GO:0055012

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Name ventricular cardiac muscle cell differentiation
Categary Process
Go Slim No
Go Link GO:0055012
Unique Molecular Interactions 115
Total Molecular Interactions 195
Total Single Events 1097
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ventricular cardiac muscle cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for ventricular cardiac muscle cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11
2 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
3 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
4 INT114947 YY1 Positive_regulation of Gene_expression of RXRA 1 0.33 0.25 0.65
5 INT114951 PPARA Positive_regulation of Gene_expression of RXRA 1 0.34 0.25 0.64
6 INT114949 NCOA1 Positive_regulation of Gene_expression of RXRA 1 0.13 0.24 0.61
7 INT44983 Ltc4s Positive_regulation of Rara 1 0.01 0.15 0.33
8 INT44985 KNG1 Positive_regulation of Rara 1 0.00 0.15 0.32
9 INT333453 Binding of PPARA and RXRA 1 0.02 0 0.31
10 INT211997 CORD1 Positive_regulation of Rara 1 0.01 0.68 0.29
11 INT141634 Binding of Alb and Nrg1 1 0.00 0.3 0.26
12 INT134522 Nrg1 Regulation of Gene_expression of Mpz 1 0.60 0.29 0.25
13 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24
14 INT134523 Nrg1 Positive_regulation of Gene_expression of Mpz 1 0.49 0.32 0.23
15 INT108842 RARA Positive_regulation of Gene_expression of GDF15 1 0.52 0.68 0.23
16 INT326575 Nrg1 Positive_regulation of Gene_expression of JUN 1 0.38 0.86 0.2
17 INT312550 DAK Positive_regulation of Rxra 1 0.00 1.48 0.18
18 INT313023 Binding of Rara and Rxra 1 0.06 0.73 0.17
19 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
20 INT231274 Nrg1 Regulation of Gene_expression of Akt1 1 0.19 0 0.14
21 INT192106 Regulation of Binding of Rara and Retsat 1 0.00 0.83 0.13
22 INT192105 Binding of Rara and Retsat 1 0.00 0.83 0.13
23 INT211996 Erbb3 Positive_regulation of Nrg1 2 0.03 0.67 0.11
24 INT192104 Binding of Rara and Rxrg 1 0.00 0.82 0.1
25 INT231273 Binding of Egfr and Nrg1 1 0.12 0 0.09
26 INT166723 Binding of Vdr and Rxrb 1 0.11 0.31 0.09
27 INT341008 Nrg1 Regulation of Binding of Erbb4 1 0.04 0 0.09
28 INT166724 Binding of Vdr and Rxra 1 0.28 0.32 0.09
29 INT54096 NRG1 Regulation of Protein_catabolism of Fgg 1 0.01 0 0.09
30 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
31 INT248704 Trib3 Positive_regulation of Phosphorylation of Rxrb 1 0.00 0.49 0.08
32 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
33 INT201380 RARA Positive_regulation of Regulation of CPOX 1 0.07 0.21 0.08
34 INT278684 Binding of NR1I3 and Rxra 1 0.00 0 0.07
35 INT236932 Binding of Rxra and Pprc1 1 0.00 0.45 0.07
36 INT278685 Binding of CASR and Rxra 1 0.00 0 0.07
37 INT197727 Binding of RARA and Positive_regulation of PPARA 1 0.02 0.96 0.05
38 INT285384 Binding of Rare1 and Rxra 1 0.01 0.08 0.05
39 INT187602 Binding of Ppara and Rxrb 1 0.00 0 0.05
40 INT307218 Binding of Rxra and D0Nrs1 1 0.00 0.1 0.05
41 INT248703 Mapk8 Positive_regulation of Phosphorylation of Rxrb 1 0.01 0.25 0.04
42 INT341009 Nrg1 Positive_regulation of Gene_expression of Fabp7 1 0.10 0.49 0.04
43 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03
44 INT231276 Erbb4 Positive_regulation of Nrg1 2 0.35 0.06 0.03
45 INT316057 Binding of Erbb4 and Nrg1 2 0.03 0.38 0.03
46 INT248700 Binding of Nr0b2 and Rxrb 1 0.01 0.29 0.03
47 INT297377 Binding of PPARA and Rxra 1 0.02 0.25 0.03
48 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 0.03 0.38 0.03
