GO:0060292

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Name long term synaptic depression
Categary Process
Go Slim No
Go Link GO:0060292
Unique Molecular Interactions 129
Total Molecular Interactions 170
Total Single Events 1322
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for long term synaptic depression. They are ordered first by their pain relevance and then by number of times they were reported for long term synaptic depression. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
2 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
3 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
4 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
5 INT168865 Cd38 Regulation of Wdtc1 1 0.03 0.12 1.35
6 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
7 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28
8 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
9 INT310069 Negative_regulation of Pain1 Positive_regulation of Mgll 1 0.02 1.32 1.23
10 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
11 INT310067 Pain1 Positive_regulation of Mgll 1 0.02 1.29 1.21
12 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
13 INT285659 Binding of Faah and Mgll 1 0.15 0.99 1.11
14 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
15 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
16 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
17 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
18 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
19 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91
20 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
21 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
22 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
23 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84
24 INT344101 Positive_regulation of Drd1a Positive_regulation of Localization of Abat 1 0.01 0 0.84
25 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
26 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
27 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
28 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
29 INT327707 Binding of Comt and Drd1a 1 0.18 0.27 0.74
30 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
31 INT99938 Drd1a Regulation of Transcription of Qrfp 1 0.03 0 0.69
32 INT71988 Drd1a Regulation of Npr1 1 0.10 0 0.68
33 INT232617 Grid2ip Regulation of Cysltr1 1 0.03 0.58 0.68
34 INT99939 Drd1a Regulation of Qrfp 1 0.03 0 0.68
35 INT317638 Ins1 Positive_regulation of Gene_expression of Drd1a 1 0.14 0.86 0.59
36 INT317634 Ins1 Positive_regulation of Drd1a 1 0.14 0.86 0.59
37 INT5111 DIO2 Positive_regulation of Drd1a 1 0.04 0 0.53
38 INT232618 Gene_expression of Grid2ip Regulation of Localization of Gria1 1 0.28 0.86 0.52
39 INT223925 Drd1a Positive_regulation of Gene_expression of Serpina1 1 0.01 0 0.51
40 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
41 INT232619 Binding of Gria1 and Grid2ip 1 0.23 0.51 0.48
42 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
43 INT285661 Binding of Mgll and FAAH2 1 0.05 0.23 0.45
44 INT317635 Positive_regulation of Drd1a Positive_regulation of Phosphorylation of Gtf3a 1 0.01 0.53 0.43
45 INT331675 Binding of Drd1a and Sptan1 1 0.03 0.33 0.4
46 INT32244 Slc3a1 Positive_regulation of Localization of Drd1a 1 0.15 0 0.39
47 INT32243 Drd1a Positive_regulation of Localization of Slc3a1 1 0.15 0 0.39
48 INT344103 Positive_regulation of Drd1a Positive_regulation of Obfc1 1 0.00 0 0.38
49 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
50 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
51 INT258763 Binding of Drd5 and ADHD1 1 0.07 1.11 0.31
52 INT93833 Binding of Fos and Srf 1 0.00 0 0.3
53 INT93832 Binding of Elk1 and Srf 1 0.00 0 0.29
54 INT97595 Penk Regulation of Gene_expression of Drd1a 1 0.25 0.1 0.28
55 INT73385 Cfp Regulation of Drd1a 1 0.10 0 0.25
56 INT73384 Positive_regulation of Cfp Regulation of Drd1a 1 0.18 0 0.25
