GO:0060158

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Name activation of phospholipase C activity by dopamine receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0060158
Unique Molecular Interactions 306
Total Molecular Interactions 426
Total Single Events 3380
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase C activity by dopamine receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for activation of phospholipase C activity by dopamine receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
2 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
3 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
4 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
5 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
6 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
7 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
8 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
9 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
10 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
11 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
12 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
13 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
14 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
15 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
16 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
17 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
18 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
19 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
20 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
21 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
22 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
23 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
24 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
25 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91
26 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
27 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
28 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
29 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
30 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
31 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
32 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84
33 INT344101 Positive_regulation of Drd1a Positive_regulation of Localization of Abat 1 0.01 0 0.84
34 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
35 INT81976 Binding of GNA15 and OPRL1 1 0.02 0 0.77
36 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
37 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
38 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
39 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
40 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
41 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
42 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
43 INT327707 Binding of Comt and Drd1a 1 0.18 0.27 0.74
44 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
45 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
46 INT99938 Drd1a Regulation of Transcription of Qrfp 1 0.03 0 0.69
47 INT71988 Drd1a Regulation of Npr1 1 0.10 0 0.68
48 INT99939 Drd1a Regulation of Qrfp 1 0.03 0 0.68
49 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
50 INT317638 Ins1 Positive_regulation of Gene_expression of Drd1a 1 0.14 0.86 0.59
51 INT317634 Ins1 Positive_regulation of Drd1a 1 0.14 0.86 0.59
52 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
53 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
54 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
55 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
56 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
57 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
58 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
59 INT5111 DIO2 Positive_regulation of Drd1a 1 0.04 0 0.53
60 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
61 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
62 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
63 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
64 INT223925 Drd1a Positive_regulation of Gene_expression of Serpina1 1 0.01 0 0.51
65 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
66 INT130975 Binding of ASIC3 and Slc9a3r1 1 0.06 0.26 0.43
67 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
68 INT317635 Positive_regulation of Drd1a Positive_regulation of Phosphorylation of Gtf3a 1 0.01 0.53 0.43
69 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
70 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
71 INT331675 Binding of Drd1a and Sptan1 1 0.03 0.33 0.4
72 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
73 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
74 INT32244 Slc3a1 Positive_regulation of Localization of Drd1a 1 0.15 0 0.39
75 INT32243 Drd1a Positive_regulation of Localization of Slc3a1 1 0.15 0 0.39
76 INT344103 Positive_regulation of Drd1a Positive_regulation of Obfc1 1 0.00 0 0.38
77 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
78 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
79 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
80 INT173356 Gnaq Positive_regulation of CDK20 1 0.06 0 0.37
81 INT130974 Slc9a3r1 Positive_regulation of ASIC3 1 0.08 0.29 0.36
82 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
83 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
