GO:0055098

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Name response to low-density lipoprotein particle stimulus
Categary Process
Go Slim No
Go Link GO:0055098
Unique Molecular Interactions 126
Total Molecular Interactions 147
Total Single Events 1492
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to low-density lipoprotein particle stimulus. They are ordered first by their pain relevance and then by number of times they were reported for response to low-density lipoprotein particle stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT151658 F3 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
2 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
3 INT284481 Binding of ABCA1 and Ighg1 1 0.00 1.39 0.7
4 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55
5 INT125699 CR1 Negative_regulation of Positive_regulation of ABCA1 1 0.03 0.64 0.53
6 INT345308 Binding of ABCA1 and TIMP2 1 0.00 0.21 0.52
7 INT187114 TIMP2 Negative_regulation of ABCA1 1 0.02 0.28 0.51
8 INT187108 TIMP1 Negative_regulation of ABCA1 1 0.02 0.28 0.51
9 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46
10 INT107703 PPARG Regulation of Gene_expression of CPOX 1 0.16 0.15 0.41
11 INT114809 Selp Positive_regulation of Gene_expression of F3 1 0.00 0.88 0.34
12 INT174266 TNF Regulation of Gene_expression of F3 1 0.00 3.2 0.33
13 INT122169 AKR1C3 Regulation of PPARG 1 0.45 0.26 0.33
14 INT116292 Gm9662 Negative_regulation of Pparg 1 0.00 0 0.33
15 INT174265 IL18 Regulation of Gene_expression of F3 1 0.00 3.21 0.33
16 INT277011 CRP Positive_regulation of Gene_expression of F3 1 0.06 1.03 0.32
17 INT116291 Gm9662 Negative_regulation of Positive_regulation of Pparg 1 0.00 0 0.32
18 INT148556 PPARG Regulation of Gene_expression of PPARA 1 0.30 1.2 0.31
19 INT122168 AKR1C1 Regulation of PPARG 1 0.12 0.25 0.31
20 INT191503 CD40LG Regulation of Gene_expression of F3 1 0.01 0.99 0.27
21 INT282647 IL6 Positive_regulation of Gene_expression of F3 1 0.00 1.89 0.27
22 INT282648 IL8 Positive_regulation of Gene_expression of F3 1 0.00 1.89 0.27
23 INT110373 CYP4A11 Positive_regulation of PPARG 1 0.00 0.94 0.26
24 INT261375 Binding of Nsdhl and Pparg 1 0.05 1.03 0.25
25 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
26 INT130060 PPARG Positive_regulation of Positive_regulation of Egr1 1 0.22 0.46 0.24
27 INT84522 IRF6 Positive_regulation of Gene_expression of F3 1 0.08 0.1 0.21
28 INT115148 PPARG Negative_regulation of Gene_expression of INSIG2 1 0.01 0.34 0.21
29 INT335046 PPARA Positive_regulation of Gene_expression of ABCA1 1 0.33 0.25 0.18
30 INT81296 Positive_regulation of Pparg Regulation of Gene_expression of Hmox1 1 0.25 0.17 0.17
31 INT207345 PTGDS Negative_regulation of Gene_expression of ABCA1 1 0.21 0 0.17
32 INT81297 Positive_regulation of Pparg Regulation of Gene_expression of Nos2 1 0.23 0.17 0.17
33 INT207359 ZNF398 Negative_regulation of ABCA1 1 0.01 0 0.17
34 INT207344 PTGER2 Negative_regulation of Gene_expression of ABCA1 1 0.04 0 0.17