57 INT327383 Il13 Positive_regulation of Gene_expression of Cd38 1 0.19 0 0.25
58 INT261465 Binding of Drd1a and Ptgdr 1 0.03 0.1 0.23
59 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
60 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2
61 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
62 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
63 INT300563 Binding of Drd5 and ADHD1 1 0.01 1.13 0.19
64 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
65 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
66 INT294106 Binding of DNASE1L3 and DRD5 1 0.02 0 0.14
67 INT241070 Klf16 Positive_regulation of Drd1a 1 0.05 0.13 0.12
68 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
69 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
70 INT249198 CD38 Positive_regulation of CA2 1 0.16 0.16 0.08
71 INT258756 Binding of Drd5 and Lmo1 1 0.03 0.64 0.08
72 INT216130 SRF Positive_regulation of Gene_expression of EGR1 1 0.49 0.32 0.07
73 INT216129 SRF Positive_regulation of Gene_expression of FOS 1 0.28 0.32 0.07
74 INT261454 Akr1d1 Regulation of Drd1a 1 0.00 0.71 0.06
75 INT319558 Positive_regulation of Creb1 Regulation of Srf 1 0.31 0.06 0.04
76 INT319559 Creb1 Regulation of Srf 1 0.28 0.06 0.04
77 INT249158 CD38 Regulation of CA2 1 0.13 0.07 0.04
78 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
79 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
80 INT89016 Oprd1 Negative_regulation of Drd1a 1 0.06 0 0
81 INT190632 Binding of Srf and Yy1 1 0.20 0.14 0
82 INT321718 Ins1 Regulation of Gene_expression of Pten 1 0.04 0.23 0
83 INT240722 Cd38 Positive_regulation of Localization of Ca2 1 0.04 0.79 0
84 INT285908 AKT1 Regulation of Pten 1 0.01 0.53 0
85 INT264864 Cd38 Positive_regulation of Localization of INS 1 0.06 0.51 0
86 INT225590 Ncoa6 Regulation of Srf 1 0.08 0.21 0
87 INT285910 Pten Regulation of AKT1 1 0.00 0.53 0
88 INT305350 Pten Regulation of Phosphorylation of Akt1 1 0.05 0.95 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for long term synaptic depression. They are ordered first by their pain relevance and then by number of times they were reported in long term synaptic depression. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
2 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
3 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
4 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
5 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
6 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
7 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
8 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
9 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
10 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
11 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
12 INT169653 Negative_regulation of Mgll 6 0.42 3.75 6.16
13 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
14 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
15 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27
16 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
17 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
18 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
19 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
20 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
21 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
22 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
23 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
24 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
25 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
26 INT153616 Gene_expression of Mgll 5 0.50 2.72 3.03
27 INT113077 Positive_regulation of Phosphorylation of Drd1a 1 0.11 0.15 2.87
28 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
29 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
30 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63
31 INT64248 Positive_regulation of Positive_regulation of Drd1a 6 0.45 1.97 2.62
