GO:0060322

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Name head development
Categary Process
Go Slim No
Go Link GO:0060322
Unique Molecular Interactions 120
Total Molecular Interactions 164
Total Single Events 1010
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for head development. They are ordered first by their pain relevance and then by number of times they were reported for head development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
2 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
3 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
4 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
5 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
6 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
7 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
8 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
9 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
10 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
11 INT219921 EDNRA Negative_regulation of Trpv1 1 0.13 0.36 0.63
12 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
13 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
14 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
15 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
16 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
17 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
18 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
19 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44
20 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
21 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
22 INT326473 Positive_regulation of PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.41
23 INT316493 Il6 Positive_regulation of Il11ra1 1 0.64 1.69 0.4
24 INT334763 Ednra Positive_regulation of Gabrg1 1 0.01 0 0.4
25 INT184135 Il11ra1 Positive_regulation of Stat3 1 0.20 0.3 0.4
26 INT326470 PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.4
27 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
28 INT326472 AGXT Negative_regulation of PGAP1 1 0.00 0.05 0.39
29 INT184092 Il11ra1 Positive_regulation of Jak1 1 0.17 0.3 0.39
30 INT77683 Ednra Negative_regulation of LH 1 0.03 0.23 0.39
31 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
32 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
33 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33
34 INT303030 Binding of Ednra and MCPH1 1 0.00 1.02 0.32
35 INT119603 H2-Ab1 Regulation of EDNRA 1 0.00 0.07 0.32
36 INT119602 EDNRA Regulation of H2-Ab1 1 0.00 0.07 0.32
37 INT303005 Binding of Ednra and Pah 1 0.06 1.02 0.32
38 INT69365 Binding of EDNRA and Pnoc 1 0.00 0 0.31
39 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
40 INT117588 Binding of C5AR1 and EDNRA 1 0.40 0.38 0.3
41 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28
42 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28
43 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
44 INT124117 Apcs Negative_regulation of Ednra 1 0.09 0 0.26
45 INT219918 Positive_regulation of EDNRA Positive_regulation of Trpv1 1 0.13 0 0.26
46 INT36875 Binding of EDNRA and SYNCRIP 1 0.01 0 0.24
47 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
48 INT316491 Socs3 Positive_regulation of Il11ra1 1 0.45 0.92 0.22
49 INT284139 EDNRB Positive_regulation of Gene_expression of EDNRA 1 0.12 0.45 0.22
50 INT36876 EDNRA Regulation of Negative_regulation of PRB1 1 0.00 0 0.21
51 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
52 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
53 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
54 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
55 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
56 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
57 INT334769 Ednra Positive_regulation of Car2 1 0.02 0.49 0.18
58 INT184103 Binding of Socs3 and Il11ra1 1 0.12 0 0.17
59 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
60 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
61 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
62 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
63 INT115205 Positive_regulation of Ednra Positive_regulation of Localization of Avp 1 0.36 0 0.14
64 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14
65 INT334765 Ednra Positive_regulation of Positive_regulation of Car2 1 0.02 0.24 0.14
