GO:0060290

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Name transdifferentiation
Categary Process
Go Slim No
Go Link GO:0060290
Unique Molecular Interactions 81
Total Molecular Interactions 122
Total Single Events 840
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transdifferentiation. They are ordered first by their pain relevance and then by number of times they were reported for transdifferentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8416 LIF Regulation of TAC1 1 0.13 0.36 1.04
2 INT8415 LIF Regulation of VIP 1 0.13 0.36 1.04
3 INT56743 LIF Positive_regulation of Cck 1 0.08 0.18 1.02
4 INT56742 LIF Positive_regulation of Chat 1 0.02 0.2 0.98
5 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
6 INT98479 Lif Regulation of Gene_expression of Grin1 1 0.04 0.35 0.82
7 INT149597 Lif Regulation of Regulation of Gal 1 0.30 0.69 0.73
8 INT149596 Lif Negative_regulation of Negative_regulation of Gal 1 0.10 0.5 0.7
9 INT82267 Lif Regulation of Gene_expression of Gal 1 0.40 2.76 0.62
10 INT149595 Lif Negative_regulation of Negative_regulation of Trpv1 1 0.34 0.44 0.61
11 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
12 INT8440 Cntf Regulation of LIF 1 0.33 0.18 0.52
13 INT98480 Lif Positive_regulation of Pnoc 1 0.18 0.2 0.49
14 INT98484 Lif Regulation of Gene_expression of Gal 1 0.04 0.16 0.47
15 INT98482 Lif Positive_regulation of Gene_expression of Pnoc 1 0.16 0.17 0.46
16 INT98481 Lif Regulation of Regulation of Oprl1 1 0.04 0.16 0.45
17 INT188205 OSM Regulation of LIF 1 0.09 1.12 0.43
18 INT188207 LIF Regulation of IL6 1 0.17 1.12 0.43
19 INT91719 Binding of BDNF and LIF 1 0.09 1.65 0.38
20 INT82268 Lif Regulation of Gene_expression of Iapp 1 0.06 0.9 0.2
21 INT222426 Lif Positive_regulation of Localization of Pomc 1 0.02 0.75 0.17
22 INT32211 POMC Positive_regulation of Gene_expression of Lif 1 0.01 0.61 0.15
23 INT139538 Binding of CD34 and KIT 2 0.39 2.73 0.14
24 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14
25 INT148594 Binding of BCL2 and CD34 1 0.39 1.17 0.13
26 INT188197 LIF Positive_regulation of STAT3 1 0.35 0.27 0.12
27 INT277986 Negative_regulation of Epo Positive_regulation of Localization of Cd34 1 0.08 0.77 0.12
28 INT294440 KLK4 Negative_regulation of LIF 1 0.00 0 0.1
29 INT118052 Binding of Pecam1 and Cd34 1 0.22 0.51 0.1
30 INT299953 Binding of CD34 and FTSJ3 1 0.04 1.07 0.09
31 INT355019 Lif Positive_regulation of JAK1 1 0.00 0.69 0.08
32 INT299539 Lif Positive_regulation of Phosphorylation of Stat3 1 0.08 0 0.08
33 INT355020 Lif Positive_regulation of SOAT1 1 0.02 0.7 0.08
34 INT355010 Lif Positive_regulation of Il6st 1 0.02 0.69 0.08
35 INT299548 Binding of TGFB1 and Lif 1 0.02 0 0.07
36 INT12987 LIF Regulation of Localization of Prl 1 0.09 0 0.07
37 INT299535 Binding of Egf and Lif 1 0.07 0 0.07
38 INT209615 Binding of KRT20 and Cd34 1 0.00 1.05 0.06
39 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
40 INT209611 Binding of Mme and Cd34 1 0.00 1.05 0.06
41 INT118227 Binding of ACTG2 and CD34 1 0.15 1.17 0.06
42 INT209610 Binding of Cd22 and Cd34 1 0.01 1.05 0.06
43 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
44 INT268652 Binding of CLDN4 and LIF 1 0.35 0.44 0.04
45 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
46 INT261388 Nsdhl Regulation of Lif 1 0.08 0.67 0.04
47 INT261377 Nsdhl Positive_regulation of Lif 1 0.08 0.6 0.03
48 INT266075 LIF Regulation of Gene_expression of PAEP 1 0.19 0.43 0.03
49 INT266070 LIF Regulation of Gene_expression of PAPPA 1 0.35 0.49 0.03
50 INT266072 LGALS1 Regulation of Gene_expression of LIF 1 0.17 0.43 0.03
51 INT266067 PAPPA Regulation of Gene_expression of LIF 1 0.35 0.49 0.03
52 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
53 INT266076 LIF Regulation of Gene_expression of LGALS1 1 0.17 0.43 0.03
