GO:0060337

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Name type I interferon-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0060337
Unique Molecular Interactions 468
Total Molecular Interactions 721
Total Single Events 3958
Pain Genes Associated 30

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for type I interferon-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for type I interferon-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
2 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
3 INT152035 Binding of HLA-A and MRAP 2 0.31 6.95 3.4
4 INT88883 IRF6 Positive_regulation of Nfkb1 1 0.11 0.53 2.01
5 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
6 INT172047 Binding of HLA-A and LRRC23 1 0.22 3.32 1.64
7 INT174503 Binding of HLA-B and KIR3DL1 6 0.37 3.48 1.61
8 INT107965 Binding of HLA-B and Mefv 2 0.34 3.91 1.61
9 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
10 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49
11 INT318491 IRF6 Positive_regulation of FPR2 1 0.10 6.14 1.44
12 INT55837 Binding of HLA-B and PHB2 3 0.20 3.52 1.37
13 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
14 INT184402 Binding of HLA-DRB4 and HLA-E 1 0.00 3.1 1.19
15 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
16 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14
17 INT107269 Binding of HLA-A and NCR3 1 0.35 1.42 1.1
18 INT122889 Ifng Positive_regulation of Gene_expression of HLA-E 1 0.02 0.97 1.1
19 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1
20 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
21 INT142661 Binding of IFIT1 and NPY2R 1 0.00 2.49 1.08
22 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
23 INT318490 IRF6 Positive_regulation of LTB4R 1 0.01 4.39 1.03
24 INT88881 Negative_regulation of IRF6 Positive_regulation of Nfkb1 1 0.09 0.27 1.03
25 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02
26 INT74934 Regulation of IRF6 Positive_regulation of Nfkb1 1 0.01 0.52 1.02
27 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
28 INT74933 IRF6 Positive_regulation of Nfkb1 1 0.02 0.52 1.01
29 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
30 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
31 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
32 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
33 INT227325 Binding of IRF6 and Cd14 1 0.01 2.51 0.93
34 INT143323 Binding of HLA-B and HP 1 0.04 0.95 0.93
35 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91
36 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9
37 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
38 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88
39 INT343847 IRF6 Positive_regulation of TBCE 1 0.01 1.11 0.87
40 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
41 INT167947 Binding of STAT1 and Oprm1 1 0.00 0 0.86
42 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
43 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
44 INT286346 IRF6 Positive_regulation of IL8 3 0.03 0.88 0.8
45 INT221415 IRF6 Positive_regulation of Gene_expression of IL10 2 0.05 1.73 0.75
46 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
47 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
48 INT172097 Binding of HLA-E and Trav6-3 10 0.02 3.71 0.71
