GO:0060218

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Name hemopoietic stem cell differentiation
Categary Process
Go Slim No
Go Link GO:0060218
Unique Molecular Interactions 93
Total Molecular Interactions 152
Total Single Events 1144
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hemopoietic stem cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for hemopoietic stem cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
2 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
3 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
4 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
5 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75
6 INT284307 Mir155 Regulation of Adrb3 1 0.00 3.44 0.73
7 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
8 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
9 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
10 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 0.03 1 0.57
11 INT284300 Tlr4 Positive_regulation of Gene_expression of Mir155 1 0.18 0.91 0.47
12 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
13 INT302840 Positive_regulation of TNF Positive_regulation of Mir155 1 0.01 0.47 0.38
14 INT302843 TNF Positive_regulation of Mir155 1 0.01 0.47 0.38
15 INT229222 Negative_regulation of ACE Negative_regulation of Protein_catabolism of KNG1 1 0.06 0.53 0.37
16 INT284308 Mir155 Regulation of Gene_expression of Csf3 1 0.36 0.8 0.36
17 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
18 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32
19 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32
20 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
21 INT93833 Binding of Fos and Srf 1 0.00 0 0.3
22 INT93832 Binding of Elk1 and Srf 1 0.00 0 0.29
23 INT191500 ACE Positive_regulation of Localization of KNG1 1 0.10 0.17 0.24
24 INT284297 Mir155 Positive_regulation of Adrb3 1 0.01 0.51 0.24
25 INT284299 Adrb3 Positive_regulation of Gene_expression of Mir155 1 0.01 0.51 0.24
26 INT265828 ACE Regulation of Gene_expression of KNG1 1 0.32 0.83 0.22
27 INT284305 Mir155 Regulation of Csf3 1 0.19 0.29 0.18
28 INT265827 ACE Negative_regulation of ANGPT2 1 0.09 0.59 0.17
29 INT75058 Negative_regulation of ACE Negative_regulation of HHIP 1 0.25 0.43 0.15
30 INT344946 AGT Regulation of Negative_regulation of ACE 1 0.21 0.61 0.14
31 INT102885 Binding of ANG and ACE 2 0.17 0.37 0.13
32 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
33 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12
34 INT284298 Adrb3 Regulation of Mir155 1 0.00 0.24 0.12
35 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12
36 INT284309 Tlr4 Positive_regulation of Mir155 3 0.18 0.51 0.11
37 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1
38 INT270731 Binding of AGTR1 and ACE 1 0.02 0.67 0.09
39 INT265829 ACE Positive_regulation of Protein_catabolism of KNG1 1 0.33 0.73 0.09
40 INT344945 Negative_regulation of ACE Positive_regulation of REN 1 0.23 0.64 0.09
41 INT284301 Mir155 Positive_regulation of Regulation of Csf3 1 0.55 0.1 0.09
42 INT284303 Mir155 Negative_regulation of Gnas 1 0.00 0.49 0.08
43 INT284310 Mir155 Negative_regulation of Adrb3 1 0.00 0.55 0.08
44 INT309511 Binding of Xrcc6 and Xrcc5 1 0.18 1.18 0.08
45 INT216130 SRF Positive_regulation of Gene_expression of EGR1 1 0.49 0.32 0.07
46 INT216129 SRF Positive_regulation of Gene_expression of FOS 1 0.28 0.32 0.07
47 INT200641 Binding of ACE and Agtr1a 1 0.12 0.92 0.06
48 INT200638 Binding of ACE and Agtr2 1 0.10 0.93 0.06
49 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
50 INT319558 Positive_regulation of Creb1 Regulation of Srf 1 0.31 0.06 0.04
51 INT319559 Creb1 Regulation of Srf 1 0.28 0.06 0.04
52 INT29521 Ace Positive_regulation of ACE 1 0.19 0 0.04
53 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04
54 INT215766 Dio1 Regulation of Cdk6 1 0.01 0.05 0
55 INT274435 Binding of Zfpm2 and Mir130a 1 0.30 0.26 0
56 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
57 INT284296 Mir155 Regulation of Spi1 1 0.25 0.36 0
58 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