66 INT219920 EDNRA Positive_regulation of Trpv1 1 0.14 0 0.13
67 INT334759 Ednra Regulation of Gabrg1 1 0.01 0 0.13
68 INT280484 Bdnf Positive_regulation of Gene_expression of Lhx1 1 0.48 1.49 0.11
69 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
70 INT334761 Binding of Ednra and Gopc 1 0.03 0 0.11
71 INT293627 GHRL Positive_regulation of EDNRA 1 0.00 0.96 0.1
72 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
73 INT284141 Binding of EDNRA and PAH 1 0.05 0.1 0.09
74 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09
75 INT214752 EDNRA Positive_regulation of PLCB1 1 0.02 0 0.08
76 INT282684 FECH Positive_regulation of Negative_regulation of Ssbp3 1 0.00 1.54 0.08
77 INT88752 Map3k7 Negative_regulation of Ednra 1 0.05 0 0.08
78 INT115204 Ednra Regulation of Localization of Avp 1 0.55 0 0.08
79 INT192908 Edn1 Positive_regulation of Ednra 1 0.21 0.35 0.07
80 INT289244 Binding of Il11ra1 and Il6ra 1 0.01 0.33 0.07
81 INT337297 PTAFR Positive_regulation of EDNRA 1 0.04 1.2 0.06
82 INT178084 EDNRA Positive_regulation of Phosphorylation of GJA1 1 0.10 0.88 0.06
83 INT337303 Positive_regulation of PTAFR Positive_regulation of EDNRA 1 0.04 1.21 0.06
84 INT339778 Binding of EDNRA and PTH 1 0.12 0.35 0.05
85 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
86 INT274095 Binding of EDNRA and OPA1 1 0.12 0.65 0.04
87 INT107859 PRSS1 Positive_regulation of EDNRA 1 0.03 0.69 0.04
88 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
89 INT239229 Regulation of Binding of Edn1 and Ednra 1 0.01 0.37 0.03
90 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
91 INT115611 Binding of EDNRA and ERBB2 1 0.08 0.78 0
92 INT186603 Binding of ERBB2 and Ednra 1 0.02 0.53 0
93 INT334771 Binding of Ednra and Gfap 1 0.03 0 0
94 INT104029 RPGRIP1L Negative_regulation of Gene_expression of LTB 1 0.16 0.06 0
95 INT207374 Gene_expression of GLI2 Negative_regulation of Gene_expression of Chol1 1 0.04 0 0
96 INT185453 Binding of PRKCB and Lhx1 1 0.35 1.99 0
97 INT244857 Lbx1 Positive_regulation of Lhx1 1 0.37 0 0
98 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
99 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0
100 INT156367 Ednra Positive_regulation of Gene_expression of Il10 1 0.01 0 0
101 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
102 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for head development. They are ordered first by their pain relevance and then by number of times they were reported in head development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
2 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
3 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
4 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
5 INT142694 Positive_regulation of PGAP1 3 0.08 2.78 8.68
6 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
7 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
8 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
9 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
10 INT167049 Binding of Ednra 3 0.07 3.47 6.84
11 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
12 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
13 INT163913 Gene_expression of Il11ra1 18 0.69 12.62 5.34
14 INT322474 Regulation of PGAP1 1 0.38 4.82 5.06
15 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
16 INT322475 Negative_regulation of PGAP1 9 0.36 4.78 4.69
17 INT246315 Localization of Ednra 22 0.15 2.73 4.64
18 INT21953 Binding of Ednra 12 0.33 4.72 4.56
19 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
20 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32
21 INT49971 Regulation of Ednra 10 0.35 2.4 3.06
22 INT93058 Positive_regulation of Gene_expression of Ednra 8 0.28 4.11 2.88
23 INT163911 Negative_regulation of Il11ra1 4 0.39 6.43 2.73
24 INT76836 Positive_regulation of Ednra 6 0.55 2.65 2.72
25 INT89250 Positive_regulation of Il11ra1 8 0.63 3.99 2.27
26 INT163912 Binding of Il11ra1 5 0.33 5.06 2.22
27 INT156677 Regulation of Gene_expression of Ednra 4 0.15 0.25 2.05
28 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
29 INT72021 Localization of Ednra 7 0.58 3.13 1.53
30 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
31 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
32 INT163915 Positive_regulation of Gene_expression of Il11ra1 2 0.41 1.84 1.37