49 INT297375 Binding of VDR and Rxra 1 0.02 0.2 0.03
50 INT231275 Erbb4 Positive_regulation of Gene_expression of Nrg1 1 0.35 0 0.03
51 INT334869 Nrg1 Positive_regulation of Phosphorylation of C3 1 0.08 0 0.03
52 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03
53 INT297374 Binding of TXNRD1 and Rxra 1 0.01 0.2 0.03
54 INT182924 Binding of RARA and NR1H4 3 0.02 1.9 0
55 INT182918 Binding of DR1 and RARA 2 0.08 0 0
56 INT182949 Binding of RARA and VDR 1 0.20 0 0
57 INT341005 Binding of Vim and Nrg1 1 0.05 0.14 0
58 INT291715 Binding of DR1 and Rxra 1 0.09 0 0
59 INT350706 Binding of Mef2c and Mir223 1 0.02 0.11 0
60 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0
61 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0
62 INT182919 TGFBI Regulation of RARA 1 0.29 0.08 0
63 INT297213 Myoz1 Regulation of Mef2c 1 0.02 0.09 0
64 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
65 INT291716 Binding of SOD1 and Rxra 1 0.21 0 0
66 INT342366 Binding of Rara and OSBPL1A 1 0.16 0 0
67 INT182961 Binding of RARA and KCNIP3 1 0.21 0.76 0
68 INT236719 Binding of Dr1 and Rxra 1 0.01 0 0
69 INT341013 Binding of Erbb3 and Nrg1 1 0.04 0.14 0
70 INT239239 Binding of PPARA and RXRB 1 0.12 0.63 0
71 INT291682 Positive_regulation of Binding of RARA and TNFRSF10B 1 0.03 0 0
72 INT330959 Binding of RXRB and VDR 1 0.05 0.14 0
73 INT291712 Binding of Rxra and SPNS1 1 0.04 0 0
74 INT248705 Binding of Nr1i2 and Rxrb 1 0.01 0.18 0
75 INT341023 PIK3CB Positive_regulation of Nrg1 1 0.03 0.06 0
76 INT291683 Binding of RARA and TNFRSF10B 1 0.03 0 0
77 INT234440 Binding of PROC and RARA 1 0.00 0.73 0
78 INT135127 Binding of RXRB and NR1I2 1 0.29 0.57 0
79 INT291711 Rxra Positive_regulation of VDR 1 0.09 0 0
80 INT342362 Binding of Irs1 and Rara 1 0.15 0 0
81 INT291713 Binding of TNFRSF10B and Rxra 1 0.05 0 0
82 INT341010 Nrg1 Positive_regulation of Regulation of Vim 1 0.07 0 0
83 INT225504 Binding of gr and Rara 1 0.02 0 0
84 INT341014 Positive_regulation of Binding of Erbb3 and Nrg1 1 0.06 0.14 0
85 INT182948 KCNIP3 Regulation of Transcription of RARA 1 0.23 0.55 0
86 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0
87 INT291681 Positive_regulation of Binding of DR1 and RARA 1 0.06 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ventricular cardiac muscle cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in ventricular cardiac muscle cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83
2 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5
3 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98
4 INT181186 Binding of Rxra 78 0.35 14.93 4.87
5 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28
6 INT90890 Positive_regulation of RARA 25 0.67 9.32 4.2
7 INT15771 Gene_expression of Nrg1 34 0.67 3.16 4.11
8 INT130080 Negative_regulation of Rxra 6 0.53 2.08 2.92
9 INT169318 Positive_regulation of Rxra 15 0.42 4.35 2.12
10 INT168983 Negative_regulation of Nrg1 11 0.43 3.4 2.03
11 INT130082 Regulation of Rxra 6 0.42 3.78 1.96
12 INT199724 Positive_regulation of Gene_expression of Rxra 11 0.45 6.22 1.88
13 INT192092 Positive_regulation of Gene_expression of Rara 8 0.32 4.41 1.68
14 INT116022 Positive_regulation of Positive_regulation of RARA 3 0.11 0.94 1.68
15 INT105784 Binding of Nrg1 7 0.37 1.29 1.52
16 INT128865 Regulation of Positive_regulation of RXRA 1 0.08 0.64 1.48
17 INT128863 Positive_regulation of RXRA 1 0.12 0.63 1.47
18 INT67457 Binding of Rara 12 0.24 8.28 1.45
19 INT187617 Binding of Rxrb 7 0.06 4.86 1.37
20 INT158056 Localization of Nrg1 13 0.79 3.11 1.28
