GO:0060038

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Name cardiac muscle cell proliferation
Categary Process
Go Slim No
Go Link GO:0060038
Unique Molecular Interactions 136
Total Molecular Interactions 234
Total Single Events 1209
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cardiac muscle cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported for cardiac muscle cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11
2 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
3 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
4 INT161949 TGFB2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.97 0.74
5 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
6 INT114947 YY1 Positive_regulation of Gene_expression of RXRA 1 0.33 0.25 0.65
7 INT114951 PPARA Positive_regulation of Gene_expression of RXRA 1 0.34 0.25 0.64
8 INT224726 Negative_regulation of Binding of Fgf2 and Cia1 1 0.01 0.92 0.62
9 INT114949 NCOA1 Positive_regulation of Gene_expression of RXRA 1 0.13 0.24 0.61
10 INT224727 Binding of Fgf2 and Cia1 1 0.01 0.91 0.61
11 INT72089 TGFB2 Positive_regulation of POMC 1 0.11 0 0.46
12 INT92690 Tgfb1 Positive_regulation of Transcription of Fgf2 1 0.32 1.8 0.4
13 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
14 INT333453 Binding of PPARA and RXRA 1 0.02 0 0.31
15 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
16 INT214594 Binding of FOXC1 and IBD9 1 0.00 1.81 0.28
17 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24
18 INT245866 Binding of VEGFA and Fgf1 1 0.07 0.52 0.22
19 INT209851 TGFB2 Negative_regulation of Gene_expression of CD36 1 0.16 0.16 0.21
20 INT92693 Tgfb1 Positive_regulation of Fgf2 1 0.32 0.9 0.2
21 INT214591 FOXC1 Regulation of ICAM1 1 0.05 0.29 0.19
22 INT312550 DAK Positive_regulation of Rxra 1 0.00 1.48 0.18
23 INT152024 Ptgs1 Regulation of Fgf2 1 0.04 0.9 0.17
24 INT224730 Fgf2 Positive_regulation of Gm2458 1 0.01 0.39 0.17
25 INT313023 Binding of Rara and Rxra 1 0.06 0.73 0.17
26 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
27 INT345999 Binding of Fgf2 and Gfap 1 0.37 0.09 0.16
28 INT172903 Fgf2 Positive_regulation of Gene_expression of Tbxa2r 1 0.03 0.58 0.15
29 INT347338 Binding of Fgf1 and S100a9 1 0.26 0.46 0.15
30 INT347331 Binding of Fgf1 and S100a8 1 0.26 0.46 0.15
31 INT345996 Fgf2 Positive_regulation of Gene_expression of Gfap 1 0.71 0.13 0.15
32 INT278265 Binding of Fgf2 and Smcp 1 0.03 0.26 0.14
33 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
34 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
35 INT214593 Binding of FOXC1 and OAP 1 0.01 0.25 0.13
36 INT345998 Fgf2 Positive_regulation of Gfap 1 0.48 0.09 0.13
37 INT300853 Ngf Positive_regulation of Fgf2 1 0.14 0.18 0.12
38 INT300860 Bdnf Positive_regulation of Fgf2 1 0.08 0.18 0.12
39 INT149178 IL4 Negative_regulation of Positive_regulation of TGFB2 1 0.15 0.29 0.1
40 INT166723 Binding of Vdr and Rxrb 1 0.11 0.31 0.09
41 INT166724 Binding of Vdr and Rxra 1 0.28 0.32 0.09
42 INT199604 Binding of FGF7 and Fgf1 1 0.03 0.21 0.08
43 INT199603 Positive_regulation of Binding of FGF7 and Fgf1 1 0.04 0.21 0.08
44 INT248704 Trib3 Positive_regulation of Phosphorylation of Rxrb 1 0.00 0.49 0.08
45 INT278684 Binding of NR1I3 and Rxra 1 0.00 0 0.07
46 INT236932 Binding of Rxra and Pprc1 1 0.00 0.45 0.07
47 INT278685 Binding of CASR and Rxra 1 0.00 0 0.07
48 INT343479 Epo Positive_regulation of Fgf2 1 0.33 0.3 0.06
49 INT285384 Binding of Rare1 and Rxra 1 0.01 0.08 0.05