59 INT190632 Binding of Srf and Yy1 1 0.20 0.14 0
60 INT215706 Binding of Cdk6 and Lamtor1 1 0.04 0 0
61 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
62 INT284302 Mir155 Regulation of Gnas 1 0.00 0.64 0
63 INT220813 Tert Positive_regulation of Terc 1 0.51 0.17 0
64 INT215700 Binding of Cdkn2b and Cdk6 1 0.02 0 0
65 INT274432 Mir130a Regulation of Zfpm2 1 0.22 0.08 0
66 INT215690 Binding of Cdk6 and Cdkn1c 1 0.03 0 0
67 INT274431 Mir130a Regulation of Gene_expression of Zfpm2 1 0.50 0.79 0
68 INT225642 Binding of XRCC5 and Acsl1 1 0.01 0 0
69 INT225590 Ncoa6 Regulation of Srf 1 0.08 0.21 0
70 INT309519 Xrcc5 Regulation of Gene_expression of Htt 1 0.18 0.08 0
71 INT253014 Binding of XRCC5 and Zic2 1 0.00 0.14 0
72 INT215682 Binding of Cdkn1b and Cdk6 1 0.03 0 0
73 INT215701 Slc3a1 Regulation of Cdk6 1 0.01 0.05 0
74 INT322255 Mir155 Regulation of Agtrap 1 0.21 0.33 0
75 INT149429 ERCC2 Negative_regulation of Localization of IL8 1 0.05 0.38 0
76 INT225614 Binding of XRCC5 and Parp1 1 0.09 0 0
77 INT252904 Binding of PRKDC and XRCC5 1 0.00 0.14 0
78 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0
79 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0
80 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
81 INT149431 ERCC2 Negative_regulation of Localization of Il6 1 0.14 0.2 0
82 INT227831 Binding of ERCC2 and PGBD3 1 0.07 0.23 0
83 INT274436 Mir130a Regulation of Transcription of Zfpm2 1 0.22 0 0
84 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0
85 INT200488 Binding of ACE and SUGT1 1 0.01 0.28 0
86 INT215703 Binding of Kras and Cdk6 1 0.01 0 0
87 INT149432 ERCC2 Regulation of Localization of Il6 1 0.15 1.06 0
88 INT315187 Binding of SFRP1 and COPD 1 0.01 4.47 0
89 INT149428 ERCC2 Regulation of Localization of IL8 1 0.05 0.53 0
90 INT213584 Binding of AGTR2 and ACE 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hemopoietic stem cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in hemopoietic stem cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
2 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19
3 INT20664 Binding of ACE 60 0.48 35.27 9.16
4 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31
5 INT42038 Localization of ACE 26 0.80 8.88 7.06
6 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
7 INT26477 Regulation of ACE 26 0.45 16.31 4.33
8 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76
9 INT284265 Gene_expression of Mir155 29 0.64 10.7 2.84
10 INT284274 Positive_regulation of Mir155 10 0.50 7.68 2.67
11 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63
12 INT10447 Negative_regulation of Srf 3 0.40 0.95 1.98
13 INT33096 Negative_regulation of Gene_expression of ACE 9 0.43 2.84 1.93
14 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
15 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77
16 INT61223 Positive_regulation of Negative_regulation of ACE 6 0.49 5.92 1.37
17 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
18 INT284257 Positive_regulation of Gene_expression of Mir155 13 0.57 3.34 1.08
19 INT10448 Positive_regulation of Srf 3 0.47 0.89 1.03
20 INT135032 Negative_regulation of SRF 1 0.49 0 1.03
21 INT182516 Negative_regulation of Negative_regulation of ACE 9 0.42 6.84 0.99
22 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
23 INT26531 Regulation of Srf 3 0.18 0.62 0.9
24 INT83995 Positive_regulation of Gene_expression of ACE 8 0.68 8.09 0.82
25 INT45293 Transcription of Srf 2 0.47 0.79 0.76
26 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71
27 INT259902 Regulation of Gene_expression of ACE 3 0.45 1.87 0.7
28 INT284266 Negative_regulation of Mir155 8 0.42 2.44 0.65
29 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
30 INT72446 Negative_regulation of Binding of ACE 4 0.42 2.48 0.62
31 INT56045 Positive_regulation of Localization of ACE 3 0.69 1.38 0.6
32 INT45292 Negative_regulation of Transcription of Srf 1 0.06 0.65 0.59
33 INT134070 Binding of ERCC2 3 0.27 0.76 0.51
34 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
35 INT103901 Regulation of ERCC2 1 0.23 0.51 0.4