35 INT207350 TBXA2R Regulation of Gene_expression of ABCA1 1 0.10 0 0.17
36 INT207338 Negative_regulation of CPOX Negative_regulation of ABCA1 1 0.11 0 0.16
37 INT335459 ABCA1 Positive_regulation of ITPR3 1 0.00 0 0.15
38 INT106506 Binding of Pparg and Ptgds 1 0.42 0.31 0.14
39 INT156531 Binding of ABCA1 and HSD11B1 1 0.22 1.06 0.14
40 INT207360 PTGDS Negative_regulation of Negative_regulation of ABCA1 1 0.25 0 0.14
41 INT207337 PTGER2 Negative_regulation of Negative_regulation of ABCA1 1 0.04 0 0.14
42 INT191001 F3 Positive_regulation of F2 1 0.00 0.62 0.14
43 INT207353 ZNF398 Regulation of ABCA1 1 0.00 0 0.14
44 INT276228 Nrtim1 Positive_regulation of PPARG 1 0.01 2.18 0.14
45 INT115140 PPARG Positive_regulation of EGR1 1 0.36 0.45 0.13
46 INT109410 RASGRP1 Regulation of Gene_expression of PPARG 1 0.03 0.76 0.13
47 INT115145 PPARG Positive_regulation of TFAM 1 0.04 0.45 0.13
48 INT101173 Pparg Regulation of Positive_regulation of Nfkb1 1 0.03 0.07 0.12
49 INT101174 Pparg Regulation of Gene_expression of IK 1 0.00 0.07 0.12
50 INT293236 IDO1 Regulation of ABCA1 1 0.00 0 0.11
51 INT276497 F3 Positive_regulation of F7 1 0.02 1.64 0.1
52 INT8675 Positive_regulation of Binding of F2 and F3 2 0.17 0.43 0.09
53 INT8671 Binding of F2 and F3 2 0.13 0.42 0.09
54 INT157265 PPARG Positive_regulation of PPARA 1 0.22 1.15 0.09
55 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09
56 INT42224 ABCA1 Positive_regulation of CYBB 1 0.01 0 0.09
57 INT8674 Positive_regulation of Binding of F3 and ANGPTL5 1 0.06 0.48 0.09
58 INT8678 Binding of F3 and ANGPTL5 1 0.04 0.48 0.09
59 INT42225 Binding of ABCA1 and DECR1 1 0.02 0 0.08
60 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
61 INT110377 Binding of Ncoa1 and Pparg 1 0.02 0.26 0.08
62 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
63 INT289258 Binding of ABCA1 and Il6ra 1 0.00 0.33 0.07
64 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
65 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
66 INT293233 IDO1 Positive_regulation of ABCA1 1 0.01 0 0.06
67 INT339583 Binding of ABCA1 and RPE 1 0.03 1.38 0.05
68 INT332641 Binding of PPARG and Ins1 1 0.12 1.05 0.05
69 INT339587 Positive_regulation of Binding of ABCA1 and RPE 1 0.04 1.38 0.05
70 INT188432 Negative_regulation of Binding of ABCA1 and IL6 1 0.02 0.47 0.05
71 INT188431 Binding of ABCA1 and IL6 1 0.02 0.47 0.05
72 INT229371 Positive_regulation of Pparg Negative_regulation of Gene_expression of Edn1 1 0.01 0.92 0.04
73 INT120449 Pparg Positive_regulation of Negative_regulation of Il2 1 0.75 0 0.04
74 INT230136 OSBPL8 Regulation of Binding of ABCA1 1 0.07 0.17 0.03
75 INT348592 Binding of HDAC1 and PPARG 1 0.23 0 0.03
76 INT207343 Negative_regulation of CPOX Negative_regulation of Gene_expression of ABCA1 1 0.09 0 0.03
77 INT348583 MECP2 Regulation of PPARG 1 0.46 0.73 0
78 INT284392 Binding of ABCA1 and Vegfa 1 0.00 0.71 0
79 INT348594 MECP2 Regulation of Gene_expression of PPARG 1 0.34 0.43 0
80 INT187621 Gnrh1 Regulation of Gene_expression of Pparg 1 0.00 0.09 0
