GO:0060080

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Name regulation of inhibitory postsynaptic membrane potential
Categary Process
Go Slim No
Go Link GO:0060080
Unique Molecular Interactions 100
Total Molecular Interactions 122
Total Single Events 1604
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of inhibitory postsynaptic membrane potential. They are ordered first by their pain relevance and then by number of times they were reported for regulation of inhibitory postsynaptic membrane potential. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT157459 Binding of CX3CR1 and CX3CL1 1 0.32 2.12 1.7
2 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
3 INT111211 Binding of Drd4 and Chdh 1 0.01 1.34 1.26
4 INT197231 Grik1 Regulation of Gabrg1 1 0.19 0.13 1.22
5 INT291377 Binding of CX3CR1 and Cx3cl1 2 0.36 3.57 1.02
6 INT110033 Adrb1 Positive_regulation of Gene_expression of Il12a 1 0.05 0 0.99
7 INT140168 Binding of Cx3cl1 and Cx3cr1 2 0.31 1.55 0.98
8 INT69084 Binding of Adrb1 and Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.08 0.83
9 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82
10 INT140281 Binding of Adora2a and Grina 1 0.19 0.64 0.82
11 INT72017 Binding of Adora2a and Ptprg 2 0.07 0 0.77
12 INT76498 Binding of Tacr1 and Adora2a 1 0.09 0 0.77
13 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
14 INT82040 Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.11 0 0.75
15 INT219274 Binding of Cx3cr1 and Cx3cl1 1 0.17 1.08 0.74
16 INT33575 ADRB1 Positive_regulation of Localization of Ahsp 1 0.00 0.33 0.73
17 INT82041 Positive_regulation of Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.12 0 0.72
18 INT197234 Grik1 Positive_regulation of Localization of Gabrg1 1 0.15 0.82 0.71
19 INT252603 Ppig Positive_regulation of Gene_expression of Cx3cl1 1 0.10 1.8 0.69
20 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69
21 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
22 INT62250 Fdft1 Regulation of Adrb1 1 0.00 0 0.65
23 INT197240 Grik2 Regulation of Gene_expression of Gabrg1 1 0.08 0.13 0.64
24 INT197238 Grik1 Regulation of Gene_expression of Gabrg1 1 0.17 0.13 0.64
25 INT239501 Binding of Adora2a and Mtx1 1 0.24 0.95 0.64
26 INT197236 Grik2 Regulation of Gabrg1 1 0.08 0.13 0.64
27 INT62249 Ghrh Regulation of Adrb1 1 0.00 0 0.62
28 INT108020 Binding of Adrb1 and Clec4d 1 0.00 1.19 0.61
29 INT197239 Grik1 Regulation of Localization of Gabrg1 1 0.10 0.56 0.61
30 INT201294 Negative_regulation of Grik1 Negative_regulation of Gabrg1 1 0.30 0 0.6
31 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 0.00 0 0.56
32 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
33 INT172207 Binding of Drd4 and ADHD1 2 0.03 1.56 0.48
34 INT88080 Binding of Chrna4 and Psmb6 1 0.03 0.56 0.46
35 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
36 INT223474 Binding of Grik1 and P2rx3 1 0.03 0.36 0.4
37 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
38 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
39 INT353392 Binding of DRD4 and NCK1 1 0.37 0.62 0.37
40 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
41 INT84602 Binding of Adrb1 and Avp 1 0.00 0 0.36
42 INT35981 Adrb1 Regulation of Localization of Prl 1 0.00 0 0.36
43 INT239503 Binding of Adora2a and Aes 1 0.24 0.85 0.35
44 INT115162 Adora2a Regulation of Gene_expression of Jun 1 0.49 0.36 0.34
45 INT115161 Adora2a Regulation of Gene_expression of Cpe 1 0.04 0.36 0.33