32 INT137616 Gene_expression of Cd38 19 0.67 9.37 2.54
33 INT89992 Positive_regulation of Gene_expression of Drd1a 5 0.39 2.11 2.54
34 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36
35 INT63394 Gene_expression of Drd5 7 0.76 1.85 2.3
36 INT24407 Negative_regulation of Binding of Drd1a 3 0.25 0.81 2.18
37 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
38 INT153611 Protein_catabolism of Mgll 3 0.86 1 2.09
39 INT63392 Positive_regulation of Drd5 5 0.46 1.73 2.08
40 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
41 INT21046 Regulation of Positive_regulation of Drd1a 3 0.44 0.09 2.06
42 INT13837 Negative_regulation of Positive_regulation of Drd1a 2 0.43 1.43 2.01
43 INT10447 Negative_regulation of Srf 3 0.40 0.95 1.98
44 INT117934 Gene_expression of Cd38 11 0.68 6.5 1.95
45 INT232607 Gene_expression of Grid2ip 1 0.65 2.35 1.85
46 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
47 INT168860 Positive_regulation of Cd38 5 0.70 4.07 1.57
48 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
49 INT168861 Positive_regulation of Gene_expression of Cd38 2 0.50 2.01 1.47
50 INT140305 Negative_regulation of Binding of Drd1a 2 0.21 0.54 1.46
51 INT228249 Binding of Pten 7 0.48 3.26 1.45
52 INT232604 Localization of Grid2ip 1 0.72 1.33 1.43
53 INT113079 Regulation of Phosphorylation of Drd1a 1 0.06 0.07 1.43
54 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
55 INT336571 Gene_expression of DRD5 1 0.06 0.73 1.41
56 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
57 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
58 INT168859 Regulation of Cd38 1 0.27 0.11 1.33
59 INT117933 Positive_regulation of Gene_expression of Cd38 3 0.38 1.62 1.23
60 INT190014 Regulation of Pten 8 0.62 6.03 1.2
61 INT168864 Positive_regulation of Positive_regulation of Cd38 1 0.47 0.05 1.18
62 INT103859 Positive_regulation of Drd5 2 0.49 0.81 1.14
63 INT103857 Gene_expression of Drd5 2 0.23 0.92 1.08
64 INT184839 Localization of Drd1a 4 0.73 0.84 1.03
65 INT10448 Positive_regulation of Srf 3 0.47 0.89 1.03
66 INT135032 Negative_regulation of SRF 1 0.49 0 1.03
67 INT63393 Positive_regulation of Gene_expression of Drd5 3 0.49 1.21 1.02
68 INT193069 Positive_regulation of Gene_expression of CD38 4 0.15 4.06 1.01
69 INT64690 Negative_regulation of Localization of Drd1a 2 0.09 0 0.95
70 INT74183 Positive_regulation of Localization of Drd1a 1 0.32 0.06 0.95
71 INT85999 Binding of Drd5 2 0.27 0.84 0.94
72 INT26531 Regulation of Srf 3 0.18 0.62 0.9
73 INT99668 Positive_regulation of Binding of Drd1a 2 0.43 0.89 0.87
74 INT276177 Regulation of Gene_expression of Pten 1 0.34 1.51 0.84
75 INT45293 Transcription of Srf 2 0.47 0.79 0.76
76 INT169651 Positive_regulation of Protein_catabolism of Mgll 1 0.49 0.07 0.72
77 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71
78 INT300588 Regulation of Drd5 1 0.32 0.67 0.69
79 INT184846 Negative_regulation of Drd5 1 0.19 2.28 0.68
80 INT276199 Binding of Pten 2 0.30 0.4 0.67
81 INT153157 Regulation of Regulation of Drd1a 2 0.25 0.2 0.66
82 INT169654 Positive_regulation of Mgll 2 0.49 0.26 0.66
83 INT184848 Positive_regulation of Transcription of Drd1a 1 0.26 0.93 0.65
84 INT140306 Regulation of Binding of Drd1a 1 0.20 0.36 0.64
85 INT72516 Regulation of Binding of Drd1a 2 0.44 0.4 0.63
86 INT276179 Regulation of Pten 1 0.46 0.81 0.63
87 INT232611 Binding of Grid2ip 1 0.36 0.46 0.61
88 INT45292 Negative_regulation of Transcription of Srf 1 0.06 0.65 0.59
89 INT103858 Regulation of Gene_expression of Drd5 1 0.08 0.92 0.58
90 INT157718 Binding of DRD5 1 0.33 0.57 0.52
91 INT232605 Negative_regulation of Gene_expression of Grid2ip 1 0.41 0.85 0.49
92 INT276174 Regulation of Negative_regulation of Pten 1 0.34 0.63 0.47
93 INT232609 Positive_regulation of Grid2ip 1 0.48 0.71 0.46
94 INT117932 Positive_regulation of Cd38 2 0.35 1.17 0.43
95 INT276180 Positive_regulation of Negative_regulation of Pten 1 0.35 0.89 0.43
