GO:0060272

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Name embryonic skeletal joint morphogenesis
Categary Process
Go Slim No
Go Link GO:0060272
Unique Molecular Interactions 91
Total Molecular Interactions 123
Total Single Events 1220
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for embryonic skeletal joint morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for embryonic skeletal joint morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
2 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 0.03 1.74 1.03
3 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
4 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
5 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
6 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
7 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
8 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35
9 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
10 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
11 INT220194 PTGER2 Negative_regulation of COL2A1 1 0.26 0.55 0.29
12 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 0.04 0.8 0.29
13 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
14 INT60347 COL2A1 Positive_regulation of Gene_expression of Hras 1 0.05 0.92 0.2
15 INT220190 PTGER2 Regulation of COL2A1 1 0.32 0.92 0.18
16 INT220191 Binding of COL2A1 and PTGER2 1 0.22 0.35 0.18
17 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
18 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17
19 INT336337 Glp2r Positive_regulation of Gene_expression of Col2a1 1 0.01 0.7 0.14
20 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
21 INT293867 Binding of COL2A1 and MEFV 1 0.01 0.52 0.14
22 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
23 INT220213 Mmp13 Regulation of Protein_catabolism of COL2A1 1 0.49 0.29 0.14
24 INT323430 Binding of Vhl and Osr1 1 0.02 0.78 0.13
25 INT323434 Osr1 Regulation of Hif1a 1 0.01 0.79 0.13
26 INT323435 Binding of Osr1 and Gtf3a 1 0.00 0.78 0.13
27 INT323433 Osr1 Regulation of Protein_catabolism of Hif1a 1 0.01 0.8 0.13
28 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
29 INT220195 PTGER2 Negative_regulation of Localization of COL2A1 1 0.26 0.51 0.09
30 INT346304 Col2a1 Positive_regulation of Localization of PTGER2 1 0.00 0.18 0.09
31 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
32 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 1 0.37 0.31 0.08
33 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
34 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 1 0.25 0.31 0.08
35 INT129627 Bmp7 Positive_regulation of Id2 1 0.24 0.25 0.07
36 INT129626 Bmp7 Positive_regulation of Id3 1 0.25 0.25 0.07
37 INT288003 Binding of COL2A1 and PADI1 1 0.09 0.11 0.06
38 INT201973 Bmp7 Positive_regulation of ap 1 0.00 0.18 0.06
39 INT118462 BMP7 Regulation of Bmp7 1 0.19 0 0.06
40 INT346302 ELANE Regulation of Col2a1 1 0.00 0.3 0.05
41 INT220189 Binding of COL2A1 and TIMP1 1 0.04 0.1 0.05
42 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
43 INT323807 NFAT5 Regulation of Gene_expression of COL2A1 1 0.29 0.19 0.04
44 INT346303 Binding of MR1 and Col2a1 1 0.00 0.09 0.04
45 INT220196 Binding of PTGER2 and Negative_regulation of Gene_expression of COL2A1 1 0.26 0.77 0.04
46 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
47 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03
48 INT287234 PDLIM7 Positive_regulation of Gene_expression of BMP7 1 0.14 0.12 0.03
49 INT220245 IL1RN Regulation of Protein_catabolism of COL2A1 1 0.09 0 0.03
50 INT293869 Binding of COL2A1 and GREM1 1 0.00 1.11 0
51 INT288002 Binding of COL2A1 and GOPC 1 0.12 0 0
52 INT63391 SLTM Regulation of Gene_expression of Col2a1 1 0.00 0 0
53 INT312230 INPP5K Regulation of Gene_expression of COL2A1 1 0.06 0 0
54 INT272977 Osr1 Regulation of ADHD1 1 0.01 1.79 0
55 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
56 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
57 INT272978 Binding of Osr1 and ADHD1 1 0.00 1.91 0
