GO:0060039

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Name pericardium development
Categary Process
Go Slim No
Go Link GO:0060039
Unique Molecular Interactions 85
Total Molecular Interactions 128
Total Single Events 987
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pericardium development. They are ordered first by their pain relevance and then by number of times they were reported for pericardium development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
2 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
3 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
4 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
5 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
6 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
7 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
8 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
9 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
10 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18
11 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
12 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
13 INT141881 Binding of MECOM and Tnfrsf1a 1 0.00 1.17 0.13
14 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
15 INT84867 Ptger1 Negative_regulation of SETD2 1 0.00 1.09 0.11
16 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
17 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
18 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08
19 INT297970 Binding of BMP2 and IL17C 1 0.15 0.26 0.08
20 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06
21 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
22 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
23 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
24 INT150089 Binding of PDCD10 and Ccm2 1 0.15 0.16 0.05
25 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
26 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
27 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
28 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
29 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
30 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
31 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
32 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
33 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03
34 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
35 INT287233 PDLIM7 Positive_regulation of Gene_expression of BMP2 1 0.07 0.12 0.03
36 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
37 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
38 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
39 INT343999 INCENP Positive_regulation of BMP2 1 0.01 0 0
40 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0
41 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
42 INT314693 Binding of TBX2 and TBX5 1 0.16 0.84 0
43 INT218669 Olr811 Negative_regulation of Phosphorylation of Smad2 1 0.01 0.18 0
44 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
45 INT104029 RPGRIP1L Negative_regulation of Gene_expression of LTB 1 0.16 0.06 0
46 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
47 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
48 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
49 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
50 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
51 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
52 INT269936 Smad2 Positive_regulation of Cdkn2b 1 0.15 0.07 0
53 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0
54 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
55 INT202404 Regulation of Binding of Mapk14 and Ccm2 1 0.30 0.05 0
56 INT202397 Hspa9-ps1 Positive_regulation of Ccm2 1 0.01 0 0
57 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
58 INT344001 INCENP Positive_regulation of Gene_expression of BMP2 1 0.01 0 0
59 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
60 INT337914 sb Negative_regulation of Phosphorylation of Smad2 1 0.00 0.13 0
61 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
62 INT295129 Proc Regulation of Bmp2 1 0.00 0.48 0
63 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
64 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
65 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
66 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
67 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
68 INT337918 sb Positive_regulation of Negative_regulation of Smad2 1 0.00 0.15 0
69 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 0.42 1.71 0
70 INT218670 Olr811 Regulation of Phosphorylation of Smad2 1 0.00 0.33 0
71 INT269938 Smad2 Positive_regulation of Tpt1 1 0.14 0.07 0
72 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
73 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
74 INT202395 Binding of Mapk14 and Ccm2 1 0.40 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pericardium development. They are ordered first by their pain relevance and then by number of times they were reported in pericardium development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
2 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
3 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
4 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
5 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
6 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
7 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
8 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
9 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
10 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
11 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
12 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
13 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
14 INT142813 Localization of RPGRIP1L 1 0.59 0.99 1.01
15 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
16 INT114664 Binding of BMP2 12 0.37 6.54 0.91
17 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
18 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
19 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
20 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
21 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
22 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
23 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