50 INT187602 Binding of Ppara and Rxrb 1 0.00 0 0.05
51 INT307218 Binding of Rxra and D0Nrs1 1 0.00 0.1 0.05
52 INT248703 Mapk8 Positive_regulation of Phosphorylation of Rxrb 1 0.01 0.25 0.04
53 INT185270 Binding of Fgf2 and Ifaprc2 1 0.08 0.4 0.04
54 INT340568 Fgf1 Positive_regulation of Mapk1 1 0.06 1.02 0.04
55 INT253017 PTTG1IP Regulation of Regulation of Fgf2 1 0.03 0.49 0.04
56 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03
57 INT248700 Binding of Nr0b2 and Rxrb 1 0.01 0.29 0.03
58 INT297377 Binding of PPARA and Rxra 1 0.02 0.25 0.03
59 INT297375 Binding of VDR and Rxra 1 0.02 0.2 0.03
60 INT253010 Binding of PTTG1 and Fgf2 1 0.07 0.51 0.03
61 INT297374 Binding of TXNRD1 and Rxra 1 0.01 0.2 0.03
62 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
63 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0
64 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
65 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
66 INT314871 Binding of Tgfbr3 and Atoh7 1 0.33 0.09 0
67 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
68 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
69 INT253021 PTTG1 Regulation of Gene_expression of Fgf2 1 0.04 0.35 0
70 INT291715 Binding of DR1 and Rxra 1 0.09 0 0
71 INT314862 Binding of Ltbp3 and Tgfb2 1 0.24 0.52 0
72 INT150378 Fgf2 Positive_regulation of Mcpt1 1 0.67 1.79 0
73 INT150379 Fgf2 Positive_regulation of Gene_expression of Mcpt1 1 0.45 0.89 0
74 INT178433 Fgf1 Positive_regulation of Mapk14 1 0.02 0.65 0
75 INT291716 Binding of SOD1 and Rxra 1 0.21 0 0
76 INT236719 Binding of Dr1 and Rxra 1 0.01 0 0
77 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
78 INT239239 Binding of PPARA and RXRB 1 0.12 0.63 0
79 INT324660 Vash1 Regulation of Gene_expression of Fgf1 1 0.14 0.44 0
80 INT330959 Binding of RXRB and VDR 1 0.05 0.14 0
81 INT291712 Binding of Rxra and SPNS1 1 0.04 0 0
82 INT248705 Binding of Nr1i2 and Rxrb 1 0.01 0.18 0
83 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
84 INT185268 Binding of Fgf2 and Sox1 1 0.19 0 0
85 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
86 INT135127 Binding of RXRB and NR1I2 1 0.29 0.57 0
87 INT291711 Rxra Positive_regulation of VDR 1 0.09 0 0
88 INT326729 Foxc1 Positive_regulation of Gene_expression of Ehf 1 0.23 0.26 0
89 INT291713 Binding of TNFRSF10B and Rxra 1 0.05 0 0
90 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
91 INT314853 Binding of Cdc7 and Tgfbr3 1 0.24 0.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cardiac muscle cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported in cardiac muscle cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5
2 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12
3 INT92679 Positive_regulation of Fgf2 13 0.69 11.43 5.18
4 INT181186 Binding of Rxra 78 0.35 14.93 4.87
5 INT168003 Localization of Fgf2 24 0.80 12.52 3.31
6 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96
7 INT130080 Negative_regulation of Rxra 6 0.53 2.08 2.92
8 INT169318 Positive_regulation of Rxra 15 0.42 4.35 2.12
9 INT87436 Regulation of Fgf2 6 0.45 3.95 2.03
10 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
11 INT130082 Regulation of Rxra 6 0.42 3.78 1.96
12 INT199724 Positive_regulation of Gene_expression of Rxra 11 0.45 6.22 1.88
13 INT92677 Positive_regulation of Gene_expression of Fgf2 11 0.69 4.25 1.68
14 INT128865 Regulation of Positive_regulation of RXRA 1 0.08 0.64 1.48
15 INT128863 Positive_regulation of RXRA 1 0.12 0.63 1.47
16 INT187617 Binding of Rxrb 7 0.06 4.86 1.37