49 INT240729 Binding of CRP and HLA-A 1 0.11 2.18 0.71
50 INT106600 ZNF398 Negative_regulation of Protein_catabolism of IFI27 1 0.03 0.21 0.7
51 INT104835 IRF6 Positive_regulation of IL10 4 0.32 0.91 0.69
52 INT28711 Binding of HLA-B and MRAP 2 0.23 0.96 0.69
53 INT129919 IFNA2 Positive_regulation of Gene_expression of SLC6A4 1 0.02 0.38 0.69
54 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
55 INT318476 IRF6 Positive_regulation of Localization of RETNLB 1 0.00 1.42 0.65
56 INT129920 IFNA2 Regulation of ADO 1 0.00 0.64 0.64
57 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64
58 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64
59 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
60 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
61 INT169101 Binding of HLA-A and HLA-DRB1 1 0.24 1.09 0.63
62 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
63 INT115592 IRF6 Positive_regulation of Gene_expression of FAS 1 0.34 0.34 0.62
64 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
65 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 0.52 0.42 0.61
66 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 0.52 0.42 0.61
67 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
68 INT85489 IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
69 INT85488 Negative_regulation of IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
70 INT122096 Binding of HLA-B and SFTPA1 2 0.04 1.81 0.6
71 INT174504 Binding of HLA-B and KIR3DL2 2 0.24 1.69 0.59
72 INT318481 IRF6 Positive_regulation of Gene_expression of FPR2 1 0.14 5.09 0.59
73 INT318487 Negative_regulation of IRF6 Positive_regulation of FPR2 1 0.09 1.39 0.59
74 INT263454 Negative_regulation of IRF6 Positive_regulation of TNF 1 0.12 0.49 0.59
75 INT87683 Binding of HLA-B and Prnd 1 0.00 0.59 0.59
76 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58
77 INT162742 Binding of HLA-A and KIR3DL1 1 0.40 0.68 0.58
78 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
79 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
80 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
81 INT286349 IRF6 Positive_regulation of Localization of IL10 1 0.03 1.22 0.55
82 INT318478 Negative_regulation of IRF6 Positive_regulation of LTB4R 1 0.01 2.38 0.53
83 INT120852 PRL Positive_regulation of IRF1 1 0.44 0.99 0.51
84 INT343859 Binding of IRF6 and TBCE 1 0.01 1.1 0.51
85 INT121821 Binding of STAT1 and Olr1583 1 0.00 0.21 0.51
86 INT97800 Gm5564 Regulation of IRF6 1 0.00 0.07 0.5
87 INT343825 IRF6 Regulation of Gene_expression of FUT1 1 0.00 1.74 0.5
88 INT341593 Binding of HLA-E and IL23R 1 0.15 1.15 0.5
89 INT217037 Binding of IRF6 and Il12a 1 0.01 0.08 0.5
90 INT169400 Negative_regulation of IRF6 Positive_regulation of Gene_expression of Il1b 1 0.50 0.62 0.5
91 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5
92 INT36143 Binding of SERPINH1 and HLA-B 1 0.00 0.66 0.49
93 INT120854 IRF1 Positive_regulation of Localization of TNF 1 0.20 0.94 0.49
94 INT84515 IRF6 Positive_regulation of Gene_expression of F2 1 0.02 0.15 0.49
95 INT348173 Binding of HLA-B and IL23R 1 0.15 0.92 0.49
96 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49
97 INT289462 Negative_regulation of IRF6 Positive_regulation of IL1B 2 0.04 0.31 0.48
98 INT172096 Binding of HLA-E and Il27ra 2 0.01 1.32 0.48
