GO:0055118

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Name negative regulation of cardiac muscle contraction
Categary Process
Go Slim No
Go Link GO:0055118
Unique Molecular Interactions 123
Total Molecular Interactions 144
Total Single Events 1418
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cardiac muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of cardiac muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
2 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
3 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
4 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
5 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94
6 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
7 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
8 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
9 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
10 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83
11 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
12 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
13 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75
14 INT257302 Cnp Regulation of Protein_catabolism of Pde5a 1 0.05 0.49 0.7
15 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65
16 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
17 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
18 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6
19 INT117707 Oprm1 Positive_regulation of PIK3CG 1 0.00 0.08 0.6
20 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
21 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
22 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48
23 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
24 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43
25 INT215651 Binding of Adora1 and Cpa1 1 0.00 0 0.42
26 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
27 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37
28 INT275094 Pde5a Regulation of Ltp 1 0.05 0 0.35
29 INT215645 Binding of Adora1 and Kcnj5 1 0.00 0.08 0.29
30 INT303948 LEPR Positive_regulation of PIK3CG 1 0.02 0.22 0.28
31 INT215653 Binding of Adora1 and Adora3 1 0.39 0.07 0.27
32 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
33 INT280181 Pde5a Positive_regulation of Regulation of Cpox 1 0.00 0.16 0.26
34 INT215652 Binding of Adora1 and Npy1r 1 0.39 0.22 0.24
35 INT121581 Negative_regulation of PIK3CG Positive_regulation of GDF15 1 0.36 0.59 0.24
36 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
37 INT257224 Pde5a Positive_regulation of Phosphorylation of Creb1 1 0.03 0.09 0.2
38 INT202297 Pde5a Positive_regulation of Prkg1 1 0.00 0.13 0.18
39 INT121580 PIK3CG Regulation of Gene_expression of GDF15 1 0.48 0.4 0.18
40 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
41 INT263180 Binding of PDE5A and COPD 1 0.01 1 0.15
42 INT263175 PDE5A Regulation of COPD 1 0.00 1 0.15
43 INT203591 Positive_regulation of PIK3CG Positive_regulation of Protein_catabolism of LAMB2 1 0.00 0.46 0.14
44 INT249322 Positive_regulation of Adora1 Regulation of Rit2 1 0.10 0 0.14
45 INT129091 Binding of PIK3CG and Lyn 1 0.00 0.47 0.12
46 INT129073 Binding of GRP and PIK3CG 1 0.00 0.49 0.12
47 INT249321 Positive_regulation of Adora1 Regulation of Preb 1 0.20 0.09 0.12
48 INT346526 Binding of ADORA1 and PTH1R 1 0.01 0 0.1
49 INT343855 Binding of MYD88 and PIK3CG 1 0.03 0.26 0.1
50 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
51 INT224021 PIK3CG Negative_regulation of EPHB2 1 0.03 0.5 0.09
52 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
53 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
54 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
55 INT222429 Nps Positive_regulation of Pde5a 1 0.00 0.16 0.07