84 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
85 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28
86 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28
87 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28
88 INT97595 Penk Regulation of Gene_expression of Drd1a 1 0.25 0.1 0.28
89 INT118852 Positive_regulation of GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
90 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
91 INT118846 GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
92 INT118848 GNA14 Positive_regulation of RAC1 1 0.01 0.14 0.26
93 INT118856 Positive_regulation of GNA14 Positive_regulation of STAT3 1 0.01 0.14 0.26
94 INT118849 GNA14 Positive_regulation of MAPK1 1 0.00 0.14 0.26
95 INT118851 GNA14 Positive_regulation of RAF1 1 0.00 0.14 0.26
96 INT73385 Cfp Regulation of Drd1a 1 0.10 0 0.25
97 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25
98 INT73384 Positive_regulation of Cfp Regulation of Drd1a 1 0.18 0 0.25
99 INT261465 Binding of Drd1a and Ptgdr 1 0.03 0.1 0.23
100 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
101 INT173358 Gnaq Positive_regulation of SMPD1 1 0.01 0.13 0.23
102 INT164136 Binding of DRD2 and Prl 1 0.09 0 0.22
103 INT173357 Gnaq Positive_regulation of PRKCA 1 0.01 0 0.22
104 INT164135 Binding of Drd2 and Prl 1 0.04 0 0.22
105 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
106 INT72019 Binding of Gnaq and Ptprg 1 0.01 0 0.21
107 INT69254 Drd2 Regulation of Gene_expression of Pomc 1 0.01 0 0.2
108 INT256987 Binding of Cd81 and Slc9a3r1 1 0.43 0.06 0.17
109 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
110 INT294106 Binding of DNASE1L3 and DRD5 1 0.02 0 0.14
111 INT227956 Drd2 Regulation of Chrm2 1 0.07 0.38 0.13
112 INT227957 Chrm4 Regulation of Localization of Drd2 1 0.19 0.38 0.13
113 INT227960 Drd2 Regulation of Chrm5 1 0.26 0.38 0.13
114 INT227958 Chrm2 Regulation of Localization of Drd2 1 0.17 0.38 0.13
115 INT227959 Drd2 Regulation of Chrm4 1 0.08 0.38 0.13
116 INT241070 Klf16 Positive_regulation of Drd1a 1 0.05 0.13 0.12
117 INT202255 Binding of DRD2 and TCN1 1 0.16 0 0.12
118 INT258767 Binding of Drd2 and ADHD1 1 0.11 1.14 0.11
119 INT8046 SORT1 Negative_regulation of Drd2 1 0.00 0 0.09
120 INT258768 Drd2 Regulation of ADHD1 1 0.14 0.79 0.07
121 INT244092 Binding of C2 and Drd2 1 0.01 0.06 0.07
122 INT261454 Akr1d1 Regulation of Drd1a 1 0.00 0.71 0.06
123 INT227593 Gnaq Negative_regulation of GLUL 1 0.01 0 0.06
124 INT327711 Binding of Drd2 and Uts2r 1 0.07 0.41 0.04
125 INT256997 Binding of RLBP1 and Slc9a3r1 1 0.44 0 0
126 INT89016 Oprd1 Negative_regulation of Drd1a 1 0.06 0 0
127 INT202571 Binding of DRD2 and DRD4 1 0.41 0.76 0
128 INT256979 Binding of Slc9a3r1 and Rlbp1 1 0.03 0 0
129 INT256980 Binding of Slc9a3r1 and Rpe 1 0.08 0.13 0
130 INT69257 Drd2 Regulation of Gene_expression of Cpe 1 0.06 0 0
131 INT256992 Binding of Slc9a3r1 and Hspb6 1 0.09 0 0
132 INT256981 Binding of Dlg1 and Slc9a3r1 1 0.22 0 0
133 INT69256 Drd2 Regulation of Regulation of Pomc 1 0.29 0 0
134 INT256989 Binding of Ezr and Slc9a3r1 1 0.10 0 0
135 INT69255 Drd2 Regulation of Transcription of Pomc 1 0.29 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase C activity by dopamine receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in activation of phospholipase C activity by dopamine receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
2 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
3 INT13501 Binding of Drd2 65 0.48 23.76 35.6
4 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
5 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
6 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
7 INT12484 Binding of Drd2 45 0.48 15.17 24.72
8 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
9 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
10 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
11 INT49774 Binding of DRD2 48 0.48 17.42 20.73
12 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
13 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
14 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
15 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
16 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
17 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
18 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
19 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
20 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
21 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
22 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
23 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
24 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
25 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
26 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
27 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
28 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
29 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
30 INT24460 Localization of Drd2 12 0.73 2.96 6.46
31 INT86772 Localization of Drd2 14 0.80 1.93 6.17
32 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
33 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
34 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
35 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
36 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48
37 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