46 INT258764 Binding of Drd4 and ADHD1 1 0.08 1.11 0.31
47 INT254122 Adora2a Regulation of Aliq1 1 0.01 0.85 0.3
48 INT281797 Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.43 0.3
49 INT88555 Adora2a Negative_regulation of Vegfc 1 0.00 0.17 0.25
50 INT197235 Binding of Grik1 and Kars 1 0.32 0.1 0.25
51 INT281798 CFD Regulation of Positive_regulation of Chrna4 1 0.01 0.24 0.24
52 INT224130 Positive_regulation of Adora2a Positive_regulation of ADCY1 1 0.01 0.11 0.22
53 INT224087 Adrbk1 Negative_regulation of Adora2a 1 0.10 0.13 0.22
54 INT72015 Binding of Adora2a and Gnai2 1 0.01 0 0.21
55 INT284519 NOVA2 Positive_regulation of Gene_expression of CX3CL1 1 0.07 1.49 0.2
56 INT165101 Positive_regulation of Binding of Cx3cl1 and Cx3cr1 1 0.13 0.39 0.2
57 INT224094 Adrbk1 Regulation of Negative_regulation of Adora2a 1 0.06 0 0.17
58 INT252326 Binding of Cx3cl1 and Klrk1 1 0.01 0.23 0.16
59 INT325532 Binding of Cx3cl1 and Cxcl10 1 0.28 0.67 0.16
60 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
61 INT83827 Negative_regulation of Binding of Adrb1 and Pnmt 1 0.02 0 0.1
62 INT139558 Chrna4 Regulation of Neurod1 1 0.17 0 0.1
63 INT83831 Binding of PNMT and Adrb1 1 0.02 0 0.1
64 INT139557 Chrna4 Regulation of Gene_expression of Neurod1 1 0.17 0 0.1
65 INT83828 Binding of Adrb1 and Pnmt 1 0.01 0 0.1
66 INT83832 Negative_regulation of Binding of PNMT and Adrb1 1 0.02 0 0.1
67 INT258758 Binding of Drd4 and Lmo1 1 0.04 0.64 0.08
68 INT272604 Binding of Dlg4 and Nlgn3 1 0.17 0 0.03
69 INT272601 Binding of Dlg4 and Grik2 1 0.22 0 0.03
70 INT202573 Binding of DIO2 and DRD4 1 0.07 0.09 0.03
71 INT282504 Binding of Grik2 and Grik3 1 0.27 0.61 0
72 INT303758 Binding of ADRB1 and IGHG3 1 0.06 0.09 0
73 INT202571 Binding of DRD2 and DRD4 1 0.41 0.76 0
74 INT240546 Binding of ADRB1 and INS 1 0.11 0.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of inhibitory postsynaptic membrane potential. They are ordered first by their pain relevance and then by number of times they were reported in regulation of inhibitory postsynaptic membrane potential. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9
2 INT157463 Gene_expression of CX3CL1 55 0.62 69.05 19.75
3 INT124670 Gene_expression of Grik1 53 0.77 4.83 19.13
4 INT197210 Positive_regulation of Grik1 24 0.69 3.15 16.24
5 INT170 Negative_regulation of Adrb1 52 0.55 13.46 14.78
6 INT121162 Gene_expression of Cx3cl1 22 0.78 11.56 14.59
7 INT95 Positive_regulation of Adrb1 34 0.62 11.95 14.41
8 INT15042 Gene_expression of Adora2a 37 0.77 3.77 14.24
9 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78
10 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75
11 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47
12 INT176607 Gene_expression of Cx3cl1 27 0.75 19.51 11.32
13 INT121161 Localization of Cx3cl1 14 0.75 10.07 10.61
14 INT59 Regulation of Adrb1 25 0.42 8.32 9.78
15 INT30247 Regulation of Adrb1 18 0.44 4.45 8.93
16 INT141502 Positive_regulation of CX3CL1 21 0.55 25.8 8.88
17 INT157467 Positive_regulation of Gene_expression of CX3CL1 6 0.55 16.67 8.84
18 INT96 Binding of Adrb1 18 0.48 2.8 8.52
19 INT23209 Binding of Adora2a 17 0.38 2.04 8.35
20 INT26115 Gene_expression of Adrb1 14 0.64 5.13 7.78
21 INT54755 Negative_regulation of Adora2a 17 0.58 2.7 7.75
22 INT23992 Positive_regulation of Adrb1 25 0.56 4.01 7.62
23 INT88079 Gene_expression of Chrna4 20 0.76 8.52 6.98
24 INT197216 Localization of Grik1 9 0.80 0.39 6.78
25 INT83014 Binding of Adora2a 13 0.48 5.57 5.33