33 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
34 INT163910 Negative_regulation of Gene_expression of Il11ra1 3 0.39 2.11 1.08
35 INT142813 Localization of RPGRIP1L 1 0.59 0.99 1.01
36 INT119674 Localization of GLI2 6 0.52 2.84 0.99
37 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
38 INT72024 Localization of EDNRA 11 0.57 8.22 0.96
39 INT76835 Negative_regulation of Gene_expression of Ednra 2 0.10 0.89 0.96
40 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
41 INT178133 Negative_regulation of Positive_regulation of EDNRA 2 0.35 2.18 0.88
42 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
43 INT326487 Positive_regulation of Positive_regulation of PGAP1 1 0.01 0.07 0.8
44 INT186579 Positive_regulation of Gene_expression of Ednra 5 0.07 0.89 0.76
45 INT104840 Binding of GLI2 6 0.08 1.89 0.72
46 INT313697 Phosphorylation of Ednra 1 0.18 0 0.7
47 INT184053 Regulation of Il11ra1 3 0.16 2.03 0.68
48 INT186686 Regulation of Positive_regulation of EDNRA 5 0.22 2.35 0.51
49 INT126442 Negative_regulation of Gene_expression of Ednra 3 0.33 1.94 0.51
50 INT115202 Positive_regulation of Positive_regulation of Ednra 2 0.39 2.88 0.49
51 INT326485 Negative_regulation of Positive_regulation of PGAP1 1 0.01 0.08 0.49
52 INT120405 Phosphorylation of EDNRA 1 0.61 0.38 0.48
53 INT324888 Transcription of Ednra 2 0.13 0.66 0.43
54 INT158057 Positive_regulation of Positive_regulation of EDNRA 2 0.15 0 0.41
55 INT92197 Gene_expression of PGAP1 1 0.00 0.3 0.4
56 INT179795 Transcription of Il11ra1 1 0.50 0 0.36
57 INT176612 Localization of Il11ra1 2 0.71 0.86 0.33
58 INT176611 Negative_regulation of Localization of Il11ra1 1 0.03 0.89 0.33
59 INT176610 Positive_regulation of Localization of Il11ra1 1 0.03 0.86 0.33
60 INT72022 Positive_regulation of Localization of Ednra 2 0.32 0.07 0.3
61 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
62 INT350970 Negative_regulation of Binding of EDNRA 1 0.41 0.86 0.29
63 INT185428 Gene_expression of Lhx1 4 0.75 2.6 0.28
64 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
65 INT334747 Regulation of Binding of Ednra 1 0.06 0.05 0.28
66 INT322476 Positive_regulation of Negative_regulation of PGAP1 1 0.29 0.46 0.28
67 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
68 INT269045 Positive_regulation of Binding of Il11ra1 1 0.19 0.72 0.22
69 INT334746 Positive_regulation of Localization of Ednra 1 0.07 0 0.2
70 INT324881 Regulation of Transcription of Ednra 1 0.08 0.66 0.19
71 INT72023 Positive_regulation of Localization of EDNRA 1 0.02 0.07 0.18
72 INT72025 Negative_regulation of Localization of EDNRA 1 0.01 0.07 0.18
73 INT72020 Negative_regulation of Localization of Ednra 1 0.24 0.07 0.18
74 INT185427 Negative_regulation of Lhx1 4 0.42 3.48 0.17
75 INT173335 Negative_regulation of Gene_expression of EDNRA 2 0.19 0.71 0.17
76 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
77 INT316435 Positive_regulation of Positive_regulation of Il11ra1 1 0.46 0.29 0.15
78 INT70908 Transcription of EDNRA 1 0.08 0.33 0.12
79 INT70906 Negative_regulation of Transcription of EDNRA 1 0.05 0.33 0.12
80 INT316446 Phosphorylation of Il11ra1 1 0.57 0.44 0.09
81 INT282678 Negative_regulation of Ssbp3 1 0.02 1.53 0.08
82 INT334742 Negative_regulation of Transcription of Ednra 1 0.06 0 0.08
83 INT334749 Positive_regulation of Transcription of Ednra 1 0.07 0 0.08
84 INT283233 Regulation of Regulation of EDNRA 1 0.04 2.22 0.05
85 INT185429 Regulation of Lhx1 1 0.12 1.33 0.04
86 INT246353 Protein_catabolism of EDNRA 1 0.01 0.48 0.04
87 INT334738 Negative_regulation of Positive_regulation of Ednra 1 0.06 0 0.03
88 INT334748 Positive_regulation of Positive_regulation of Ednra 1 0.07 0 0.03
89 INT185426 Binding of Lhx1 1 0.36 1.96 0
90 INT35638 Localization of PGAP1 1 0.01 0.69 0
91 INT207371 Positive_regulation of Transcription of GLI2 1 0.03 0.08 0
92 INT282677 Gene_expression of Ssbp3 1 0.03 0.89 0
93 INT246319 Regulation of Gene_expression of Ednra 1 0.05 0 0
94 INT307407 Regulation of Localization of GLI2 1 0.01 0.67 0
95 INT207369 Transcription of GLI2 1 0.05 0.08 0
96 INT334743 Negative_regulation of Binding of Ednra 1 0.06 0 0
97 INT186688 Regulation of Binding of EDNRA 1 0.03 0.36 0
98 INT334741 Regulation of Localization of Ednra 1 0.06 0 0
99 INT186687 Negative_regulation of Regulation of EDNRA 1 0.03 0.28 0
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