56 INT337608 Pde5a Regulation of Cnga1 1 0.00 0 0.04
57 INT263197 Binding of PDE3A and Pde5a 1 0.03 0.18 0.04
58 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
59 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
60 INT263198 Pde5a Negative_regulation of PDE4A 1 0.09 0.16 0.03
61 INT265880 IGF1 Regulation of PIK3CG 1 0.10 1.23 0.03
62 INT331897 Binding of PDE5A and Pde5a 1 0.02 0.64 0.03
63 INT176131 Binding of AKT1 and PIK3CG 2 0.15 1.08 0
64 INT201767 Igf1 Positive_regulation of PIK3CG 1 0.00 0.84 0
65 INT336033 PIK3CG Regulation of AKT1 1 0.03 0.43 0
66 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0
67 INT222556 Pde5a Regulation of Localization of LH 1 0.00 0.06 0
68 INT176137 Negative_regulation of Binding of AKT1 and PIK3CG 1 0.17 0.25 0
69 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0
70 INT209159 Binding of LHCGR and PDE5A 1 0.01 0 0
71 INT354122 MIR126 Regulation of PIK3CG 1 0.03 2.01 0
72 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0
73 INT262759 PIK3CG Positive_regulation of MTOR 1 0.38 0.54 0
74 INT225903 Binding of GAB1 and PIK3CG 1 0.01 0.13 0
75 INT201773 Binding of BCL2L1 and Positive_regulation of Negative_regulation of PIK3CG 1 0.01 0.3 0
76 INT225876 PIK3CG Positive_regulation of Ilk 1 0.00 0 0
77 INT263181 Binding of Pde1a and Pde5a 1 0.03 0 0
78 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
79 INT293806 AR Positive_regulation of PIK3CG 1 0.06 0.12 0
80 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0
81 INT287269 Binding of ERBB3 and PIK3CG 1 0.11 0.74 0
82 INT98236 LOC360919 Positive_regulation of Pde5a 1 0.00 0.33 0
83 INT293802 PTEN Regulation of PIK3CG 1 0.03 0.07 0
84 INT268021 Pde5a Positive_regulation of Kcnj5 1 0.01 0 0
85 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0
86 INT263183 Binding of Pde1b and Pde5a 1 0.03 0 0
87 INT223579 PTEN Negative_regulation of PIK3CG 1 0.18 0.56 0
88 INT268052 Pde5a Positive_regulation of Positive_regulation of PRKG1 1 0.00 0 0
89 INT268022 Pde5a Positive_regulation of Gene_expression of Kcnj5 1 0.01 0 0
90 INT293816 Binding of AR and PIK3CG 1 0.03 0.27 0
91 INT225894 Binding of MET and PIK3CG 1 0.00 0.13 0
92 INT201759 Ngf Positive_regulation of PIK3CG 1 0.01 0.84 0
93 INT262753 Binding of MTOR and PIK3CG 1 0.20 0.82 0
94 INT223578 INS Positive_regulation of PIK3CG 1 0.05 0.87 0
95 INT222471 Gnrh1 Positive_regulation of Pde5a 1 0.00 0.07 0
96 INT223576 PIK3CG Regulation of MTOR 1 0.15 0.37 0
97 INT223580 Positive_regulation of PIK3CG Regulation of MTOR 1 0.25 0.42 0
98 INT98235 Pde5a Negative_regulation of Pdpk1 1 0.00 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cardiac muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of cardiac muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
2 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09
3 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65
4 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
5 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
6 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27
7 INT19155 Binding of Adora1 25 0.47 6.41 10.72
8 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28
9 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
10 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
11 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25
12 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
13 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
14 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
15 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
16 INT9167 Binding of Adora1 6 0.40 0.53 6.9
17 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
18 INT94862 Positive_regulation of Gene_expression of Pde5a 10 0.20 4.23 5.18