81 INT229927 CD59 Negative_regulation of Binding of ABCA1 1 0.01 0 0
82 INT290027 Binding of PPARG and NR1H4 1 0.03 0.39 0
83 INT348584 EZH2 Regulation of Gene_expression of PPARG 1 0.30 0.43 0
84 INT229923 Binding of ABCA1 and C9 1 0.00 0.74 0
85 INT290031 Binding of INS and PPARG 1 0.11 0.47 0
86 INT284372 Binding of ABCA1 and AMT 1 0.00 0 0
87 INT355636 OLR1 Positive_regulation of Positive_regulation of F3 1 0.01 0.57 0
88 INT339693 HMGCR Positive_regulation of SREBF2 1 0.05 0.54 0
89 INT290022 Binding of PPARG and DDX12P 1 0.00 1.77 0
90 INT348593 ZACN Regulation of Positive_regulation of PPARG 1 0.14 0.41 0
91 INT297056 Binding of ABCA1 and Oas1b 1 0.00 0.13 0
92 INT117795 ABCA1 Regulation of GHRL 1 0.00 0 0
93 INT290030 Binding of PPARD and PPARG 1 0.09 0.38 0
94 INT284393 Positive_regulation of Binding of ABCA1 and Vegfa 1 0.00 0.36 0
95 INT326085 Prkaca Regulation of Phosphorylation of ABCA1 1 0.02 0.44 0
96 INT290024 Binding of PPARG and RXRG 1 0.15 0.39 0
97 INT229981 Binding of ABCA1 and Cdca3 1 0.00 0.74 0
98 INT144760 Binding of ABCA1 and Insr 1 0.00 0 0
99 INT339580 TIMP3 Positive_regulation of ABCA1 1 0.16 0.73 0
100 INT348587 Binding of MECP2 and PPARG 1 0.32 0.25 0
101 INT130602 Pparg Regulation of Pscs 1 0.11 0.29 0
102 INT187623 Lhb Regulation of Gene_expression of Pparg 1 0.02 0.09 0
103 INT326060 Binding of ABCA1 and APOA1 1 0.39 1.5 0
104 INT307283 Binding of ABCA1 and PMP2 1 0.00 0 0
105 INT348586 RSPH1 Positive_regulation of Gene_expression of PPARG 1 0.02 0.23 0
106 INT290026 Binding of PPARG and CHDH 1 0.10 6.61 0
107 INT339709 HMGCR Positive_regulation of Gene_expression of SREBF2 1 0.05 0.54 0
108 INT326084 Prkaca Positive_regulation of Phosphorylation of ABCA1 1 0.06 0.44 0
109 INT339699 LDLR Positive_regulation of SREBF2 1 0.08 1.08 0
110 INT130413 TNFSF14 Positive_regulation of F3 1 0.11 0 0
111 INT355640 OLR1 Positive_regulation of Gene_expression of F3 1 0.01 0.57 0
112 INT339694 LDLR Positive_regulation of Gene_expression of SREBF2 1 0.08 1.08 0
113 INT348585 EZH2 Regulation of PPARG 1 0.41 0.73 0
114 INT348595 Binding of PPARG and ZACN 1 0.07 0.38 0
115 INT230416 F3 Regulation of MSLN 1 0.06 0.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to low-density lipoprotein particle stimulus. They are ordered first by their pain relevance and then by number of times they were reported in response to low-density lipoprotein particle stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38
2 INT67610 Positive_regulation of Pparg 53 0.70 31.91 25.2
3 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42
4 INT67608 Gene_expression of Pparg 41 0.78 25.09 19.53
5 INT59870 Gene_expression of F3 51 0.65 51.83 14.01
6 INT67611 Positive_regulation of Pparg 39 0.69 18.33 13.23
7 INT79685 Positive_regulation of Gene_expression of Pparg 17 0.70 14.63 11.03
8 INT36453 Binding of ABCA1 48 0.45 19.9 10.84
9 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27
10 INT67612 Binding of PPARG 38 0.48 22.67 8.94