58 INT196038 Gene_expression of Bmp7 Positive_regulation of ALPP 1 0.03 0.1 0
59 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0
60 INT147529 TGFB1 Negative_regulation of Gene_expression of Col2a1 1 0.05 0.32 0
61 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
62 INT88567 COL2A1 Positive_regulation of A1cf 1 0.09 0.36 0
63 INT312227 INPP5K Regulation of Negative_regulation of COL2A1 1 0.06 0 0
64 INT88409 BMP7 Positive_regulation of Gene_expression of ACTA1 1 0.09 0 0
65 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
66 INT312345 Binding of COL2A1 and COL5A2 1 0.00 1.21 0
67 INT323804 NFAT5 Regulation of Transcription of COL2A1 1 0.43 0.07 0
68 INT312213 INPP5K Regulation of COL2A1 1 0.06 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for embryonic skeletal joint morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in embryonic skeletal joint morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
2 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
3 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41
4 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
5 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
6 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
7 INT124815 Binding of Col2a1 9 0.37 10.27 3.93
8 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
9 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
10 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
11 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
12 INT39867 Binding of Col2a1 9 0.35 7.65 3.18
13 INT54832 Negative_regulation of Gene_expression of Col2a1 6 0.50 2.53 3.16
14 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02
15 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
16 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
17 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78
18 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
19 INT220992 Protein_catabolism of Col2a1 8 0.40 5.55 1.64
20 INT164410 Negative_regulation of Col2a1 4 0.39 3.75 1.53
21 INT32184 Negative_regulation of Col2a1 9 0.42 3.05 1.43
22 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
23 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
24 INT54831 Regulation of Gene_expression of Col2a1 4 0.39 2.3 1.31
25 INT117232 Localization of COL2A1 11 0.72 7.34 1.3
26 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24
27 INT176463 Protein_catabolism of Col2a1 4 0.35 1.94 1.2
28 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11
29 INT54835 Regulation of Col2a1 5 0.59 2.08 1.07
30 INT168233 Positive_regulation of Transcription of Col2a1 2 0.45 1.78 0.99
31 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
32 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
33 INT173506 Positive_regulation of Col2a1 4 0.20 3.42 0.76
34 INT141150 Localization of BMP7 4 0.56 2.84 0.76
35 INT37617 Regulation of Gene_expression of Col2a1 3 0.31 1.48 0.7
36 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
37 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61
38 INT63389 Localization of Col2a1 7 0.68 1.95 0.6
39 INT89126 Regulation of BMP7 7 0.45 2.5 0.58
40 INT165537 Negative_regulation of Bmp7 2 0.43 0.55 0.52
41 INT159214 Positive_regulation of Gene_expression of BMP7 6 0.46 2.16 0.51
42 INT32183 Positive_regulation of Negative_regulation of Col2a1 2 0.46 1.01 0.49
43 INT129620 Regulation of Gene_expression of Bmp7 3 0.42 3.2 0.47
44 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
45 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
46 INT125840 Positive_regulation of Binding of Col2a1 1 0.43 1.21 0.45
47 INT9732 Regulation of COL2A1 9 0.58 6.93 0.44
48 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
49 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
50 INT118460 Binding of Bmp7 3 0.46 1.3 0.4
51 INT54833 Positive_regulation of Col2a1 5 0.52 1.1 0.32
52 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31
53 INT180577 Positive_regulation of Protein_catabolism of COL2A1 2 0.12 0.91 0.31
