GO:0060129

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Name thyroid-stimulating hormone-secreting cell differentiation
Categary Process
Go Slim No
Go Link GO:0060129
Unique Molecular Interactions 156
Total Molecular Interactions 215
Total Single Events 1768
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for thyroid-stimulating hormone-secreting cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for thyroid-stimulating hormone-secreting cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
3 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
4 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
5 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
6 INT13282 Fgf2 Regulation of Ngf 1 0.66 0.21 0.91
7 INT66334 Fgf2 Regulation of Fgf1 1 0.37 0.17 0.9
8 INT13280 Ngf Regulation of Fgf2 1 0.48 0.2 0.9
9 INT66333 Fgf2 Negative_regulation of Positive_regulation of Npy 1 0.20 0.17 0.85
10 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
11 INT183175 Binding of FGF2 and NUDT6 1 0.07 1.07 0.84
12 INT224726 Negative_regulation of Binding of Fgf2 and Cia1 1 0.01 0.92 0.62
13 INT224727 Binding of Fgf2 and Cia1 1 0.01 0.91 0.61
14 INT129270 Binding of Wnt4 and Efs 1 0.00 0 0.55
15 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
16 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54
17 INT66336 Fgf2 Regulation of Gene_expression of Npy 1 0.12 0.09 0.5
18 INT228449 PMAIP1 Negative_regulation of Fgf2 1 0.00 0.07 0.49
19 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
20 INT66335 Fgf1 Regulation of Fgf2 1 0.10 0.08 0.45
21 INT13283 Egf Regulation of Fgf2 1 0.49 0.11 0.41
22 INT13284 Fgf2 Regulation of Egf 1 0.49 0.11 0.41
23 INT92690 Tgfb1 Positive_regulation of Transcription of Fgf2 1 0.32 1.8 0.4
24 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
25 INT295755 Fgf2 Regulation of MMP9 1 0.07 0.99 0.33
26 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
27 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
28 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
29 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
30 INT56091 FGF2 Positive_regulation of Transcription of SERPINE1 1 0.43 0.41 0.28
31 INT250864 Fgf8 Positive_regulation of Positive_regulation of Ptger2 1 0.03 0.55 0.28
32 INT250854 Fgf8 Positive_regulation of Positive_regulation of Mmp3 1 0.11 0.55 0.28
33 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23
34 INT339535 FGF2 Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.55 0.22
35 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
36 INT174861 Binding of FGF2 and VEGFA 1 0.34 0.59 0.2
37 INT92693 Tgfb1 Positive_regulation of Fgf2 1 0.32 0.9 0.2
38 INT201212 FGF2 Regulation of FGFR1 2 0.09 1.01 0.18
39 INT337697 FGF2 Regulation of VEGFA 1 0.03 0.51 0.18
40 INT152024 Ptgs1 Regulation of Fgf2 1 0.04 0.9 0.17
41 INT224730 Fgf2 Positive_regulation of Gm2458 1 0.01 0.39 0.17
42 INT24667 Binding of COL7A1 and FGF2 1 0.13 0.25 0.16
43 INT345999 Binding of Fgf2 and Gfap 1 0.37 0.09 0.16
44 INT298717 Fgf2 Positive_regulation of Gene_expression of PDGFA 1 0.01 0.23 0.15
45 INT172903 Fgf2 Positive_regulation of Gene_expression of Tbxa2r 1 0.03 0.58 0.15
46 INT345996 Fgf2 Positive_regulation of Gene_expression of Gfap 1 0.71 0.13 0.15
47 INT249849 Ufm1 Positive_regulation of Fgf2 1 0.01 0.56 0.14
48 INT250863 Fgf8 Positive_regulation of Ptger2 1 0.03 0.19 0.14
49 INT278265 Binding of Fgf2 and Smcp 1 0.03 0.26 0.14
50 INT274472 IL12A Negative_regulation of Gene_expression of FGF2 1 0.02 0.36 0.14
51 INT274473 IL12A Regulation of Gene_expression of FGF2 1 0.02 0.36 0.14
52 INT345998 Fgf2 Positive_regulation of Gfap 1 0.48 0.09 0.13
53 INT170991 FGF2 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.72 0.13
54 INT300853 Ngf Positive_regulation of Fgf2 1 0.14 0.18 0.12
55 INT300860 Bdnf Positive_regulation of Fgf2 1 0.08 0.18 0.12
56 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
57 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
58 INT351545 FGF2 Positive_regulation of CDH16 1 0.01 0.19 0.1