99 INT127663 IRF6 Positive_regulation of PDE4A 1 0.14 0.76 0.48
100 INT289463 IRF6 Positive_regulation of Localization of IL1B 1 0.05 0.52 0.48
101 INT328936 Binding of HLA-B and KIR3DS1 1 0.25 0.7 0.48
102 INT217040 Negative_regulation of IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
103 INT340440 Binding of HLA-B and BTG3 1 0.05 1.57 0.47
104 INT217039 IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
105 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46
106 INT48848 Binding of HLA-B and HLA-E 3 0.34 1.95 0.45
107 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45
108 INT45035 Binding of HLA-B and HLA-DRB4 2 0.16 0.74 0.44
109 INT79151 Binding of HLA-B and OLAH 1 0.01 0.79 0.44
110 INT84517 IRF6 Positive_regulation of TF 1 0.14 0.19 0.44
111 INT188564 IRF6 Positive_regulation of Gene_expression of PRF1 1 0.01 0.44 0.44
112 INT188565 IRF6 Regulation of Gene_expression of CD28 1 0.03 0.7 0.43
113 INT174507 Binding of HLA-B and LILRB4 1 0.02 1.16 0.43
114 INT243682 IRF6 Positive_regulation of NEU2 1 0.01 0.18 0.43
115 INT343853 IRF6 Positive_regulation of PECAM1 1 0.00 0.53 0.43
116 INT188562 IRF6 Regulation of Gene_expression of PRF1 1 0.01 0.7 0.43
117 INT79150 HLA-B Positive_regulation of OLAH 1 0.02 0.77 0.43
118 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42
119 INT293007 IRF6 Positive_regulation of ELANE 1 0.00 0 0.42
120 INT328935 Binding of HLA-G and KIR2DS4 1 0.39 0.75 0.41
121 INT84518 IRF6 Positive_regulation of Gene_expression of TF 1 0.14 0.09 0.41
122 INT184406 Binding of HLA-DRB1 and HLA-E 1 0.00 1.03 0.4
123 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4
124 INT349290 Binding of HLA-B and SPATA19 1 0.00 1.25 0.4
125 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
126 INT183924 Binding of CHI3L1 and HLA-E 1 0.08 0.9 0.39
127 INT234607 Socs3 Negative_regulation of JAK1 1 0.01 0.54 0.39
128 INT237369 SOAT1 Negative_regulation of Phosphorylation of JAK1 1 0.00 0 0.38
129 INT127587 Binding of HLA-B and CD300A 1 0.00 0.84 0.38
130 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
131 INT318489 Positive_regulation of IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38
132 INT318482 IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38
133 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
134 INT144044 IRF6 Positive_regulation of PTGES 1 0.10 0.43 0.37
135 INT118285 Binding of EFNA1 and HLA-B 1 0.03 0.29 0.37
136 INT286351 IL8 Positive_regulation of Gene_expression of IRF6 1 0.03 0.71 0.36
137 INT286350 IL6 Positive_regulation of Gene_expression of IRF6 1 0.04 0.71 0.36
138 INT185379 Binding of IRF6 and TLR2 4 0.08 2.88 0.35
139 INT250781 IRF6 Positive_regulation of AMIGO2 1 0.02 1.25 0.35
140 INT312124 EGR1 Regulation of Binding of PTGES 1 0.31 0.41 0.35
141 INT318484 IRF6 Positive_regulation of Positive_regulation of LTB4R 1 0.01 1.38 0.35
142 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35
143 INT144048 IRF6 Positive_regulation of Gene_expression of PTGES 1 0.12 0.46 0.35
144 INT318486 IRF6 Positive_regulation of Negative_regulation of FPR2 1 0.10 1.39 0.35
145 INT182126 IRF6 Positive_regulation of Gene_expression of SELE 1 0.03 0.86 0.34
146 INT133021 IRF6 Positive_regulation of Gene_expression of IL8 1 0.11 0.51 0.32
