GO:0055119

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Name relaxation of cardiac muscle
Categary Process
Go Slim No
Go Link GO:0055119
Unique Molecular Interactions 90
Total Molecular Interactions 105
Total Single Events 1402
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for relaxation of cardiac muscle. They are ordered first by their pain relevance and then by number of times they were reported for relaxation of cardiac muscle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT165183 Ifnb1 Positive_regulation of P2rx4 1 0.04 1.73 1.73
2 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
3 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
4 INT155663 Positive_regulation of P2rx4 Positive_regulation of Localization of Bdnf 1 0.42 0.84 1.25
5 INT274899 Positive_regulation of P2rx4 Positive_regulation of Localization of Gtf3a 1 0.02 1.67 0.95
6 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
7 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
8 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83
9 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75
10 INT126304 Binding of Rgs2 and Pag1 1 0.16 0.41 0.72
11 INT257302 Cnp Regulation of Protein_catabolism of Pde5a 1 0.05 0.49 0.7
12 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6
13 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48
14 INT146276 Binding of P2RX4 and P2RX7 1 0.38 0.38 0.43
15 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
16 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37
17 INT275094 Pde5a Regulation of Ltp 1 0.05 0 0.35
18 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
19 INT158708 Positive_regulation of P2RX4 Positive_regulation of Localization of Bdnf 1 0.09 0.48 0.3
20 INT158707 P2RX4 Positive_regulation of Localization of Bdnf 1 0.40 0.59 0.29
21 INT165171 Tpsab1 Positive_regulation of Gene_expression of P2RX4 1 0.02 0.47 0.28
22 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
23 INT280181 Pde5a Positive_regulation of Regulation of Cpox 1 0.00 0.16 0.26
24 INT257224 Pde5a Positive_regulation of Phosphorylation of Creb1 1 0.03 0.09 0.2
25 INT202297 Pde5a Positive_regulation of Prkg1 1 0.00 0.13 0.18
26 INT304458 Binding of P2rx4 and P2rx6 1 0.14 0 0.17
27 INT263180 Binding of PDE5A and COPD 1 0.01 1 0.15
28 INT307459 P2rx4 Positive_regulation of Localization of Bdnf 1 0.15 0.1 0.15
29 INT263175 PDE5A Regulation of COPD 1 0.00 1 0.15
30 INT304463 Ass1 Positive_regulation of P2rx4 1 0.01 0 0.14
31 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
32 INT304462 Binding of P2rx4 and P2rx5 1 0.17 0 0.08
33 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
34 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
35 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
36 INT304456 Binding of P2rx1 and P2rx4 1 0.14 0 0.07
37 INT222429 Nps Positive_regulation of Pde5a 1 0.00 0.16 0.07
38 INT304457 Ass1 Positive_regulation of Transcription of P2rx4 1 0.01 0 0.05
39 INT337608 Pde5a Regulation of Cnga1 1 0.00 0 0.04
40 INT263197 Binding of PDE3A and Pde5a 1 0.03 0.18 0.04
41 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
42 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
43 INT263198 Pde5a Negative_regulation of PDE4A 1 0.09 0.16 0.03
44 INT215684 Binding of P2ry2 and P2rx4 1 0.06 0.46 0.03
45 INT331897 Binding of PDE5A and Pde5a 1 0.02 0.64 0.03
46 INT222556 Pde5a Regulation of Localization of LH 1 0.00 0.06 0
47 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0
48 INT325599 Pls1 Regulation of Rgs2 1 0.00 0 0
49 INT209159 Binding of LHCGR and PDE5A 1 0.01 0 0
50 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
51 INT263181 Binding of Pde1a and Pde5a 1 0.03 0 0
52 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
53 INT98236 LOC360919 Positive_regulation of Pde5a 1 0.00 0.33 0
54 INT268021 Pde5a Positive_regulation of Kcnj5 1 0.01 0 0
55 INT263183 Binding of Pde1b and Pde5a 1 0.03 0 0
56 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
57 INT325588 Nppa Regulation of Localization of Rgs2 1 0.32 0 0
58 INT268052 Pde5a Positive_regulation of Positive_regulation of PRKG1 1 0.00 0 0
59 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0
60 INT268022 Pde5a Positive_regulation of Gene_expression of Kcnj5 1 0.01 0 0