59 INT351546 FGF2 Positive_regulation of L1CAM 1 0.34 0.19 0.1
60 INT351543 FGF2 Positive_regulation of NCAM1 1 0.03 0.14 0.1
61 INT122546 FGF2 Regulation of Localization of IL6 1 0.55 0.1 0.1
62 INT250860 Fgf8 Regulation of Localization of Ptger2 1 0.02 0.13 0.1
63 INT249848 Fgf2 Positive_regulation of Gene_expression of Nos3 1 0.33 0.44 0.1
64 INT250862 Fgf8 Regulation of Localization of Mmp3 1 0.13 0.13 0.1
65 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
66 INT250859 Fgf8 Negative_regulation of Gene_expression of Mmp3 1 0.09 0.12 0.09
67 INT250872 Fgf8 Positive_regulation of Mmp3 1 0.11 0.12 0.09
68 INT122542 FGF2 Positive_regulation of Localization of IL6 1 0.62 0.09 0.09
69 INT117838 FGFR1 Regulation of FGF2 1 0.33 0.17 0.09
70 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08
71 INT301921 UCK2 Regulation of Gene_expression of FGF2 1 0.01 1.22 0.08
72 INT297970 Binding of BMP2 and IL17C 1 0.15 0.26 0.08
73 INT222139 Binding of Egf and Fgf2 1 0.12 0 0.07
74 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06
75 INT343479 Epo Positive_regulation of Fgf2 1 0.33 0.3 0.06
76 INT24666 Binding of EGF and FGF2 1 0.35 0 0.06
77 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
78 INT348690 Atp9a Positive_regulation of Gene_expression of Fgf2 1 0.00 0.21 0.05
79 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
80 INT295715 PTGER2 Regulation of Localization of FGF2 1 0.02 0.6 0.05
81 INT295723 VEGFA Regulation of Localization of FGF2 1 0.07 0.6 0.05
82 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
83 INT185270 Binding of Fgf2 and Ifaprc2 1 0.08 0.4 0.04
84 INT253017 PTTG1IP Regulation of Regulation of Fgf2 1 0.03 0.49 0.04
85 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03
86 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
87 INT253010 Binding of PTTG1 and Fgf2 1 0.07 0.51 0.03
88 INT287233 PDLIM7 Positive_regulation of Gene_expression of BMP2 1 0.07 0.12 0.03
89 INT351155 AKT1 Positive_regulation of Positive_regulation of FGF2 1 0.03 0.81 0
90 INT260268 Binding of FGF2 and FGFR1 1 0.46 0.94 0
91 INT348687 Fgf2 Regulation of Gene_expression of Plau 1 0.14 0 0
92 INT348688 Fgf2 Regulation of Plau 1 0.14 0 0
93 INT343999 INCENP Positive_regulation of BMP2 1 0.01 0 0
94 INT245078 FGF2 Positive_regulation of CXCR4 1 0.07 1.36 0
95 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0
96 INT183090 Gene_expression of SULF1 Positive_regulation of Phosphorylation of FGF2 1 0.19 0.42 0
97 INT348693 Atp9a Positive_regulation of Fgf2 1 0.00 0.07 0
98 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
99 INT253021 PTTG1 Regulation of Gene_expression of Fgf2 1 0.04 0.35 0
100 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
101 INT175076 Binding of Fgf2 and Klk1c9 1 0.02 0.38 0
102 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0
103 INT150378 Fgf2 Positive_regulation of Mcpt1 1 0.67 1.79 0
104 INT150379 Fgf2 Positive_regulation of Gene_expression of Mcpt1 1 0.45 0.89 0
105 INT183093 SULF1 Negative_regulation of Binding of FGF2 1 0.17 0.41 0
106 INT180856 FGF2 Positive_regulation of Transcription of MT1L 1 0.30 1.06 0
107 INT299130 Cxcl12 Positive_regulation of Gene_expression of Fgf2 1 0.15 0.38 0
108 INT122541 FGF2 Positive_regulation of Transcription of IL6 1 0.42 0 0
109 INT122544 FGF2 Positive_regulation of Positive_regulation of GRAP2 1 0.20 0 0
110 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
111 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0
112 INT344001 INCENP Positive_regulation of Gene_expression of BMP2 1 0.01 0 0
113 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
114 INT249454 us Positive_regulation of Gene_expression of FGF2 1 0.01 0.13 0
115 INT295129 Proc Regulation of Bmp2 1 0.00 0.48 0
116 INT342559 FGF2 Positive_regulation of MAPK1 1 0.08 1.22 0
117 INT122539 FGF2 Regulation of Transcription of IL6 1 0.24 0 0
118 INT299129 Cxcl12 Positive_regulation of Transcription of Fgf2 1 0.16 0.38 0
119 INT260266 Binding of FGF2 and FGFBP1 1 0.48 0.94 0
120 INT185268 Binding of Fgf2 and Sox1 1 0.19 0 0