17 INT132577 Binding of RXRB 12 0.30 6.58 1.25
18 INT39711 Negative_regulation of FOXC1 4 0.41 4.29 1.2
19 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18
20 INT166720 Positive_regulation of Rxrb 2 0.36 0.84 1.13
21 INT156427 Localization of FOXC1 2 0.73 1.36 1.07
22 INT214609 Positive_regulation of Gene_expression of FOXC1 1 0.08 1.78 1
23 INT46334 Binding of FOXC1 2 0.36 2.66 0.99
24 INT43131 Regulation of FOXC1 3 0.36 1.09 0.98
25 INT81878 Gene_expression of TGFB2 3 0.42 2.02 0.97
26 INT184236 Positive_regulation of Localization of Fgf2 1 0.27 2.23 0.95
27 INT114704 Positive_regulation of Fgf1 13 0.50 8.89 0.89
28 INT178498 Negative_regulation of Fgf2 11 0.42 4.21 0.84
29 INT93737 Gene_expression of Tgfb2 2 0.03 1.16 0.77
30 INT93736 Positive_regulation of Gene_expression of Tgfb2 2 0.02 1.16 0.77
31 INT169421 Positive_regulation of FOXC1 4 0.49 2.42 0.7
32 INT115297 Positive_regulation of TGFB2 4 0.29 1.91 0.65
33 INT220433 Gene_expression of RXRB 3 0.14 1.83 0.63
34 INT114959 Gene_expression of RXRA 2 0.50 1.06 0.63
35 INT114960 Positive_regulation of Gene_expression of RXRA 1 0.32 0.24 0.61
36 INT185240 Binding of Fgf2 14 0.37 7.39 0.59
37 INT199723 Localization of Rxra 8 0.59 1.31 0.58
38 INT248682 Gene_expression of Rxrb 8 0.60 1.41 0.58
39 INT115292 Regulation of TGFB2 4 0.17 2.79 0.58
40 INT114277 Regulation of Gene_expression of Rxra 1 0.28 0.75 0.58
41 INT184690 Transcription of Fgf1 6 0.51 1.97 0.55
42 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
43 INT130047 Localization of TGFB2 3 0.16 3.65 0.53
44 INT265656 Positive_regulation of Gene_expression of RXRB 1 0.04 0.24 0.5
45 INT92683 Transcription of Fgf2 3 0.51 1.83 0.49
46 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
47 INT337348 Regulation of Gene_expression of Fgf2 2 0.45 0.54 0.44
48 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
49 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
50 INT300851 Negative_regulation of Positive_regulation of Fgf2 3 0.42 1.01 0.4
51 INT248931 Positive_regulation of Tgfb2 1 0.03 0 0.4
52 INT264487 Regulation of Positive_regulation of Rxrb 1 0.21 0.36 0.4
53 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
54 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
55 INT133874 Negative_regulation of Gene_expression of Fgf1 2 0.24 2.82 0.36
56 INT285391 Binding of RXRA 2 0.03 0.08 0.36
57 INT252961 Localization of Fgf1 3 0.27 5.91 0.35
58 INT128754 Binding of Foxc1 1 0.01 0.43 0.32
59 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
60 INT199725 Negative_regulation of Gene_expression of Rxra 2 0.38 0.3 0.3
61 INT316692 Regulation of Localization of TGFB2 1 0.03 1.13 0.3
62 INT114699 Positive_regulation of Gene_expression of Fgf1 4 0.32 2.21 0.29
63 INT345995 Negative_regulation of Gene_expression of Fgf2 1 0.43 0.43 0.29
64 INT214611 Positive_regulation of Localization of FOXC1 1 0.07 0.34 0.26
65 INT236564 Positive_regulation of Binding of Rxra 2 0.18 1.3 0.24
66 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
67 INT332259 Positive_regulation of Positive_regulation of Fgf1 1 0.18 2.33 0.23
68 INT332258 Positive_regulation of Localization of Fgf1 1 0.18 2.32 0.23
69 INT345990 Regulation of Positive_regulation of Fgf2 1 0.45 0.14 0.21
70 INT245856 Regulation of Transcription of Fgf1 1 0.21 0.51 0.21
71 INT245863 Positive_regulation of Transcription of Fgf1 1 0.22 0.51 0.21
72 INT206946 Gene_expression of Rxra 4 0.60 2.2 0.17
73 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
