GO:0060174

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Name limb bud formation
Categary Process
Go Slim No
Go Link GO:0060174
Unique Molecular Interactions 96
Total Molecular Interactions 130
Total Single Events 1254
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for limb bud formation. They are ordered first by their pain relevance and then by number of times they were reported for limb bud formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168185 Binding of PLXNA2 and MRI1 1 0.25 0.78 1.08
2 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
3 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
4 INT144129 Prkce Positive_regulation of Phosphorylation of Gja1 1 0.42 0.48 0.55
5 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
6 INT144128 Binding of Gja1 and Prkce 1 0.40 0.5 0.52
7 INT144130 Binding of Gja1 and Prkcg 1 0.48 0.5 0.52
8 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
9 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
10 INT220194 PTGER2 Negative_regulation of COL2A1 1 0.26 0.55 0.29
11 INT60347 COL2A1 Positive_regulation of Gene_expression of Hras 1 0.05 0.92 0.2
12 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
13 INT220190 PTGER2 Regulation of COL2A1 1 0.32 0.92 0.18
14 INT220191 Binding of COL2A1 and PTGER2 1 0.22 0.35 0.18
15 INT293867 Binding of COL2A1 and MEFV 1 0.01 0.52 0.14
16 INT220213 Mmp13 Regulation of Protein_catabolism of COL2A1 1 0.49 0.29 0.14
17 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
18 INT252421 Gja1 Regulation of P2ry1 1 0.00 0.28 0.09
19 INT220195 PTGER2 Negative_regulation of Localization of COL2A1 1 0.26 0.51 0.09
20 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
21 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
22 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
23 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
24 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
25 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
26 INT288003 Binding of COL2A1 and PADI1 1 0.09 0.11 0.06
27 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
28 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
29 INT220189 Binding of COL2A1 and TIMP1 1 0.04 0.1 0.05
30 INT323807 NFAT5 Regulation of Gene_expression of COL2A1 1 0.29 0.19 0.04
31 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
32 INT220196 Binding of PTGER2 and Negative_regulation of Gene_expression of COL2A1 1 0.26 0.77 0.04
33 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
34 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
35 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03
36 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
37 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
38 INT220245 IL1RN Regulation of Protein_catabolism of COL2A1 1 0.09 0 0.03
39 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03
40 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
41 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
42 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
43 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
44 INT293869 Binding of COL2A1 and GREM1 1 0.00 1.11 0
45 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
46 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
47 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
48 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
49 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
50 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
51 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
52 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
53 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
54 INT288002 Binding of COL2A1 and GOPC 1 0.12 0 0
55 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
56 INT312230 INPP5K Regulation of Gene_expression of COL2A1 1 0.06 0 0
57 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
58 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
59 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
60 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
61 INT88567 COL2A1 Positive_regulation of A1cf 1 0.09 0.36 0
62 INT312227 INPP5K Regulation of Negative_regulation of COL2A1 1 0.06 0 0
63 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
64 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
65 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
66 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
67 INT312345 Binding of COL2A1 and COL5A2 1 0.00 1.21 0
68 INT323804 NFAT5 Regulation of Transcription of COL2A1 1 0.43 0.07 0
69 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
70 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
71 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
72 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
73 INT312213 INPP5K Regulation of COL2A1 1 0.06 0 0
74 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
75 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0
76 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
77 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
78 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0
79 INT283711 Sox11 Regulation of 4930579C15Rik 1 0.28 0.74 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for limb bud formation. They are ordered first by their pain relevance and then by number of times they were reported in limb bud formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
2 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
3 INT87775 Phosphorylation of Gja1 13 0.82 2.75 6.56
4 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
5 INT87780 Gene_expression of Gja1 22 0.77 5.84 4.24
6 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
7 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
8 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
9 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73
10 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
11 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
12 INT87778 Positive_regulation of Gene_expression of Gja1 6 0.69 1.46 2.14
13 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
14 INT87779 Positive_regulation of Gja1 4 0.53 0.9 1.95
15 INT87776 Positive_regulation of Phosphorylation of Gja1 3 0.62 0.71 1.86
16 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
17 INT117232 Localization of COL2A1 11 0.72 7.34 1.3