121 INT122537 FGF2 Positive_regulation of Gene_expression of IL6 1 0.45 0 0
122 INT222481 Fgf2 Positive_regulation of Gene_expression of Prl 1 0.10 0 0
123 INT122536 FGF2 Positive_regulation of Positive_regulation of SGSM3 1 0.73 0 0
124 INT122540 FGF2 Positive_regulation of Binding of JUN 1 0.24 0 0
125 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 0.42 1.71 0
126 INT122543 FGF2 Positive_regulation of JUN 1 0.36 0 0
127 INT122545 FGF2 Positive_regulation of Positive_regulation of MAPK3 1 0.53 0 0
128 INT342557 FGF2 Positive_regulation of MAPK3 1 0.03 1.21 0
129 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for thyroid-stimulating hormone-secreting cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in thyroid-stimulating hormone-secreting cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48
2 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12
3 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49
4 INT68133 Localization of Fgf2 36 0.81 15.37 9.14
5 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12
6 INT64689 Positive_regulation of Gene_expression of Fgf2 30 0.70 12.05 6.2
7 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
8 INT92679 Positive_regulation of Fgf2 13 0.69 11.43 5.18
9 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17
10 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24
11 INT168003 Localization of Fgf2 24 0.80 12.52 3.31
12 INT61547 Regulation of Fgf2 21 0.47 7.23 3.24
13 INT101083 Binding of Fgf2 14 0.42 4.12 3.14
14 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
15 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
16 INT115317 Transcription of FGF2 14 0.62 12.79 3
17 INT174864 Positive_regulation of Transcription of FGF2 8 0.44 7.58 3
18 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98
19 INT65033 Negative_regulation of Fgf2 21 0.59 12.36 2.94
20 INT64688 Negative_regulation of Gene_expression of Fgf2 5 0.59 5.07 2.56
21 INT24672 Localization of FGF2 27 0.71 14.59 2.48
22 INT97898 Regulation of FGF2 8 0.60 3.85 2.09
23 INT65207 Positive_regulation of Positive_regulation of Fgf2 10 0.70 3.5 2.08
24 INT87436 Regulation of Fgf2 6 0.45 3.95 2.03
25 INT99636 Negative_regulation of Localization of Fgf2 4 0.41 1.32 1.97
26 INT64687 Regulation of Gene_expression of Fgf2 7 0.62 2.29 1.89
27 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
28 INT92677 Positive_regulation of Gene_expression of Fgf2 11 0.69 4.25 1.68
29 INT122547 Positive_regulation of Positive_regulation of FGF2 3 0.44 3.1 1.49
30 INT97900 Negative_regulation of Gene_expression of FGF2 9 0.57 8.37 1.48
31 INT24671 Binding of FGF2 14 0.35 8.73 1.43
32 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
33 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
34 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
35 INT174866 Regulation of Gene_expression of FGF2 4 0.39 7.13 1.2
36 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
37 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
38 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
39 INT147407 Protein_catabolism of FGF2 1 0.91 0.33 1.06
40 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
41 INT184236 Positive_regulation of Localization of Fgf2 1 0.27 2.23 0.95
42 INT114664 Binding of BMP2 12 0.37 6.54 0.91
43 INT178498 Negative_regulation of Fgf2 11 0.42 4.21 0.84
44 INT101886 Transcription of Fgf2 8 0.65 4.46 0.78
45 INT76142 Positive_regulation of Regulation of Fgf2 2 0.47 0.34 0.64
46 INT185240 Binding of Fgf2 14 0.37 7.39 0.59
47 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
48 INT142907 Regulation of Localization of Fgf2 1 0.44 1.16 0.53
49 INT85808 Localization of BMP2 7 0.77 1.94 0.51
50 INT249843 Positive_regulation of Transcription of Fgf2 3 0.59 2.26 0.5
51 INT92683 Transcription of Fgf2 3 0.51 1.83 0.49
52 INT142906 Positive_regulation of Localization of Fgf2 2 0.43 1.82 0.49
53 INT250845 Protein_catabolism of Fgf8 1 0.98 1.64 0.48
54 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
55 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47