21 INT81400 Binding of RARA 25 0.36 12.93 1.27
22 INT132577 Binding of RXRB 12 0.30 6.58 1.25
23 INT166720 Positive_regulation of Rxrb 2 0.36 0.84 1.13
24 INT182985 Transcription of RARA 9 0.60 3.52 1.12
25 INT30851 Gene_expression of NRG1 8 0.67 4.64 1.12
26 INT101994 Positive_regulation of Nrg1 10 0.50 1.24 1.05
27 INT69758 Negative_regulation of Positive_regulation of Rara 2 0.32 0.24 0.97
28 INT19084 Negative_regulation of NRG1 5 0.42 4.9 0.96
29 INT192090 Localization of Rara 6 0.46 4.15 0.89
30 INT48251 Regulation of Positive_regulation of Rara 2 0.33 0 0.88
31 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
32 INT120366 Negative_regulation of Rara 2 0.35 0.15 0.86
33 INT48250 Regulation of Rara 3 0.29 2.47 0.83
34 INT48249 Positive_regulation of Positive_regulation of Rara 2 0.26 0 0.83
35 INT212109 Localization of RARA 5 0.65 3.17 0.79
36 INT139846 Protein_catabolism of Nrg1 5 0.60 1.78 0.74
37 INT126736 Positive_regulation of Gene_expression of Nrg1 3 0.50 0.42 0.71
38 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
39 INT91398 Regulation of RARA 7 0.59 5.84 0.67
40 INT220433 Gene_expression of RXRB 3 0.14 1.83 0.63
41 INT114959 Gene_expression of RXRA 2 0.50 1.06 0.63
42 INT114960 Positive_regulation of Gene_expression of RXRA 1 0.32 0.24 0.61
43 INT290081 Regulation of NRG1 7 0.26 5.24 0.59
44 INT199723 Localization of Rxra 8 0.59 1.31 0.58
45 INT248682 Gene_expression of Rxrb 8 0.60 1.41 0.58
46 INT234472 Positive_regulation of Transcription of RARA 2 0.44 0.13 0.58
47 INT114277 Regulation of Gene_expression of Rxra 1 0.28 0.75 0.58
48 INT201392 Negative_regulation of RARA 8 0.30 2.99 0.5
49 INT15770 Negative_regulation of Gene_expression of Nrg1 3 0.43 1.27 0.5
50 INT265656 Positive_regulation of Gene_expression of RXRB 1 0.04 0.24 0.5
51 INT19083 Positive_regulation of NRG1 3 0.20 0.65 0.48
52 INT182966 Regulation of Gene_expression of RARA 2 0.39 0.12 0.42
53 INT211982 Negative_regulation of Binding of Rara 1 0.28 0.24 0.42
54 INT264487 Regulation of Positive_regulation of Rxrb 1 0.21 0.36 0.4
55 INT285391 Binding of RXRA 2 0.03 0.08 0.36
56 INT290096 Regulation of Gene_expression of NRG1 2 0.06 2.21 0.35
57 INT334851 Positive_regulation of Localization of Nrg1 1 0.30 0.68 0.34
58 INT238560 Regulation of Mef2c 9 0.45 2.12 0.33
59 INT199725 Negative_regulation of Gene_expression of Rxra 2 0.38 0.3 0.3
60 INT236564 Positive_regulation of Binding of Rxra 2 0.18 1.3 0.24
61 INT203557 Transcription of NRG1 2 0.31 0.7 0.24
62 INT10375 Negative_regulation of Gene_expression of RARA 1 0.57 0.97 0.22
63 INT202355 Transcription of Mef2c 3 0.69 0.6 0.21
64 INT248543 Positive_regulation of Mef2c 7 0.69 2.82 0.18
65 INT206946 Gene_expression of Rxra 4 0.60 2.2 0.17
66 INT277602 Binding of Mef2c 10 0.39 4.35 0.16
67 INT54093 Protein_catabolism of NRG1 1 0.26 0 0.16
68 INT231261 Regulation of Nrg1 3 0.31 1.32 0.15
69 INT220571 Positive_regulation of Protein_catabolism of Nrg1 1 0.30 0.08 0.15
70 INT192091 Regulation of Localization of Rara 1 0.04 0.67 0.13
71 INT332915 Positive_regulation of Localization of Rxra 1 0.03 0.3 0.11
72 INT203559 Positive_regulation of Transcription of NRG1 1 0.22 0 0.11
73 INT54092 Regulation of Protein_catabolism of NRG1 1 0.13 0 0.09
74 INT214072 Regulation of Gene_expression of RXRA 1 0.01 0.83 0.09
75 INT166719 Positive_regulation of Rxra 1 0.36 0.31 0.09
76 INT329735 Negative_regulation of Protein_catabolism of Nrg1 1 0.36 0.49 0.08
77 INT290404 Positive_regulation of Negative_regulation of Mef2c 1 0.50 0.72 0.08