38 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
39 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
40 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
41 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
42 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
43 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
44 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
45 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
46 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
47 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
48 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
49 INT113077 Positive_regulation of Phosphorylation of Drd1a 1 0.11 0.15 2.87
50 INT64248 Positive_regulation of Positive_regulation of Drd1a 6 0.45 1.97 2.62
51 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
52 INT89992 Positive_regulation of Gene_expression of Drd1a 5 0.39 2.11 2.54
53 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36
54 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
55 INT24407 Negative_regulation of Binding of Drd1a 3 0.25 0.81 2.18
56 INT21046 Regulation of Positive_regulation of Drd1a 3 0.44 0.09 2.06
57 INT13837 Negative_regulation of Positive_regulation of Drd1a 2 0.43 1.43 2.01
58 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
59 INT112880 Positive_regulation of Gnaq 17 0.49 1.97 1.95
60 INT110189 Regulation of Gnaq 3 0.02 0.26 1.63
61 INT71999 Negative_regulation of Gene_expression of Gnaq 3 0.41 0.08 1.56
62 INT140305 Negative_regulation of Binding of Drd1a 2 0.21 0.54 1.46
63 INT113079 Regulation of Phosphorylation of Drd1a 1 0.06 0.07 1.43
64 INT336571 Gene_expression of DRD5 1 0.06 0.73 1.41
65 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
66 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
67 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
68 INT110188 Regulation of Gene_expression of Gnaq 2 0.25 0.85 1.22
69 INT77216 Localization of DRD2 3 0.75 0 1.19
70 INT184839 Localization of Drd1a 4 0.73 0.84 1.03
71 INT72002 Negative_regulation of Gnaq 7 0.35 0.2 1.02
72 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
73 INT64690 Negative_regulation of Localization of Drd1a 2 0.09 0 0.95
74 INT74183 Positive_regulation of Localization of Drd1a 1 0.32 0.06 0.95
75 INT99668 Positive_regulation of Binding of Drd1a 2 0.43 0.89 0.87
76 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
77 INT110187 Regulation of Regulation of Gnaq 1 0.00 0.07 0.82
78 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
79 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
80 INT16434 Regulation of Positive_regulation of Drd2 1 0.30 0 0.78
81 INT141915 Positive_regulation of Gene_expression of Gnaq 3 0.19 1.31 0.76
82 INT12885 Negative_regulation of Binding of Drd2 2 0.53 0.26 0.71
83 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69
84 INT15662 Positive_regulation of Transcription of Drd2 3 0.39 0 0.68
85 INT153157 Regulation of Regulation of Drd1a 2 0.25 0.2 0.66
86 INT184840 Positive_regulation of Transcription of Drd2 2 0.35 1.03 0.65
87 INT184848 Positive_regulation of Transcription of Drd1a 1 0.26 0.93 0.65
88 INT140306 Regulation of Binding of Drd1a 1 0.20 0.36 0.64
89 INT72516 Regulation of Binding of Drd1a 2 0.44 0.4 0.63
90 INT130971 Binding of Slc9a3r1 2 0.39 0.32 0.59
91 INT12483 Regulation of Binding of Drd2 1 0.38 0 0.57
92 INT47933 Positive_regulation of Localization of Drd2 1 0.10 0.23 0.56
93 INT47934 Negative_regulation of Localization of Drd2 1 0.10 0.22 0.56
94 INT112881 Positive_regulation of Positive_regulation of Gnaq 2 0.49 0.86 0.54
95 INT157718 Binding of DRD5 1 0.33 0.57 0.52
96 INT141919 Positive_regulation of Transcription of Gnaq 1 0.21 1.05 0.49
97 INT141912 Negative_regulation of Transcription of Gnaq 1 0.18 1.07 0.49
98 INT141917 Transcription of Gnaq 1 0.29 1.05 0.49
99 INT202581 Positive_regulation of Gene_expression of DRD2 2 0.49 0.81 0.47
100 INT66984 Regulation of Binding of Drd2 1 0.60 0 0.47
101 INT130969 Positive_regulation of Binding of Slc9a3r1 1 0.09 0.26 0.43
102 INT130972 Gene_expression of Slc9a3r1 2 0.63 0.36 0.37
103 INT48566 Regulation of Transcription of Drd1a 1 0.32 0 0.37
104 INT278102 Binding of GNA15 1 0.01 0.16 0.32
105 INT118873 Binding of GNA14 1 0.01 0.13 0.27
106 INT136052 Negative_regulation of Negative_regulation of Drd1a 1 0.13 0.66 0.27
107 INT149315 Binding of Gnaq 2 0.04 0 0.26
108 INT118875 Gene_expression of GNA14 1 0.02 0.09 0.26
109 INT124366 Gene_expression of GNA15 1 0.11 0 0.25
110 INT326600 Negative_regulation of Gene_expression of DRD2 1 0.53 0.35 0.23
111 INT118869 Phosphorylation of GNA14 1 0.02 0.15 0.23
112 INT224096 Positive_regulation of Negative_regulation of DRD2 1 0.05 0.38 0.15
113 INT118872 Positive_regulation of GNA14 1 0.02 0.1 0.14
114 INT272710 Phosphorylation of Gnaq 1 0.09 0.12 0.12
115 INT223763 Negative_regulation of DRD5 1 0.01 0.06 0.06
116 INT227570 Localization of Gnaq 1 0.07 0 0.04
117 INT227569 Negative_regulation of Positive_regulation of Gnaq 1 0.04 0.08 0.04
118 INT337102 Protein_catabolism of Drd2 1 0.88 0 0
119 INT256965 Positive_regulation of Slc9a3r1 1 0.38 0 0
120 INT256950 Negative_regulation of Gene_expression of Slc9a3r1 1 0.35 0 0
121 INT263506 Regulation of Regulation of Drd2 1 0.26 0.34 0
122 INT256962 Positive_regulation of Gene_expression of Slc9a3r1 1 0.38 0 0
123 INT256968 Localization of Slc9a3r1 1 0.57 0 0
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