19 INT118274 Positive_regulation of Positive_regulation of PIK3CG 8 0.64 4.81 4.62
20 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27
21 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97
22 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
23 INT215604 Localization of Adora1 10 0.78 1.47 3.49
24 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31
25 INT101477 Binding of ADORA1 8 0.31 0.42 3.07
26 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06
27 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
28 INT215608 Negative_regulation of Binding of Adora1 5 0.41 1.35 2.73
29 INT136675 Transcription of Pde5a 6 0.63 4.74 2.71
30 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7
31 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66
32 INT94860 Negative_regulation of Gene_expression of Pde5a 2 0.33 3.2 2.64
33 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58
34 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
35 INT257298 Regulation of Positive_regulation of Pde5a 1 0.19 2.03 2.54
36 INT257299 Binding of Pde5a 14 0.27 4.31 2.45
37 INT257301 Protein_catabolism of Pde5a 5 0.30 1.97 2.26
38 INT215611 Negative_regulation of Positive_regulation of Adora1 6 0.43 1.18 2.16
39 INT108422 Binding of Pde5a 11 0.36 3.07 2.07
40 INT165648 Negative_regulation of Transcription of Pde5a 1 0.41 3.6 1.93
41 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86
42 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
43 INT168519 Positive_regulation of Gene_expression of Adora1 4 0.61 0.75 1.75
44 INT29763 Negative_regulation of Adora1 3 0.42 0 1.64
45 INT291576 Positive_regulation of Protein_catabolism of Pde5a 1 0.12 1.15 1.43
46 INT241721 Positive_regulation of Transcription of Adora1 3 0.50 1.39 1.41
47 INT241737 Transcription of Adora1 3 0.72 0.89 1.32
48 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31
49 INT242945 Localization of PDE5A 9 0.75 4.57 1.28
50 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17
51 INT76254 Positive_regulation of Positive_regulation of ADORA1 2 0.43 1.27 1.14
52 INT103043 Binding of PDE5A 16 0.37 7.79 1.12
53 INT155696 Gene_expression of PIK3CG 16 0.65 8.54 1.02
54 INT257200 Phosphorylation of Pde5a 1 0.25 0 0.94
55 INT165644 Regulation of Transcription of Pde5a 1 0.44 1.65 0.91
56 INT164144 Phosphorylation of Pde5a 4 0.19 1.15 0.87
57 INT215606 Positive_regulation of Localization of Adora1 3 0.49 0.44 0.87
58 INT92880 Localization of ADORA1 2 0.80 0.09 0.84
59 INT177532 Localization of Pde5a 2 0.56 0.96 0.81
60 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75
61 INT165645 Positive_regulation of Negative_regulation of Pde5a 3 0.37 1.58 0.74
62 INT113512 Regulation of Gene_expression of ADORA1 1 0.11 0.19 0.73
63 INT165647 Negative_regulation of Negative_regulation of Pde5a 1 0.31 1.22 0.67
64 INT257202 Protein_catabolism of Pde5a 2 0.38 0.36 0.66
65 INT165646 Positive_regulation of Transcription of Pde5a 1 0.33 1.21 0.66
66 INT208 Negative_regulation of Positive_regulation of Pde5a 3 0.17 2.02 0.65
67 INT54183 Regulation of Positive_regulation of Adora1 1 0.17 0 0.65
68 INT190187 Regulation of Gene_expression of PIK3CG 1 0.13 0 0.65
69 INT215607 Positive_regulation of Negative_regulation of Adora1 1 0.45 0 0.63
70 INT275071 Negative_regulation of Protein_catabolism of Pde5a 1 0.17 0.36 0.6
71 INT242944 Negative_regulation of Localization of PDE5A 3 0.35 3.18 0.59
72 INT132781 Phosphorylation of PIK3CG 8 0.52 4.83 0.53
73 INT216748 Regulation of Localization of ADORA1 1 0.07 0.09 0.53
74 INT279525 Negative_regulation of Transcription of Adora1 1 0.43 0.26 0.51
75 INT249309 Regulation of Gene_expression of Adora1 6 0.39 0.51 0.49
76 INT215600 Regulation of Binding of Adora1 1 0.08 0.09 0.48