54 INT66341 LIF Positive_regulation of Gene_expression of FOS 1 0.11 1.07 0
55 INT66339 LIF Positive_regulation of Phosphorylation of CLIP2 1 0.45 1.57 0
56 INT268651 NUPL2 Positive_regulation of Gene_expression of LIF 1 0.66 0.07 0
57 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
58 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
59 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
60 INT308314 Binding of CD34 and Pfpl 1 0.03 0.57 0
61 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
62 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
63 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
64 INT49943 Binding of Th and Pdx1 1 0.02 0.17 0
65 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
66 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
67 INT249850 Binding of Ptprc and Cd34 1 0.13 0.48 0
68 INT347035 Binding of Kit and Cd34 1 0.02 1.38 0
69 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
70 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
71 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
72 INT66342 LIF Positive_regulation of Phosphorylation of CLIP1 1 0.60 1.57 0
73 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
74 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
75 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
76 INT236171 Binding of LIF and Hmgcr 1 0.02 0 0
77 INT66353 LIF Regulation of Ctf2p 1 0.02 0.47 0
78 INT66340 LIF Positive_regulation of C1orf61 1 0.12 0.52 0
79 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
80 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
81 INT213744 Binding of Cd34 and Epc1 1 0.12 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transdifferentiation. They are ordered first by their pain relevance and then by number of times they were reported in transdifferentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39
2 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97
3 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76
4 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14
5 INT32208 Gene_expression of Lif 23 0.74 6.23 3.7
6 INT82265 Gene_expression of Lif 7 0.50 6.17 3.4
7 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28
8 INT76240 Positive_regulation of Lif 6 0.69 6.04 3.13
9 INT33895 Positive_regulation of LIF 9 0.67 2.47 2.34
10 INT44027 Positive_regulation of Lif 7 0.40 2.76 1.9
11 INT253751 Localization of Lif 3 0.73 3.94 1.58
12 INT50437 Regulation of LIF 6 0.44 2.12 1.53
13 INT21682 Binding of CD34 18 0.47 13.19 1.47
14 INT50436 Negative_regulation of Positive_regulation of LIF 1 0.37 0.33 1.42
15 INT34933 Positive_regulation of Gene_expression of LIF 6 0.67 3.41 1.38
16 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
17 INT149594 Positive_regulation of Gene_expression of Lif 2 0.47 0.89 1
18 INT119168 Negative_regulation of Cd34 8 0.37 4.91 0.96
19 INT126967 Localization of Cd34 9 0.79 3.69 0.87
20 INT102819 Regulation of Lif 8 0.53 2.05 0.87
21 INT98478 Negative_regulation of Lif 3 0.42 1.29 0.84
22 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
23 INT82262 Regulation of Lif 3 0.31 1.67 0.83
24 INT354449 Positive_regulation of Localization of Lif 1 0.33 1.24 0.83
25 INT96188 Binding of Cd34 11 0.31 10.4 0.82
26 INT68794 Negative_regulation of LIF 6 0.41 1.38 0.7
27 INT2109 Negative_regulation of Gene_expression of LIF 4 0.41 0.89 0.66
28 INT94713 Regulation of CD34 11 0.45 8.02 0.58
29 INT128472 Negative_regulation of CD34 7 0.42 3.92 0.58
30 INT196003 Regulation of Cd34 4 0.30 3.38 0.5
31 INT87819 Localization of CD34 21 0.81 7.69 0.47
32 INT216834 Localization of Lif 2 0.34 0.23 0.46
33 INT299516 Phosphorylation of Lif 1 0.26 0.56 0.46
34 INT119251 Positive_regulation of Gene_expression of CD34 12 0.49 5.2 0.44
35 INT2110 Localization of LIF 5 0.73 1.59 0.44