61 INT222471 Gnrh1 Positive_regulation of Pde5a 1 0.00 0.07 0
62 INT98235 Pde5a Negative_regulation of Pdpk1 1 0.00 0.32 0
63 INT325608 Rgs2 Regulation of Pls1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for relaxation of cardiac muscle. They are ordered first by their pain relevance and then by number of times they were reported in relaxation of cardiac muscle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86789 Gene_expression of P2rx4 46 0.77 30.66 25.68
2 INT112427 Positive_regulation of P2rx4 27 0.68 26.29 21.31
3 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09
4 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65
5 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
6 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27
7 INT122053 Positive_regulation of P2rx4 16 0.69 13.02 11.98
8 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28
9 INT98329 Gene_expression of P2RX4 23 0.75 13.13 10.25
10 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
11 INT112428 Positive_regulation of Gene_expression of P2rx4 12 0.68 12.67 9.57
12 INT168991 Negative_regulation of P2rx4 9 0.43 12.77 9.39
13 INT136177 Gene_expression of P2rx4 8 0.75 6.74 8.05
14 INT112430 Negative_regulation of P2rx4 9 0.57 8.4 6.63
15 INT215594 Negative_regulation of Gene_expression of P2rx4 7 0.48 6.46 5.22
16 INT94862 Positive_regulation of Gene_expression of Pde5a 10 0.20 4.23 5.18
17 INT145681 Regulation of P2rx4 4 0.61 3.41 5.09
18 INT158603 Positive_regulation of Gene_expression of P2RX4 7 0.55 5.85 4.56
19 INT136179 Positive_regulation of P2RX4 9 0.67 7.06 4.27
20 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27
21 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31
22 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06
23 INT112429 Negative_regulation of Positive_regulation of P2rx4 4 0.57 4.03 2.94
24 INT93777 Negative_regulation of Rgs2 3 0.43 2.5 2.81
25 INT112431 Positive_regulation of Positive_regulation of P2rx4 2 0.49 3.52 2.81
26 INT136675 Transcription of Pde5a 6 0.63 4.74 2.71
27 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7
28 INT122054 Positive_regulation of Positive_regulation of P2rx4 3 0.49 2.85 2.65
29 INT136176 Positive_regulation of Gene_expression of P2rx4 5 0.60 3.18 2.64
30 INT94860 Negative_regulation of Gene_expression of Pde5a 2 0.33 3.2 2.64
31 INT257298 Regulation of Positive_regulation of Pde5a 1 0.19 2.03 2.54
32 INT257299 Binding of Pde5a 14 0.27 4.31 2.45
33 INT257301 Protein_catabolism of Pde5a 5 0.30 1.97 2.26
34 INT108422 Binding of Pde5a 11 0.36 3.07 2.07
35 INT165648 Negative_regulation of Transcription of Pde5a 1 0.41 3.6 1.93
36 INT158602 Regulation of P2RX4 3 0.48 2.46 1.7
37 INT146941 Negative_regulation of Positive_regulation of P2rx4 2 0.37 1.36 1.47
38 INT304433 Localization of P2rx4 1 0.69 0 1.44
39 INT291576 Positive_regulation of Protein_catabolism of Pde5a 1 0.12 1.15 1.43
40 INT304444 Negative_regulation of Gene_expression of P2rx4 1 0.51 0.75 1.43
41 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31
42 INT242945 Localization of PDE5A 9 0.75 4.57 1.28
43 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17
44 INT103043 Binding of PDE5A 16 0.37 7.79 1.12
45 INT146616 Localization of P2RX4 3 0.68 1.65 0.96
46 INT126912 Localization of P2rx4 4 0.70 1.04 0.95
47 INT257200 Phosphorylation of Pde5a 1 0.25 0 0.94
48 INT165644 Regulation of Transcription of Pde5a 1 0.44 1.65 0.91
49 INT84571 Gene_expression of Rgs2 6 0.67 3.18 0.89
50 INT168989 Phosphorylation of P2rx4 1 0.13 1.15 0.88
51 INT164144 Phosphorylation of Pde5a 4 0.19 1.15 0.87
52 INT177532 Localization of Pde5a 2 0.56 0.96 0.81
53 INT304454 Negative_regulation of Localization of P2rx4 1 0.32 0 0.81
54 INT146277 Binding of P2RX4 5 0.45 1.1 0.79
55 INT165645 Positive_regulation of Negative_regulation of Pde5a 3 0.37 1.58 0.74
56 INT216509 Negative_regulation of Positive_regulation of P2RX4 1 0.34 1.12 0.73
57 INT271590 Positive_regulation of Transcription of P2rx4 1 0.35 0.4 0.7
58 INT215816 Transcription of P2rx4 1 0.36 0.39 0.7
59 INT136594 Negative_regulation of P2RX4 1 0.57 1.16 0.7
60 INT84570 Positive_regulation of Gene_expression of Rgs2 3 0.50 0.67 0.67
61 INT165647 Negative_regulation of Negative_regulation of Pde5a 1 0.31 1.22 0.67
62 INT257202 Protein_catabolism of Pde5a 2 0.38 0.36 0.66