18 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
19 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
20 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11
21 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
22 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
23 INT134822 Gene_expression of Gja1 18 0.72 4.2 1
24 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
25 INT87777 Regulation of Gja1 1 0.62 0.76 0.81
26 INT143306 Positive_regulation of Gja1 3 0.50 0.42 0.75
27 INT168189 Positive_regulation of PLXNA2 1 0.20 0.49 0.75
28 INT128402 Negative_regulation of Phosphorylation of Gja1 1 0.58 0.73 0.73
29 INT152909 Regulation of Gene_expression of Gja1 1 0.61 0.46 0.69
30 INT342318 Localization of PLXNA2 1 0.25 0.75 0.67
31 INT87781 Regulation of Phosphorylation of Gja1 1 0.27 0 0.67
32 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
33 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
34 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
35 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57
36 INT296594 Regulation of Fgf10 1 0.15 1.53 0.56
37 INT154837 Regulation of Gja1 2 0.45 1.42 0.53
38 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
39 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
40 INT134820 Positive_regulation of Gene_expression of Gja1 3 0.64 0.84 0.49
41 INT87774 Binding of Gja1 2 0.48 0.19 0.48
42 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
43 INT248346 Binding of PLXNA2 4 0.29 1.38 0.46
44 INT206484 Localization of Shh 2 0.75 1.14 0.46
45 INT9732 Regulation of COL2A1 9 0.58 6.93 0.44
46 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
47 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
48 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
49 INT283698 Gene_expression of Sox11 1 0.68 4.6 0.33
50 INT180577 Positive_regulation of Protein_catabolism of COL2A1 2 0.12 0.91 0.31
51 INT220209 Negative_regulation of Localization of COL2A1 1 0.41 0.48 0.29
52 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
53 INT274104 Regulation of PLXNA2 2 0.33 2.66 0.25
54 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
55 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
56 INT126761 Negative_regulation of Gja1 1 0.33 0.08 0.22
57 INT248347 Negative_regulation of PLXNA2 1 0.38 0.24 0.22
58 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
59 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
60 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
61 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
62 INT311446 Negative_regulation of Gene_expression of PLXNA2 1 0.12 1.1 0.18
63 INT220208 Regulation of Protein_catabolism of COL2A1 1 0.26 0.28 0.17
64 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
65 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
66 INT253190 Localization of Shh 2 0.77 1.06 0.13
67 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12
68 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
69 INT221000 Phosphorylation of COL2A1 1 0.19 0.18 0.12
70 INT155667 Negative_regulation of Gene_expression of Gja1 3 0.42 1.16 0.1
71 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
72 INT270442 Transcription of Shh 1 0.53 0.25 0.09
73 INT213515 Binding of Shh 8 0.37 1.92 0.08
74 INT283695 Binding of Sox11 1 0.32 0.18 0.08
75 INT270453 Regulation of Shh 1 0.27 0.83 0.08
76 INT205973 Binding of SHH 3 0.35 1.03 0.07
77 INT256862 Regulation of Shh 1 0.25 0 0.07
78 INT354592 Positive_regulation of Gene_expression of PLXNA2 1 0.04 0.37 0.07
79 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06
80 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
81 INT250505 Positive_regulation of Negative_regulation of COL2A1 1 0.41 0.57 0.05
82 INT283696 Localization of Sox11 1 0.65 0.37 0.05
83 INT272249 Negative_regulation of Negative_regulation of COL2A1 1 0.06 0 0.05
84 INT257689 Negative_regulation of Gja1 1 0.37 0.58 0.05
85 INT354593 Regulation of Gene_expression of PLXNA2 1 0.04 0.34 0.05
86 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
87 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
88 INT228786 Regulation of Gene_expression of Gja1 2 0.29 0.49 0.04
89 INT228802 Negative_regulation of Gene_expression of Gja1 4 0.37 0.87 0.03
90 INT260760 Positive_regulation of Fgf10 2 0.53 0.43 0.03
91 INT216569 Localization of Gja1 2 0.36 0.35 0.03
92 INT303535 Positive_regulation of Gene_expression of Fgf10 1 0.53 0.34 0.03
93 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03
94 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
95 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03
96 INT253181 Transcription of Shh 1 0.68 0.54 0.03
97 INT184729 Transcription of COL2A1 4 0.67 1.1 0
98 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
99 INT207729 Regulation of FGFR2 4 0.22 2.35 0
100 INT245757 Localization of SOX9 4 0.62 0.8 0
101 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0
102 INT247813 Localization of Gja1 2 0.45 0.47 0
103 INT99716 Transcription of FGFR2 2 0.34 0.22 0
104 INT305351 Positive_regulation of Regulation of FGFR2 2 0.37 0.97 0
105 INT99715 Regulation of Gene_expression of FGFR2 2 0.22 0.19 0
106 INT247793 Regulation of Localization of Gja1 2 0.17 0.47 0
107 INT165862 Positive_regulation of Binding of COL2A1 2 0.43 0 0
108 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0
109 INT202623 Negative_regulation of Gene_expression of Fgfr2 1 0.32 0 0
110 INT319036 Gene_expression of Fgfr2 1 0.48 0.08 0
111 INT312246 Regulation of Negative_regulation of COL2A1 1 0.07 0 0
112 INT283699 Positive_regulation of Sox11 1 0.35 0.62 0
113 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
114 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
115 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
116 INT99717 Positive_regulation of Transcription of FGFR2 1 0.10 0.08 0
117 INT183117 Positive_regulation of Binding of FGFR2 1 0.09 0.81 0
118 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
119 INT322897 Negative_regulation of Transcription of COL2A1 1 0.17 0 0
120 INT290929 Binding of Shh 1 0.31 0.1 0
121 INT245765 Binding of SOX9 1 0.31 0.87 0
122 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
123 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
124 INT303524 Positive_regulation of Fgfr2 1 0.66 0.22 0
125 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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