56 INT337348 Regulation of Gene_expression of Fgf2 2 0.45 0.54 0.44
57 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
58 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43
59 INT300851 Negative_regulation of Positive_regulation of Fgf2 3 0.42 1.01 0.4
60 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38
61 INT174870 Negative_regulation of Transcription of FGF2 1 0.37 1.66 0.38
62 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
63 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
64 INT250826 Transcription of Fgf8 1 0.71 0.71 0.34
65 INT345995 Negative_regulation of Gene_expression of Fgf2 1 0.43 0.43 0.29
66 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
67 INT250836 Binding of Fgf8 3 0.35 0.66 0.24
68 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
69 INT122548 Negative_regulation of Localization of FGF2 3 0.41 1.01 0.22
70 INT174869 Regulation of Negative_regulation of FGF2 1 0.39 1.59 0.22
71 INT175919 Negative_regulation of Positive_regulation of FGF2 1 0.22 0.96 0.22
72 INT345990 Regulation of Positive_regulation of Fgf2 1 0.45 0.14 0.21
73 INT289335 Negative_regulation of Binding of Fgf2 1 0.28 0.33 0.21
74 INT250833 Localization of Fgf8 1 0.74 0.46 0.21
75 INT250842 Negative_regulation of Binding of Fgf8 1 0.43 0.33 0.21
76 INT331725 Regulation of Localization of FGF2 2 0.17 0.52 0.19
77 INT148064 Localization of Bmp2 2 0.29 0.14 0.17
78 INT106010 Positive_regulation of Bmp2 2 0.26 0.91 0.15
79 INT293714 Regulation of Localization of Fgf2 2 0.45 0.1 0.14
80 INT250835 Positive_regulation of Fgf8 1 0.50 0.42 0.14
81 INT345994 Regulation of Binding of Fgf2 1 0.45 0 0.14
82 INT326978 Regulation of Binding of FGF2 1 0.21 0.06 0.13
83 INT254992 Negative_regulation of Gene_expression of BMP2 3 0.34 0.56 0.11
84 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11
85 INT174865 Regulation of Transcription of FGF2 1 0.39 0.72 0.11
86 INT326976 Regulation of Localization of BMP2 1 0.59 0.08 0.1
87 INT196035 Localization of Bmp2 3 0.63 0.23 0.09
88 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09
89 INT114663 Regulation of Binding of BMP2 1 0.38 0.19 0.09
90 INT183123 Phosphorylation of FGF2 3 0.30 1.2 0.08
91 INT163072 Regulation of Binding of Bmp2 1 0.30 0.52 0.08
92 INT281762 Negative_regulation of Localization of Fgf2 1 0.16 1 0.08
93 INT240518 Negative_regulation of Positive_regulation of Fgf2 2 0.35 0.66 0.07
94 INT196025 Negative_regulation of Bmp2 2 0.34 0.14 0.05
95 INT185253 Positive_regulation of Binding of Fgf2 1 0.28 0 0.05
96 INT65032 Positive_regulation of Negative_regulation of Fgf2 2 0.47 0.63 0.04
97 INT229753 Positive_regulation of Gene_expression of Bmp2 2 0.11 1.22 0.04
98 INT287236 Positive_regulation of Positive_regulation of BMP2 1 0.29 0.08 0.04
99 INT301929 Positive_regulation of Localization of FGF2 1 0.23 1.05 0.04
100 INT144612 Positive_regulation of Binding of FGF2 2 0.28 0.93 0
101 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0
102 INT145300 Positive_regulation of Positive_regulation of Bmp2 2 0.34 1.03 0
103 INT183130 Positive_regulation of Phosphorylation of FGF2 1 0.18 0.2 0
104 INT196031 Binding of Bmp2 1 0.16 0 0
105 INT355397 Regulation of Transcription of Fgf2 1 0.37 0.24 0
106 INT278735 Negative_regulation of Gene_expression of Bmp2 1 0.43 0.06 0
107 INT183115 Negative_regulation of Phosphorylation of FGF2 1 0.15 0.25 0
108 INT278737 Positive_regulation of Transcription of Bmp2 1 0.47 1.4 0
109 INT120087 Negative_regulation of Gene_expression of Bmp2 1 0.11 0.14 0
110 INT205585 Regulation of Wnt4 1 0.45 0.7 0
111 INT250830 Regulation of Protein_catabolism of Fgf8 1 0.45 0.08 0
112 INT311651 Positive_regulation of Fgf8 1 0.46 0.26 0
113 INT205578 Negative_regulation of Wnt4 1 0.43 1.69 0
114 INT343455 Phosphorylation of Fgf2 1 0.39 0.1 0
115 INT250846 Positive_regulation of Protein_catabolism of Fgf8 1 0.50 0.07 0
116 INT278040 Negative_regulation of Localization of BMP2 1 0.32 0.32 0
117 INT205581 Regulation of Negative_regulation of Wnt4 1 0.27 0.7 0
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