 5.35
100 INT30209 Localization of SCN5A 24 0.72 7.95 5.35
101 INT83014 Binding of Adora2a 13 0.48 5.57 5.33
102 INT215594 Negative_regulation of Gene_expression of P2rx4 7 0.48 6.46 5.22
103 INT93484 Negative_regulation of Positive_regulation of Jun 30 0.58 9.31 5.18
104 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
105 INT145681 Regulation of P2rx4 4 0.61 3.41 5.09
106 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
107 INT89664 Negative_regulation of Adora2a 11 0.59 7.81 5.07
108 INT100920 Positive_regulation of Gene_expression of Grm1 7 0.70 5.88 4.87
109 INT91055 Negative_regulation of Grm1 7 0.45 5.14 4.87
110 INT51468 Regulation of Adora2a 8 0.48 1.5 4.84
111 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
112 INT106524 Phosphorylation of Jun 23 0.80 15.35 4.78
113 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
114 INT197219 Positive_regulation of Gene_expression of Grik1 5 0.69 0.83 4.67
115 INT158603 Positive_regulation of Gene_expression of P2RX4 7 0.55 5.85 4.56
116 INT197230 Regulation of Positive_regulation of Grik1 4 0.45 0 4.42
117 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
118 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
119 INT136179 Positive_regulation of P2RX4 9 0.67 7.06 4.27
120 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
121 INT67936 Transcription of JUN 18 0.52 9.52 4.13
122 INT74814 Binding of Grm1 5 0.45 2.69 4.1
123 INT64163 Negative_regulation of Gene_expression of Jun 13 0.58 3.86 4.03
124 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
125 INT127047 Negative_regulation of P2RX7 10 0.39 7.17 4.01
126 INT50228 Positive_regulation of Positive_regulation of Adora2a 8 0.39 0.1 4
127 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
128 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
129 INT6661 Positive_regulation of Positive_regulation of Jun 31 0.50 7.12 3.89
130 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
131 INT110180 Phosphorylation of JUN 23 0.80 11.21 3.83
132 INT64817 Positive_regulation of Binding of Jun 16 0.69 6.78 3.81
133 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81
134 INT15776 Localization of Jun 10 0.74 3.9 3.69
135 INT131969 Regulation of Grik1 6 0.61 0.57 3.69
136 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
137 INT101701 Regulation of Adora2a 8 0.45 2.3 3.63
138 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
139 INT197207 Negative_regulation of Grik1 5 0.43 1.91 3.5
140 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47
141 INT61570 Positive_regulation of Transcription of Jun 10 0.35 1.62 3.45
142 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
143 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36
144 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
145 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
146 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23
147 INT70387 Negative_regulation of Positive_regulation of Jun 14 0.37 3.76 3.23
148 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
149 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
150 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08
151 INT68651 Negative_regulation of Positive_regulation of JUN 11 0.58 4.28 3.04
152 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
153 INT53374 Binding of Edn1 17 0.43 11.66 2.98
154 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
155 INT191120 Regulation of P2RX7 8 0.41 5.29 2.96
156 INT112429 Negative_regulation of Positive_regulation of P2rx4 4 0.57 4.03 2.94
157 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
158 INT137978 Localization of P2RX7 6 0.73 5.04 2.84
159 INT112431 Positive_regulation of Positive_regulation of P2rx4 2 0.49 3.52 2.81
160 INT64819 Positive_regulation of Transcription of Jun 6 0.50 4.41 2.79
161 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
162 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
163 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
164 INT122054 Positive_regulation of Positive_regulation of P2rx4 3 0.49 2.85 2.65
165 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
166 INT136176 Positive_regulation of Gene_expression of P2rx4 5 0.60 3.18 2.64
167 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
168 INT194495 Regulation of Transcription of Jun 4 0.26 2.85 2.6
169 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
170 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
171 INT254118 Negative_regulation of Gene_expression of Adora2a 3 0.42 2.54 2.43
172 INT123682 Localization of JUN 8 0.50 4.15 2.38
173 INT139556 Positive_regulation of Chrna4 10 0.25 4.52 2.36
174 INT60199 Positive_regulation of Binding of JUN 5 0.49 1.3 2.34
175 INT183167 Positive_regulation of Gene_expression of Adora2a 4 0.70 2.37 2.31
176 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
177 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26
178 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
179 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
180 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
181 INT137972 Binding of P2RX7 12 0.36 8.01 2.18
182 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
183 INT53981 Regulation of Binding of Jun 5 0.44 0.63 2.12
184 INT59358 Regulation of Gene_expression of Jun 10 0.61 3.7 2.11
185 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
186 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
187 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
188 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
189 INT57939 Negative_regulation of Gene_expression of Adora2a 4 0.36 0.15 2.02
190 INT123253 Localization of Chrna4 4 0.44 1.31 1.99
191 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98
192 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
193 INT98927 Localization of Grm1 4 0.71 0.42 1.97
194 INT72785 Positive_regulation of Positive_regulation of Adora2a 2 0.10 1.34 1.96
195 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
196 INT130208 Positive_regulation of Phosphorylation of JUN 4 0.38 3.07 1.92
197 INT53982 Regulation of Positive_regulation of Jun 4 0.54 0.9 1.89
198 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
199 INT194847 Negative_regulation of Positive_regulation of Adora2a 3 0.32 4.52 1.88
200 INT127250 Positive_regulation of Positive_regulation of SCN5A 3 0.38 1.71 1.86
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