96 INT276202 Negative_regulation of Protein_catabolism of Pten 1 0.32 0.78 0.42
97 INT134731 Localization of Cd38 4 0.70 0.87 0.41
98 INT276204 Protein_catabolism of Pten 1 0.75 0.77 0.41
99 INT203816 Localization of Pten 4 0.75 1.37 0.4
100 INT344086 Binding of Drd5 1 0.36 0.06 0.37
101 INT48566 Regulation of Transcription of Drd1a 1 0.32 0 0.37
102 INT22236 Negative_regulation of CD38 2 0.41 0.1 0.36
103 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35
104 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35
105 INT281469 Transcription of Pten 2 0.72 1.12 0.32
106 INT281474 Regulation of Transcription of Pten 1 0.62 0.35 0.32
107 INT18821 Positive_regulation of Gene_expression of Srf 2 0.35 0.63 0.31
108 INT264860 Binding of Cd38 1 0.39 2.36 0.31
109 INT214579 Positive_regulation of CD38 4 0.24 1.22 0.3
110 INT300593 Regulation of Gene_expression of Drd5 1 0.33 0.13 0.28
111 INT7610 Localization of Srf 3 0.67 0.98 0.27
112 INT136052 Negative_regulation of Negative_regulation of Drd1a 1 0.13 0.66 0.27
113 INT117931 Positive_regulation of Positive_regulation of Cd38 1 0.35 0.3 0.26
114 INT325293 Negative_regulation of Gene_expression of CD38 1 0.14 0.55 0.22
115 INT224616 Regulation of Negative_regulation of Pten 1 0.13 1.21 0.18
116 INT130457 Binding of CD38 2 0.16 0.75 0.17
117 INT154771 Positive_regulation of Localization of Cd38 1 0.08 0.87 0.16
118 INT89766 Binding of SRF 1 0.17 0.89 0.15
119 INT89767 Positive_regulation of Binding of SRF 1 0.23 0.89 0.15
120 INT164729 Binding of Mgll 3 0.48 0.2 0.14
121 INT264858 Negative_regulation of Binding of Cd38 1 0.34 0.79 0.14
122 INT264863 Negative_regulation of Cd38 1 0.34 0.79 0.14
123 INT264857 Negative_regulation of Gene_expression of Cd38 1 0.34 1.57 0.12
124 INT133351 Regulation of Cd38 1 0.15 1.6 0.09
125 INT22789 Binding of Srf 1 0.37 0.07 0.07
126 INT22790 Positive_regulation of Binding of Srf 1 0.50 0.07 0.07
127 INT190544 Transcription of Srf 1 0.19 0.43 0.06
128 INT106237 Protein_catabolism of CD38 1 0.62 0.06 0.06
129 INT190570 Localization of Srf 1 0.20 0.49 0.06
130 INT223763 Negative_regulation of DRD5 1 0.01 0.06 0.06
131 INT214575 Localization of CD38 3 0.34 2.31 0.04
132 INT236108 Positive_regulation of Positive_regulation of Pten 3 0.39 2.3 0.04
133 INT233844 Negative_regulation of Positive_regulation of Pten 1 0.17 0.73 0.04
134 INT225411 Positive_regulation of Srf 1 0.05 0.27 0.03
135 INT268102 Transcription of SRF 1 0.53 0.85 0.03
136 INT225413 Binding of Srf 1 0.10 0.27 0.03
137 INT232606 Negative_regulation of Grid2ip 1 0.36 0 0.03
138 INT157800 Gene_expression of Srf 2 0.45 0.88 0
139 INT305346 Positive_regulation of Negative_regulation of Pten 2 0.41 0.91 0
140 INT321706 Negative_regulation of Phosphorylation of Pten 1 0.38 0.16 0
141 INT105753 Positive_regulation of Gene_expression of SRF 1 0.01 0.13 0
142 INT214568 Positive_regulation of Localization of CD38 1 0.21 1.09 0
143 INT323511 Positive_regulation of Gene_expression of Mgll 1 0.15 0.52 0
144 INT323522 Regulation of Mgll 1 0.03 0.09 0
145 INT323518 Regulation of Gene_expression of Mgll 1 0.11 0.1 0
146 INT264862 Regulation of Gene_expression of Cd38 1 0.36 0.84 0
147 INT105752 Positive_regulation of SRF 1 0.01 0.13 0
148 INT323515 Positive_regulation of Positive_regulation of Mgll 1 0.11 0.1 0
149 INT323524 Negative_regulation of Binding of Mgll 1 0.09 0.2 0
150 INT268104 Negative_regulation of Gene_expression of SRF 1 0.38 0.16 0
151 INT323510 Negative_regulation of Gene_expression of Mgll 1 0.11 0.06 0
152 INT213446 Regulation of Gene_expression of SRF 1 0.22 0.71 0
153 INT228244 Negative_regulation of Binding of Pten 1 0.16 0.72 0
154 INT225408 Negative_regulation of Srf 1 0.05 0.39 0
155 INT157799 Negative_regulation of Gene_expression of Srf 1 0.18 0.07 0
156 INT157794 Phosphorylation of Srf 1 0.26 0.07 0
157 INT323516 Localization of Mgll 1 0.19 0.19 0
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