147 INT204091 Binding of HLA-G and KIR2DL1 1 0.15 0.86 0.32
148 INT76088 IFNA1 Positive_regulation of IRF6 1 0.19 0.18 0.31
149 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
150 INT76086 IRF6 Positive_regulation of ISYNA1 1 0.07 0.18 0.31
151 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
152 INT105437 IRF6 Positive_regulation of Localization of PTGER1 1 0.01 0.61 0.31
153 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
154 INT187523 IRF6 Positive_regulation of Gene_expression of Cpox 1 0.00 1.38 0.31
155 INT105438 IRF6 Positive_regulation of PTGER1 1 0.01 0.61 0.3
156 INT227760 Binding of HLA-A and HLA-B 1 0.20 3.35 0.3
157 INT160923 Binding of ACLS and HLA-B 1 0.03 1.44 0.29
158 INT318480 IRF6 Positive_regulation of Gene_expression of LTB4R 1 0.01 1.63 0.29
159 INT160924 Binding of ACLS and HLA-A 1 0.01 1.44 0.29
160 INT250951 Binding of HLA-E and SFTPA1 1 0.01 0.44 0.29
161 INT250958 Binding of HLA-A and SFTPA1 1 0.01 0.45 0.29
162 INT45048 Binding of HLA-B and TNFRSF10B 1 0.21 0.44 0.29
163 INT141882 Binding of CD8A and HLA-A 1 0.32 0.9 0.29
164 INT174499 Binding of CD4 and HLA-E 1 0.04 1.08 0.29
165 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28
166 INT181843 PHB2 Regulation of HLA-B 1 0.03 1.4 0.28
167 INT294709 IRF6 Positive_regulation of Gene_expression of CCL2 1 0.08 0.14 0.28
168 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
169 INT193479 TLR2 Regulation of Binding of IRF6 1 0.04 0.75 0.28
170 INT295472 IRF6 Positive_regulation of Gene_expression of TNF 2 0.16 0.95 0.27
171 INT71640 Binding of HLA-A and TYR 1 0.16 0.36 0.27
172 INT318477 Regulation of IRF6 Positive_regulation of LTB4R 1 0.00 1 0.27
173 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
174 INT71642 Binding of HLA-A and PMEL 2 0.20 1.05 0.26
175 INT71643 Binding of HLA-A and TYRP1 1 0.24 0.36 0.26
176 INT174506 Binding of HLA-B and HLA-G 1 0.01 0.41 0.26
177 INT155530 IRF6 Regulation of Gene_expression of IL8 1 0.06 0.79 0.26
178 INT71641 Binding of MLANA and HLA-A 1 0.28 0.36 0.26
179 INT155529 IRF6 Regulation of Transcription of IL6 1 0.08 0.79 0.26
180 INT125521 EGR1 Regulation of GDF15 1 0.13 0.47 0.26
181 INT267631 IRF6 Positive_regulation of Gene_expression of Il1 1 0.00 0.96 0.25
182 INT179233 IRF6 Negative_regulation of Binding of GSR 1 0.03 0.83 0.25
183 INT355567 IRF6 Positive_regulation of MIF 1 0.01 0.29 0.25
184 INT162743 Binding of HLA-A and TNFRSF10B 1 0.40 0.4 0.25
185 INT188561 IRF6 Positive_regulation of Transcription of CD14 1 0.03 0.25 0.25
186 INT120853 PRL Positive_regulation of Positive_regulation of IRF1 1 0.41 0.49 0.25
187 INT14065 IRF6 Positive_regulation of PCA 1 0.24 0.51 0.24
188 INT98631 Negative_regulation of VEGFA Positive_regulation of EGR1 1 0.44 0.18 0.24
189 INT14064 Negative_regulation of IRF6 Positive_regulation of PCA 1 0.22 0.52 0.24
190 INT98630 VEGFA Positive_regulation of EGR1 1 0.52 0.18 0.24
191 INT144967 MAPK1 Positive_regulation of Positive_regulation of EGR1 1 0.08 0.63 0.24
192 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23
193 INT318485 Positive_regulation of IRF6 Positive_regulation of LTB4R 1 0.00 1.03 0.23
194 INT41787 IFNA2 Negative_regulation of Glb1 1 0.04 0.09 0.23
195 INT355981 IFNAR2 Positive_regulation of IDO1 1 0.01 1.13 0.23