11 INT44003 Gene_expression of F3 40 0.75 27.92 8.29
12 INT103399 Positive_regulation of Positive_regulation of Pparg 11 0.66 7 7.36
13 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21
14 INT67609 Binding of Pparg 17 0.46 9.53 6.06
15 INT100078 Positive_regulation of Positive_regulation of PPARG 11 0.70 3.6 5.86
16 INT2848 Localization of ABCA1 23 0.70 10.64 4.73
17 INT73626 Positive_regulation of Gene_expression of PPARG 22 0.70 18.82 4.4
18 INT79692 Negative_regulation of PPARG 24 0.59 16 4.31
19 INT72936 Gene_expression of Pparg 39 0.77 19.01 4.02
20 INT112070 Negative_regulation of Gene_expression of Pparg 6 0.59 3.72 3.96
21 INT78493 Negative_regulation of F3 11 0.27 8.35 3.76
22 INT78845 Binding of Pparg 16 0.44 11.67 3.53
23 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39
24 INT28130 Positive_regulation of ABCA1 18 0.61 7.08 3.22
25 INT110956 Negative_regulation of Positive_regulation of Pparg 5 0.41 3.68 3.11
26 INT112071 Regulation of Gene_expression of Pparg 4 0.62 4.62 3.09
27 INT99187 Negative_regulation of Positive_regulation of PPARG 5 0.42 5.07 2.99
28 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85
29 INT46088 Localization of F3 15 0.37 13.7 2.23
30 INT81294 Negative_regulation of Positive_regulation of Pparg 7 0.58 4.39 2.2
31 INT78844 Regulation of Pparg 6 0.41 4 2.19
32 INT9106 Positive_regulation of F3 8 0.22 4.92 1.85
33 INT207370 Negative_regulation of Gene_expression of ABCA1 1 0.54 2.75 1.78
34 INT117438 Positive_regulation of Gene_expression of Pparg 11 0.69 8 1.63
35 INT79691 Regulation of Gene_expression of PPARG 10 0.50 10.44 1.62
36 INT79690 Negative_regulation of Gene_expression of PPARG 10 0.59 10.48 1.55
37 INT88820 Positive_regulation of Gene_expression of F3 8 0.67 5.48 1.08
38 INT79689 Regulation of PPARG 10 0.62 8.04 1.07
39 INT21546 Regulation of ABCA1 16 0.40 4.21 1.04
40 INT98817 Regulation of Pparg 3 0.26 1.62 1.03
41 INT44002 Negative_regulation of Gene_expression of F3 5 0.20 1.64 0.98
42 INT107714 Localization of PPARG 4 0.73 0.88 0.91
43 INT103400 Transcription of Pparg 2 0.67 3.15 0.85
44 INT110089 Positive_regulation of Binding of PPARG 1 0.70 1.04 0.7
45 INT46087 Regulation of F3 4 0.45 3.49 0.68
46 INT164627 Positive_regulation of Gene_expression of ABCA1 9 0.61 3.95 0.67
47 INT94148 Positive_regulation of Binding of Pparg 2 0.43 1.16 0.66
48 INT116288 Negative_regulation of Pparg 4 0.42 1.69 0.62
49 INT67346 Regulation of Gene_expression of F3 2 0.13 1.42 0.6
50 INT165706 Negative_regulation of Negative_regulation of PPARG 3 0.23 1.05 0.58
51 INT277710 Regulation of Localization of ABCA1 1 0.04 1.73 0.56
52 INT82930 Localization of F3 3 0.26 2.07 0.54
53 INT115156 Regulation of Positive_regulation of PPARG 2 0.25 0.86 0.54
54 INT130600 Negative_regulation of Binding of Pparg 1 0.42 1.96 0.54
55 INT174271 Binding of F3 6 0.15 6.85 0.53
56 INT144098 Localization of Pparg 2 0.59 0.73 0.52
57 INT73485 Binding of F3 3 0.03 1.53 0.51
58 INT158946 Negative_regulation of Pparg 3 0.43 1.53 0.51
