GO:0060081

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Name membrane hyperpolarization
Categary Process
Go Slim No
Go Link GO:0060081
Unique Molecular Interactions 129
Total Molecular Interactions 169
Total Single Events 1134
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for membrane hyperpolarization. They are ordered first by their pain relevance and then by number of times they were reported for membrane hyperpolarization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
2 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
3 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
4 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
5 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
6 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
7 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
8 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
9 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
10 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
11 INT291386 Cntf Regulation of Gene_expression of Gria2 1 0.11 0.13 0.53
12 INT8438 Cntf Regulation of TAC1 1 0.20 0.18 0.52
13 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
14 INT8439 Cntf Regulation of VIP 1 0.20 0.18 0.52
15 INT8440 Cntf Regulation of LIF 1 0.33 0.18 0.52
16 INT56744 CNTF Positive_regulation of Cck 1 0.08 0.09 0.51
17 INT228448 PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
18 INT56736 Cntf Positive_regulation of Chat 1 0.00 0.1 0.49
19 INT228447 Negative_regulation of PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
20 INT56745 CNTF Positive_regulation of Chat 1 0.02 0.1 0.49
21 INT291384 Cntf Positive_regulation of Slc1a3 1 0.26 0.34 0.45
22 INT291387 Cntf Positive_regulation of Slc1a2 1 0.12 0.34 0.45
23 INT296477 Binding of Cacng2 and Dlg4 1 0.04 0.22 0.42
24 INT291393 Cntf Regulation of GTS 1 0.05 0 0.42
25 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
26 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
27 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4
28 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
29 INT91720 Binding of BDNF and CNTF 1 0.09 1.71 0.38
30 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37
31 INT352231 VEGFA Negative_regulation of Cntf 1 0.04 0.22 0.34
32 INT352230 VEGFA Negative_regulation of Gene_expression of Cntf 1 0.04 0.22 0.34
33 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
34 INT291383 Fig4 Regulation of Gene_expression of Cntf 1 0.10 0 0.28
35 INT63988 Cntf Regulation of Positive_regulation of Sds 1 0.22 0 0.28
36 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28
37 INT296450 Cacng2 Regulation of Gria2 1 0.13 0.24 0.26
38 INT346745 Binding of Cacng2 and Grip2 1 0.01 0 0.25
39 INT296470 Binding of Cacng2 and Myo18a 1 0.00 0.22 0.24
40 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
41 INT296467 Binding of Cacng2 and Gria1 1 0.12 0.25 0.23
42 INT179492 Binding of Ins1 and Adipoq 1 0.16 1.16 0.23
43 INT296464 Binding of Cacng2 and Tinagl1 1 0.06 0.25 0.23
44 INT296474 Binding of Cacng2 and Gria2 1 0.18 0.26 0.23
45 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
46 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
47 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
48 INT249760 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Adipoq 1 0.20 0.81 0.22
49 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
50 INT242996 Adipoq Negative_regulation of Transcription of Cd68 1 0.22 0.6 0.21
51 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21
52 INT332304 Binding of Il6 and Adipoq 1 0.03 0.4 0.2
53 INT145886 Binding of CXCL1 and Adipoq 1 0.00 0.77 0.2
54 INT352518 Binding of FAT1 and Adipoq 1 0.01 2.79 0.2
55 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19
56 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
57 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18