36 INT32207 Regulation of Gene_expression of Lif 3 0.19 1.01 0.42
37 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
38 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
39 INT232153 Regulation of Negative_regulation of Cd34 1 0.05 0.07 0.35
40 INT156399 Regulation of Pdx1 1 0.00 0.96 0.33
41 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
42 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
43 INT299519 Binding of Lif 2 0.21 0.67 0.29
44 INT49942 Positive_regulation of Pdx1 5 0.02 1.24 0.26
45 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
46 INT232504 Negative_regulation of Gene_expression of CD34 4 0.38 1.89 0.23
47 INT188235 Phosphorylation of LIF 1 0.53 0.48 0.23
48 INT318610 Positive_regulation of Binding of Lif 1 0.28 0.67 0.19
49 INT188224 Regulation of Gene_expression of LIF 1 0.23 0.53 0.18
50 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
51 INT188216 Positive_regulation of Regulation of LIF 1 0.39 1.13 0.17
52 INT135706 Negative_regulation of Binding of CD34 1 0.40 1.19 0.16
53 INT137457 Positive_regulation of Localization of Cd34 1 0.46 0.55 0.16
54 INT338147 Negative_regulation of Gene_expression of Lif 1 0.38 0.29 0.15
55 INT216451 Negative_regulation of Lif 1 0.36 0.77 0.15
56 INT232508 Regulation of Gene_expression of CD34 4 0.43 2.73 0.13
57 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
58 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
59 INT123875 Localization of Pdx1 1 0.80 0.28 0.09
60 INT70606 Positive_regulation of Positive_regulation of Pdx1 1 0.02 0.4 0.09
61 INT333440 Protein_catabolism of Lif 1 0.23 0.2 0.08
62 INT216454 Binding of Lif 2 0.27 0.85 0.07
63 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
64 INT299524 Positive_regulation of Localization of Lif 1 0.21 0 0.06
65 INT308300 Positive_regulation of Localization of CD34 3 0.44 1.82 0.05
66 INT229654 Positive_regulation of Gene_expression of Cd34 2 0.45 1.19 0.05
67 INT262799 Localization of Smad3 6 0.56 2.09 0.04
68 INT221855 Regulation of Positive_regulation of CD34 1 0.31 0.83 0.04
69 INT333439 Positive_regulation of Gene_expression of Lif 1 0.18 0.18 0.04
70 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
71 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
72 INT266088 Positive_regulation of Localization of LIF 1 0.34 0.45 0.03
73 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
74 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
75 INT66346 Binding of LIF 7 0.47 0.9 0
76 INT97829 Gene_expression of Pdx1 7 0.32 1.14 0
77 INT265337 Binding of Smad3 2 0.35 1 0
78 INT269913 Positive_regulation of Binding of Smad3 1 0.34 0.3 0
79 INT218693 Negative_regulation of Phosphorylation of Smad3 1 0.19 0.32 0
80 INT132735 Positive_regulation of Gene_expression of Pdx1 1 0.29 0 0
81 INT329784 Gene_expression of SMAD3 1 0.31 0.41 0
82 INT159329 Transcription of Lif 1 0.36 0.15 0
83 INT268384 Positive_regulation of Phosphorylation of SMAD3 1 0.29 1.22 0
84 INT300189 Negative_regulation of Localization of Lif 1 0.41 0.47 0
85 INT49941 Negative_regulation of Pdx1 1 0.02 0.07 0
86 INT320552 Transcription of CD34 1 0.67 1.23 0
87 INT49938 Negative_regulation of Positive_regulation of Pdx1 1 0.02 0.07 0
88 INT269873 Positive_regulation of Negative_regulation of Smad3 1 0.34 0.31 0
89 INT268657 Regulation of Localization of LIF 1 0.38 0.07 0
90 INT268382 Phosphorylation of SMAD3 1 0.34 0.6 0
91 INT49940 Positive_regulation of Negative_regulation of Pdx1 1 0.02 0.07 0
92 INT308295 Positive_regulation of Positive_regulation of CD34 1 0.60 0.44 0
93 INT254809 Positive_regulation of Transcription of Smad3 1 0.25 0.24 0
94 INT294258 Phosphorylation of CD34 1 0.69 0.06 0
95 INT268363 Binding of SMAD3 1 0.20 0.56 0
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