59 INT73624 Transcription of PPARG 7 0.72 3.25 0.49
60 INT167468 Regulation of Gene_expression of ABCA1 5 0.52 0.08 0.43
61 INT98818 Regulation of Positive_regulation of Pparg 1 0.03 0.14 0.41
62 INT209180 Transcription of ABCA1 4 0.47 1.09 0.39
63 INT345322 Regulation of Transcription of ABCA1 1 0.01 0 0.39
64 INT78849 Transcription of Pparg 3 0.53 2.31 0.38
65 INT167122 Protein_catabolism of ABCA1 3 0.02 0.27 0.37
66 INT81290 Positive_regulation of Positive_regulation of Pparg 1 0.45 0.37 0.36
67 INT107713 Positive_regulation of Localization of PPARG 1 0.59 0.07 0.36
68 INT78847 Positive_regulation of Transcription of Pparg 2 0.44 0.47 0.35
69 INT174272 Negative_regulation of Gene_expression of F3 5 0.14 4.06 0.31
70 INT252656 Positive_regulation of Binding of F3 1 0.07 1.89 0.29
71 INT210686 Regulation of F3 2 0.12 0.91 0.27
72 INT166885 Negative_regulation of Gene_expression of Pparg 5 0.41 2.6 0.26
73 INT158945 Negative_regulation of Negative_regulation of Pparg 1 0.43 0.73 0.26
74 INT284385 Positive_regulation of Localization of ABCA1 2 0.02 0.22 0.25
75 INT78848 Regulation of Binding of Pparg 1 0.45 0.5 0.25
76 INT178257 Positive_regulation of Transcription of Pparg 1 0.49 2.25 0.21
77 INT138506 Negative_regulation of F3 2 0.04 1.23 0.2
78 INT161753 Regulation of Gene_expression of Pparg 2 0.35 1.28 0.19
79 INT300227 Positive_regulation of Binding of ABCA1 1 0.41 1.85 0.19
80 INT277709 Regulation of Binding of ABCA1 1 0.04 0.52 0.19
81 INT35073 Transcription of F3 1 0.03 0.34 0.17
82 INT255393 Regulation of SREBF2 1 0.27 0.78 0.17
83 INT81292 Regulation of Positive_regulation of Pparg 1 0.41 0.17 0.17
84 INT242196 Positive_regulation of Localization of F3 3 0.09 1.71 0.15
85 INT255398 Regulation of Localization of SREBF2 1 0.45 0.81 0.13
86 INT115155 Phosphorylation of PPARG 1 0.58 0.44 0.13
87 INT101172 Localization of Pparg 6 0.58 3.62 0.12
88 INT78846 Negative_regulation of Regulation of Pparg 1 0.32 0.23 0.12
89 INT255391 Localization of SREBF2 1 0.74 0.8 0.11
90 INT229009 Positive_regulation of Localization of Pparg 1 0.39 1.86 0.1
91 INT42227 Negative_regulation of Positive_regulation of ABCA1 1 0.03 0 0.09
92 INT42226 Positive_regulation of Positive_regulation of ABCA1 1 0.02 0 0.09
93 INT255389 Gene_expression of SREBF2 3 0.77 1.67 0.08
94 INT327443 Regulation of Gene_expression of F3 1 0.03 0.67 0.08
95 INT339734 Positive_regulation of SREBF2 1 0.11 0.56 0.03
96 INT339773 Negative_regulation of SREBF2 1 0.11 0.57 0.03
97 INT326077 Positive_regulation of Transcription of ABCA1 1 0.41 0.22 0
98 INT326076 Phosphorylation of ABCA1 1 0.73 0.66 0
99 INT229010 Phosphorylation of Pparg 1 0.63 2.95 0
100 INT290036 Regulation of Binding of PPARG 1 0.45 0.66 0
101 INT326083 Positive_regulation of Phosphorylation of ABCA1 1 0.61 0.66 0
102 INT348617 Regulation of Negative_regulation of PPARG 1 0.24 0.42 0
103 INT332933 Regulation of Transcription of PPARG 1 0.43 1.71 0
104 INT332925 Protein_catabolism of PPARG 1 0.63 1.04 0
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