26 INT89664 Negative_regulation of Adora2a 11 0.59 7.81 5.07
27 INT51468 Regulation of Adora2a 8 0.48 1.5 4.84
28 INT197219 Positive_regulation of Gene_expression of Grik1 5 0.69 0.83 4.67
29 INT197230 Regulation of Positive_regulation of Grik1 4 0.45 0 4.42
30 INT88274 Positive_regulation of Drd4 7 0.69 3.48 4.1
31 INT465 Binding of Adrb1 14 0.35 3.04 4.07
32 INT50228 Positive_regulation of Positive_regulation of Adora2a 8 0.39 0.1 4
33 INT131969 Regulation of Grik1 6 0.61 0.57 3.69
34 INT101701 Regulation of Adora2a 8 0.45 2.3 3.63
35 INT197207 Negative_regulation of Grik1 5 0.43 1.91 3.5
36 INT121159 Regulation of Cx3cl1 4 0.45 3.78 3.38
37 INT109095 Binding of Drd4 7 0.40 3.6 3.18
38 INT88273 Gene_expression of Drd4 6 0.54 1.84 3.01
39 INT120827 Regulation of CX3CL1 3 0.14 2.24 2.94
40 INT128304 Positive_regulation of Gene_expression of Cx3cl1 3 0.70 2.3 2.84
41 INT147412 Binding of DRD4 11 0.47 7.57 2.77
42 INT297300 Positive_regulation of Gene_expression of Cx3cl1 6 0.34 4.78 2.73
43 INT189863 Gene_expression of DRD4 11 0.68 7.65 2.66
44 INT88272 Gene_expression of Drd4 5 0.66 1.07 2.53
45 INT254118 Negative_regulation of Gene_expression of Adora2a 3 0.42 2.54 2.43
46 INT139556 Positive_regulation of Chrna4 10 0.25 4.52 2.36
47 INT25666 Negative_regulation of ADRB1 11 0.44 3.12 2.33
48 INT183167 Positive_regulation of Gene_expression of Adora2a 4 0.70 2.37 2.31
49 INT4495 Gene_expression of Adrb1 7 0.66 2.43 2.29
50 INT94 Positive_regulation of Negative_regulation of Adrb1 4 0.46 0.97 2.16
51 INT57939 Negative_regulation of Gene_expression of Adora2a 4 0.36 0.15 2.02
52 INT123253 Localization of Chrna4 4 0.44 1.31 1.99
53 INT72785 Positive_regulation of Positive_regulation of Adora2a 2 0.10 1.34 1.96
54 INT194847 Negative_regulation of Positive_regulation of Adora2a 3 0.32 4.52 1.88
55 INT284521 Negative_regulation of CX3CL1 11 0.27 13.86 1.87
56 INT23884 Negative_regulation of Negative_regulation of Adrb1 7 0.38 2.3 1.83
57 INT32176 Negative_regulation of Negative_regulation of Adrb1 2 0.40 0.4 1.77
58 INT197209 Positive_regulation of Positive_regulation of Grik1 4 0.50 0.36 1.74
59 INT110026 Localization of Adrb1 4 0.72 1.56 1.71
60 INT124667 Negative_regulation of Grik2 4 0.41 2.06 1.7
61 INT150078 Negative_regulation of Gene_expression of Cx3cl1 1 0.43 1.72 1.7
62 INT311593 Localization of Cx3cl1 3 0.49 1.99 1.69
63 INT1731 Localization of Adrb1 5 0.43 0.31 1.67
64 INT138083 Positive_regulation of Gene_expression of Drd4 2 0.40 1.34 1.55
65 INT76496 Localization of Adora2a 3 0.48 0.3 1.54
66 INT131968 Transcription of Grik1 3 0.51 1.44 1.51
67 INT124669 Gene_expression of Grik2 6 0.75 1.66 1.47
68 INT168537 Negative_regulation of Gene_expression of Grik1 3 0.57 0.11 1.44
69 INT165493 Binding of CX3CL1 5 0.21 3.08 1.41
70 INT38312 Positive_regulation of Gene_expression of Adrb1 2 0.07 0.22 1.33
71 INT69498 Positive_regulation of DRD4 3 0.50 0.95 1.3
72 INT197224 Negative_regulation of Localization of Grik1 2 0.37 0 1.29
73 INT140166 Binding of Cx3cl1 2 0.27 1.21 1.22
74 INT81768 Negative_regulation of Chrna4 5 0.42 1.97 1.2
75 INT91595 Regulation of Gene_expression of Adora2a 1 0.52 0 1.19
76 INT125676 Positive_regulation of Phosphorylation of Grik1 1 0.01 0 1.17
77 INT131970 Regulation of Grik2 3 0.26 0.65 1.15
78 INT291359 Binding of Cx3cl1 2 0.36 2.31 1.13
79 INT140159 Regulation of Gene_expression of Adrb1 1 0.00 0.17 1.07
80 INT71031 Gene_expression of ADRB1 5 0.55 2.96 1.01