78 INT214071 Negative_regulation of Transcription of RARA 3 0.37 1.77 0.07
79 INT182975 Phosphorylation of RARA 2 0.58 0.23 0.07
80 INT277578 Regulation of Negative_regulation of Mef2c 2 0.45 1.17 0.07
81 INT264489 Transcription of Rxrb 1 0.53 0.09 0.07
82 INT54094 Positive_regulation of Protein_catabolism of NRG1 1 0.14 0 0.07
83 INT220435 Regulation of Gene_expression of RXRB 1 0.01 0.25 0.06
84 INT290417 Positive_regulation of Gene_expression of Mef2c 1 0.50 1.25 0.06
85 INT256518 Positive_regulation of Transcription of Rxra 1 0.04 0.24 0.06
86 INT234452 Phosphorylation of RXRB 1 0.29 0.66 0.06
87 INT334840 Positive_regulation of Phosphorylation of Nrg1 1 0.30 0 0.06
88 INT290102 Localization of NRG1 1 0.15 0.76 0.06
89 INT220430 Negative_regulation of Gene_expression of RXRB 1 0.02 0.25 0.06
90 INT291692 Regulation of Binding of Rxra 4 0.32 0.57 0.05
91 INT220593 Negative_regulation of Localization of Nrg1 1 0.26 0.07 0.04
92 INT290407 Positive_regulation of Binding of Mef2c 1 0.44 0.93 0.04
93 INT248665 Phosphorylation of Rxrb 1 0.07 0.42 0.04
94 INT248680 Positive_regulation of Phosphorylation of Rxrb 1 0.05 0.24 0.04
95 INT225406 Transcription of Rxra 3 0.41 0.33 0.03
96 INT248671 Regulation of Rxrb 1 0.02 0.86 0.03
97 INT334841 Negative_regulation of Phosphorylation of Nrg1 1 0.26 0 0.03
98 INT256507 Regulation of Transcription of Rxra 1 0.04 0.12 0.03
99 INT290419 Regulation of Gene_expression of Mef2c 1 0.62 0.41 0.03
100 INT291693 Negative_regulation of Binding of Rxra 1 0.22 0.07 0.03
101 INT290399 Negative_regulation of Gene_expression of Mef2c 1 0.59 0.59 0.03
102 INT340964 Positive_regulation of Negative_regulation of Nrg1 1 0.28 0.12 0.03
103 INT334845 Phosphorylation of Nrg1 1 0.49 0 0.03
104 INT182990 Positive_regulation of Gene_expression of RARA 5 0.40 3.45 0
105 INT182965 Positive_regulation of Phosphorylation of RARA 1 0.29 0 0
106 INT290400 Regulation of Regulation of Mef2c 1 0.45 0.24 0
107 INT340965 Negative_regulation of Binding of Nrg1 1 0.24 0 0
108 INT335229 Regulation of Transcription of RARA 1 0.15 0.95 0
109 INT248676 Positive_regulation of Gene_expression of Rxrb 1 0.05 0.18 0
110 INT220588 Transcription of Nrg1 1 0.41 0.64 0
111 INT183002 Positive_regulation of Binding of RARA 1 0.29 1.08 0
112 INT231922 Negative_regulation of Positive_regulation of Rxra 1 0.06 0.33 0
113 INT171658 Binding of NRG1 1 0.05 0.17 0
114 INT335226 Negative_regulation of Negative_regulation of RARA 1 0.24 0.71 0
115 INT290429 Negative_regulation of Negative_regulation of Mef2c 1 0.37 0.05 0
116 INT346487 Negative_regulation of Phosphorylation of RXRA 1 0.01 0.63 0
117 INT290425 Negative_regulation of Binding of Mef2c 1 0.37 0 0
118 INT291694 Negative_regulation of Localization of Rxra 1 0.22 0 0
119 INT248686 Regulation of Gene_expression of Rxrb 1 0.04 0.23 0
120 INT290409 Negative_regulation of Transcription of Mef2c 1 0.43 0.08 0
121 INT291695 Regulation of Negative_regulation of Rxra 1 0.23 0.14 0
122 INT346494 Phosphorylation of RXRA 1 0.01 0.63 0
123 INT340954 Positive_regulation of Positive_regulation of Nrg1 1 0.28 0 0
124 INT234187 Positive_regulation of Gene_expression of NRG1 1 0.02 0.32 0
125 INT291698 Negative_regulation of Negative_regulation of Rxra 1 0.22 0 0
126 INT340974 Negative_regulation of Negative_regulation of Nrg1 1 0.24 0 0
127 INT277587 Localization of Mef2c 1 0.65 0.43 0
128 INT231271 Regulation of Localization of Nrg1 1 0.45 0 0
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