58 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
59 INT228168 Adipoq Positive_regulation of Prkag1 2 0.05 1.08 0.17
60 INT296469 Gene_expression of Cacng2 Positive_regulation of Gria2 1 0.15 0 0.16
61 INT296461 Gene_expression of Cacng2 Positive_regulation of Rbm39 1 0.00 0 0.16
62 INT240622 Binding of ADIPOQ and Etv3 1 0.04 1.32 0.15
63 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
64 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
65 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
66 INT270663 Adipoq Positive_regulation of Il6 1 0.02 1.05 0.12
67 INT179493 Adipoq Positive_regulation of Ins1 1 0.20 0.99 0.12
68 INT270669 Adipoq Positive_regulation of IL8 1 0.01 1.06 0.12
69 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
70 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
71 INT270665 Adipoq Positive_regulation of Ccl2 1 0.07 1.06 0.12
72 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
73 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12
74 INT204996 Binding of Park7 and Pink1 2 0.34 1.09 0.11
75 INT257467 Fat1 Regulation of Gene_expression of Adipoq 1 0.08 0.56 0.11
76 INT296468 Cacng2 Regulation of Regulation of Gria2 1 0.10 0 0.11
77 INT240624 Binding of ADIPOQ and Hdl1 1 0.02 0.85 0.1
78 INT349860 Binding of Cntf and Lifr 1 0.39 0.22 0.1
79 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1
80 INT310275 Negative_regulation of Binding of Adipoq and Ins1 1 0.19 1.14 0.09
81 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09
82 INT157274 Adipoq Positive_regulation of ADIPOR1 1 0.00 1.2 0.09
83 INT310274 Binding of Adipoq and Ins1 1 0.21 1.14 0.09
84 INT228174 RNU1-1 Positive_regulation of Gene_expression of Adipoq 1 0.12 0.55 0.08
85 INT355021 Cntf Positive_regulation of SOAT1 1 0.02 0.7 0.08
86 INT355022 Cntf Positive_regulation of JAK1 1 0.00 0.69 0.08
87 INT257466 Psd Negative_regulation of Gene_expression of Adipoq 1 0.22 0.66 0.08
88 INT355009 Cntf Positive_regulation of Il6st 1 0.02 0.69 0.08
89 INT267154 ADIPOQ Regulation of Positive_regulation of SUGT1 1 0.03 1.18 0.08
90 INT352517 Binding of INS and Adipoq 1 0.09 1.32 0.07
91 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07
92 INT352579 CNTF Negative_regulation of Gene_expression of NPY 1 0.17 0.89 0.07
93 INT260392 Hmox1 Positive_regulation of Adipoq 1 0.32 0.65 0.07
94 INT336380 Gene_expression of Adipoq Positive_regulation of Ppara 1 0.06 1.77 0.07
95 INT140813 Binding of Retn and Adipoq 1 0.03 1.18 0.06
96 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
97 INT112281 Cntf Regulation of Igf1 1 0.22 0.14 0.05
98 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05
99 INT228169 Gm2733 Regulation of Adipoq 1 0.00 0.51 0.05
100 INT112280 Ntf3 Regulation of Cntf 1 0.11 0.13 0.05
101 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
102 INT236590 Binding of Adipoq and Ncoa2 1 0.15 0.2 0.03
103 INT236587 Binding of Adipoq and Ncoa1 1 0.17 0.2 0.03
104 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03
105 INT236592 Positive_regulation of Binding of Adipoq and Ncoa2 1 0.19 0.2 0.03
106 INT317301 Binding of Park2 and Park7 1 0.36 0.62 0
107 INT346742 Binding of Cacng2 and Dlg4 1 0.03 0 0
108 INT116407 Binding of Bdnf and Cntf 1 0.19 0.05 0
109 INT227305 Zbp1 Regulation of Gene_expression of Adipoq 1 0.21 1.27 0
110 INT204323 Binding of ADIPOQ and Negative_regulation of Gene_expression of ROS1 1 0.08 0.12 0
111 INT317316 Park7 Positive_regulation of Protein_catabolism of Hmbs 1 0.11 0.68 0
112 INT352516 Binding of POMT1 and Adipoq 1 0.01 0.4 0
113 INT204322 Binding of ADIPOQ and Positive_regulation of Gene_expression of PPARGC1A 1 0.30 0.07 0
114 INT346746 Binding of Cacng2 and Gria2 1 0.21 0.18 0
115 INT260395 Positive_regulation of Adipoq Negative_regulation of Gene_expression of Hmox1 1 0.34 1.4 0
116 INT317324 Park7 Positive_regulation of Protein_catabolism of SNCAIP 1 0.38 0.69 0