81 INT311592 Positive_regulation of Cx3cl1 2 0.67 1.93 1.01
82 INT33442 Regulation of ADRB1 2 0.04 0.38 0.98
83 INT12555 Binding of ADRB1 7 0.39 3.78 0.97
84 INT42420 Negative_regulation of Binding of Adrb1 2 0.58 0.8 0.97
85 INT52090 Transcription of Adora2a 3 0.41 0.33 0.96
86 INT31828 Transcription of Adrb1 2 0.27 0.18 0.94
87 INT72006 Positive_regulation of Negative_regulation of Adora2a 2 0.40 0.26 0.94
88 INT284523 Localization of CX3CL1 1 0.37 2.18 0.92
89 INT220175 Negative_regulation of Cx3cl1 3 0.29 3.61 0.89
90 INT201276 Negative_regulation of Positive_regulation of Grik1 1 0.34 0.3 0.89
91 INT70724 Positive_regulation of Negative_regulation of ADRB1 1 0.38 0.2 0.86
92 INT131967 Transcription of Grik2 2 0.67 0.73 0.82
93 INT88271 Positive_regulation of Drd4 2 0.19 0.5 0.82
94 INT1732 Positive_regulation of Localization of Adrb1 2 0.22 0.06 0.8
95 INT302869 Phosphorylation of Adora2a 1 0.49 0.25 0.78
96 INT302868 Positive_regulation of Phosphorylation of Adora2a 1 0.41 0.25 0.78
97 INT80147 Negative_regulation of Binding of Adora2a 2 0.43 0.15 0.77
98 INT32751 Regulation of Positive_regulation of Adrb1 2 0.36 0.07 0.77
99 INT123254 Regulation of Chrna4 3 0.27 0.84 0.76
100 INT152539 Positive_regulation of Localization of Cx3cl1 1 0.34 0.9 0.75
101 INT89663 Localization of Adora2a 1 0.74 0.74 0.75
102 INT131966 Regulation of Regulation of Grik2 1 0.26 0.45 0.75
103 INT194852 Protein_catabolism of Adora2a 1 0.56 0.6 0.75
104 INT140165 Negative_regulation of Cx3cl1 1 0.32 0.53 0.73
105 INT197222 Regulation of Localization of Grik1 1 0.39 0 0.72
106 INT197206 Regulation of Gene_expression of Grik1 2 0.39 0.13 0.71
107 INT224109 Phosphorylation of Adora2a 1 0.52 0.07 0.69
108 INT43481 Positive_regulation of ADRB1 3 0.19 1.36 0.68
109 INT165492 Negative_regulation of Gene_expression of CX3CL1 1 0.20 6.76 0.68
110 INT123251 Regulation of Gene_expression of Chrna4 2 0.27 0.36 0.67
111 INT128306 Transcription of Cx3cl1 1 0.60 0.36 0.64
112 INT24095 Protein_catabolism of Adrb1 2 0.10 0.59 0.61
113 INT215637 Regulation of Regulation of Adora2a 1 0.14 0.16 0.61
114 INT83826 Negative_regulation of Binding of Adrb1 3 0.25 0.67 0.6
115 INT99329 Binding of Chrna4 3 0.37 0.45 0.6
116 INT125675 Phosphorylation of Grik1 1 0.01 0 0.59
117 INT125677 Negative_regulation of Phosphorylation of Grik1 1 0.01 0 0.59
118 INT123256 Regulation of Localization of Chrna4 1 0.27 0.28 0.58
119 INT29111 Negative_regulation of Positive_regulation of Adrb1 1 0.37 0.14 0.58
120 INT141458 Regulation of Gene_expression of Adora2a 2 0.45 0.67 0.57
121 INT135534 Regulation of Gene_expression of Drd4 1 0.30 0.18 0.56
122 INT215639 Positive_regulation of Binding of Adora2a 1 0.24 0.24 0.55
123 INT224106 Regulation of Negative_regulation of Adora2a 1 0.17 0.26 0.51
124 INT178675 Regulation of Gene_expression of CX3CL1 2 0.21 2.96 0.5
125 INT42184 Positive_regulation of Binding of Adrb1 1 0.31 0.19 0.5
126 INT56662 Regulation of Protein_catabolism of Adrb1 1 0.05 0.27 0.5
127 INT56661 Positive_regulation of Protein_catabolism of Adrb1 1 0.06 0.27 0.49
128 INT156210 Regulation of Positive_regulation of Drd4 1 0.45 0.72 0.49
129 INT224107 Negative_regulation of Negative_regulation of Adora2a 1 0.28 0.32 0.48
130 INT72143 Regulation of Binding of Adora2a 1 0.17 0 0.45
131 INT311594 Regulation of Cx3cl1 1 0.19 0.3 0.43
132 INT281775 Regulation of Positive_regulation of Chrna4 1 0.02 0.98 0.41