196 INT260870 Binding of HLA-E and IL7R 1 0.19 0.5 0.22
197 INT84522 IRF6 Positive_regulation of Gene_expression of F3 1 0.08 0.1 0.21
198 INT103869 Binding of IRF6 and Positive_regulation of Hmox1 1 0.10 0.27 0.21
199 INT299787 Binding of IL2 and ISG20 1 0.04 0.82 0.21
200 INT156251 Binding of HLA-A and Drb1 2 0.15 0.64 0.19

Single Events

The table below shows the top 100 pain related interactions that have been reported for type I interferon-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in type I interferon-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1878 Binding of HLA-B 440 0.48 321.16 127.36
2 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37
3 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72
4 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81
5 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51
6 INT19330 Binding of HLA-A 99 0.48 76.26 22.85
7 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08
8 INT97798 Localization of IRF6 86 0.73 33.27 20.94
9 INT22046 Negative_regulation of IRF6 52 0.43 25.69 14.13
10 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1
11 INT11699 Binding of HLA-E 85 0.47 52.51 13.41
12 INT99586 Binding of IRF6 60 0.36 27.87 13.2
13 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58
14 INT49660 Positive_regulation of EGR1 54 0.69 32.17 9.89
15 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46
16 INT73021 Gene_expression of EGR1 43 0.77 24.65 9.18
17 INT80420 Gene_expression of IFI27 145 0.78 63.61 8.83
18 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68
19 INT3353 Localization of HLA-B 25 0.75 16.05 8.62
20 INT28671 Positive_regulation of Gene_expression of HLA-E 43 0.67 22.85 8.39
21 INT5284 Regulation of HLA-B 25 0.59 12.91 7.74
22 INT73022 Positive_regulation of Gene_expression of EGR1 21 0.69 10.61 6.5
23 INT5871 Binding of IFNA2 38 0.48 20.35 6.46
24 INT76096 Positive_regulation of Gene_expression of IRF6 37 0.49 14.24 6.39
25 INT150417 Negative_regulation of Gene_expression of IRF6 20 0.41 11.48 6.28
26 INT4697 Positive_regulation of Gene_expression of HLA-B 32 0.61 17.32 5.97
27 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46
28 INT64767 Negative_regulation of Gene_expression of HLA-E 18 0.57 12.64 5.23
29 INT5297 Regulation of IFNA2 20 0.56 10.81 5.13
30 INT15797 Positive_regulation of HLA-E 36 0.67 15.17 5.07
31 INT57376 Transcription of EGR1 20 0.69 12.94 4.84
32 INT138779 Positive_regulation of Localization of IRF6 25 0.45 11.51 4.51
33 INT5870 Negative_regulation of IFNA2 20 0.49 12 4.3
34 INT15802 Positive_regulation of Gene_expression of ISG20 16 0.42 8.16 4.03
35 INT80421 Positive_regulation of IFI27 26 0.65 15.32 3.93
36 INT118583 Positive_regulation of IRF1 10 0.68 3.75 3.91
37 INT174195 Negative_regulation of HLA-E 31 0.42 11.98 3.88
38 INT97799 Regulation of IRF6 23 0.26 6.54 3.75
39 INT94408 Positive_regulation of Gene_expression of IFI27 28 0.65 12.89 3.53
40 INT76098 Positive_regulation of Positive_regulation of IRF6 16 0.27 6.05 3.35
41 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29
42 INT19331 Positive_regulation of HLA-A 12 0.49 7.72 3.28
43 INT181008 Negative_regulation of Localization of IRF6 13 0.14 2.32 2.96
44 INT16959 Positive_regulation of Binding of HLA-B 8 0.50 6.77 2.96