117 INT222569 Cntf Regulation of Localization of Prl 1 0.01 0.06 0
118 INT140814 Adipoq Regulation of Retn 1 0.03 0.8 0
119 INT227302 Zbp1 Regulation of Transcription of Adipoq 1 0.09 1.27 0
120 INT313502 Binding of ALOX5AP and ADIPOQ 1 0.05 0.44 0
121 INT350254 Slc12a6 Regulation of Gene_expression of Adipoq 1 0.02 0.63 0
122 INT197915 Des Positive_regulation of Adipoq 1 0.07 0 0
123 INT332943 Binding of SNRNP70 and Adipoq 1 0.00 1.35 0
124 INT353062 HSD11B1 Regulation of Gene_expression of ADIPOQ 1 0.13 5.03 0
125 INT317308 Binding of Park7 and Mul1 1 0.01 0.62 0
126 INT222530 Cntf Regulation of Localization of Gh1 1 0.00 0.06 0
127 INT325283 Negative_regulation of MCL1 Positive_regulation of Gene_expression of ADIPOQ 1 0.14 1.53 0
128 INT349296 Binding of CSF2 and PARK7 1 0.24 1.24 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for membrane hyperpolarization. They are ordered first by their pain relevance and then by number of times they were reported in membrane hyperpolarization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
2 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
3 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
4 INT8423 Gene_expression of Cntf 29 0.69 11.69 8.4
5 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
6 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
7 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
8 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
9 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
10 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
11 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
12 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
13 INT81458 Positive_regulation of Cntf 11 0.47 4.18 3.18
14 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
15 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
16 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
17 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
18 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
19 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
20 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
21 INT228442 Localization of Cntf 8 0.63 4.2 2.12
22 INT286801 Positive_regulation of Gene_expression of Cntf 4 0.62 3.01 2.12
23 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
24 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
25 INT288630 Gene_expression of Cntf 6 0.75 3.99 1.89
26 INT227273 Localization of Adipoq 22 0.72 18.04 1.72
27 INT8422 Binding of Cntf 8 0.37 4.54 1.72
28 INT68582 Localization of CNTF 4 0.73 2.02 1.68
29 INT8421 Regulation of Cntf 6 0.44 1.46 1.67
30 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
31 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
32 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
33 INT164706 Positive_regulation of Park7 2 0.50 2.28 1.28
34 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15
35 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14
36 INT164400 Positive_regulation of CNTF 3 0.49 1.66 0.96
37 INT160140 Regulation of Binding of Adipoq 1 0.37 0.87 0.92
38 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
39 INT227270 Regulation of Gene_expression of Adipoq 5 0.55 7.35 0.85
40 INT352587 Transcription of CNTF 1 0.30 5.18 0.84
41 INT151927 Regulation of Gene_expression of Adipoq 3 0.43 3.32 0.81
42 INT286804 Negative_regulation of Gene_expression of Cntf 2 0.38 0.71 0.79
43 INT120603 Negative_regulation of Cntf 6 0.35 3.57 0.78
44 INT142013 Positive_regulation of Regulation of Adipoq 1 0.03 0.65 0.78
45 INT28020 Binding of Adipoq 10 0.36 11.49 0.77
46 INT148756 Regulation of Adipoq 10 0.60 7.83 0.67
47 INT70418 Negative_regulation of CNTF 1 0.58 0.62 0.63
48 INT118310 Negative_regulation of Positive_regulation of Adipoq 2 0.34 2.47 0.61
49 INT179488 Positive_regulation of Transcription of Adipoq 3 0.37 0.5 0.6