24 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
25 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
26 INT85808 Localization of BMP2 7 0.77 1.94 0.51
27 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
28 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
29 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
30 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
31 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
32 INT150081 Gene_expression of Ccm2 4 0.77 1.56 0.36
33 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
34 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
35 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
36 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
37 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
38 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
39 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
40 INT163891 Positive_regulation of Phosphorylation of MECOM 1 0.00 0.4 0.29
41 INT163894 Phosphorylation of MECOM 1 0.00 0.4 0.28
42 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
43 INT150085 Binding of Ccm2 7 0.39 0.85 0.25
44 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
45 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
46 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
47 INT129907 Regulation of Smad2 1 0.40 0.87 0.23
48 INT265311 Localization of Smad2 5 0.50 1.57 0.21
49 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2
50 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
51 INT148064 Localization of Bmp2 2 0.29 0.14 0.17
52 INT268365 Binding of SMAD2 2 0.47 0.56 0.17
53 INT106010 Positive_regulation of Bmp2 2 0.26 0.91 0.15
54 INT135490 Localization of Smad2 1 0.51 0.08 0.14
55 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
56 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
57 INT158893 Negative_regulation of Gene_expression of Smad2 1 0.30 0.13 0.13
58 INT129616 Negative_regulation of Phosphorylation of Smad2 4 0.38 0.78 0.12
59 INT311892 Regulation of Positive_regulation of Smad2 1 0.23 0.24 0.12
60 INT254992 Negative_regulation of Gene_expression of BMP2 3 0.34 0.56 0.11
61 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11
62 INT150086 Positive_regulation of Binding of Ccm2 2 0.46 0.29 0.1
63 INT235381 Gene_expression of MECOM 1 0.02 5.25 0.1
64 INT326976 Regulation of Localization of BMP2 1 0.59 0.08 0.1
65 INT196035 Localization of Bmp2 3 0.63 0.23 0.09
66 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09
67 INT150082 Negative_regulation of Gene_expression of Ccm2 1 0.35 0.28 0.09
68 INT114663 Regulation of Binding of BMP2 1 0.38 0.19 0.09
69 INT325505 Transcription of Smad2 1 0.67 0.16 0.09
70 INT160285 Negative_regulation of Ccm2 2 0.43 0.24 0.08
71 INT163072 Regulation of Binding of Bmp2 1 0.30 0.52 0.08
72 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
73 INT196025 Negative_regulation of Bmp2 2 0.34 0.14 0.05
74 INT254814 Positive_regulation of Phosphorylation of Smad2 7 0.33 3.74 0.04
75 INT262799 Localization of Smad3 6 0.56 2.09 0.04
76 INT337908 Binding of Smad2 3 0.24 1.06 0.04
77 INT229753 Positive_regulation of Gene_expression of Bmp2 2 0.11 1.22 0.04
78 INT353261 Negative_regulation of Localization of Smad2 1 0.33 0 0.04
79 INT287236 Positive_regulation of Positive_regulation of BMP2 1 0.29 0.08 0.04
80 INT353263 Positive_regulation of Localization of Smad2 1 0.33 0.15 0.04
81 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
82 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
83 INT254799 Transcription of Smad2 1 0.19 0.52 0.03
84 INT353266 Negative_regulation of Negative_regulation of Smad2 1 0.28 0 0.03
85 INT296618 Negative_regulation of Smad2 1 0.37 1.42 0.03
86 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
87 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
88 INT262960 Gene_expression of TBX5 1 0.23 0.09 0.03
89 INT268378 Positive_regulation of Phosphorylation of SMAD2 3 0.67 1.22 0
90 INT271411 Positive_regulation of Positive_regulation of Smad2 2 0.45 0.9 0
91 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0
92 INT145300 Positive_regulation of Positive_regulation of Bmp2 2 0.34 1.03 0
93 INT265337 Binding of Smad3 2 0.35 1 0
94 INT269913 Positive_regulation of Binding of Smad3 1 0.34 0.3 0
95 INT218693 Negative_regulation of Phosphorylation of Smad3 1 0.19 0.32 0
96 INT196031 Binding of Bmp2 1 0.16 0 0
97 INT202340 Phosphorylation of Ccm2 1 0.62 0.08 0
98 INT202383 Positive_regulation of Positive_regulation of Ccm2 1 0.46 0.06 0
99 INT202352 Positive_regulation of Ccm2 1 0.69 0.52 0
100 INT329784 Gene_expression of SMAD3 1 0.31 0.41 0
101 INT278735 Negative_regulation of Gene_expression of Bmp2 1 0.43 0.06 0
102 INT202380 Negative_regulation of Protein_catabolism of Ccm2 1 0.43 0 0
103 INT268384 Positive_regulation of Phosphorylation of SMAD3 1 0.29 1.22 0
104 INT202346 Regulation of Gene_expression of Ccm2 1 0.61 0.09 0
105 INT202356 Regulation of Localization of Ccm2 1 0.45 0.06 0
106 INT296615 Positive_regulation of Smad2 1 0.50 1.51 0
107 INT202362 Positive_regulation of Protein_catabolism of Ccm2 1 0.46 0 0
108 INT202353 Transcription of Ccm2 1 0.71 0.42 0
109 INT202364 Negative_regulation of Transcription of Ccm2 1 0.42 0 0
110 INT269873 Positive_regulation of Negative_regulation of Smad3 1 0.34 0.31 0
111 INT278737 Positive_regulation of Transcription of Bmp2 1 0.47 1.4 0
112 INT120087 Negative_regulation of Gene_expression of Bmp2 1 0.11 0.14 0
113 INT202384 Regulation of Ccm2 1 0.61 0.13 0
114 INT202369 Localization of Ccm2 1 0.74 0.06 0
115 INT268382 Phosphorylation of SMAD3 1 0.34 0.6 0
116 INT235380 Localization of MECOM 1 0.02 0.1 0
117 INT254809 Positive_regulation of Transcription of Smad3 1 0.25 0.24 0
118 INT295579 Negative_regulation of Phosphorylation of SMAD2 1 0.42 0.08 0
119 INT202381 Protein_catabolism of Ccm2 1 0.65 0 0
120 INT278040 Negative_regulation of Localization of BMP2 1 0.32 0.32 0
121 INT235383 Positive_regulation of Gene_expression of MECOM 1 0.02 0.39 0
122 INT202371 Regulation of Transcription of Ccm2 1 0.61 0 0
123 INT202377 Positive_regulation of Gene_expression of Ccm2 1 0.46 0 0
124 INT202351 Regulation of Positive_regulation of Ccm2 1 0.27 0.05 0
125 INT268363 Binding of SMAD3 1 0.20 0.56 0
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