45 INT2249 Negative_regulation of Binding of HLA-B 5 0.54 6.82 2.94
46 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7
47 INT65472 Binding of HLA-G 9 0.36 6.06 2.6
48 INT237700 Regulation of Negative_regulation of IRF6 2 0.11 1.08 2.58
49 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57
50 INT98634 Positive_regulation of Positive_regulation of EGR1 9 0.68 3.43 2.47
51 INT50006 Regulation of HLA-E 12 0.44 8.78 2.37
52 INT34644 Binding of HLA-C 19 0.47 9.41 2.2
53 INT105332 Regulation of Gene_expression of IFI27 14 0.45 8.39 2.02
54 INT15799 Positive_regulation of ISG20 18 0.38 9.78 2.01
55 INT106607 Protein_catabolism of IFI27 6 0.93 1.76 2.01
56 INT76008 Positive_regulation of ADAR 7 0.60 2.24 2
57 INT118884 Gene_expression of IRF1 5 0.66 2.71 2
58 INT117545 Regulation of Gene_expression of HLA-A 2 0.33 2.3 1.99
59 INT85178 Gene_expression of OAS2 10 0.21 4.17 1.93
60 INT118882 Positive_regulation of Gene_expression of IRF1 1 0.49 1.35 1.92
61 INT100689 Negative_regulation of JAK1 8 0.57 5.36 1.87
62 INT73023 Binding of EGR1 7 0.48 4.23 1.86
63 INT101013 Regulation of HLA-A 7 0.33 6.7 1.8
64 INT57375 Regulation of EGR1 5 0.40 1.94 1.78
65 INT119837 Positive_regulation of Gene_expression of STAT1 6 0.49 3.66 1.73
66 INT122951 Regulation of Binding of HLA-B 4 0.39 3.08 1.65
67 INT206144 Phosphorylation of JAK1 6 0.57 1.77 1.64
68 INT62430 Negative_regulation of HLA-A 5 0.32 4.3 1.63
69 INT186064 Phosphorylation of STAT1 19 0.59 7.14 1.48
70 INT188397 Regulation of Positive_regulation of IRF6 4 0.12 1.34 1.47
71 INT22075 Positive_regulation of Gene_expression of IFNA2 7 0.64 4.7 1.45
72 INT98635 Negative_regulation of Gene_expression of EGR1 5 0.58 2.2 1.42
73 INT121820 Binding of STAT1 9 0.46 2.54 1.4
74 INT95367 Negative_regulation of Positive_regulation of IRF6 7 0.21 3.5 1.34
75 INT106605 Regulation of Protein_catabolism of IFI27 1 0.42 0.46 1.29
76 INT69398 Regulation of Gene_expression of HLA-E 14 0.60 3.54 1.27
77 INT260114 Regulation of ISG20 5 0.37 4.98 1.27
78 INT260111 Localization of ISG20 6 0.41 3.46 1.25
79 INT119827 Gene_expression of PTPN11 31 0.75 24.21 1.22
80 INT155846 Transcription of JAK1 4 0.67 1.93 1.19
81 INT82547 Negative_regulation of Gene_expression of ISG20 7 0.29 3.04 1.18
82 INT121814 Regulation of STAT1 3 0.43 0.83 1.15
83 INT179884 Gene_expression of SOCS3 10 0.67 16.57 1.14
84 INT98633 Negative_regulation of Transcription of EGR1 3 0.43 0.79 1.11
85 INT160010 Positive_regulation of Transcription of IFI27 1 0.28 0.98 1.1
86 INT160007 Transcription of IFI27 1 0.38 0.97 1.09
87 INT147336 Gene_expression of HLA-G 12 0.75 7.27 1.08
88 INT40189 Localization of IFNA2 6 0.74 7.7 1.04
89 INT185929 Regulation of Gene_expression of IRF6 9 0.20 1.66 0.99
90 INT55562 Gene_expression of IFNAR2 2 0.31 0.44 0.98
91 INT139019 Negative_regulation of STAT1 10 0.57 5.04 0.97
92 INT64903 Positive_regulation of HLA-C 3 0.49 2.54 0.93
93 INT748 Transcription of HLA-B 6 0.67 1.56 0.91
94 INT98638 Positive_regulation of Transcription of EGR1 3 0.49 2.83 0.91
95 INT128424 Transcription of STAT1 5 0.37 3.28 0.9
96 INT37080 Negative_regulation of OAS2 4 0.05 1.3 0.89
97 INT303636 Gene_expression of OAS1 6 0.56 2.29 0.87
98 INT240736 Localization of HLA-A 7 0.21 6.88 0.86
99 INT174516 Regulation of Gene_expression of ISG20 6 0.27 4.2 0.85