50 INT272575 Binding of Cacng2 3 0.36 0.54 0.58
51 INT286805 Positive_regulation of Localization of Cntf 1 0.40 1.3 0.52
52 INT227272 Transcription of Adipoq 8 0.64 8.29 0.49
53 INT83430 Positive_regulation of Binding of ADIPOQ 2 0.21 0.85 0.49
54 INT228441 Negative_regulation of Localization of Cntf 1 0.19 0.07 0.49
55 INT83434 Negative_regulation of Binding of ADIPOQ 1 0.39 1.14 0.45
56 INT308980 Positive_regulation of Negative_regulation of Adipoq 3 0.33 2.3 0.4
57 INT81457 Positive_regulation of Regulation of Cntf 1 0.47 0.09 0.34
58 INT164399 Gene_expression of CNTF 5 0.65 1.73 0.33
59 INT179491 Transcription of Adipoq 4 0.51 0.98 0.32
60 INT227268 Negative_regulation of Transcription of Adipoq 4 0.52 4.93 0.3
61 INT349301 Negative_regulation of PARK7 1 0.41 3.44 0.26
62 INT289992 Phosphorylation of Cntf 1 0.30 1 0.22
63 INT253941 Positive_regulation of Localization of Adipoq 5 0.24 2.59 0.21
64 INT289982 Phosphorylation of CNTF 1 0.79 0.99 0.21
65 INT170513 Gene_expression of Cacng2 3 0.65 0.06 0.18
66 INT150529 Positive_regulation of Negative_regulation of Adipoq 2 0.37 1.76 0.18
67 INT197872 Regulation of Regulation of Adipoq 3 0.35 1.11 0.17
68 INT28026 Positive_regulation of Binding of Adipoq 1 0.27 0 0.17
69 INT137455 Protein_catabolism of ADIPOQ 1 0.66 0.25 0.17
70 INT228162 Negative_regulation of Localization of Adipoq 1 0.38 1.29 0.17
71 INT308978 Negative_regulation of Regulation of Adipoq 1 0.28 0.92 0.17
72 INT263001 Regulation of Gene_expression of ADIPOQ 5 0.45 3.77 0.16
73 INT296433 Positive_regulation of Gene_expression of Cacng2 1 0.18 0 0.16
74 INT289348 Positive_regulation of Positive_regulation of Cntf 1 0.20 0.19 0.15
75 INT163262 Transcription of ADIPOQ 5 0.52 2.81 0.14
76 INT281868 Negative_regulation of Park7 1 0.00 1.69 0.14
77 INT262999 Negative_regulation of Gene_expression of ADIPOQ 7 0.43 9.52 0.12
78 INT349300 Gene_expression of PARK7 1 0.75 8.65 0.12
79 INT204986 Gene_expression of Park7 5 0.38 5.48 0.1
80 INT173981 Gene_expression of Park7 2 0.56 0.73 0.1
81 INT157267 Negative_regulation of Localization of Adipoq 1 0.24 0.94 0.09
82 INT327816 Regulation of Positive_regulation of ADIPOQ 1 0.04 1.2 0.09
83 INT144614 Binding of CNTF 2 0.36 1.44 0.07
84 INT349815 Regulation of Cntf 1 0.26 0.21 0.07
85 INT243711 Binding of Park7 3 0.25 1.5 0.06
86 INT346730 Positive_regulation of Cacng2 1 0.49 0 0.06
87 INT204990 Positive_regulation of Gene_expression of Park7 2 0.24 1.79 0.05
88 INT353069 Positive_regulation of Positive_regulation of ADIPOQ 1 0.13 1.75 0.05
89 INT245905 Negative_regulation of Transcription of ADIPOQ 1 0.42 1.26 0.05
90 INT228584 Phosphorylation of Adipoq 1 0.38 0.61 0.04
91 INT251940 Positive_regulation of Transcription of ADIPOQ 1 0.01 0 0.04
92 INT204973 Positive_regulation of Park7 2 0.23 1.62 0.03
93 INT346727 Regulation of Cacng2 1 0.26 0 0.03
94 INT240621 Negative_regulation of Localization of ADIPOQ 1 0.39 0.64 0.03
95 INT204970 Localization of Park7 3 0.54 2.76 0
96 INT349303 Positive_regulation of Positive_regulation of PARK7 1 0.49 1 0
97 INT164401 Regulation of Gene_expression of CNTF 1 0.52 0.47 0
98 INT349298 Phosphorylation of PARK7 1 0.79 0.9 0
99 INT257464 Negative_regulation of Transcription of Adipoq 1 0.41 0.45 0
100 INT349304 Positive_regulation of PARK7 1 0.67 9.44 0
101 INT263530 Negative_regulation of Positive_regulation of ADIPOQ 1 0.31 1.43 0
102 INT164398 Regulation of CNTF 1 0.26 0.77 0
103 INT120602 Positive_regulation of Negative_regulation of Cntf 1 0.27 0 0
104 INT346728 Localization of Cacng2 1 0.73 0 0
105 INT227262 Regulation of Transcription of Adipoq 1 0.35 0.47 0
106 INT208272 Regulation of Gene_expression of Park7 1 0.19 0.27 0
107 INT349302 Localization of PARK7 1 0.78 3.09 0
108 INT349299 Binding of PARK7 1 0.41 1.86 0
109 INT144616 Positive_regulation of Binding of CNTF 1 0.49 0.53 0
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