74 INT185203 Regulation of Regulation of FOXC1 1 0.16 0 0.15
75 INT293714 Regulation of Localization of Fgf2 2 0.45 0.1 0.14
76 INT345994 Regulation of Binding of Fgf2 1 0.45 0 0.14
77 INT193777 Negative_regulation of Fgf1 6 0.13 4.26 0.12
78 INT332915 Positive_regulation of Localization of Rxra 1 0.03 0.3 0.11
79 INT143835 Gene_expression of Foxc1 2 0.39 1.17 0.09
80 INT143833 Positive_regulation of Foxc1 2 0.42 1.02 0.09
81 INT214072 Regulation of Gene_expression of RXRA 1 0.01 0.83 0.09
82 INT143836 Negative_regulation of Foxc1 1 0.35 0.92 0.09
83 INT166719 Positive_regulation of Rxra 1 0.36 0.31 0.09
84 INT281762 Negative_regulation of Localization of Fgf2 1 0.16 1 0.08
85 INT343551 Positive_regulation of Localization of TGFB2 1 0.10 1.48 0.08
86 INT266341 Regulation of Localization of Fgf1 1 0.03 0.92 0.08
87 INT264489 Transcription of Rxrb 1 0.53 0.09 0.07
88 INT251229 Negative_regulation of Tgfb2 1 0.34 0.06 0.07
89 INT220435 Regulation of Gene_expression of RXRB 1 0.01 0.25 0.06
90 INT256518 Positive_regulation of Transcription of Rxra 1 0.04 0.24 0.06
91 INT234452 Phosphorylation of RXRB 1 0.29 0.66 0.06
92 INT220430 Negative_regulation of Gene_expression of RXRB 1 0.02 0.25 0.06
93 INT291692 Regulation of Binding of Rxra 4 0.32 0.57 0.05
94 INT185253 Positive_regulation of Binding of Fgf2 1 0.28 0 0.05
95 INT205607 Regulation of Fgf1 4 0.24 3.34 0.04
96 INT248665 Phosphorylation of Rxrb 1 0.07 0.42 0.04
97 INT258058 Phosphorylation of TGFB2 1 0.08 0.89 0.04
98 INT248680 Positive_regulation of Phosphorylation of Rxrb 1 0.05 0.24 0.04
99 INT225406 Transcription of Rxra 3 0.41 0.33 0.03
100 INT248671 Regulation of Rxrb 1 0.02 0.86 0.03
101 INT185206 Transcription of FOXC1 1 0.31 0 0.03
102 INT256507 Regulation of Transcription of Rxra 1 0.04 0.12 0.03
103 INT185204 Positive_regulation of Transcription of FOXC1 1 0.27 0 0.03
104 INT291693 Negative_regulation of Binding of Rxra 1 0.22 0.07 0.03
105 INT185208 Positive_regulation of Positive_regulation of FOXC1 1 0.29 0 0.03
106 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
107 INT265570 Binding of Fgf1 2 0.10 0.91 0
108 INT248544 Transcription of Foxc1 2 0.67 0.48 0
109 INT314821 Binding of Tgfb2 1 0.36 0.51 0
110 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
111 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
112 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
113 INT248676 Positive_regulation of Gene_expression of Rxrb 1 0.05 0.18 0
114 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
115 INT159211 Positive_regulation of Gene_expression of TGFB2 1 0.06 0 0
116 INT231922 Negative_regulation of Positive_regulation of Rxra 1 0.06 0.33 0
117 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
118 INT346487 Negative_regulation of Phosphorylation of RXRA 1 0.01 0.63 0
119 INT291694 Negative_regulation of Localization of Rxra 1 0.22 0 0
120 INT351109 Transcription of TGFB2 1 0.24 0.94 0
121 INT248686 Regulation of Gene_expression of Rxrb 1 0.04 0.23 0
122 INT314839 Binding of Tgfbr3 1 0.42 0.09 0
123 INT291695 Regulation of Negative_regulation of Rxra 1 0.23 0.14 0
124 INT346494 Phosphorylation of RXRA 1 0.01 0.63 0
125 INT311652 Negative_regulation of Regulation of Fgf1 1 0.13 0.32 0
126 INT343455 Phosphorylation of Fgf2 1 0.39 0.1 0
127 INT314836 Gene_expression of Tgfbr3 1 0.59 0.09 0
128 INT291698 Negative_regulation of Negative_regulation of Rxra 1 0.22 0 0
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