63 INT165646 Positive_regulation of Transcription of Pde5a 1 0.33 1.21 0.66
64 INT208 Negative_regulation of Positive_regulation of Pde5a 3 0.17 2.02 0.65
65 INT252418 Binding of P2rx4 2 0.32 0 0.64
66 INT215722 Regulation of P2rx4 2 0.20 0.89 0.6
67 INT275071 Negative_regulation of Protein_catabolism of Pde5a 1 0.17 0.36 0.6
68 INT242944 Negative_regulation of Localization of PDE5A 3 0.35 3.18 0.59
69 INT304448 Negative_regulation of Regulation of P2rx4 1 0.37 0.09 0.55
70 INT215751 Regulation of Gene_expression of P2rx4 1 0.20 1.33 0.52
71 INT304441 Negative_regulation of Binding of P2rx4 1 0.37 0 0.49
72 INT278118 Positive_regulation of Positive_regulation of P2RX4 1 0.16 0.59 0.49
73 INT257211 Negative_regulation of Localization of Pde5a 1 0.13 0.2 0.48
74 INT291577 Positive_regulation of Phosphorylation of Pde5a 1 0.12 0.35 0.48
75 INT130371 Negative_regulation of Gene_expression of PDE5A 3 0.43 1.59 0.45
76 INT79597 Positive_regulation of Negative_regulation of PDE5A 5 0.50 3.39 0.41
77 INT130372 Transcription of PDE5A 7 0.72 1.93 0.4
78 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39
79 INT296724 Binding of P2rx4 1 0.29 0 0.35
80 INT275073 Positive_regulation of Negative_regulation of Pde5a 1 0.22 0.45 0.3
81 INT117995 Regulation of Negative_regulation of PDE5A 3 0.44 2.4 0.29
82 INT146279 Negative_regulation of Gene_expression of P2RX4 2 0.46 0.33 0.28
83 INT215497 Phosphorylation of P2rx4 1 0.11 0 0.28
84 INT183429 Localization of Pde5a 5 0.56 1.61 0.25
85 INT158704 Regulation of Localization of P2RX4 1 0.13 0.42 0.25
86 INT303483 Positive_regulation of PDE5A 2 0.39 1.5 0.23
87 INT261276 Positive_regulation of Positive_regulation of Pde5a 1 0.26 0.07 0.21
88 INT325579 Phosphorylation of Rgs2 2 0.55 0.06 0.2
89 INT42375 Positive_regulation of Positive_regulation of Pde5a 2 0.14 0.1 0.19
90 INT261275 Negative_regulation of Localization of Pde5a 2 0.31 1.11 0.18
91 INT42376 Regulation of Positive_regulation of Pde5a 1 0.03 0 0.18
92 INT213222 Negative_regulation of Protein_catabolism of PDE5A 1 0.24 0.65 0.16
93 INT263243 Regulation of Gene_expression of Rgs2 1 0.27 1.65 0.15
94 INT177528 Negative_regulation of Binding of Pde5a 1 0.34 0.46 0.15
95 INT217015 Transcription of P2RX4 1 0.20 0.05 0.15
96 INT263121 Negative_regulation of Negative_regulation of PDE5A 2 0.43 1.33 0.14
97 INT242949 Phosphorylation of PDE5A 2 0.68 0.05 0.13
98 INT275069 Negative_regulation of Gene_expression of Pde5a 1 0.26 0.54 0.13
99 INT304434 Transcription of P2rx4 1 0.60 0 0.11
100 INT303482 Positive_regulation of Protein_catabolism of PDE5A 1 0.20 1.27 0.1
101 INT261274 Negative_regulation of Protein_catabolism of Pde5a 1 0.20 0.18 0.09
102 INT257205 Transcription of Pde5a 1 0.21 0 0.08
103 INT325569 Binding of Rgs2 2 0.30 0.19 0.07
104 INT325568 Positive_regulation of Rgs2 1 0.41 0.13 0.05
105 INT304435 Positive_regulation of Negative_regulation of P2rx4 1 0.43 0.05 0.05
106 INT213216 Positive_regulation of Gene_expression of PDE5A 2 0.37 2.08 0.04
107 INT183435 Regulation of Localization of Pde5a 1 0.34 0.35 0.04
108 INT323262 Negative_regulation of Negative_regulation of Pde5a 1 0.03 1.32 0.04
109 INT263238 Localization of Rgs2 2 0.75 0.96 0.03
110 INT263185 Regulation of Gene_expression of Pde5a 1 0.12 0.19 0.03
111 INT263239 Negative_regulation of Localization of Rgs2 1 0.43 0.96 0.03
112 INT269744 Negative_regulation of Binding of PDE5A 2 0.43 0.74 0
113 INT162907 Regulation of Gene_expression of PDE5A 2 0.51 0 0
114 INT269741 Positive_regulation of Localization of PDE5A 1 0.04 0.65 0
115 INT268038 Regulation of Negative_regulation of Pde5a 1 0.03 0 0
116 INT263242 Regulation of Rgs2 1 0.27 0.59 0
117 INT325566 Negative_regulation of Gene_expression of Rgs2 1 0.35 0 0
118 INT325567 Positive_regulation of Localization of Rgs2 1 0.41 0 0
119 INT162922 Negative_regulation of Transcription of PDE5A 1 0.41 0 0
120 INT304449 Regulation of Gene_expression of P2rx4 1 0.39 0 0
121 INT92876 Regulation of Protein_catabolism of PDE5A 1 0.45 0.71 0
122 INT162912 Regulation of Transcription of PDE5A 1 0.44 0 0
123 INT325577 Positive_regulation of Binding of Rgs2 1 0.41 0.05 0
124 INT162915 Positive_regulation of Regulation of PDE5A 1 0.40 0 0
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