54 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3
55 INT220209 Negative_regulation of Localization of COL2A1 1 0.41 0.48 0.29
56 INT181524 Negative_regulation of Binding of Col2a1 1 0.13 1.05 0.25
57 INT275310 Positive_regulation of Protein_catabolism of Col2a1 1 0.16 0.88 0.22
58 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
59 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
60 INT339267 Negative_regulation of BMP7 1 0.43 0.55 0.17
61 INT210123 Localization of Axin1 1 0.04 0.84 0.17
62 INT220208 Regulation of Protein_catabolism of COL2A1 1 0.26 0.28 0.17
63 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
64 INT63646 Localization of Col2a1 3 0.77 0.37 0.16
65 INT118459 Regulation of Bmp7 3 0.43 0.25 0.15
66 INT201968 Positive_regulation of Bmp7 2 0.43 1.11 0.14
67 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
68 INT95278 Positive_regulation of Gene_expression of Col2a1 2 0.47 0.21 0.13
69 INT323417 Protein_catabolism of Osr1 1 0.07 0.84 0.13
70 INT221000 Phosphorylation of COL2A1 1 0.19 0.18 0.12
71 INT203079 Regulation of Transcription of Col2a1 1 0.05 0.07 0.11
72 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
73 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
74 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
75 INT346288 Phosphorylation of Col2a1 1 0.02 0.73 0.08
76 INT355332 Localization of Bmp7 1 0.09 1.92 0.08
77 INT316570 Binding of BMP7 3 0.37 0.95 0.07
78 INT287244 Transcription of BMP7 1 0.66 0.15 0.07
79 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
80 INT287242 Positive_regulation of Transcription of BMP7 1 0.64 0.15 0.07
81 INT231709 Negative_regulation of Negative_regulation of Col2a1 1 0.27 0.18 0.06
82 INT153022 Negative_regulation of Bmp7 1 0.01 0.27 0.06
83 INT339669 Regulation of Col2a1 1 0.01 1.02 0.05
84 INT250505 Positive_regulation of Negative_regulation of COL2A1 1 0.41 0.57 0.05
85 INT244699 Positive_regulation of AXIN1 1 0.02 0 0.05
86 INT272249 Negative_regulation of Negative_regulation of COL2A1 1 0.06 0 0.05
87 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
88 INT201964 Transcription of Col2a1 2 0.38 0.55 0.04
89 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
90 INT346287 Regulation of Binding of Col2a1 1 0.01 0.07 0.04
91 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
92 INT201965 Transcription of Bmp7 2 0.49 0.93 0.03
93 INT323421 Gene_expression of Osr1 1 0.05 0.46 0.03
94 INT184729 Transcription of COL2A1 4 0.67 1.1 0
95 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
96 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
97 INT196027 Binding of Bmp4 2 0.13 0.97 0
98 INT142119 Regulation of Bmp4 2 0.58 0.29 0
99 INT294025 Phosphorylation of AXIN1 2 0.38 0.47 0
100 INT165862 Positive_regulation of Binding of COL2A1 2 0.43 0 0
101 INT151839 Positive_regulation of Bmp7 2 0.27 0.24 0
102 INT272974 Negative_regulation of Gene_expression of Osr1 1 0.04 1.58 0
103 INT312246 Regulation of Negative_regulation of COL2A1 1 0.07 0 0
104 INT260766 Negative_regulation of Gene_expression of Bmp7 1 0.35 0 0
105 INT287932 Negative_regulation of Binding of AXIN1 1 0.12 0 0
106 INT339667 Localization of Bmp4 1 0.38 0.27 0
107 INT201963 Positive_regulation of Binding of Bmp7 1 0.05 0 0
108 INT176462 Positive_regulation of Protein_catabolism of Col2a1 1 0.16 0.21 0
109 INT314125 Regulation of Transcription of Bmp7 1 0.25 0.88 0
110 INT264309 Regulation of Localization of Col2a1 1 0.26 0 0
111 INT272976 Regulation of Osr1 1 0.04 1.54 0
112 INT314127 Regulation of Bmp7 1 0.25 0.88 0
113 INT272973 Gene_expression of Osr1 1 0.06 5.27 0
114 INT322897 Negative_regulation of Transcription of COL2A1 1 0.17 0 0
115 INT63388 Positive_regulation of Localization of Col2a1 1 0.01 0.16 0
116 INT272975 Negative_regulation of Osr1 1 0.05 1.51 0
117 INT196028 Transcription of Bmp7 1 0.18 0 0
118 INT196029 Localization of Bmp7 1 0.27 0.09 0
119 INT287935 Positive_regulation of Binding of AXIN1 1 0.14 0 0
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