100 INT328959 Localization of HLA-G 3 0.73 2.22 0.83
101 INT11698 Positive_regulation of Gene_expression of HLA-A 5 0.67 4.64 0.76
102 INT106621 Negative_regulation of Protein_catabolism of IFI27 3 0.40 0.49 0.76
103 INT98636 Negative_regulation of Positive_regulation of EGR1 3 0.58 2.21 0.73
104 INT30568 Regulation of IFNAR2 2 0.12 0.42 0.73
105 INT10710 Positive_regulation of Positive_regulation of HLA-B 2 0.38 0.83 0.73
106 INT140637 Negative_regulation of IFI27 11 0.40 9.48 0.69
107 INT119836 Positive_regulation of Gene_expression of PTPN11 5 0.67 3.44 0.69
108 INT5285 Regulation of Gene_expression of HLA-B 4 0.41 3.39 0.68
109 INT40190 Positive_regulation of Regulation of IFNA2 1 0.49 0.07 0.68
110 INT128422 Positive_regulation of Positive_regulation of STAT1 5 0.35 4.24 0.67
111 INT106613 Regulation of IFI27 6 0.57 3.12 0.66
112 INT142662 Binding of IFIT1 2 0.02 2.26 0.66
113 INT93752 Positive_regulation of OAS2 2 0.13 0.67 0.64
114 INT278714 Regulation of Phosphorylation of STAT1 1 0.21 0.81 0.62
115 INT11700 Negative_regulation of Gene_expression of HLA-B 3 0.50 2.61 0.6
116 INT100941 Positive_regulation of Gene_expression of OAS2 2 0.16 0.53 0.6
117 INT164268 Phosphorylation of IFI27 3 0.39 5.82 0.59
118 INT161152 Binding of IRF9 1 0.04 0.28 0.59
119 INT185397 Positive_regulation of Binding of IRF6 3 0.12 0.56 0.57
120 INT73020 Positive_regulation of Binding of EGR1 1 0.49 0.46 0.56
121 INT36619 Gene_expression of SOCS1 9 0.44 4.83 0.55
122 INT264129 Protein_catabolism of JAK1 1 0.02 0.38 0.55
123 INT98632 Negative_regulation of EGR1 6 0.42 3.38 0.54
124 INT146523 Negative_regulation of Positive_regulation of IFI27 3 0.31 2.28 0.54
125 INT177951 Transcription of HLA-E 7 0.67 2.36 0.52
126 INT97796 Regulation of Localization of IRF6 2 0.20 0.32 0.5
127 INT129635 Positive_regulation of SOCS1 3 0.49 0.92 0.49
128 INT226580 Localization of JAK1 3 0.11 0.52 0.49
129 INT216998 Regulation of Binding of IRF6 2 0.05 0.06 0.48
130 INT237703 Phosphorylation of IRF6 2 0.05 0.91 0.47
131 INT29058 Localization of ADAR 2 0.75 3.88 0.46
132 INT188395 Regulation of Regulation of IRF6 1 0.06 0.89 0.46
133 INT179887 Positive_regulation of SOCS3 10 0.50 13.06 0.45
134 INT129636 Transcription of SOCS1 2 0.52 1.29 0.45
135 INT289471 Negative_regulation of Negative_regulation of IRF6 1 0.10 0.31 0.45
136 INT119826 Positive_regulation of PTPN11 2 0.45 2.67 0.43
137 INT328952 Negative_regulation of Localization of HLA-G 1 0.41 1.07 0.43
138 INT71024 Negative_regulation of Gene_expression of IFNA2 1 0.53 0.08 0.42
139 INT241304 Regulation of Transcription of PTPN11 3 0.43 4.49 0.41
140 INT321429 Positive_regulation of Gene_expression of PTPN6 1 0.03 1.78 0.41
141 INT260121 Regulation of Localization of ISG20 1 0.14 0.81 0.41
142 INT152647 Gene_expression of IRF7 2 0.57 4 0.4
143 INT328956 Positive_regulation of Localization of HLA-G 1 0.49 1.03 0.4
144 INT181007 Protein_catabolism of IRF6 3 0.61 1.17 0.39
145 INT279298 Gene_expression of JAK1 7 0.65 5.5 0.37
146 INT280551 Negative_regulation of Gene_expression of JAK1 2 0.41 1.02 0.37
147 INT22074 Negative_regulation of Regulation of IFNA2 1 0.39 1.16 0.36
148 INT30567 Negative_regulation of IFNAR2 1 0.03 1.12 0.36
149 INT144968 Positive_regulation of Localization of EGR1 1 0.69 0.82 0.35