77 INT257211 Negative_regulation of Localization of Pde5a 1 0.13 0.2 0.48
78 INT291577 Positive_regulation of Phosphorylation of Pde5a 1 0.12 0.35 0.48
79 INT130371 Negative_regulation of Gene_expression of PDE5A 3 0.43 1.59 0.45
80 INT79597 Positive_regulation of Negative_regulation of PDE5A 5 0.50 3.39 0.41
81 INT130372 Transcription of PDE5A 7 0.72 1.93 0.4
82 INT132780 Positive_regulation of Phosphorylation of PIK3CG 1 0.01 0.37 0.4
83 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39
84 INT279524 Protein_catabolism of Adora1 1 0.88 0.34 0.38
85 INT279523 Positive_regulation of Protein_catabolism of Adora1 1 0.50 0.34 0.38
86 INT92881 Transcription of ADORA1 1 0.69 0 0.31
87 INT224100 Regulation of Negative_regulation of ADORA1 1 0.01 0.05 0.3
88 INT275073 Positive_regulation of Negative_regulation of Pde5a 1 0.22 0.45 0.3
89 INT117995 Regulation of Negative_regulation of PDE5A 3 0.44 2.4 0.29
90 INT183429 Localization of Pde5a 5 0.56 1.61 0.25
91 INT303483 Positive_regulation of PDE5A 2 0.39 1.5 0.23
92 INT186700 Localization of Adora1 1 0.23 0 0.23
93 INT176145 Positive_regulation of Gene_expression of PIK3CG 3 0.20 1.36 0.22
94 INT261276 Positive_regulation of Positive_regulation of Pde5a 1 0.26 0.07 0.21
95 INT42375 Positive_regulation of Positive_regulation of Pde5a 2 0.14 0.1 0.19
96 INT261275 Negative_regulation of Localization of Pde5a 2 0.31 1.11 0.18
97 INT42376 Regulation of Positive_regulation of Pde5a 1 0.03 0 0.18
98 INT213222 Negative_regulation of Protein_catabolism of PDE5A 1 0.24 0.65 0.16
99 INT177528 Negative_regulation of Binding of Pde5a 1 0.34 0.46 0.15
100 INT263121 Negative_regulation of Negative_regulation of PDE5A 2 0.43 1.33 0.14
101 INT249313 Negative_regulation of Gene_expression of Adora1 1 0.37 0 0.14
102 INT127623 Protein_catabolism of ADORA1 1 0.49 0.19 0.14
103 INT242949 Phosphorylation of PDE5A 2 0.68 0.05 0.13
104 INT275069 Negative_regulation of Gene_expression of Pde5a 1 0.26 0.54 0.13
105 INT303482 Positive_regulation of Protein_catabolism of PDE5A 1 0.20 1.27 0.1
106 INT261274 Negative_regulation of Protein_catabolism of Pde5a 1 0.20 0.18 0.09
107 INT262775 Negative_regulation of Phosphorylation of PIK3CG 1 0.28 1.1 0.09
108 INT257205 Transcription of Pde5a 1 0.21 0 0.08
109 INT230866 Negative_regulation of Gene_expression of PIK3CG 2 0.28 1.37 0.07
110 INT241720 Regulation of Transcription of Adora1 1 0.40 0.27 0.07
111 INT213216 Positive_regulation of Gene_expression of PDE5A 2 0.37 2.08 0.04
112 INT341853 Negative_regulation of Negative_regulation of PIK3CG 1 0.14 0.85 0.04
113 INT183435 Regulation of Localization of Pde5a 1 0.34 0.35 0.04
114 INT323262 Negative_regulation of Negative_regulation of Pde5a 1 0.03 1.32 0.04
115 INT201693 Negative_regulation of Positive_regulation of PIK3CG 1 0.05 1.04 0.04
116 INT176162 Binding of PIK3CG 5 0.15 1.3 0.03
117 INT263185 Regulation of Gene_expression of Pde5a 1 0.12 0.19 0.03
118 INT269744 Negative_regulation of Binding of PDE5A 2 0.43 0.74 0
119 INT176151 Regulation of Negative_regulation of PIK3CG 2 0.28 0.92 0
120 INT162907 Regulation of Gene_expression of PDE5A 2 0.51 0 0
121 INT269741 Positive_regulation of Localization of PDE5A 1 0.04 0.65 0
122 INT268038 Regulation of Negative_regulation of Pde5a 1 0.03 0 0
123 INT162922 Negative_regulation of Transcription of PDE5A 1 0.41 0 0
124 INT92876 Regulation of Protein_catabolism of PDE5A 1 0.45 0.71 0
125 INT193985 Regulation of Phosphorylation of PIK3CG 1 0.03 0.32 0
126 INT162912 Regulation of Transcription of PDE5A 1 0.44 0 0
127 INT176159 Regulation of Positive_regulation of PIK3CG 1 0.18 0.21 0
128 INT162915 Positive_regulation of Regulation of PDE5A 1 0.40 0 0
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