133 INT184866 Positive_regulation of Binding of Drd4 1 0.20 0.87 0.41
134 INT102385 Regulation of Transcription of Adora2a 1 0.21 0.09 0.4
135 INT220164 Negative_regulation of Negative_regulation of Cx3cl1 1 0.20 0.96 0.39
136 INT172201 Localization of Drd4 1 0.58 0.18 0.38
137 INT102387 Negative_regulation of Transcription of Adora2a 1 0.09 0.24 0.37
138 INT88082 Negative_regulation of Drd4 1 0.18 0.65 0.35
139 INT63924 Regulation of Binding of Adrb1 1 0.16 0.27 0.34
140 INT197217 Binding of Grik1 1 0.37 0.09 0.34
141 INT52207 Positive_regulation of Positive_regulation of Adrb1 1 0.09 0 0.33
142 INT69187 Regulation of Positive_regulation of Adrb1 1 0.25 0 0.33
143 INT43325 Regulation of Binding of ADRB1 1 0.37 0.36 0.3
144 INT280583 Negative_regulation of Gene_expression of ADRB1 2 0.09 1.18 0.29
145 INT10857 Regulation of Negative_regulation of Adrb1 2 0.45 0.65 0.28
146 INT221765 Positive_regulation of Gene_expression of Adora2a 2 0.49 0.2 0.27
147 INT353393 Transcription of DRD4 1 0.63 0.57 0.27
148 INT224108 Positive_regulation of Localization of Adora2a 1 0.32 0.14 0.27
149 INT224114 Regulation of Localization of Adora2a 1 0.29 0.14 0.27
150 INT178665 Regulation of Gene_expression of Cx3cl1 1 0.04 0.43 0.26
151 INT284520 Negative_regulation of Localization of CX3CL1 1 0.27 0.8 0.24
152 INT137662 Negative_regulation of Drd4 2 0.39 0.86 0.23
153 INT197208 Positive_regulation of Localization of Grik1 1 0.50 0.1 0.22
154 INT224117 Negative_regulation of Positive_regulation of Adora2a 1 0.27 0.11 0.22
155 INT209146 Negative_regulation of Negative_regulation of ADRB1 1 0.31 0 0.21
156 INT172200 Transcription of Drd4 1 0.41 0.73 0.21
157 INT224105 Regulation of Phosphorylation of Adora2a 1 0.17 0 0.21
158 INT172199 Positive_regulation of Transcription of Drd4 1 0.36 0.73 0.21
159 INT300559 Positive_regulation of Gene_expression of Drd4 1 0.43 0.15 0.19
160 INT165100 Positive_regulation of Cx3cl1 1 0.21 0.38 0.19
161 INT224115 Positive_regulation of Phosphorylation of Adora2a 1 0.32 0 0.16
162 INT224103 Negative_regulation of Phosphorylation of Adora2a 1 0.27 0 0.16
163 INT167120 Protein_catabolism of Cx3cl1 1 0.07 0.19 0.15
164 INT284522 Positive_regulation of Binding of CX3CL1 1 0.23 1.44 0.13
165 INT139554 Positive_regulation of Gene_expression of Chrna4 2 0.25 0 0.1
166 INT40871 Regulation of Negative_regulation of Adrb1 1 0.24 0.32 0.1
167 INT139553 Transcription of Chrna4 1 0.27 0 0.1
168 INT139555 Positive_regulation of Positive_regulation of Chrna4 1 0.25 0 0.1
169 INT44040 Negative_regulation of Gene_expression of Adrb1 1 0.35 0.34 0.09
170 INT45551 Regulation of Regulation of Adrb1 1 0.22 0.29 0.08
171 INT241728 Regulation of Transcription of Adora2a 1 0.42 0.27 0.07
172 INT271054 Regulation of DRD4 1 0.12 0.61 0.07
173 INT241725 Transcription of Adora2a 1 0.67 0.27 0.07
174 INT172202 Binding of Drd4 1 0.28 0.05 0.03
175 INT272566 Gene_expression of Nlgn3 1 0.28 0 0.03
176 INT202574 Negative_regulation of DRD4 1 0.42 0.29 0
177 INT124941 Negative_regulation of Gene_expression of Grik2 1 0.41 0 0
178 INT303767 Localization of ADRB1 1 0.18 0.2 0
179 INT303766 Positive_regulation of Gene_expression of ADRB1 1 0.11 0.15 0
180 INT202583 Negative_regulation of Binding of DRD4 1 0.42 0.29 0
181 INT303768 Negative_regulation of Binding of ADRB1 1 0.09 0.5 0
182 INT282476 Binding of Grik2 1 0.31 0.61 0
183 INT202576 Regulation of Gene_expression of DRD4 1 0.44 0.45 0
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