150 INT317742 Positive_regulation of Transcription of JAK1 1 0.49 0.57 0.35
151 INT144970 Localization of EGR1 1 0.80 0.82 0.34
152 INT177954 Negative_regulation of Positive_regulation of HLA-E 2 0.07 0.61 0.33
153 INT188706 Localization of HLA-E 8 0.33 2.43 0.32
154 INT206142 Localization of STAT1 7 0.78 3.09 0.31
155 INT121817 Positive_regulation of Binding of STAT1 2 0.67 0.49 0.3
156 INT201084 Localization of HLA-C 2 0.73 1.04 0.3
157 INT44012 Phosphorylation of HLA-B 3 0.81 0.96 0.27
158 INT82541 Negative_regulation of ISG20 2 0.27 0.15 0.27
159 INT147335 Positive_regulation of Gene_expression of HLA-G 2 0.49 2.38 0.27
160 INT136760 Regulation of OAS2 1 0.01 0.21 0.27
161 INT234410 Binding of ISG20 4 0.22 1.66 0.26
162 INT280561 Binding of JAK1 2 0.26 0.39 0.26
163 INT252757 Negative_regulation of PTPN6 4 0.10 0.74 0.25
164 INT177838 Regulation of Gene_expression of EGR1 2 0.17 2.38 0.25
165 INT185399 Negative_regulation of Binding of IRF6 1 0.07 1.12 0.25
166 INT160925 Transcription of HLA-A 1 0.31 1.41 0.24
167 INT139765 Regulation of Positive_regulation of IFI27 1 0.02 0.44 0.24
168 INT303626 Positive_regulation of IFIT1 1 0.02 1.59 0.23
169 INT226426 Negative_regulation of SOCS3 2 0.15 10.24 0.22
170 INT258447 Positive_regulation of TYK2 1 0.21 1.27 0.21
171 INT118614 Regulation of IFIT1 1 0.00 0.38 0.21
172 INT263475 Negative_regulation of Protein_catabolism of IRF6 1 0.36 0.48 0.21
173 INT335716 Localization of IRF7 1 0.37 0.16 0.21
174 INT250818 Positive_regulation of Localization of IFNA2 4 0.12 5.06 0.2
175 INT241302 Transcription of PTPN11 3 0.67 2.81 0.2
176 INT152646 Positive_regulation of Gene_expression of IRF7 2 0.37 2.54 0.2
177 INT210199 Negative_regulation of Positive_regulation of ISG20 2 0.15 2.52 0.2
178 INT294137 Positive_regulation of Positive_regulation of HLA-E 1 0.09 0.33 0.2
179 INT321425 Gene_expression of PTPN6 1 0.03 0.89 0.2
180 INT333601 Phosphorylation of IRF3 6 0.73 2.09 0.19
181 INT177956 Positive_regulation of Transcription of HLA-E 3 0.49 1.02 0.19
182 INT121819 Regulation of Binding of STAT1 1 0.59 0.05 0.19
183 INT318506 Positive_regulation of Negative_regulation of IRF6 1 0.11 0.75 0.19
184 INT285553 Binding of IRF7 1 0.17 0.26 0.18
185 INT188215 Negative_regulation of Phosphorylation of STAT1 2 0.31 0.48 0.17
186 INT250970 Positive_regulation of Localization of HLA-B 1 0.48 0.57 0.17
187 INT346978 Negative_regulation of IFIT1 1 0.13 1.83 0.17
188 INT156328 Protein_catabolism of HLA-B 1 0.09 0.17 0.17
189 INT343899 Localization of IRF1 1 0.23 0.12 0.17
190 INT131128 Gene_expression of ADAR 4 0.59 4.3 0.16
191 INT115159 Regulation of Positive_regulation of EGR1 1 0.20 0.18 0.16
192 INT20012 Positive_regulation of OAS1 3 0.45 1.14 0.15
193 INT335807 Localization of SOCS1 1 0.36 0.41 0.15
194 INT231559 Negative_regulation of Gene_expression of STAT1 2 0.06 0.36 0.14
195 INT328942 Negative_regulation of Binding of HLA-G 1 0.41 0.39 0.13
196 INT226477 Positive_regulation of Transcription of SOCS1 1 0.21 0.41 0.13
197 INT197053 Negative_regulation of Binding of HLA-E 1 0.20 1.07 0.12
198 INT333604 Localization of IRF3 1 0.71 2.75 0.12
199 INT246372 Positive_regulation of GBP2 1 0.04 0.48 0.11
200 INT273407 Transcription of SOCS3 1 0.62 0.17 0.11
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