36 INT181635 Positive_regulation of Protein_catabolism of ACE 1 0.15 0.41 0.38
37 INT229626 Negative_regulation of Localization of ACE 3 0.41 2 0.36
38 INT284282 Regulation of Mir155 1 0.32 1.25 0.32
39 INT18821 Positive_regulation of Gene_expression of Srf 2 0.35 0.63 0.31
40 INT96863 Transcription of ACE 3 0.69 0.38 0.29
41 INT230864 Regulation of Binding of ACE 1 0.22 0.79 0.29
42 INT288846 Negative_regulation of Transcription of ACE 1 0.43 0 0.29
43 INT7610 Localization of Srf 3 0.67 0.98 0.27
44 INT226422 Negative_regulation of Cdk6 3 0.12 1.83 0.19
45 INT108414 Negative_regulation of Regulation of ACE 1 0.43 0.67 0.17
46 INT89766 Binding of SRF 1 0.17 0.89 0.15
47 INT89767 Positive_regulation of Binding of SRF 1 0.23 0.89 0.15
48 INT284263 Positive_regulation of Positive_regulation of Mir155 3 0.41 0.52 0.11
49 INT79993 Positive_regulation of Positive_regulation of ACE 2 0.49 0.78 0.1
50 INT309460 Binding of Xrcc5 1 0.16 0.09 0.08
51 INT22789 Binding of Srf 1 0.37 0.07 0.07
52 INT22790 Positive_regulation of Binding of Srf 1 0.50 0.07 0.07
53 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07
54 INT190544 Transcription of Srf 1 0.19 0.43 0.06
55 INT271084 Negative_regulation of Gene_expression of Cdk6 1 0.11 1.1 0.06
56 INT190570 Localization of Srf 1 0.20 0.49 0.06
57 INT271086 Gene_expression of Cdk6 1 0.14 1.09 0.06
58 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
59 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
60 INT284261 Negative_regulation of Gene_expression of Mir155 1 0.31 0.62 0.05
61 INT284267 Regulation of Gene_expression of Mir155 1 0.32 0.26 0.05
62 INT284277 Localization of Mir155 1 0.54 0.39 0.04
63 INT225411 Positive_regulation of Srf 1 0.05 0.27 0.03
64 INT268102 Transcription of SRF 1 0.53 0.85 0.03
65 INT225413 Binding of Srf 1 0.10 0.27 0.03
66 INT284286 Binding of Mir155 1 0.31 0.23 0.03
67 INT284256 Transcription of Mir155 1 0.57 0.11 0.03
68 INT291906 Positive_regulation of Negative_regulation of ERCC2 1 0.40 0 0.03
69 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
70 INT204060 Gene_expression of Cdk6 3 0.26 0.83 0
71 INT157800 Gene_expression of Srf 2 0.45 0.88 0
72 INT105753 Positive_regulation of Gene_expression of SRF 1 0.01 0.13 0
73 INT274426 Regulation of Binding of Mir130a 1 0.32 0.41 0
74 INT348467 Positive_regulation of XRCC5 1 0.25 0.43 0
75 INT270742 Negative_regulation of Phosphorylation of ACE 1 0.40 0.65 0
76 INT309467 Gene_expression of Xrcc5 1 0.26 0.1 0
77 INT309483 Positive_regulation of Xrcc5 1 0.20 0.1 0
78 INT315189 Binding of SFRP1 1 0.15 2.96 0
79 INT226287 Regulation of Gene_expression of SFRP1 1 0.38 0.37 0
80 INT274421 Gene_expression of Mir130a 1 0.55 15.48 0
81 INT270740 Phosphorylation of ACE 1 0.76 0.65 0
82 INT333821 Regulation of Cdk6 1 0.23 0 0
83 INT310726 Localization of Terc 1 0.24 0.27 0
84 INT149430 Localization of ERCC2 1 0.43 0.76 0
85 INT274406 Negative_regulation of Mir130a 1 0.31 0.4 0
86 INT105752 Positive_regulation of SRF 1 0.01 0.13 0
87 INT204061 Negative_regulation of Gene_expression of Cdk6 1 0.12 0.47 0
88 INT274407 Positive_regulation of Gene_expression of Mir130a 1 0.49 5.1 0
89 INT284264 Phosphorylation of Mir155 1 0.45 0 0
90 INT268104 Negative_regulation of Gene_expression of SRF 1 0.38 0.16 0
91 INT213446 Regulation of Gene_expression of SRF 1 0.22 0.71 0
92 INT215749 Regulation of Gene_expression of Cdk6 1 0.17 0 0
93 INT225463 Binding of XRCC5 1 0.36 0 0
94 INT226286 Negative_regulation of Gene_expression of SFRP1 1 0.31 0.7 0
95 INT225408 Negative_regulation of Srf 1 0.05 0.39 0
96 INT274419 Regulation of Gene_expression of Mir130a 1 0.32 1.02 0
97 INT294017 Negative_regulation of Localization of SFRP1 1 0.32 0.47 0
98 INT274427 Negative_regulation of Gene_expression of Mir130a 1 0.30 0.14 0
99 INT236709 Phosphorylation of Cdk6 1 0.34 0.82 0
100 INT157799 Negative_regulation of Gene_expression of Srf 1 0.18 0.07 0
101 INT274413 Regulation of Mir130a 1 0.32 0.21 0
102 INT157794 Phosphorylation of Srf 1 0.26 0.07 0
103 INT274410 Binding of Mir130a 1 0.27 0.66 0
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